Detailed information for compound 773531

Basic information

Technical information
  • TDR Targets ID: 773531
  • Name: 3-[2-[(1-ethyl-6-methylquinolin-1-ium-2-yl)me thylidene]-1,3-benzothiazol-3-yl]propane-1-su lfonate
  • MW: 440.578 | Formula: C23H24N2O3S2
  • H donors: 0 H acceptors: 3 LogP: 4.98 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c(=Cc2sc3c([n+]2CCCS(=O)(=O)[O-])cccc3)ccc2c1ccc(c2)C
  • InChi: 1S/C23H24N2O3S2/c1-3-24-19(11-10-18-15-17(2)9-12-20(18)24)16-23-25(13-6-14-30(26,27)28)21-7-4-5-8-22(21)29-23/h4-5,7-12,15-16H,3,6,13-14H2,1-2H3
  • InChiKey: ZOMJFHYNIIYMQB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-[(1-ethyl-6-methyl-quinolin-1-ium-2-yl)methylene]-1,3-benzothiazol-3-yl]propane-1-sulfonate
  • 3-[2-[(1-ethyl-6-methyl-2-quinolin-1-iumyl)methylene]-1,3-benzothiazol-3-yl]propane-1-sulfonate
  • 3-[2-[(1-ethyl-6-methyl-quinolin-1-ium-2-yl)methylidene]-1,3-benzothiazol-3-yl]propane-1-sulfonate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/EGFR protein kinase 0.017 0.1615 0.1615
Echinococcus granulosus tyrosine protein kinase Lyn 0.0174 0.1665 0.1737
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.2107 0.2107
Echinococcus multilocularis tyrosine protein kinase Srms 0.0157 0.1468 0.1532
Schistosoma mansoni protein kinase 0.0098 0.0792 0.0827
Schistosoma mansoni hypothetical protein 0.0036 0.0077 0.008
Brugia malayi Peroxidasin 0.0066 0.0415 0.0415
Brugia malayi Disorganized muscle protein 1 0.0036 0.0077 0.0077
Brugia malayi P21-Rho-binding domain containing protein 0.0096 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Echinococcus granulosus tyrosine protein kinase Src64B 0.0172 0.1643 0.1714
Schistosoma mansoni nck2/grb4 0.0031 0.0016 0.0016
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0052 0.0256 0.0267
Echinococcus multilocularis peroxidasin 0.0066 0.0415 0.0433
Brugia malayi Prion-like- 0.0036 0.0077 0.0077
Schistosoma mansoni vesicular amine transporter 0.0088 0.0668 0.0697
Loa Loa (eye worm) hypothetical protein 0.0088 0.0668 0.0668
Echinococcus granulosus c src tyrosine kinase 0.0052 0.0256 0.0267
Onchocerca volvulus 0.0051 0.0247 0.0964
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0036 0.0081 0.0085
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0036 0.0081 0.0085
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0102 0.0833 0.0833
Loa Loa (eye worm) projectin 0.0036 0.0077 0.0077
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0066 0.0415 0.0433
Loa Loa (eye worm) hypothetical protein 0.0066 0.0415 0.0415
Echinococcus granulosus tyrosine kinase 0.0157 0.1468 0.1532
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0415 0.0415
Entamoeba histolytica protein kinase, putative 0.0098 0.0792 0.3821
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0138 0.1246 0.1246
Entamoeba histolytica protein kinase, putative 0.0142 0.1289 0.6493
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0172 0.1643 0.1714
Schistosoma mansoni tyrosine kinase 0.0101 0.0818 0.0854
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0172 0.1643 0.1714
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0172 0.1643 0.1714
Echinococcus multilocularis titin 0.0036 0.0077 0.008
Brugia malayi SRC-1 0.0172 0.1643 0.1643
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0415 0.0415
Trypanosoma cruzi p21-activated kinase 3, putative 0.0102 0.0833 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0415 0.0415
Brugia malayi Tyrosine-protein kinase abl-1 0.0052 0.0256 0.0256
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0036 0.0077 0.008
Schistosoma mansoni nephrin related 0.0036 0.0077 0.008
Echinococcus multilocularis down syndrome cell adhesion 0.0036 0.0077 0.008
Echinococcus multilocularis tyrosine kinase 0.0036 0.0081 0.0085
Entamoeba histolytica p21-activated kinase 0.0198 0.1942 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0066 0.0415 0.0415
Echinococcus granulosus down syndrome cell adhesion 0.0036 0.0077 0.008
Echinococcus granulosus roundabout 2 0.0153 0.1421 0.1482
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0098 0.0103
Brugia malayi Prion-like- 0.0036 0.0077 0.0077
Brugia malayi protein unc-22 0.0038 0.0098 0.0098
Echinococcus granulosus titin 0.0036 0.0077 0.008
Echinococcus granulosus epidermal growth factor receptor 0.0101 0.0818 0.0854
Echinococcus granulosus tyrosine protein kinase Src42A 0.0136 0.1228 0.1281
