Detailed information for compound 796277

Basic information

Technical information
  • TDR Targets ID: 796277
  • Name: 1,3-diethyl-5-methoxy-6-nitrobenzimidazol-2-o ne
  • MW: 265.265 | Formula: C12H15N3O4
  • H donors: 0 H acceptors: 3 LogP: 1.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2n(CC)c(=O)n(c2cc1[N+](=O)[O-])CC
  • InChi: 1S/C12H15N3O4/c1-4-13-8-6-10(15(17)18)11(19-3)7-9(8)14(5-2)12(13)16/h6-7H,4-5H2,1-3H3
  • InChiKey: SCGYISXIFOUPQT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-diethyl-5-methoxy-6-nitro-benzimidazol-2-one
  • 1,3-diethyl-5-methoxy-6-nitro-2-benzimidazolone
  • ZINC00088693
  • 1,3-Diethyl-5-methoxy-6-nitro-1,3-dihydro-benzoimidazol-2-one
  • A2534/0107776
  • Oprea1_753997

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0413
Echinococcus multilocularis thyroid hormone receptor alpha 0.0141 0.0221 0.0221
Schistosoma mansoni smad 0.0017 0.0005 0.0001
Echinococcus multilocularis lamin dm0 0.003 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0069 0.0095 0.1152
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0049 0.006 0.1976
Echinococcus granulosus ferritin 0.0018 0.0007 0.0007
Brugia malayi RNA binding protein 0.0066 0.0089 0.1058
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0111 0.4538
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.004 0.0827
Plasmodium vivax glutathione reductase, putative 0.0141 0.0221 1
Brugia malayi beta-lactamase family protein 0.0035 0.0036 0.0406
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0036 0.0032
Leishmania major hypothetical protein, conserved 0.0035 0.0036 0.1476
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2066 0.3599 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0356 0.06 0.1651
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0036 0.0406
Echinococcus multilocularis ferritin 0.0018 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0032 0.0636
Onchocerca volvulus 0.0098 0.0147 0.2906
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.0203 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0027 0.0531
Treponema pallidum NADH oxidase 0.0049 0.006 0.5087
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0064 0.016
Onchocerca volvulus 0.0152 0.0241 0.5174
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0033 0.0033
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0005 0.0005
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0049 0.006 0.1976
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0036 0.0735
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0356 0.06 0.1651
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0049 0.006 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0413
Loa Loa (eye worm) glutathione reductase 0.0141 0.0221 0.2691
Brugia malayi MH1 domain containing protein 0.0017 0.0005 0.0023
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0095 0.1122
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0036 0.0082
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0049 0.006 0.2574
Schistosoma mansoni hypothetical protein 0.0032 0.003 0.0026
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0049 0.006 0.0148
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0147 0.1764
Schistosoma mansoni smad1 5 8 and 0.0017 0.0005 0.0001
Echinococcus multilocularis musashi 0.003 0.0027 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0033 0.0029
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0036 0.0037 0.042
Trichomonas vaginalis esterase, putative 0.0035 0.0036 0.0735
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.006 0.5087
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Schistosoma mansoni ferritin 0.0018 0.0007 0.0003
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0111 0.4538
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0049 0.006 0.0697
Loa Loa (eye worm) Smad1 0.0017 0.0005 0.0057
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0036 0.0036
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0004 0.0049
Brugia malayi Latrophilin receptor protein 2 0.0032 0.003 0.0333
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0111 0.4538
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0089 0.0089
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0111 0.4538
Schistosoma mansoni ferritin 0.0018 0.0007 0.0003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0111 0.0291
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0089 0.1089
Plasmodium vivax SET domain protein, putative 0.0033 0.0033 0.0641
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.005 0.0063 0.0063
Schistosoma mansoni ferritin 0.0018 0.0007 0.0003
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0089 0.1058
Toxoplasma gondii ABC1 family protein 0.0035 0.0036 0.079
Brugia malayi MH2 domain containing protein 0.0253 0.0419 0.508
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0111 1
Trypanosoma brucei trypanothione reductase 0.0141 0.0221 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0111 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0036 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.006 0.2574
Brugia malayi Probable ClpP-like protease 0.0078 0.0111 0.1326
Schistosoma mansoni hypothetical protein 0.0032 0.003 0.0026
Schistosoma mansoni hypothetical protein 0.0069 0.0095 0.0091
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0049 0.006 0.0148
