Detailed information for compound 795668

Basic information

Technical information
  • TDR Targets ID: 795668
  • Name: N-(3-diethylaminopropyl)-2,3-diethoxy-8-oxo-5 ,6,13,13a-tetrahydroisoquinolino[2,1-b]isoqui noline-13-carboxamide
  • MW: 493.638 | Formula: C29H39N3O4
  • H donors: 1 H acceptors: 2 LogP: 3.77 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc2c(cc1OCC)CCN1C2C(C(=O)NCCCN(CC)CC)c2c(C1=O)cccc2
  • InChi: 1S/C29H39N3O4/c1-5-31(6-2)16-11-15-30-28(33)26-21-12-9-10-13-22(21)29(34)32-17-14-20-18-24(35-7-3)25(36-8-4)19-23(20)27(26)32/h9-10,12-13,18-19,26-27H,5-8,11,14-17H2,1-4H3,(H,30,33)
  • InChiKey: DBVVPXXCCULVDF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-diethylaminopropyl)-2,3-diethoxy-8-keto-5,6,13,13a-tetrahydroisoquinolino[2,1-b]isoquinoline-13-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0113 0.0599 0.0596
Mycobacterium tuberculosis Probable hydrolase 0.0113 0.0599 0.1023
Brugia malayi PHD-finger family protein 0.002 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0012
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0087 0.0085
Schistosoma mansoni rab6-interacting 0.0083 0.0408 0.0919
Brugia malayi jmjC domain containing protein 0.0071 0.0332 0.0329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0174 0.0389
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0342 0.0422
Mycobacterium tuberculosis Conserved protein 0.0113 0.0599 0.1023
Trichomonas vaginalis maltase-glucoamylase, putative 0.0043 0.0158 0.0457
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0113 0.0599 0.0596
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0004 0.0024
Loa Loa (eye worm) hypothetical protein 0.0113 0.0599 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0076 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0076 0.0073
Onchocerca volvulus 0.0112 0.0593 0.1194
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0113 0.0599 0.1023
Brugia malayi Transient-receptor-potential like protein 0.008 0.039 0.0387
Loa Loa (eye worm) hypothetical protein 0.0083 0.0408 0.0405
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0087 0.0176
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0158 0.0155
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0076 0.0002
Echinococcus granulosus expressed protein 0.0044 0.0162 0.0361
Schistosoma mansoni apoferritin-2 0.0044 0.0162 0.0361
Echinococcus multilocularis expressed protein 0.0044 0.0162 0.033
Brugia malayi MH2 domain containing protein 0.0142 0.0781 0.0779
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0332 0.0329
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0599 0.1732
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0076 0.0073
Echinococcus multilocularis survival motor neuron protein 1 0.0478 0.2892 0.5985
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0076 0.0165
Brugia malayi hypothetical protein 0.0083 0.0408 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0128 0.0371
Echinococcus granulosus vesicular acetylcholine transporter 0.072 0.4414 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0075 0.0072
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0076 0.0073
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0076 0.0165
Onchocerca volvulus 0.0059 0.0258 0.0421
Brugia malayi hypothetical protein 0.0083 0.0408 0.0405
Mycobacterium ulcerans lipase LipD 0.0113 0.0599 0.2974
Schistosoma mansoni transient receptor potential channel 4 0.0215 0.1239 0.2804
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0073
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0076 0.0151
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0567 0.3456 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0266 0.4418
Trypanosoma brucei glucosidase, putative 0.0043 0.0158 0.0155
Brugia malayi PHD-finger family protein 0.0057 0.0245 0.0243
Schistosoma mansoni transient receptor potential channel 0.0215 0.1239 0.2804
Echinococcus multilocularis lipoxygenase domain containing protein 0.0083 0.0408 0.084
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0266 0.0597
Echinococcus granulosus microtubule associated protein 2 0.0688 0.4211 0.9541
Echinococcus granulosus lipoxygenase domain containing protein 0.0083 0.0408 0.0919
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.072 0.4414 1
Onchocerca volvulus Alhambra homolog 0.0057 0.0245 0.0393
Schistosoma mansoni rab6-interacting 0.0083 0.0408 0.0919
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0158 0.0457
Echinococcus granulosus Polycystic kidney disease protein 0.0083 0.0408 0.0919
Echinococcus granulosus short transient receptor potential channel 6 0.0142 0.0782 0.1766
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0299 0.0672
Echinococcus granulosus chromobox protein 1 0.0068 0.0317 0.0714
Schistosoma mansoni alpha-glucosidase 0.0167 0.0938 0.2119
Brugia malayi beta-lactamase family protein 0.0113 0.0599 0.0596
Schistosoma mansoni polycystin 1-related 0.0083 0.0408 0.0919
Giardia lamblia Fructose-bisphosphate aldolase 0.0567 0.3456 1
Mycobacterium tuberculosis Probable lipase LipD 0.0113 0.0599 0.1023
