Detailed information for compound 796277

Basic information

Technical information
  • TDR Targets ID: 796277
  • Name: 1,3-diethyl-5-methoxy-6-nitrobenzimidazol-2-o ne
  • MW: 265.265 | Formula: C12H15N3O4
  • H donors: 0 H acceptors: 3 LogP: 1.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2n(CC)c(=O)n(c2cc1[N+](=O)[O-])CC
  • InChi: 1S/C12H15N3O4/c1-4-13-8-6-10(15(17)18)11(19-3)7-9(8)14(5-2)12(13)16/h6-7H,4-5H2,1-3H3
  • InChiKey: SCGYISXIFOUPQT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1,3-diethyl-5-methoxy-6-nitro-benzimidazol-2-one
  • 1,3-diethyl-5-methoxy-6-nitro-2-benzimidazolone
  • ZINC00088693
  • 1,3-Diethyl-5-methoxy-6-nitro-1,3-dihydro-benzoimidazol-2-one
  • A2534/0107776
  • Oprea1_753997

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thioredoxin glutathione reductase 0.0141 0.0222 0.0222
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0036 0.1476
Schistosoma mansoni microtubule-associated protein tau 0.5716 1 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0036 0.0082
Plasmodium falciparum glutathione reductase 0.0049 0.006 0.1976
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0141 0.0221 0.0597
Trichomonas vaginalis mercuric reductase, putative 0.0049 0.006 0.1282
Mycobacterium ulcerans hypothetical protein 0.0035 0.0036 0.0082
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.005 0.0063 0.2703
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0036 0.0082
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0111 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.003 0.003
Onchocerca volvulus 0.0035 0.0036 0.021
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0049 0.006 0.0056
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0049 0.006 0.1976
Loa Loa (eye worm) hypothetical protein 0.0033 0.0033 0.0403
Echinococcus granulosus expressed protein 0.0018 0.0007 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0036 0.0406
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.003 0.0333
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0322
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.005 0.0063 0.2703
Schistosoma mansoni hypothetical protein 0.0032 0.003 0.0026
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0321 0.0537 0.1476
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0049 0.006 0.0148
Brugia malayi RNA binding protein 0.0066 0.0089 0.1058
Schistosoma mansoni smad1 5 8 and 0.0017 0.0005 0.0001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0036 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0032 0.0636
Schistosoma mansoni lamin 0.003 0.0027 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0415
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0064 0.0064
Mycobacterium ulcerans lipase LipD 0.0035 0.0036 0.0082
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.006 0.2574
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0036 0.0082
Echinococcus multilocularis ferritin 0.0018 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0026 0.002 0.0745
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0049 0.006 0.2574
Loa Loa (eye worm) transcription factor SMAD2 0.0253 0.0419 0.5097
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0111 0.0291
Schistosoma mansoni smad1 5 8 and 0.0017 0.0005 0.0001
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0036 0.0082
Echinococcus granulosus tumor protein p63 0.1037 0.1794 0.1794
Brugia malayi glutathione reductase 0.0141 0.0221 0.2666
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0027 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0027 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.004 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0063 0.1347
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0033 0.0641
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0033 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0045 0.0932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.004 0.0827
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Schistosoma mansoni ferritin 0.0018 0.0007 0.0003
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0089 0.1089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0033 0.0029
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0036 0.0082
Brugia malayi MH2 domain containing protein 0.0017 0.0005 0.0023
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0033 0.0033
Leishmania major hypothetical protein, conserved 0.0035 0.0036 0.1476
Brugia malayi beta-lactamase family protein 0.0035 0.0036 0.0406
Echinococcus multilocularis GPCR, family 2 0.0032 0.003 0.003
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.0174 0.017
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.004 0.0045 0.1875
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0321 0.0537 0.1476
Loa Loa (eye worm) hypothetical protein 0.01 0.015 0.1829
Loa Loa (eye worm) thioredoxin reductase 0.0141 0.0221 0.2691
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Schistosoma mansoni hypothetical protein 0.0098 0.0147 0.0143
Onchocerca volvulus 0.0033 0.0033 0.0137
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0111 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0045 0.0932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.004 0.0827
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0089 0.0085
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0439
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0111 0.0111
