Detailed information for compound 776651

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 357.49 | Formula: C21H31N3O2
  • H donors: 1 H acceptors: 2 LogP: 2.91 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCC1CN(CCN1CC(C)C)Cc1ccc2c(n1)c(OC)ccc2
  • InChi: 1S/C21H31N3O2/c1-16(2)13-24-11-10-23(15-19(24)9-12-25)14-18-8-7-17-5-4-6-20(26-3)21(17)22-18/h4-8,16,19,25H,9-15H2,1-3H3
  • InChiKey: SWCVHGGKKZTHJE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase 0.0075 0.102 0.2378
Schistosoma mansoni hypothetical protein 0.0018 0.0111 0.0111
Entamoeba histolytica Ran family GTPase 0.0044 0.0521 0.3554
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0126 0.0856
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0126 0.0856
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0111 0.0258
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0521 0.2951
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0031 0.0209
Loa Loa (eye worm) hypothetical protein 0.0058 0.0739 0.0739
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.102 0.6669
Plasmodium falciparum importin beta, putative 0.006 0.0773 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0739 0.1723
Entamoeba histolytica hypothetical protein 0.0077 0.1052 0.7167
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.1467 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.028 0.028
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.102 0.2378
Loa Loa (eye worm) hypothetical protein 0.0075 0.102 0.102
Echinococcus granulosus calcium activated potassium channel 0.0094 0.1313 0.1313
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0593 0.3484
Brugia malayi Protein kinase domain containing protein 0.0281 0.429 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0475 0.1108
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0955 0.0955
Leishmania major DNA polymerase eta, putative 0.0045 0.0529 0.3608
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.3156 0.3156
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0126 0.0856
Brugia malayi Pre-SET motif family protein 0.0202 0.3032 0.7067
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1467 0.342
Mycobacterium tuberculosis Conserved protein 0.0075 0.102 0.1215
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0554 0.5427
Leishmania major GTP-binding protein, putative 0.0044 0.0521 0.3554
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0666 0.0666
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0593 0.1382
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2813 0.6557
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1467 0.342
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0521 0.6744
Plasmodium vivax importin-beta 2, putative 0.006 0.0773 0.7579
Loa Loa (eye worm) MBCTL1 0.006 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0075 0.102 0.102
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0126 0.0856
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1313 0.1313
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0521 0.5111
Mycobacterium leprae Probable lipase LipE 0.0075 0.102 1
Plasmodium vivax hypothetical protein, conserved 0.0075 0.102 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0126 0.0126
Brugia malayi mbt repeat family protein 0.0053 0.0666 0.1553
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0126 0.0126
Echinococcus granulosus importin subunit beta 1 0.006 0.0773 0.0773
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0773 0.7579
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0639 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.028 0.028
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0188 0.2813 0.2813
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0521 0.0521
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0126 0.0856
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0126 0.0126
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0475 0.3909
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0188 0.2813 0.2813
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0094 0.1313 0.1313
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.1467 0.342
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0111 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.1475 0.1475
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0093 0.1297 0.1297
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0554 0.129
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0475 0.2607
Mycobacterium ulcerans hypothetical protein 0.0075 0.102 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.1052 0.1052
Onchocerca volvulus 0.0075 0.102 0.2316
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.102 0.1215
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0126 0.0293
Onchocerca volvulus 0.0075 0.102 0.2316
Schistosoma mansoni importin beta-1 0.006 0.0773 0.0773
Loa Loa (eye worm) inositol-1 0.0041 0.0475 0.0475
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0094 0.1313 0.1313
Brugia malayi Kinase associated domain 1 family protein 0.0093 0.1297 0.3023
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0475 0.324
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0475 0.4659
Loa Loa (eye worm) hypothetical protein 0.0045 0.0529 0.0529
Loa Loa (eye worm) beta-lactamase 0.0075 0.102 0.102
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.102 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.1467 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0031 0.0209
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0529 0.301
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0666 0.1208
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.2316 0.2316
Mycobacterium leprae conserved hypothetical protein 0.0075 0.102 1
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1467 0.342
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1313 0.1313
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0666 0.0666
Brugia malayi Pre-SET motif family protein 0.0029 0.028 0.0653
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0955 0.2227
Schistosoma mansoni hypothetical protein 0.0093 0.1297 0.1297
Loa Loa (eye worm) hypothetical protein 0.0029 0.028 0.028
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.102 0.1215
Schistosoma mansoni ran 0.0044 0.0521 0.0521
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0126 0.0856
Loa Loa (eye worm) hypothetical protein 0.0053 0.0666 0.0666
Loa Loa (eye worm) hypothetical protein 0.006 0.0784 0.0784
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0784 0.0784
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1313 0.1313