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0599 0.1732
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0076 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0076 0.0073
Echinococcus granulosus ferritin 0.0044 0.0162 0.0361
Echinococcus granulosus neutral alpha glucosidase AB 0.0043 0.0158 0.0352
Echinococcus granulosus survival motor neuron protein 1 0.0478 0.2892 0.6551
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0599 0.0596
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0248 0.0556
Brugia malayi beta-lactamase family protein 0.0113 0.0599 0.0596
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0076 0.0165
Echinococcus granulosus lipoxygenase domain containing protein 0.0083 0.0408 0.0919
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0342 0.0703
Brugia malayi jmjC domain containing protein 0.0187 0.1061 0.1059
Echinococcus multilocularis transient receptor potential ion channel A 0.0208 0.1194 0.2468
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0087 0.0176
Echinococcus multilocularis TRP (transient receptor potential) channel 0.008 0.039 0.0802
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0478 0.2892 0.289
Schistosoma mansoni survival motor neuron protein 0.0097 0.05 0.1127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0174 0.0389
Echinococcus multilocularis geminin 0.034 0.2025 0.419
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0128 0.0123
Toxoplasma gondii ABC1 family protein 0.0113 0.0599 1
Onchocerca volvulus 0.0113 0.0599 0.1207
Schistosoma mansoni hypothetical protein 0.034 0.2025 0.4586
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0257 0.4262
Schistosoma mansoni vesicular acetylcholine transporter 0.072 0.4414 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0043 0.0158 0.0321
Loa Loa (eye worm) hypothetical protein 0.1608 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0599 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0076 0.0073
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0245 0.0243
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0187 0.1061 0.2399
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0567 0.3456 1
Brugia malayi CXXC zinc finger family protein 0.003 0.0075 0.0072
Echinococcus granulosus RUN 0.0083 0.0408 0.0919
Treponema pallidum fructose-bisphosphate aldolase 0.0567 0.3456 1
Brugia malayi nuclear hormone receptor 0.003 0.0076 0.0073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0174 0.0389
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0567 0.3456 1
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0076 0.0165
Mycobacterium tuberculosis Conserved protein 0.0113 0.0599 0.1023
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0044 0.0162 0.5
Leishmania major alpha glucosidase II subunit, putative 0.0043 0.0158 0.0155
Schistosoma mansoni nuclear hormone receptor 0.003 0.0076 0.0165
Brugia malayi Pre-SET motif family protein 0.0416 0.2505 0.2503
Schistosoma mansoni hypothetical protein 0.0032 0.0087 0.0192
Schistosoma mansoni hypothetical protein 0.034 0.2025 0.4586
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0076 0.0165
Echinococcus granulosus GPCR family 2 0.0032 0.0087 0.0192
Mycobacterium tuberculosis Probable esterase LipL 0.0113 0.0599 0.1023
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0723 0.4434 1
Brugia malayi beta-lactamase 0.0113 0.0599 0.0596
Brugia malayi nuclear receptor NHR-88 0.003 0.0076 0.0073
Echinococcus granulosus transient receptor potential gamma protein 0.0215 0.1239 0.2804
Trichomonas vaginalis set domain proteins, putative 0.0474 0.2866 0.8291
Echinococcus granulosus FTZ F1 alpha 0.003 0.0076 0.0165
Echinococcus granulosus cpg binding protein 0.0032 0.0086 0.0188
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0174 0.0355
Echinococcus multilocularis vesicular acetylcholine transporter 0.072 0.4414 0.9136
Echinococcus granulosus lysosomal alpha glucosidase 0.0194 0.1108 0.2505
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0076 0.0165
Schistosoma mansoni hypothetical protein 0.0032 0.0087 0.0192
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0147 0.0165
Schistosoma mansoni hypothetical protein 0.0032 0.0087 0.0192
Schistosoma mansoni cpg binding protein 0.0032 0.0086 0.0188
Echinococcus granulosus transient receptor potential ion channel A 0.0208 0.1194 0.2701
Echinococcus granulosus TRP transient receptor potential channel 0.008 0.039 0.0878
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0158 0.0457
Brugia malayi ecdysteroid receptor 0.003 0.0076 0.0073
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0076 0.0165
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0496 0.3004 0.6804
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0076 0.0073
Trichomonas vaginalis sucrase-isomaltase, putative 0.0043 0.0158 0.0457
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0266 0.0597
Brugia malayi vesicular acetylcholine transporter unc-17 0.072 0.4414 0.4412
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0076 0.0165
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0317 0.0315