Echinococcus multilocularis tumor protein p63 0.1037 0.1794 0.1794
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0356 0.06 0.1651
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0089 0.0089
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0049 0.006 0.006
Brugia malayi Thioredoxin reductase 0.0141 0.0221 0.2666
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0064 0.016
Mycobacterium tuberculosis Probable dehydrogenase 0.0321 0.0537 0.1476
Echinococcus multilocularis smad 0.0017 0.0005 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0036 0.0735
Giardia lamblia GTOR 0.005 0.0063 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0036 0.0037 0.042
Echinococcus granulosus smad 0.0017 0.0005 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0036 0.0032
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0022 0.143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0413
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0033 0.0029
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0036 0.0036
Echinococcus multilocularis thyroid hormone receptor alpha 0.0141 0.0221 0.0221
Echinococcus multilocularis microtubule associated protein 2 0.5716 1 1
Plasmodium falciparum thioredoxin reductase 0.0141 0.0221 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0036 0.0082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0439
Schistosoma mansoni survival motor neuron protein 0.0098 0.0147 0.0143
Schistosoma mansoni intermediate filament proteins 0.003 0.0027 0.0023
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0147 0.1764
Schistosoma mansoni hypothetical protein 0.0032 0.003 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0413
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0036 0.1476
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0356 0.06 0.1648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.004 0.0827
Mycobacterium tuberculosis Conserved protein 0.0035 0.0036 0.0082
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0022 0.0042
Trypanosoma brucei target of rapamycin kinase 3, putative 0.004 0.0045 0.1875
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.002 0.0745
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0036 0.0082
Loa Loa (eye worm) hypothetical protein 0.0069 0.0095 0.1152
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0004 0.0004
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2066 0.3599 1
Schistosoma mansoni hypothetical protein 0.0032 0.003 0.0026
Schistosoma mansoni thyroid hormone receptor 0.0141 0.0221 0.0217
Loa Loa (eye worm) RNA binding protein 0.0066 0.0089 0.1089
Treponema pallidum NADH oxidase 0.0049 0.006 0.5087
Echinococcus multilocularis expressed protein 0.0018 0.0007 0.0007
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0356 0.06 0.1651
Entamoeba histolytica hypothetical protein 0.0114 0.0174 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0439
Brugia malayi intermediate filament protein 0.003 0.0027 0.03
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0321 0.0537 0.1474
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0064 0.0064
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.005 0.0063 0.2703
Schistosoma mansoni smad 0.0017 0.0005 0.0001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.0174 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.005 0.105
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0005 0.0005
Brugia malayi TAR-binding protein 0.0066 0.0089 0.1058
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.005 0.0063 0.2703
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0049 0.006 0.1976
Schistosoma mansoni hypothetical protein 0.0069 0.0095 0.0091
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0022 0.007
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0036 0.0082
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0005 0.0005
Loa Loa (eye worm) beta-lactamase 0.0035 0.0036 0.0439
Onchocerca volvulus 0.0035 0.0036 0.021
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0089 0.1089
Schistosoma mansoni hypothetical protein 0.0114 0.0174 0.017
Echinococcus granulosus intermediate filament protein 0.003 0.0027 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0027 0.0519
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0036 0.0735
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.207 0.3606 1
Schistosoma mansoni Smad4 0.0017 0.0005 0.0001
Onchocerca volvulus 0.0152 0.0241 0.5174
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0027 0.0334
Schistosoma mansoni ferritin light chain 0.0018 0.0007 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0036 0.0032
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0027 0.03
Toxoplasma gondii thioredoxin reductase 0.0141 0.0221 1
Schistosoma mansoni thyroid hormone receptor 0.0141 0.0221 0.0217
Echinococcus granulosus lamin 0.003 0.0027 0.0027
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0004 0.0049
Leishmania major trypanothione reductase 0.0141 0.0221 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0005 0.0001
Brugia malayi hypothetical protein 0.0483 0.0822 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0368 0.1006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.0174 0.0174
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0036 0.0082
Loa Loa (eye worm) phosphatidylinositol 3 0.005 0.0063 0.0763
