Detailed information for compound 784035

Basic information

Technical information
  • TDR Targets ID: 784035
  • Name: 4-[(3-bromophenyl)methylidene]-2-(4-methyl-3- nitrophenyl)-1,3-oxazol-5-one
  • MW: 387.184 | Formula: C17H11BrN2O4
  • H donors: 0 H acceptors: 3 LogP: 4.45 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cccc(c1)C=C1N=C(OC1=O)c1ccc(c(c1)[N+](=O)[O-])C
  • InChi: 1S/C17H11BrN2O4/c1-10-5-6-12(9-15(10)20(22)23)16-19-14(17(21)24-16)8-11-3-2-4-13(18)7-11/h2-9H,1H3/b14-8-
  • InChiKey: PZSRWVJGCGRBIV-ZSOIEALJSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4Z)-4-[(3-bromophenyl)methylidene]-2-(4-methyl-3-nitrophenyl)-1,3-oxazol-5-one
  • 4-[(3-bromophenyl)methylene]-2-(4-methyl-3-nitro-phenyl)oxazol-5-one
  • (4Z)-4-[(3-bromophenyl)methylene]-2-(4-methyl-3-nitro-phenyl)oxazol-5-one
  • 4-[(3-bromophenyl)methylene]-2-(4-methyl-3-nitrophenyl)-5-oxazolone
  • (4Z)-4-[(3-bromophenyl)methylene]-2-(4-methyl-3-nitrophenyl)-5-oxazolone
  • 4-(3-bromobenzylidene)-2-(4-methyl-3-nitro-phenyl)oxazol-5-one
  • (4Z)-4-(3-bromobenzylidene)-2-(4-methyl-3-nitro-phenyl)oxazol-5-one
  • 4-[(3-bromophenyl)methylidene]-2-(4-methyl-3-nitro-phenyl)-1,3-oxazol-5-one
  • (4Z)-4-[(3-bromophenyl)methylidene]-2-(4-methyl-3-nitro-phenyl)-1,3-oxazol-5-one
  • ZINC00716818
  • ZINC04534638
  • AG-205/40120126

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0462 0.0314
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.005 0.007
Trypanosoma brucei Metacaspase-4 0.0045 0.072 0.4557
Trypanosoma brucei metacaspase MCA2 0.0045 0.072 0.4557
Echinococcus granulosus lysosomal alpha glucosidase 0.0339 0.7214 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0777 0.1259
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0047 0.0777 0.1077
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0462 0.2733
Loa Loa (eye worm) hypothetical protein 0.0073 0.1345 0.1808
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0321 0.1349
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0399 0.0552
Schistosoma mansoni nuclear hormone receptor 0.003 0.0399 0.0646
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0455 0.2427
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1809 0.293
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0243 0.0659
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0399 0.0486
Onchocerca volvulus 0.0073 0.1345 0.2232
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.1345 0.1865
Echinococcus multilocularis pyruvate kinase 0.0017 0.011 0.0153
Schistosoma mansoni nuclear receptor 0.0014 0.005 0.0081
Toxoplasma gondii hypothetical protein 0.0047 0.0777 0.5178
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0045 0.072 0.1166
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.072 0.4557
Loa Loa (eye worm) norepinephrine transporter 0.0277 0.5853 0.8099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1809 0.2507
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.072 0.4557
Schistosoma mansoni caspase-7 (C14 family) 0.0086 0.1634 0.2646
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0399 0.0486
Brugia malayi Cell death protein 3 precursor 0.0086 0.1634 0.221
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0455 0.2427
Schistosoma mansoni alpha glucosidase 0.0075 0.1398 0.2264
Loa Loa (eye worm) hypothetical protein 0.0028 0.0357 0.0428
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.072 0.4736
Echinococcus multilocularis neutral alpha glucosidase AB 0.0075 0.1398 0.1938
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0321 0.3157
Brugia malayi hypothetical protein 0.0047 0.0777 0.1014
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.072 0.4736
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0399 0.0646
Plasmodium vivax metacaspase 1, putative 0.0045 0.072 0.4938
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0472 0.0589
Trypanosoma brucei glucosidase, putative 0.0075 0.1398 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.1345 0.1808
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0777 0.5399
Loa Loa (eye worm) hypothetical protein 0.0277 0.5853 0.8099
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.1345 0.1865
Mycobacterium tuberculosis Conserved protein 0.0073 0.1345 0.1211
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0777 0.1259
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0462 0.2849
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.072 0.4557
Echinococcus granulosus cpg binding protein 0.003 0.0397 0.055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0399 0.0486
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0462 0.0575
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0399 0.0486
Loa Loa (eye worm) hypothetical protein 0.003 0.0399 0.0486
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1398 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0399 0.0486
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.005 0.007
Leishmania major hypothetical protein, conserved 0.0073 0.1345 0.9577
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0399 0.06
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0777 0.1259
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0472 0.2566
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0462 0.071
Onchocerca volvulus 0.0073 0.1345 0.2232
Echinococcus multilocularis caspase 0.0118 0.2333 0.3234
Onchocerca volvulus 0.0048 0.0804 0.1299
Echinococcus granulosus caspase 8 0.0045 0.072 0.0998
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0047 0.0777 0.1077
Schistosoma mansoni pyruvate kinase 0.0033 0.0462 0.0749
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.072 0.4557