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0199 0.0208
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0096 0.077 0.077
Onchocerca volvulus Peroxidasin homolog 0.0036 0.0077 0.0263
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0077 0.0077
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0088 0.0668 0.0697
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0013 0.0013
Schistosoma mansoni tyrosine kinase 0.0052 0.0256 0.0267
Echinococcus granulosus tyrosine kinase 0.0036 0.0081 0.0085
Echinococcus multilocularis neuroglian 0.0124 0.1082 0.1129
Schistosoma mansoni tyrosine kinase 0.017 0.1615 0.1685
Schistosoma mansoni hypothetical protein 0.0036 0.0077 0.008
Onchocerca volvulus Netrin receptor homolog 0.0051 0.0247 0.0964
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0198 0.1942 0.2026
Brugia malayi hypothetical protein 0.0036 0.0081 0.0081
Schistosoma mansoni nephrin 0.0066 0.0415 0.0433
Schistosoma mansoni titin 0.0036 0.0077 0.008
Brugia malayi Fibronectin type III domain containing protein 0.0088 0.0668 0.0668
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0016 0.0016
Onchocerca volvulus Basement membrane proteoglycan homolog 0.008 0.0585 0.2354
Schistosoma mansoni tyrosine kinase 0.008 0.0578 0.0603
Schistosoma mansoni roundabout 0.0066 0.0415 0.0433
Brugia malayi Protein kinase domain 0.0198 0.1942 0.1942
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0088 0.0668 0.0668
Echinococcus multilocularis titin 0.0036 0.0077 0.008
Echinococcus granulosus hemicentin 1 0.008 0.0585 0.0611
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0088 0.0668 0.0697
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0016 0.0016
Onchocerca volvulus 0.0036 0.0077 0.0263
Loa Loa (eye worm) hypothetical protein 0.0036 0.0081 0.0081
Onchocerca volvulus 0.0036 0.0077 0.0263
Onchocerca volvulus 0.0038 0.0098 0.0353
Echinococcus multilocularis hemicentin 1 0.008 0.0585 0.0611
Loa Loa (eye worm) hypothetical protein 0.0066 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0038 0.0098 0.0098
Schistosoma mansoni growth factor receptor-bound protein 0.0031 0.0016 0.0016
Echinococcus multilocularis roundabout 2 0.0066 0.0415 0.0433
Echinococcus granulosus roundabout 2 0.0066 0.0415 0.0433
Schistosoma mansoni tyrosine kinase 0.0052 0.0256 0.0267
Brugia malayi Immunoglobulin I-set domain containing protein 0.0138 0.1246 0.1246
Loa Loa (eye worm) TK protein kinase 0.09 1 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.1006 0.1006
Onchocerca volvulus 0.0036 0.0081 0.0282
Loa Loa (eye worm) disorganized muscle protein 1 0.0036 0.0077 0.0077
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0863 0.9585 1
Schistosoma mansoni hypothetical protein 0.0036 0.0077 0.008
Echinococcus granulosus tyrosine protein kinase Fyn 0.0172 0.1643 0.1714
Loa Loa (eye worm) SRC-1 0.0172 0.1643 0.1643
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.026 0.2648 0.2763
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Brugia malayi Sex muscle abnormal protein 5 0.0031 0.0016 0.0016
Echinococcus granulosus neuroglian 0.0124 0.1082 0.1129
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0172 0.1643 0.1714
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0199 0.0208
Brugia malayi Prion-like- 0.0036 0.0077 0.0077
Echinococcus granulosus tyrosine protein kinase Srms 0.0036 0.0081 0.0085
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0066 0.0415 0.0415
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0102 0.0833 0.0249
Echinococcus multilocularis tyrosine protein kinase Blk 0.0157 0.1468 0.1532
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0066 0.0415 0.0433
Echinococcus multilocularis PAK box P21 Rho binding 0.0098 0.0792 0.0827
Schistosoma mansoni hypothetical protein 0.0096 0.077 0.0804
Onchocerca volvulus 0.0036 0.0077 0.0263
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0077 0.0077
Brugia malayi Protein kinase domain containing protein 0.0068 0.0443 0.0443
Loa Loa (eye worm) TK/INSR protein kinase 0.0068 0.0443 0.0443
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0198 0.1942 0.2026
Echinococcus granulosus tyrosine protein kinase Blk 0.0157 0.1468 0.1532
Echinococcus multilocularis Immunoglobulin 0.0088 0.0668 0.0697
Brugia malayi Protein kinase domain containing protein 0.0036 0.0081 0.0081
Loa Loa (eye worm) TK/ROR protein kinase 0.0057 0.0317 0.0317
Onchocerca volvulus 0.0051 0.0247 0.0964