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.005 0.0063 0.0732
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0095 0.1122
Loa Loa (eye worm) hypothetical protein 0.0078 0.0111 0.1355
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0049 0.006 0.1976
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0004 0.0015
Entamoeba histolytica hypothetical protein 0.0114 0.0174 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0089 0.0085
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0439
Mycobacterium ulcerans AcrR family transcriptional regulator 0.207 0.3606 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0016 0.056
Brugia malayi beta-lactamase family protein 0.0035 0.0036 0.0406
Mycobacterium ulcerans transcriptional regulator 0.207 0.3606 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0036 0.0082
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0049 0.006 0.0148
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0483 0.0822 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0049 0.006 0.0148
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.005 0.0063 0.2703
Brugia malayi Smad1 0.0017 0.0005 0.0023
Entamoeba histolytica hypothetical protein 0.0114 0.0174 1
Toxoplasma gondii NADPH-glutathione reductase 0.0049 0.006 0.1976
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0027 0.0531
Loa Loa (eye worm) hypothetical protein 0.0152 0.0241 0.293
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0036 0.079
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0064 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0415
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0321 0.0537 0.1476
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0064 0.016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.015 0.1801
Onchocerca volvulus 0.0265 0.044 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0049 0.006 0.2574
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.004 0.0827
Trichomonas vaginalis esterase, putative 0.0035 0.0036 0.0735
Entamoeba histolytica hypothetical protein 0.0114 0.0174 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.003 0.003
Mycobacterium tuberculosis Probable reductase 0.0321 0.0537 0.1476
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.002 0.0745
Echinococcus granulosus tar DNA binding protein 0.0066 0.0089 0.0089
Schistosoma mansoni ferritin light chain 0.0018 0.0007 0.0003
Plasmodium vivax thioredoxin reductase, putative 0.0141 0.0221 1
Echinococcus granulosus ferritin 0.0018 0.0007 0.0007
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0003 0.0034
Echinococcus granulosus GPCR family 2 0.0032 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.004 0.0827
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0049 0.006 0.006
Schistosoma mansoni ferritin 0.0018 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.0366
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0036 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Mycobacterium tuberculosis Probable oxidoreductase 0.0356 0.06 0.1651
Brugia malayi Probable ClpP-like protease 0.0078 0.0111 0.1326
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.015 0.1801
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.006 0.2574
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.006 0.2574
Brugia malayi MH2 domain containing protein 0.0253 0.0419 0.508
Brugia malayi Pre-SET motif family protein 0.0033 0.0033 0.037
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0027 0.0519
Onchocerca volvulus 0.0098 0.0147 0.2906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0413
Trichomonas vaginalis set domain proteins, putative 0.0265 0.044 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0022 0.007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.0383 0.4665
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Trichomonas vaginalis ferritin, putative 0.0018 0.0007 0.006
Schistosoma mansoni hypothetical protein 0.0032 0.003 0.0026
Echinococcus granulosus thioredoxin glutathione reductase 0.0141 0.0222 0.0222
Schistosoma mansoni hypothetical protein 0.013 0.0203 0.0199
Plasmodium falciparum glutathione reductase 0.0141 0.0221 1
Loa Loa (eye worm) intermediate filament protein 0.003 0.0027 0.0334
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.006 0.2574
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0111 0.4538
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.006 0.2574
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0049 0.006 0.1976
Onchocerca volvulus 0.0035 0.0036 0.021
Loa Loa (eye worm) hypothetical protein 0.003 0.0027 0.0334
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.015 0.1829
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0005 0.0005
Mycobacterium leprae Probable lipase LipE 0.0035 0.0036 0.0082
Mycobacterium tuberculosis Conserved protein 0.0035 0.0036 0.0082
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.006 0.5087
Echinococcus multilocularis musashi 0.003 0.0027 0.0027
Mycobacterium tuberculosis Conserved protein 0.0035 0.0036 0.0082
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0321 0.0537 0.1476
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0049 0.006 0.2574
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0111 0.0291
Brugia malayi beta-lactamase 0.0035 0.0036 0.0406
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.005 0.0063 0.0063
Schistosoma mansoni ferritin 0.0018 0.0007 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0089 0.0085