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0005 0.0005
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0033 0.0033
Trypanosoma cruzi target of rapamycin kinase 3 0.004 0.0045 0.1875
Loa Loa (eye worm) transcription factor SMAD2 0.0253 0.0419 0.5097
Echinococcus multilocularis lamin 0.003 0.0027 0.0027
Mycobacterium ulcerans lipase LipD 0.0035 0.0036 0.0082
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0439
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0033 0.0641
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.003 0.0366
Echinococcus granulosus smad 0.0017 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0413
Schistosoma mansoni smad1 5 8 and 0.0017 0.0005 0.0001
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0036 0.0082
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0011 0.0325
Trypanosoma brucei target of rapamycin kinase 3, putative 0.004 0.0045 0.1875
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0063 0.1347
Loa Loa (eye worm) phosphatidylinositol 3 0.005 0.0063 0.0763
Schistosoma mansoni lamin 0.003 0.0027 0.0023
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0022 0.0042
Loa Loa (eye worm) intermediate filament protein 0.003 0.0027 0.0334
Echinococcus granulosus intermediate filament protein 0.003 0.0027 0.0027
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0005 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0036 0.0735
Loa Loa (eye worm) hypothetical protein 0.003 0.0027 0.0334
Brugia malayi hypothetical protein 0.0114 0.0174 0.2091
Mycobacterium ulcerans transcriptional regulator 0.207 0.3606 1
Echinococcus granulosus tumor protein p63 0.1037 0.1794 0.1794
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.003 0.003
Echinococcus multilocularis microtubule associated protein 2 0.5716 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0045 0.0932
Mycobacterium tuberculosis Probable oxidoreductase 0.0356 0.06 0.1651
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0033 0.0029
Echinococcus multilocularis tumor protein p63 0.1037 0.1794 0.1794
Echinococcus multilocularis GPCR, family 2 0.0032 0.003 0.003
Loa Loa (eye worm) RNA binding protein 0.0066 0.0089 0.1089
Schistosoma mansoni apoferritin-2 0.0018 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0246
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0049 0.006 0.1976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0034 0.068
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0111 0.0291
Toxoplasma gondii thioredoxin reductase 0.0141 0.0221 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0141 0.0222 0.0222
Mycobacterium ulcerans TetR family transcriptional regulator 0.207 0.3606 1
Leishmania major trypanothione reductase 0.0141 0.0221 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0005 0.0005
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.207 0.3606 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0321 0.0537 0.1476
Schistosoma mansoni cellular tumor antigen P53 0.0152 0.0241 0.0237
Brugia malayi Pre-SET motif family protein 0.0233 0.0383 0.4647
Plasmodium falciparum glutathione reductase 0.0049 0.006 0.1976
Brugia malayi MH2 domain containing protein 0.0017 0.0005 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.004 0.0827
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.0383 0.4665
Brugia malayi beta-lactamase 0.0035 0.0036 0.0406
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0004 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0036 0.0735
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0089 0.0085
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.0366
Mycobacterium tuberculosis Conserved protein 0.0035 0.0036 0.0082
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0152 0.0241 0.293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0415
Brugia malayi TAR-binding protein 0.0066 0.0089 0.1058
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.006 0.2574
Brugia malayi Pre-SET motif family protein 0.0033 0.0033 0.037
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0033 0.0033
Mycobacterium ulcerans AcrR family transcriptional regulator 0.207 0.3606 1
Brugia malayi Smad1 0.0017 0.0005 0.0023
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0022 0.143
Entamoeba histolytica hypothetical protein 0.0114 0.0174 1
Entamoeba histolytica hypothetical protein 0.0114 0.0174 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.0174 0.0174
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.005 0.0063 0.2703
Schistosoma mansoni thyroid hormone receptor 0.0141 0.0221 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0027 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0045 0.0932
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Onchocerca volvulus 0.0035 0.0036 0.021
Mycobacterium tuberculosis Probable reductase 0.0321 0.0537 0.1476
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.0174 0.0174
Mycobacterium tuberculosis Conserved protein 0.0035 0.0036 0.0082
Brugia malayi glutathione reductase 0.0141 0.0221 0.2666
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0321 0.0537 0.1476
Plasmodium vivax thioredoxin reductase, putative 0.0141 0.0221 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.015 0.1801
Schistosoma mansoni ferritin light chain 0.0018 0.0007 0.0003
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0027 0.03