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0088 0.0121
Trichomonas vaginalis sucrase-isomaltase, putative 0.0075 0.1398 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1398 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0777 0.1259
Schistosoma mansoni ap endonuclease 0.0019 0.0153 0.0247
Brugia malayi nuclear hormone receptor 0.003 0.0399 0.0486
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0321 0.1704
Loa Loa (eye worm) hypothetical protein 0.003 0.0399 0.0486
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.005 0.007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0321 0.0378
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0777 0.1259
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.005 0.007
Loa Loa (eye worm) hypothetical protein 0.0073 0.1345 0.1808
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0462 0.071
Trichomonas vaginalis maltase-glucoamylase, putative 0.0075 0.1398 1
Echinococcus granulosus expressed protein 0.0033 0.0472 0.0655
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0399 0.0552
Loa Loa (eye worm) serotonin transporter b 0.0277 0.5853 0.8099
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0777 0.1014
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.005 0.0081
Echinococcus multilocularis pyruvate kinase 0.0033 0.0462 0.0641
Loa Loa (eye worm) hypothetical protein 0.0047 0.0777 0.1014
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0357 0.164
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0045 0.072 0.0935
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.072 0.4557
Loa Loa (eye worm) hypothetical protein 0.0045 0.072 0.0935
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.1345 0.1211
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0357 0.164
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0088 0.0121
Echinococcus granulosus pyruvate kinase 0.0033 0.0462 0.0641
Brugia malayi nuclear receptor NHR-88 0.003 0.0399 0.0486
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.1345 0.1211
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0357 0.164
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0777 0.1077
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0777 0.1077
Loa Loa (eye worm) hypothetical protein 0.003 0.0399 0.0486
Leishmania major pyruvate kinase 0.0033 0.0462 0.2485
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0399 0.0552
Brugia malayi hypothetical protein 0.0017 0.0115 0.009
Schistosoma mansoni cpg binding protein 0.0028 0.0362 0.0586
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0357 0.164
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0472 0.0589
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0321 0.1635
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0399 0.0646
Mycobacterium tuberculosis Conserved protein 0.0073 0.1345 0.1211
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.1345 0.1211
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.0357 0.164
Schistosoma mansoni alpha-glucosidase 0.0292 0.6173 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1809 0.2507
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1809 0.293
Trypanosoma cruzi metacaspase, putative 0.0045 0.072 0.4557
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0153 0.0344
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0153 0.0143
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0047 0.0777 0.1077
Trypanosoma cruzi metacaspase, putative 0.0045 0.072 0.4557
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.072 0.4557
Echinococcus granulosus caspase 0.0118 0.2333 0.3234
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.005 0.007
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0399 0.0552
Trichomonas vaginalis esterase, putative 0.0073 0.1345 0.9577
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.005 0.0081
Echinococcus multilocularis serotonin transporter 0.0277 0.5853 0.8113
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1809 0.2455
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0777 0.1014
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0462 0.2485
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0052
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0277 0.5853 0.8099
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0399 0.0552
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.1345 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0455 0.2427
Loa Loa (eye worm) hypothetical protein 0.0023 0.0243 0.027
Loa Loa (eye worm) hypothetical protein 0.003 0.0399 0.0486
Mycobacterium ulcerans hypothetical protein 0.0073 0.1345 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0357 0.164
Trypanosoma cruzi metacaspase, putative 0.0045 0.072 0.4557
Schistosoma mansoni cpg binding protein 0.003 0.0397 0.0643
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0399 0.0486
Echinococcus multilocularis tumor protein p63 0.033 0.7016 0.9725
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0399 0.0646
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0399 0.0552
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0357 0.164
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.072 0.4557
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0052
Schistosoma mansoni cpg binding protein 0.003 0.0397 0.0643
Schistosoma mansoni pyruvate kinase 0.0017 0.011 0.0179
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0088 0.0052
Onchocerca volvulus 0.0047 0.0777 0.1252
Echinococcus granulosus tumor protein p63 0.033 0.7016 0.9725
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0399 0.06
Echinococcus granulosus caspase 2 0.0086 0.1634 0.2265