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0111 0.4538
Loa Loa (eye worm) glutathione reductase 0.0141 0.0221 0.2691
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0111 0.0107
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0111 0.0111
Schistosoma mansoni lamin 0.003 0.0027 0.0023
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.005 0.0063 0.0059
Trypanosoma brucei trypanothione reductase 0.0141 0.0221 1
Echinococcus granulosus survival motor neuron protein 1 0.0483 0.0822 0.0822
Loa Loa (eye worm) Smad1 0.0017 0.0005 0.0057
Schistosoma mansoni cellular tumor antigen P53 0.0152 0.0241 0.0237
Echinococcus granulosus lamin dm0 0.003 0.0027 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.004 0.0827
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0111 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.003 0.0366
Plasmodium vivax glutathione reductase, putative 0.0141 0.0221 1
Schistosoma mansoni apoferritin-2 0.0018 0.0007 0.0003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.003 0.003
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0005 0.0057
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.005 0.0063 0.2703
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0005 0.0057
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0036 0.0082
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.005 0.0063 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0033 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0415
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0246
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0111 1
Trypanosoma cruzi trypanothione reductase, putative 0.0141 0.0221 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0011 0.0325
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0111 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0034 0.068
Plasmodium vivax SET domain protein, putative 0.0033 0.0033 0.0641
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.002 0.0745
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0036 0.0037 0.042
Brugia malayi hypothetical protein 0.0026 0.002 0.0212
Trichomonas vaginalis glutathione reductase, putative 0.0049 0.006 0.1282
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0439
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0036 0.0735
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0439
Echinococcus multilocularis lamin 0.003 0.0027 0.0027
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Brugia malayi MH1 domain containing protein 0.0017 0.0005 0.0023
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0089 0.1058
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0111 0.4538
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0045 0.0932
Brugia malayi Latrophilin receptor protein 2 0.0032 0.003 0.0333
Schistosoma mansoni apoferritin-2 0.0018 0.0007 0.0003
Plasmodium falciparum thioredoxin reductase 0.0049 0.006 0.1976
Echinococcus granulosus Smad4 0.0017 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0063 0.1347
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0031 0.0031
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0036 0.0735
Echinococcus multilocularis Smad4 0.0017 0.0005 0.0005
Toxoplasma gondii target of rapamycin (TOR), putative 0.0037 0.004 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0063 0.1347
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.003 0.003
Echinococcus multilocularis lamin dm0 0.003 0.0027 0.0027
Mycobacterium ulcerans TetR family transcriptional regulator 0.207 0.3606 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0111 0.4538
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0005 0.0005
Brugia malayi Pre-SET motif family protein 0.0233 0.0383 0.4647
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0049 0.006 0.1976
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0036 0.1476
Echinococcus multilocularis survival motor neuron protein 1 0.0483 0.0822 0.0822
Schistosoma mansoni ferritin 0.0018 0.0007 0.0003
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0049 0.006 0.2574
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0036 0.0735
Brugia malayi hypothetical protein 0.0017 0.0004 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0033 0.0033
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.006 0.5087
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.0203 0.0203
Brugia malayi hypothetical protein 0.0114 0.0174 0.2091
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0089 0.0085
Trypanosoma cruzi target of rapamycin kinase 3 0.004 0.0045 0.1875
Brugia malayi MH2 domain containing protein 0.0017 0.0005 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0045 0.0932
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0045 0.0932
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Toxoplasma gondii hypothetical protein 0.0027 0.0022 0.007
Loa Loa (eye worm) MH2 domain-containing protein 0.0253 0.0419 0.5097
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0089 0.0085
Toxoplasma gondii ABC1 family protein 0.0035 0.0036 0.079
Schistosoma mansoni smad1 5 8 and 0.0017 0.0005 0.0001
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0049 0.006 0.0148
Brugia malayi MH1 domain containing protein 0.0017 0.0005 0.0023
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0049 0.006 0.0697

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.