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0199 0.0208
Loa Loa (eye worm) hypothetical protein 0.0153 0.1421 0.1421
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0081 0.0081
Entamoeba histolytica hypothetical protein 0.0096 0.077 0.3704
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Echinococcus multilocularis tyrosine protein kinase otk 0.0066 0.0415 0.0433
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0044 0.0171 0.0178
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0096 0.077 0.0804
Onchocerca volvulus 0.0036 0.0077 0.0263
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0088 0.0668 0.0697
Schistosoma mansoni cell adhesion molecule 0.0036 0.0077 0.008
Onchocerca volvulus 0.0036 0.0081 0.0282
Loa Loa (eye worm) TK protein kinase 0.0142 0.1289 0.1289
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0057 0.0317 0.0331
Echinococcus multilocularis neuroglian 0.0066 0.0415 0.0433
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0172 0.1643 0.1714
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0066 0.0415 0.0415
Trichomonas vaginalis set domain proteins, putative 0.0242 0.2445 1
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0102 0.0833 0.5
Schistosoma mansoni nephrin 0.0124 0.1082 0.1129
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0057 0.0317 0.0331
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0198 0.1942 0.2026
Onchocerca volvulus 0.0036 0.0077 0.0263
Entamoeba histolytica protein kinase, putative 0.0198 0.1942 1
Schistosoma mansoni titin 0.008 0.0585 0.0611
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0031 0.0016 0.0016
Echinococcus multilocularis tyrosine protein kinase Abl 0.0052 0.0256 0.0267
Echinococcus granulosus tyrosine protein kinase shark 0.0036 0.0081 0.0085
Schistosoma mansoni tyrosine kinase 0.0036 0.0081 0.0085
Echinococcus multilocularis epidermal growth factor receptor 0.0101 0.0818 0.0854
Echinococcus granulosus epidermal growth factor receptor 0.017 0.1615 0.1685
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Schistosoma mansoni tyrosine kinase 0.0863 0.9585 1
Onchocerca volvulus 0.0036 0.0077 0.0263
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0036 0.0077 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Schistosoma mansoni cell adhesion molecule 0.0036 0.0077 0.008
Entamoeba histolytica protein kinase, putative 0.0098 0.0792 0.3821
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0136 0.1228 0.1281
Schistosoma mansoni tyrosine kinase 0.008 0.0578 0.0603
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0199 0.0199
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0081 0.0081
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0157 0.1468 0.1532
Schistosoma mansoni septate junction protein 0.0066 0.0415 0.0433
Trichomonas vaginalis STE family protein kinase 0.0198 0.1942 0.6956
Plasmodium vivax SET domain protein, putative 0.0031 0.0013 0.5
Echinococcus granulosus lachesin 0.0066 0.0415 0.0433
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0199 0.0208
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Echinococcus granulosus twitchin 0.0126 0.1104 0.1152
Echinococcus granulosus tyrosine protein kinase HCK 0.0142 0.1289 0.1345
Echinococcus multilocularis titin 0.0038 0.0098 0.0103
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0172 0.1643 0.1714
Loa Loa (eye worm) one IG domain family member 0.0036 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0066 0.0415 0.0415
Brugia malayi kettin 0.0036 0.0077 0.0077
Echinococcus granulosus growth factor receptor bound protein 2 0.0031 0.0016 0.0016
Schistosoma mansoni tyrosine kinase 0.0101 0.0818 0.0854
Brugia malayi serine/threonine-protein kinase PAK 7 0.0356 0.3757 0.3757
Loa Loa (eye worm) hypothetical protein 0.0088 0.0668 0.0668
Echinococcus multilocularis hemicentin 1 0.0066 0.0415 0.0433
Onchocerca volvulus 0.0036 0.0077 0.0263
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0077 0.0077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Schistosoma mansoni cell adhesion molecule 0.0036 0.0077 0.008
Echinococcus multilocularis epidermal growth factor receptor 0.017 0.1615 0.1685
Echinococcus multilocularis 0.0046 0.0195 0.0204
Schistosoma mansoni hypothetical protein 0.0051 0.0247 0.0258
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.026 0.2648 0.2763
Echinococcus granulosus peroxidasin 0.0066 0.0415 0.0433