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0399 0.0552
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0399 0.0486
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0052
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.1345 0.1211
Onchocerca volvulus 0.0028 0.0362 0.0537
Brugia malayi steroid hormone receptor 0.003 0.0399 0.0486
Plasmodium vivax amine transporter, putative 0.0047 0.0777 0.5399
Schistosoma mansoni alpha-glucosidase 0.0292 0.6173 1
Mycobacterium leprae conserved hypothetical protein 0.0073 0.1345 1
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0462 0.0575
Echinococcus granulosus geminin 0.0184 0.3795 0.526
Loa Loa (eye worm) hypothetical protein 0.0047 0.0777 0.1014
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.1398 0.9047
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0777 0.1014
Echinococcus granulosus serotonin transporter 0.0277 0.5853 0.8113
Echinococcus multilocularis lysosomal alpha glucosidase 0.0339 0.7214 1
Echinococcus granulosus pyruvate kinase 0.0017 0.011 0.0153
Loa Loa (eye worm) hypothetical protein 0.0073 0.1345 0.1808
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0399 0.0486
Loa Loa (eye worm) hypothetical protein 0.0048 0.0804 0.1053
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0653 0.0905
Onchocerca volvulus 0.0047 0.0777 0.1252
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0153 0.1207
Loa Loa (eye worm) hypothetical protein 0.0073 0.1345 0.1808
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0399 0.0486
Trypanosoma brucei metacaspase 5, putative 0.0045 0.072 0.4557
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0399 0.0486
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0075 0.1398 0.1881
Schistosoma mansoni nuclear hormone receptor 0.0014 0.005 0.0081
Schistosoma mansoni sodium-dependent amino acid transporter 0.0047 0.0777 0.1259
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.1529 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0399 0.0486
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0399 0.0552
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0339 0.7214 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.072 0.4557
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0399 0.0646
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0399 0.0552
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0777 0.1014
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.005 0.0081
Trypanosoma brucei metacaspase MCA3 0.0045 0.072 0.4557
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0153 0.0143
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0777 0.1259
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.1398 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.1529 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0399 0.0486
Loa Loa (eye worm) hypothetical protein 0.0047 0.0777 0.1014
Loa Loa (eye worm) hypothetical protein 0.003 0.0399 0.0486
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0777 0.1077
Trypanosoma cruzi metacaspase, putative 0.0045 0.072 0.4557
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.1345 0.1211
Schistosoma mansoni coup transcription factor 0.003 0.0399 0.0646
Mycobacterium ulcerans lipase LipD 0.0073 0.1345 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0399 0.0552
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1809 0.293
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.1398 1
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0462 0.2485
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0052
Toxoplasma gondii exonuclease III APE 0.0019 0.0153 0.033
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0462 0.2595
Loa Loa (eye worm) hypothetical protein 0.0086 0.1634 0.221
Plasmodium falciparum amino acid transporter, putative 0.0047 0.0777 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0462 0.2485
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0777 0.1259
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0047 0.0777 0.1077
Loa Loa (eye worm) hypothetical protein 0.003 0.0399 0.0486
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0777 0.5178
Toxoplasma gondii ABC1 family protein 0.0073 0.1345 0.9591
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0321 0.3157
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1059 0.1716
Plasmodium vivax hypothetical protein, conserved 0.0073 0.1345 1
Brugia malayi hypothetical protein 0.0041 0.0653 0.0841
Brugia malayi nuclear receptor RXR 0.0016 0.0088 0.0052
Brugia malayi Glycosyl hydrolases family 31 protein 0.0339 0.7214 1
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0455 0.2677
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.005 0.007
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0399 0.0552
Schistosoma mansoni hypothetical protein 0.0184 0.3795 0.6147
Trypanosoma brucei metacaspase 0.0045 0.072 0.4557
Onchocerca volvulus 0.003 0.0399 0.06
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.072 0.4557
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0088 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0399 0.0486
Echinococcus multilocularis pyruvate kinase 0.0017 0.011 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0399 0.0486
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1809 0.2455
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.005 0.007
Schistosoma mansoni caspase-7 (C14 family) 0.0118 0.2333 0.3779
Leishmania major pyruvate kinase 0.0033 0.0462 0.2485
Echinococcus granulosus caspase 3 0.0073 0.1352 0.1874
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1345 0.9577