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.4831 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0245 0.4073
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0147 0.0424
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0342 0.5692
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0245 0.4073
Schistosoma mansoni ferritin 0.0044 0.0162 0.0361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0076 0.0073
Loa Loa (eye worm) hypothetical protein 0.0101 0.0521 0.0518
Brugia malayi chromobox protein homolog 3 0.0038 0.0128 0.0126
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0158 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0058 0.0167
Echinococcus multilocularis peregrin 0.0057 0.0245 0.0503
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0332 0.0746
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0158 0.0155
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0599 0.1351
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0342 0.0769
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0174 0.0389
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0158 0.0457
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0158 0.0457
Schistosoma mansoni cellular tumor antigen P53 0.0059 0.0258 0.0578
Trypanosoma brucei C-8 sterol isomerase, putative 0.1608 1 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0736 0.0734
Mycobacterium leprae Probable lipase LipE 0.0113 0.0599 0.2974
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0075 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0073
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0076 0.0165
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0317 0.0918
Brugia malayi Glycosyl hydrolases family 31 protein 0.0043 0.0158 0.0155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0266 0.0597
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0321 0.0659
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0076 0.0151
Schistosoma mansoni transient receptor potential channel 0.0142 0.0782 0.1766
Loa Loa (eye worm) hypothetical protein 0.0113 0.0599 0.0596
Mycobacterium ulcerans esterase/lipase LipP 0.0113 0.0599 0.2974
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0076 0.0151
Schistosoma mansoni hypothetical protein 0.0083 0.0408 0.0919
Schistosoma mansoni loxhd1 0.0083 0.0408 0.0919
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0076 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0071 0.0336 0.0757
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0085
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.4211 0.8717
Schistosoma mansoni ferritin 0.0044 0.0162 0.0361
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0076 0.0151
Brugia malayi hypothetical protein 0.0478 0.2892 0.289
Brugia malayi Pre-SET motif family protein 0.006 0.0266 0.0263
Brugia malayi Bromodomain containing protein 0.0057 0.0245 0.0243
Plasmodium falciparum phd finger protein, putative 0.0057 0.0245 0.5988
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0073
Schistosoma mansoni thyroid hormone receptor 0.003 0.0076 0.0165
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0245 0.055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0043 0.0158 0.0155
Leishmania major hypothetical protein, conserved 0.0113 0.0599 0.0596
Brugia malayi Glycosyl hydrolases family 31 protein 0.0194 0.1108 0.1105
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0076 0.0165
Schistosoma mansoni apoferritin-2 0.0044 0.0162 0.0361
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0147 0.0424
Loa Loa (eye worm) hypothetical protein 0.0113 0.0599 0.0596
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0277 0.1631 1
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0599 0.2974
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.032 0.0317
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.05 0.0497
Schistosoma mansoni coup transcription factor 0.003 0.0076 0.0165
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0013 0.0024
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0245 0.055
Loa Loa (eye worm) transcription factor SMAD2 0.0142 0.0781 0.0779
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.0599 0.0596
Brugia malayi Heterochromatin protein 1 0.0068 0.0317 0.0315
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0342 0.0769
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0567 0.3456 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0142 0.0782 0.1613
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0521 0.0518
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0076 0.0073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0076 0.0151
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0174 0.0172
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0386 0.0793
Loa Loa (eye worm) MH2 domain-containing protein 0.0142 0.0781 0.0779
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0113 0.0599 0.1023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0076 0.0073
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0342 0.0339
Loa Loa (eye worm) hypothetical protein 0.0113 0.0599 0.0596