Schistosoma mansoni cell adhesion molecule 0.0066 0.0415 0.0433
Echinococcus multilocularis twitchin 0.0038 0.0098 0.0103
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0066 0.0415 0.0433
Schistosoma mansoni titin 0.0036 0.0077 0.008
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0081 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0199 0.0208
Schistosoma mansoni hypothetical protein 0.0036 0.0077 0.008
Onchocerca volvulus 0.0036 0.0081 0.0282
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0096 0.077 0.0804
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0157 0.1468 0.1532
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0098 0.0103
Schistosoma mansoni tyrosine kinase 0.008 0.0578 0.0603
Schistosoma mansoni protein kinase 0.0198 0.1942 0.2026
Loa Loa (eye worm) hypothetical protein 0.0088 0.0668 0.0668
Loa Loa (eye worm) hypothetical protein 0.0168 0.1591 0.1591
Onchocerca volvulus Tyrosine kinase homolog 0.0072 0.0487 0.1952
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0199 0.0208
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0356 0.3757 0.3757
Loa Loa (eye worm) hypothetical protein 0.0066 0.0415 0.0415
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0077 0.0077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0102 0.0833 0.0833
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.192 0.6824
Echinococcus multilocularis roundabout 2 0.0153 0.1421 0.1482
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0199 0.0199
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0066 0.0415 0.0433
Echinococcus multilocularis tyrosine protein kinase shark 0.0036 0.0081 0.0085
Brugia malayi Furin-like cysteine rich region family protein 0.017 0.1615 0.1615
Echinococcus multilocularis NCK adaptor protein 0.0031 0.0016 0.0016
Echinococcus granulosus nephrin 0.0036 0.0077 0.008
Brugia malayi P21-Rho-binding domain containing protein 0.0096 0.077 0.077
Brugia malayi Protein kinase domain containing protein 0.0036 0.0081 0.0081
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0052 0.0256 0.0267
Echinococcus granulosus tyrosine protein kinase Fyn 0.0172 0.1643 0.1714
Schistosoma mansoni cell adhesion molecule 0.0066 0.0415 0.0433
Trichomonas vaginalis STE family protein kinase 0.0198 0.1942 0.6956
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Echinococcus granulosus titin 0.0036 0.0077 0.008
Schistosoma mansoni titin 0.0038 0.0098 0.0103
Echinococcus multilocularis roundabout 2 0.0066 0.0415 0.0433
Schistosoma mansoni slit 0.0036 0.0077 0.008
Brugia malayi Prion-like- 0.0066 0.0415 0.0415
Schistosoma mansoni cell adhesion molecule 0.0066 0.0415 0.0433
Schistosoma mansoni neuroglian 0.0066 0.0415 0.0433
Brugia malayi hypothetical protein 0.0088 0.0668 0.0668
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0067 0.0437 0.0437
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0101 0.0818 0.0854
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Echinococcus granulosus titin 0.0036 0.0077 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0415 0.0415
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0088 0.0668 0.0668
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0198 0.1942 0.2026
Loa Loa (eye worm) hypothetical protein 0.0197 0.192 0.192
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0077 0.0077
Echinococcus granulosus titin 0.0038 0.0098 0.0103
Schistosoma mansoni titin 0.0036 0.0077 0.008
Brugia malayi Protein kinase domain containing protein 0.0036 0.0081 0.0081
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0013 0.0013
Echinococcus granulosus insulin growth factor binding 0.0036 0.0077 0.008
Brugia malayi hypothetical protein 0.0044 0.0171 0.0171
Schistosoma mansoni growth factor receptor-bound protein 0.0031 0.0016 0.0016
Echinococcus granulosus PAK box P21 Rho binding 0.0096 0.077 0.0804
Onchocerca volvulus 0.0036 0.0081 0.0282
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0077 0.0077
Schistosoma mansoni tyrosine kinase 0.0117 0.1011 0.1054
Schistosoma mansoni tyrosine kinase 0.0068 0.0443 0.0462
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0066 0.0415 0.0433
Echinococcus granulosus tyrosine protein kinase Fyn 0.0172 0.1643 0.1714
Echinococcus granulosus tyrosine protein kinase ABL1 0.0036 0.0081 0.0085
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0066 0.0415 0.0415
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0036 0.0077 0.008