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0357 0.164
Loa Loa (eye worm) hypothetical protein 0.0073 0.1345 0.1808
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0118 0.2333 0.3234
Echinococcus granulosus pyruvate kinase 0.0017 0.011 0.0153
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0777 0.1077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1345 0.2179
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0153 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.072 0.4557
Loa Loa (eye worm) hypothetical protein 0.0033 0.0462 0.0575
Loa Loa (eye worm) hypothetical protein 0.0277 0.5853 0.8099
Leishmania major alpha glucosidase II subunit, putative 0.0075 0.1398 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1809 0.2507
Mycobacterium ulcerans beta-lactamase 0.0073 0.1345 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0321 0.1349
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0399 0.0486
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0399 0.0646
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0399 0.0552
Loa Loa (eye worm) solute carrier family 6 member 4 0.0277 0.5853 0.8099
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0462 0.2485
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0357 0.1484
Loa Loa (eye worm) hypothetical protein 0.0041 0.0653 0.0841
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.072 0.4736
Treponema pallidum sodium- and chloride- dependent transporter 0.0277 0.5853 1
Schistosoma mansoni hypothetical protein 0.0041 0.0653 0.1057
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.005 0.007
Schistosoma mansoni nuclear hormone receptor 0.0014 0.005 0.0081
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.1345 0.1808
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0399 0.0552
Echinococcus multilocularis caspase 3 0.0073 0.1352 0.1874
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0357 0.164
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1398 1
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0462 0.0575
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0399 0.0552
Onchocerca volvulus 0.0073 0.1345 0.2232
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1345 0.2179
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0153 0.0212
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0462 0.0575
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0399 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.072 0.4557
Echinococcus multilocularis pyruvate kinase 0.0033 0.0462 0.0641
Echinococcus multilocularis caspase 8 0.0045 0.072 0.0998
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0357 0.0428
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0462 0.2485
Onchocerca volvulus Cell death protein 3 homolog 0.0086 0.1634 0.2729
Trichomonas vaginalis rotamase, putative 0.0032 0.0455 0.2427
Leishmania major hypothetical protein, conserved 0.0026 0.0321 0.1349
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0918 0.6276
Brugia malayi hypothetical protein 0.0016 0.0088 0.0052
Echinococcus granulosus neutral alpha glucosidase AB 0.0075 0.1398 0.1938
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0455 0.2427
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.005 0.007
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0777 0.1259
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0399 0.0646
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.005 0.007
Echinococcus multilocularis lysosomal alpha glucosidase 0.0339 0.7214 1
Plasmodium vivax hypothetical protein, conserved 0.0045 0.072 0.4938
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0399 0.0486
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.072 0.4557
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0462 0.2485
Echinococcus multilocularis expressed protein 0.0033 0.0472 0.0655
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0088 0.0142
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.1345 0.9577
Schistosoma mansoni sodium/chloride dependent transporter 0.0277 0.5853 0.9481
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.072 0.4557
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0399 0.0486
Brugia malayi Glycosyl hydrolases family 31 protein 0.0075 0.1398 0.1881
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.072 0.4557
Loa Loa (eye worm) hypothetical protein 0.003 0.0399 0.0486
Brugia malayi beta-lactamase family protein 0.0073 0.1345 0.1808
Schistosoma mansoni thyroid hormone receptor 0.003 0.0399 0.0646
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0399 0.0486
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1398 1
Onchocerca volvulus 0.0277 0.5853 1
Brugia malayi beta-lactamase family protein 0.0073 0.1345 0.1808
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1345 0.9577
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0277 0.5853 0.9481
Schistosoma mansoni caspase-3 (C14 family) 0.0118 0.2333 0.3779
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.1345 0.1211
Loa Loa (eye worm) beta-lactamase 0.0073 0.1345 0.1808
Brugia malayi hypothetical protein 0.0016 0.0088 0.0052
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0153 0.5
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0777 0.5178
Plasmodium falciparum metacaspase-like protein 0.0045 0.072 0.9147
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0399 0.0486
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0777 0.1014
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.072 0.4557
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0455 0.2196
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0047 0.0777 0.1077