Entamoeba histolytica hypothetical protein 0.0114 0.0174 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0049 0.006 0.2574
Schistosoma mansoni survival motor neuron protein 0.0098 0.0147 0.0143
Mycobacterium ulcerans hypothetical protein 0.0035 0.0036 0.0082
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0049 0.006 0.1976
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0005 0.0005
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.006 0.5087
Echinococcus granulosus tar DNA binding protein 0.0066 0.0089 0.0089
Echinococcus multilocularis Smad4 0.0017 0.0005 0.0005
Schistosoma mansoni lamin 0.003 0.0027 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0089 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0036 0.1476
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0036 0.079
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0141 0.0221 0.0597
Mycobacterium leprae Probable lipase LipE 0.0035 0.0036 0.0082
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.006 0.2574
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0036 0.0082
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0036 0.0082
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0111 0.0291
Schistosoma mansoni hypothetical protein 0.0098 0.0147 0.0143
Schistosoma mansoni smad1 5 8 and 0.0017 0.0005 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.004 0.0827
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.003 0.003
Schistosoma mansoni hypothetical protein 0.013 0.0203 0.0199
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.004 0.0045 0.1875
Echinococcus multilocularis expressed protein 0.0018 0.0007 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0253 0.0419 0.5097
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0439
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0064 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0063 0.1347
Plasmodium falciparum thioredoxin reductase 0.0141 0.0221 1
Brugia malayi hypothetical protein 0.0017 0.0004 0.0014
Brugia malayi MH1 domain containing protein 0.0017 0.0005 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.004 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0027 0.0531
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0049 0.006 0.1976
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0111 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.003 0.0333
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0064 0.0064
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0036 0.0082
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0049 0.006 0.0056
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.002 0.0745
Mycobacterium ulcerans beta-lactamase 0.0035 0.0036 0.0082
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0064 0.016
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.0203 0.0203
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0016 0.056
Toxoplasma gondii hypothetical protein 0.0027 0.0022 0.007
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0036 0.0735
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0036 0.0037 0.042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.004 0.0827
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.003 0.003
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0089 0.0085
Schistosoma mansoni apoferritin-2 0.0018 0.0007 0.0003
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0356 0.06 0.1648
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0089 0.0085
Leishmania major hypothetical protein, conserved 0.0026 0.002 0.0745
Trichomonas vaginalis set domain proteins, putative 0.0265 0.044 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.005 0.0063 0.0732
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0368 0.1006
Schistosoma mansoni hypothetical protein 0.0032 0.003 0.0026
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0005 0.0001
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0114 0.0174 0.017
Echinococcus granulosus survival motor neuron protein 1 0.0483 0.0822 0.0822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.004 0.0827
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0036 0.0082
Echinococcus multilocularis smad 0.0017 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0322
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.005 0.0063 0.2703
Loa Loa (eye worm) thioredoxin reductase 0.0141 0.0221 0.2691
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0045 0.0932
Plasmodium falciparum thioredoxin reductase 0.0049 0.006 0.1976
Echinococcus multilocularis survival motor neuron protein 1 0.0483 0.0822 0.0822
Schistosoma mansoni ferritin 0.0018 0.0007 0.0003
Toxoplasma gondii target of rapamycin (TOR), putative 0.0037 0.004 0.099
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0036 0.0735
Onchocerca volvulus 0.0033 0.0033 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Brugia malayi hypothetical protein 0.0483 0.0822 1
Trichomonas vaginalis mercuric reductase, putative 0.0049 0.006 0.1282
Brugia malayi intermediate filament protein 0.003 0.0027 0.03
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0063 0.1347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.005 0.105
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.002 0.0745
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.006 0.2574