Echinococcus multilocularis 0.0036 0.0077 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0833 0.0869
Schistosoma mansoni tyrosine kinase 0.0172 0.1643 0.1714
Brugia malayi protein-tyrosine kinase 0.0157 0.1468 0.1468
Echinococcus multilocularis lachesin 0.0066 0.0415 0.0433
Echinococcus granulosus neuroglian 0.0066 0.0415 0.0433
Schistosoma mansoni cell adhesion molecule 0.0117 0.1006 0.1049
Echinococcus multilocularis insulin receptor 0.0068 0.0443 0.0462
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Brugia malayi WH1 domain containing protein 0.0096 0.077 0.077
Echinococcus multilocularis titin 0.0036 0.0077 0.008
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0863 0.9585 1
Echinococcus granulosus Immunoglobulin 0.0088 0.0668 0.0697
Echinococcus multilocularis transfer RNA-Phe 0.0036 0.0077 0.008
Echinococcus multilocularis growth factor receptor bound protein 2 0.0031 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0013 0.0013
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Echinococcus granulosus fibroblast growth factor receptor 4 0.0863 0.9585 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Trichomonas vaginalis STE family protein kinase 0.0198 0.1942 0.6956
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0102 0.0833 0.0833
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0172 0.1643 0.1714
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0172 0.1643 0.1714
Echinococcus granulosus roundabout 2 0.0066 0.0415 0.0433
Entamoeba histolytica hypothetical protein 0.0096 0.077 0.3704
Brugia malayi Myb-like DNA-binding domain containing protein 0.0036 0.0077 0.0077
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0198 0.1942 0.2026
Entamoeba histolytica protein kinase, putative 0.0098 0.0792 0.3821
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Brugia malayi SH2 domain containing protein 0.0036 0.0081 0.0081
Trichomonas vaginalis STE family protein kinase 0.0198 0.1942 0.6956
Schistosoma mansoni myosin-binding protein-related 0.0036 0.0077 0.008
Schistosoma mansoni protein kinase 0.0096 0.077 0.0804
Echinococcus multilocularis c src tyrosine kinase 0.0052 0.0256 0.0267
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0199 0.0208
Onchocerca volvulus 0.0036 0.0081 0.0282
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0415 0.0415
Echinococcus granulosus contactin 0.008 0.0585 0.0611
Schistosoma mansoni protein kinase 0.0198 0.1942 0.2026
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0066 0.0415 0.0433
Loa Loa (eye worm) animal heme peroxidase 0.0036 0.0077 0.0077
Schistosoma mansoni tyrosine kinase 0.0086 0.0655 0.0683
Brugia malayi Leucine Rich Repeat family protein 0.0036 0.0077 0.0077
Schistosoma mansoni tyrosine kinase 0.0068 0.0443 0.0462
Loa Loa (eye worm) TK/ABL protein kinase 0.0036 0.0081 0.0081
Echinococcus granulosus leucine rich repeat containing protein 4 0.0036 0.0077 0.008
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0117 0.1006 0.1049
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0031 0.0016 0.0016
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0036 0.0077 0.008
Schistosoma mansoni titin 0.0036 0.0077 0.008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0415 0.0415
Loa Loa (eye worm) TK protein kinase 0.0157 0.1468 0.1468
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0013 0.0013
Onchocerca volvulus 0.0242 0.2445 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0833 0.0869
Loa Loa (eye worm) hypothetical protein 0.0031 0.0016 0.0016
Echinococcus multilocularis Immunoglobulin 0.0088 0.0668 0.0697
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Giardia lamblia Kinase, STE STE20 0.0198 0.1942 0.5
Loa Loa (eye worm) CAMK protein kinase 0.0038 0.0098 0.0098
Echinococcus granulosus tyrosine protein kinase Src42A 0.0172 0.1643 0.1714
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0096 0.077 0.0804
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0172 0.1643 0.1714
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0081 0.0081
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0198 0.1942 0.2026
Brugia malayi Protein kinase domain containing protein 0.0036 0.0081 0.0081
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0036 0.0077 0.008
Brugia malayi Animal haem peroxidase family protein 0.0036 0.0077 0.0077
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0081 0.0081