Plasmodium falciparum metacaspase 1 0.0045 0.072 0.9147
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.1345 1
Schistosoma mansoni hypothetical protein 0.0184 0.3795 0.6147
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0357 0.164
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0399 0.0552
Giardia lamblia Pyruvate kinase 0.0033 0.0462 1
Echinococcus multilocularis geminin 0.0184 0.3795 0.526
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0777 0.1259
Onchocerca volvulus 0.0041 0.0653 0.1038
Leishmania major metacaspase, putative 0.0045 0.072 0.4557
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0088 0.0142
Echinococcus granulosus pyruvate kinase 0.0033 0.0462 0.0641
Schistosoma mansoni ap endonuclease 0.0019 0.0153 0.0247
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.1345 0.1211
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0777 0.1077
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0047 0.0777 0.1014
Brugia malayi hypothetical protein 0.0026 0.0321 0.0378
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0399 0.0646
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0399 0.0646
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.1398 0.9047
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0362 0.0435
Loa Loa (eye worm) hypothetical protein 0.0047 0.0777 0.1014
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0777 0.1077
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0321 0.1349
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1809 0.2507
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1398 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.072 0.4557
Echinococcus multilocularis pyruvate kinase 0.0026 0.031 0.0429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0399 0.0486
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1345 0.9577
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0243 0.027
Schistosoma mansoni pyruvate kinase 0.0033 0.0462 0.0749
Brugia malayi CXXC zinc finger family protein 0.0028 0.0362 0.0435
Loa Loa (eye worm) hypothetical protein 0.0277 0.5853 0.8099
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0047 0.0777 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.072 0.4557
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0118 0.2333 0.3234
Trichomonas vaginalis rotamase, putative 0.0033 0.0472 0.2566
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0153 0.0637
Echinococcus granulosus FTZ F1 alpha 0.003 0.0399 0.0552
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0399 0.0646
Toxoplasma gondii hypothetical protein 0.0047 0.0777 0.5178
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0777 0.1259
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1345 0.9577
Schistosoma mansoni nuclear receptor 0.0014 0.005 0.0081
Brugia malayi ecdysteroid receptor 0.003 0.0399 0.0486
Plasmodium falciparum transporter, putative 0.0047 0.0777 1
Plasmodium falciparum pyruvate kinase 0.0033 0.0462 0.5278
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1398 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0777 0.1014
Onchocerca volvulus 0.0196 0.4063 0.6915
Loa Loa (eye worm) hypothetical protein 0.0047 0.0777 0.1014
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0777 0.5178
Loa Loa (eye worm) hypothetical protein 0.0073 0.1345 0.1808
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1345 0.9577
Loa Loa (eye worm) hypothetical protein 0.0081 0.1529 0.2064
Mycobacterium leprae Probable lipase LipE 0.0073 0.1345 1
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0399 0.06
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0462 0.071
Schistosoma mansoni thyroid hormone receptor 0.003 0.0399 0.0646
Schistosoma mansoni rotamase 0.0033 0.0472 0.0765
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0804 0.1303
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0462 0.0575
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1345 0.9577
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0357 0.164
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0075 0.1398 1
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0399 0.0552
Onchocerca volvulus 0.0047 0.0777 0.1252
Schistosoma mansoni zinc finger protein 0.0014 0.005 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1398 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0088 0.0052
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0399 0.0486
Loa Loa (eye worm) hypothetical protein 0.003 0.0399 0.0486
Echinococcus multilocularis caspase 2 0.0086 0.1634 0.2265
Brugia malayi beta-lactamase 0.0073 0.1345 0.1808
Mycobacterium tuberculosis Conserved protein 0.0073 0.1345 0.1211
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.0357 0.0529
Echinococcus multilocularis pyruvate kinase 0.0017 0.011 0.0153
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0052
Echinococcus granulosus pyruvate kinase 0.0017 0.011 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0399 0.0486
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.005 0.007
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.005 0.007
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0653 0.0905
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0399 0.0486
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0399 0.0486
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0357 0.164
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1345 0.9577
Loa Loa (eye worm) hypothetical protein 0.0047 0.0777 0.1014
Echinococcus multilocularis cpg binding protein 0.003 0.0397 0.055

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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