Mycobacterium tuberculosis Probable lipase LipE 0.0113 0.0599 0.1023
Echinococcus multilocularis short transient receptor potential channel 6 0.0142 0.0782 0.1613
Mycobacterium ulcerans hypothetical protein 0.0113 0.0599 0.2974
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0076 0.0151
Onchocerca volvulus 0.0113 0.0599 0.1207
Schistosoma mansoni ferritin light chain 0.0044 0.0162 0.0361
Onchocerca volvulus 0.0083 0.0408 0.0768
Echinococcus granulosus geminin 0.034 0.2025 0.4586
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0076 0.0073
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0004 0.0024
Echinococcus multilocularis lipoxygenase domain containing protein 0.0083 0.0408 0.084
Schistosoma mansoni lipoxygenase 0.0496 0.3004 0.6804
Loa Loa (eye worm) hypothetical protein 0.0113 0.0599 0.0596
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0187 0.1061 0.2192
Schistosoma mansoni cpg binding protein 0.0032 0.0086 0.0188
Mycobacterium tuberculosis Conserved protein 0.0113 0.0599 0.1023
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.008 0.039 0.0387
Echinococcus granulosus peregrin 0.0057 0.0245 0.055
Loa Loa (eye worm) hypothetical protein 0.0113 0.0599 0.0596
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0076 0.0165
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0058 0.0167
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0599 0.1732
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0076 0.0073
Onchocerca volvulus 0.003 0.0076 0.0003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0076 0.0002
Loa Loa (eye worm) hypothetical protein 0.0098 0.0501 0.0499
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0174 0.0389
Echinococcus multilocularis ferritin 0.0044 0.0162 0.033
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0076 0.0165
Schistosoma mansoni ferritin 0.0044 0.0162 0.0361
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0342 0.1226
Brugia malayi steroid hormone receptor 0.003 0.0076 0.0073
Schistosoma mansoni ferritin light chain 0.0044 0.0162 0.0361
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1608 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0004 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0076 0.0073
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0076 0.0165
Plasmodium falciparum LCCL domain-containing protein 0.0083 0.0408 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0113 0.0599 0.1351
Schistosoma mansoni hypothetical protein 0.0032 0.0087 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0076 0.0073
Schistosoma mansoni ferritin 0.0044 0.0162 0.0361
Trichomonas vaginalis esterase, putative 0.0113 0.0599 0.1732
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0174 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0128 0.0371
Echinococcus granulosus short transient receptor potential channel 6 0.0142 0.0782 0.1766
Echinococcus multilocularis cpg binding protein 0.0032 0.0086 0.0172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0567 0.3456 1
Onchocerca volvulus 0.0071 0.0336 0.0603
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0113 0.0599 0.1023
Schistosoma mansoni lipoxygenase 0.0346 0.2066 0.4678
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0567 0.3456 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0076 0.0165
Onchocerca volvulus 0.003 0.0076 0.0002
Schistosoma mansoni chromobox protein 0.0068 0.0317 0.0714
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0076 0.0073
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0277 0.1631 1
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0342 0.0769
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0245 0.0503
Leishmania major C-8 sterol isomerase-like protein 0.1608 1 1
Schistosoma mansoni alpha glucosidase 0.0043 0.0158 0.0352
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0158 0.0457
Schistosoma mansoni alpha-glucosidase 0.0167 0.0938 0.2119
Loa Loa (eye worm) hypothetical protein 0.0057 0.0245 0.0243
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0174 0.0355
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0332 0.0746
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0332 0.0746
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0567 0.3456 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0567 0.3456 1
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0245 0.4073
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0087 0.0192
Onchocerca volvulus 0.0083 0.0408 0.0768
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0599 0.1732
Echinococcus multilocularis chromobox protein 1 0.0068 0.0317 0.0652
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0076 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0076 0.0073
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.002 0.0016 0.0318
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0076 0.0165
Echinococcus multilocularis lysosomal alpha glucosidase 0.0194 0.1108 0.2288
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0126
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0004 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0342 0.1226