Entamoeba histolytica hypothetical protein 0.0049 0.0593 0.4041
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0955 0.0955
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0773 0.5271
Trichomonas vaginalis ran, putative 0.0044 0.0521 0.1215
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.1052 0.1052
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0521 0.0521
Schistosoma mansoni DNA polymerase eta 0.0045 0.0529 0.0529
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.1467 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0554 0.5427
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.102 0.102
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0126 0.0856
Loa Loa (eye worm) hypothetical protein 0.0075 0.102 0.102
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0475 0.5
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0955 0.0955
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.102 0.1215
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0281 0.429 0.429
Trypanosoma brucei unspecified product 0.0013 0.0031 0.0209
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0666 0.0666
Leishmania major importin beta-1 subunit, putative 0.0049 0.0593 0.4041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1475 0.1475
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0739 0.0739
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0126 0.0856
Leishmania major hypothetical protein, conserved 0.0075 0.102 0.6954
Mycobacterium tuberculosis Conserved protein 0.0075 0.102 0.1215
Brugia malayi beta-lactamase family protein 0.0075 0.102 0.2378
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1475 0.1475
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0784 0.0784
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0111 0.0111
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0955 0.0955
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0666 0.0666
Mycobacterium ulcerans beta-lactamase 0.0075 0.102 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0475 0.1108
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0784 0.0784
Schistosoma mansoni serine/threonine kinase 0.0281 0.429 0.429
Toxoplasma gondii ABC1 family protein 0.0075 0.102 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0126 0.0856
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0318 0.312
Giardia lamblia Kinase, PLK 0.0103 0.1467 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0126 0.0856
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0111 0.0258
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0666 0.0666
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0529 0.3608
Onchocerca volvulus 0.0053 0.0666 0.1208
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0593 0.1382
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.102 0.2378
Schistosoma mansoni hypothetical protein 0.0018 0.0111 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0281 0.429 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0666 0.0666
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0554 0.5427
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.028 0.028
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.1467 0.1467
Mycobacterium ulcerans lipase LipD 0.0075 0.102 1
Brugia malayi hypothetical protein 0.0156 0.2304 0.537
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.102 0.102
Trichomonas vaginalis esterase, putative 0.0075 0.102 0.2378
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0261 0.3979 0.3979
Schistosoma mansoni hypothetical protein 0.0018 0.0111 0.0111
Brugia malayi RNA, U transporter 1 0.017 0.2531 0.59
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0448 0.1045
Loa Loa (eye worm) hypothetical protein 0.0075 0.102 0.102
Leishmania major DNA polymerase eta, putative 0.0031 0.0318 0.217
Schistosoma mansoni hypothetical protein 0.0323 0.4967 0.4967
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0018 0.0111 0.0111
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.102 0.102
Brugia malayi Importin beta-1 subunit 0.006 0.0773 0.1802
Onchocerca volvulus 0.0229 0.3476 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0481 0.749 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0126 0.0856
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.1467 0.1467
Echinococcus granulosus geminin 0.0374 0.5776 0.5776
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.028 0.2748
Echinococcus multilocularis snurportin 1 0.0639 1 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0126 0.0126
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0521 0.1215
Onchocerca volvulus 0.0156 0.2304 0.6333
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0784 0.0784
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1467 0.1467
Schistosoma mansoni hypothetical protein 0.0639 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.1475 0.1475
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2813 0.6557
Entamoeba histolytica hypothetical protein 0.0077 0.1052 0.7167
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.1467 0.1467
Echinococcus multilocularis geminin 0.0374 0.5776 0.5776
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0104 0.1475 0.1475
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0475 0.2607
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.2316 0.5397
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0263 0.0263
Schistosoma mansoni inositol monophosphatase 0.0041 0.0475 0.0475
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0784 0.1826
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.102 0.2378
Loa Loa (eye worm) hypothetical protein 0.006 0.0773 0.0773
Brugia malayi hypothetical protein 0.0077 0.1052 0.2451
Plasmodium vivax SET domain protein, putative 0.0029 0.028 0.2748
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0126 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0126 0.0856
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0126 0.0856
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0111 0.0111
Echinococcus multilocularis GPCR, family 2 0.0018 0.0111 0.0111
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0521 0.3554
Brugia malayi beta-lactamase family protein 0.0075 0.102 0.2378
Schistosoma mansoni kinase 0.0053 0.0662 0.0662
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.102 0.1215
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0554 0.129
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.028 0.028
Echinococcus multilocularis dna polymerase eta 0.0045 0.0529 0.0529
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0475 0.324