Echinococcus granulosus NCK adaptor protein 0.0031 0.0016 0.0016
Echinococcus multilocularis insulin growth factor binding 0.0036 0.0077 0.008
Schistosoma mansoni titin 0.0036 0.0077 0.008
Echinococcus granulosus insulin receptor 0.0068 0.0443 0.0462
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0052 0.0256 0.0267
Schistosoma mansoni adapter molecule crk 0.0031 0.0016 0.0016
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0081 0.0081
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0066 0.0415 0.0433
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0036 0.0077 0.008
Loa Loa (eye worm) hypothetical protein 0.0088 0.0668 0.0668
Brugia malayi Pre-SET motif family protein 0.0213 0.2107 0.2107
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0036 0.0077 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.1185 0.1237
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0096 0.077 0.0804
Brugia malayi Immunoglobulin I-set domain containing protein 0.0088 0.0668 0.0668
Onchocerca volvulus Putative titin 0.0051 0.0247 0.0964
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0066 0.0415 0.0415
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0068 0.0443 0.0462
Brugia malayi Protein kinase domain containing protein 0.0036 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Echinococcus multilocularis PAK box P21 Rho binding 0.0096 0.077 0.0804
Loa Loa (eye worm) hypothetical protein 0.0066 0.0415 0.0415
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0031 0.0016 0.0016
Schistosoma mansoni hemicentin 0.0036 0.0077 0.008
Loa Loa (eye worm) hypothetical protein 0.0066 0.0415 0.0415
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0077 0.0077
Echinococcus granulosus tyrosine protein kinase otk 0.0066 0.0415 0.0433
Schistosoma mansoni septate junction protein 0.0066 0.0415 0.0433
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0415 0.0415
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Brugia malayi SH2 domain containing protein 0.0036 0.0081 0.0081
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0036 0.0077 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0013 0.0013
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0066 0.0415 0.0433
Echinococcus granulosus titin 0.0038 0.0098 0.0103
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0415 0.0415
Schistosoma mansoni hypothetical protein 0.0096 0.077 0.0804
Echinococcus multilocularis tyrosine protein kinase HCK 0.0142 0.1289 0.1345
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0013 0.0013
Brugia malayi Pre-SET motif family protein 0.0031 0.0013 0.0013
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0096 0.077 0.0804
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Schistosoma mansoni tyrosine kinase 0.0036 0.0081 0.0085
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0172 0.1643 0.1714
Echinococcus granulosus defective proboscis extension response 0.0088 0.0668 0.0697
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0077 0.0077
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0013 0.5
Onchocerca volvulus 0.0036 0.0081 0.0282
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0036 0.0081 0.0085
Onchocerca volvulus 0.0036 0.0077 0.0263
Schistosoma mansoni tyrosine kinase 0.0172 0.1643 0.1714
Onchocerca volvulus Peroxidasin homolog 0.0036 0.0077 0.0263
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0415 0.0415
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0863 0.9585 1
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0081 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0013 0.0013
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0036 0.0077 0.008
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0077 0.0077
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0068 0.0443 0.0462
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Schistosoma mansoni titin 0.0036 0.0077 0.008
Schistosoma mansoni hypothetical protein 0.0036 0.0077 0.008
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.01 0.0812 0.0847
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0036 0.0077 0.008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0098 0.0098
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0172 0.1643 0.1714
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0077

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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