Plasmodium vivax multidomain scavenger receptor, putative 0.0083 0.0408 0.6802
Echinococcus granulosus tumor protein p63 0.0402 0.2418 0.5477
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0043 0.0158 0.2603
Schistosoma mansoni hypothetical protein 0.0069 0.032 0.072
Echinococcus multilocularis tumor protein p63 0.0402 0.2418 0.5004
Loa Loa (eye worm) hypothetical protein 0.0083 0.0408 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0076 0.0073
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0266 0.0545
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0599 1
Loa Loa (eye worm) hypothetical protein 0.0215 0.1239 0.1237
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0599 0.1351
Echinococcus granulosus chromobox protein 1 0.0068 0.0317 0.0714
Echinococcus multilocularis RUN 0.0083 0.0408 0.084
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0073
Echinococcus multilocularis lysosomal alpha glucosidase 0.0194 0.1108 0.2288
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Loa Loa (eye worm) doublecortin family protein 0.0083 0.0408 0.0405
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0521 0.0518
Schistosoma mansoni hypothetical protein 0.0097 0.05 0.1127
Echinococcus multilocularis Polycystic kidney disease protein 0.0083 0.0408 0.084
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0076 0.0151
Echinococcus multilocularis GPCR, family 2 0.0032 0.0087 0.0176
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0087 0.0085
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.0627 0.0625
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0076 0.0002
Brugia malayi AF-10 protein 0.0019 0.0004 0.0001
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0087 0.0085
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0076 0.0165
Echinococcus multilocularis transient receptor potential gamma protein 0.0215 0.1239 0.2562
Echinococcus multilocularis beta LACTamase domain containing family member 0.0113 0.0599 0.1234
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0158 0.0457
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0076 0.0165
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0521 0.0518
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0277 0.1631 0.3438
Schistosoma mansoni hypothetical protein 0.0057 0.0245 0.055
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0073
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0496 0.3004 0.6216
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0599 0.1732
Schistosoma mansoni jumonji domain containing protein 0.0148 0.082 0.1852
Onchocerca volvulus 0.0474 0.2866 0.6432
Mycobacterium ulcerans beta-lactamase 0.0113 0.0599 0.2974
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0076 0.0151
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0076 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0076 0.0073
Brugia malayi Doublecortin family protein 0.0083 0.0408 0.0405
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0087 0.0192
Schistosoma mansoni cpg binding protein 0.003 0.0075 0.0164
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0073
Loa Loa (eye worm) hypothetical protein 0.0822 0.5056 0.5055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0567 0.3456 1
Trichomonas vaginalis ferritin, putative 0.0044 0.0162 0.0468
Schistosoma mansoni thyroid hormone receptor 0.003 0.0076 0.0165
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0386 0.0868
Schistosoma mansoni chromobox protein 0.0068 0.0317 0.0714
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0194 0.1108 0.1105
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0076 0.0073
Loa Loa (eye worm) beta-lactamase 0.0113 0.0599 0.0596
Plasmodium vivax SET domain protein, putative 0.006 0.0266 0.4418
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0266 0.0545
Plasmodium vivax hypothetical protein, conserved 0.002 0.0016 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0076 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0567 0.3456 1
Onchocerca volvulus 0.0113 0.0599 0.1207
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0416 0.2505 0.2503
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.072 0.4414 0.4412
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0113 0.0599 0.2974
Loa Loa (eye worm) hypothetical protein 0.0073 0.0345 0.0342
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0317 0.0918
Schistosoma mansoni transient receptor potential channel 0.0142 0.0782 0.1766
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0065 0.014
Onchocerca volvulus 0.0097 0.05 0.098
Loa Loa (eye worm) hypothetical protein 0.0059 0.0258 0.0255
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.4211 0.9541
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0266 0.0597
Loa Loa (eye worm) hypothetical protein 0.006 0.0266 0.0263
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0076 0.0151
Echinococcus multilocularis chromobox protein 1 0.0068 0.0317 0.0652
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0342 0.1226

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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