Loa Loa (eye worm) hypothetical protein 0.0039 0.0448 0.0448
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.102 0.1215
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1467 0.342
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1313 0.1313
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.1467 1
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0475 0.0475
Schistosoma mansoni hypothetical protein 0.0374 0.5776 0.5776
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0126 0.0126
Echinococcus granulosus tar DNA binding protein 0.0071 0.0955 0.0955
Schistosoma mansoni hypothetical protein 0.0039 0.0448 0.0448
Trypanosoma brucei unspecified product 0.0019 0.0126 0.0856
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1467 0.342
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0955 0.0955
Schistosoma mansoni ran 0.0044 0.0521 0.0521
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0104 0.1475 0.3439
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.3032 0.3032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.1475 0.1475
Echinococcus multilocularis calcium activated potassium channel 0.0094 0.1313 0.1313
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0111 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1313 0.1313
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0739 0.1723
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0126 0.0856
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.1467 0.3714
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0773 0.5271
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0521 0.2951
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.3156 0.3156
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0641 0.1494
Loa Loa (eye worm) hypothetical protein 0.0075 0.102 0.102
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0493 0.3357
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.2316 0.2316
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0666 0.0666
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0126 0.0856
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.102 0.6669
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.028 0.028
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.2246 0.2246
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0493 0.6369
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0318 0.1437
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.102 0.6954
Brugia malayi follicle stimulating hormone receptor 0.0261 0.3979 0.9274
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0126 0.0293
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0593 0.1382
Brugia malayi TAR-binding protein 0.0071 0.0955 0.2227
Onchocerca volvulus 0.0075 0.102 0.2316
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0094 0.1313 0.1313
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0955 0.0955
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0641 0.1494
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0075 0.102 0.102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1475 0.1475
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.102 0.2378
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0784 0.0784
Trypanosoma brucei unspecified product 0.0013 0.0031 0.0209
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.102 0.1215
Entamoeba histolytica hypothetical protein 0.0077 0.1052 0.7167
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.1475 0.1475
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0126 0.0856
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0126 0.0126
Loa Loa (eye worm) RNA binding protein 0.0071 0.0955 0.0955
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0126 0.0293
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.102 0.102
Schistosoma mansoni inositol monophosphatase 0.0041 0.0475 0.0475
Loa Loa (eye worm) hypothetical protein 0.0156 0.2304 0.2304
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0475 0.1108
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0094 0.1313 0.1313
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1467 0.342
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0521 0.2951
Schistosoma mansoni hypothetical protein 0.0374 0.5776 0.5776
Trichomonas vaginalis set domain proteins, putative 0.0229 0.3476 0.8101
Echinococcus granulosus dna polymerase eta 0.0045 0.0529 0.0529
Trypanosoma brucei polo-like protein kinase 0.0103 0.1467 1
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0666 0.0666
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0493 0.2735
Brugia malayi Inositol-1 0.0041 0.0475 0.1108
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0475 0.324
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.102 0.2378
Schistosoma mansoni hypothetical protein 0.0077 0.1052 0.1052
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0955 0.0955
Echinococcus multilocularis importin subunit beta 1 0.006 0.0773 0.0773
Loa Loa (eye worm) acetyltransferase 0.0157 0.2316 0.2316
Loa Loa (eye worm) hypothetical protein 0.0093 0.1297 0.1297
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0521 0.5111
Entamoeba histolytica hypothetical protein 0.0077 0.1052 0.7167
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1467 0.342
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0554 0.0554
Mycobacterium tuberculosis Conserved protein 0.0075 0.102 0.1215
Echinococcus granulosus GPCR family 2 0.0018 0.0111 0.0111
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.102 1
Echinococcus multilocularis hypothetical protein 0.0093 0.1297 0.1297
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0031 0.0209
Brugia malayi RNA binding protein 0.0071 0.0955 0.2227
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0529 0.1234
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0955 0.0955
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.028 0.028
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0475 0.0475
Brugia malayi mbt repeat family protein 0.0053 0.0666 0.1553
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0407 0.0382
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.102 0.2378
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.102 0.102
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.1052 0.1052
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.0017 0.0113
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0521 0.0521
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.102 0.1215

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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