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.005 0.0063 0.0059
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0064 0.0064
Brugia malayi Thioredoxin reductase 0.0141 0.0221 0.2666
Schistosoma mansoni thyroid hormone receptor 0.0141 0.0221 0.0217
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0049 0.006 0.0148
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0005 0.0057
Brugia malayi MH2 domain containing protein 0.0017 0.0005 0.0023
Echinococcus granulosus lamin dm0 0.003 0.0027 0.0027
Mycobacterium tuberculosis Probable dehydrogenase 0.0321 0.0537 0.1476
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0321 0.0537 0.1474
Loa Loa (eye worm) hypothetical protein 0.0483 0.0822 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0033 0.0029
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0049 0.006 0.2574
Loa Loa (eye worm) beta-lactamase 0.0035 0.0036 0.0439
Schistosoma mansoni Smad4 0.0017 0.0005 0.0001
Schistosoma mansoni intermediate filament proteins 0.003 0.0027 0.0023
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0089 0.1089
Onchocerca volvulus 0.0265 0.044 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0439
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0004 0.0015
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0036 0.0082
Plasmodium falciparum glutathione reductase 0.0141 0.0221 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0439
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0036 0.1476
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.005 0.0063 0.0063
Toxoplasma gondii NADPH-glutathione reductase 0.0049 0.006 0.1976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0415
Schistosoma mansoni ferritin light chain 0.0018 0.0007 0.0003
Onchocerca volvulus 0.0035 0.0036 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0045 0.0932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0415
Mycobacterium tuberculosis Conserved protein 0.0035 0.0036 0.0082
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0027 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0027 0.0531
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.005 0.0063 0.2703
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0089 0.0085
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.0174 0.017
Brugia malayi beta-lactamase family protein 0.0035 0.0036 0.0406
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0003 0.0034
Schistosoma mansoni hypothetical protein 0.0032 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0078 0.0111 0.1355
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0045 0.0932
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0111 0.0111
Entamoeba histolytica hypothetical protein 0.0114 0.0174 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0111 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.005 0.0063 0.2703
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0036 0.0082
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.005 0.0063 0.2703
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0111 0.0107
Brugia malayi hypothetical protein 0.0026 0.002 0.0212
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0036 0.0439
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.002 0.0745
Trypanosoma cruzi trypanothione reductase, putative 0.0141 0.0221 1
Echinococcus granulosus Smad4 0.0017 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0439
Onchocerca volvulus 0.0035 0.0036 0.021
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.006 0.2574
Giardia lamblia GTOR 0.005 0.0063 1
Trichomonas vaginalis glutathione reductase, putative 0.0049 0.006 0.1282
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.01 0.015 0.1829
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0033 0.0033 0.0403
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.005 0.0063 0.2703
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0022 0.0415
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0022 0.007
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0022 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.004 0.0827
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0049 0.006 0.006
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0049 0.006 0.0148
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0049 0.006 0.2574
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0036 0.0082
Echinococcus granulosus expressed protein 0.0018 0.0007 0.0007
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.015 0.1801
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0321 0.0537 0.1476
Echinococcus multilocularis thioredoxin glutathione reductase 0.0141 0.0222 0.0222
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.015 0.1829
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0027 0.0519
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0036 0.1476
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0321 0.0537 0.1476
Trichomonas vaginalis ferritin, putative 0.0018 0.0007 0.006
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0036 0.0082
Echinococcus granulosus lamin 0.003 0.0027 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.006 0.2574
Schistosoma mansoni microtubule-associated protein tau 0.5716 1 1
Echinococcus granulosus GPCR family 2 0.0032 0.003 0.003

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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