Detailed information for compound 796437

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.477 | Formula: C21H22N2O2S
  • H donors: 0 H acceptors: 1 LogP: 5.23 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCSC1=N/C(=C/c2ccccc2)/C(=O)N1c1cccc(c1)OC
  • InChi: 1S/C21H22N2O2S/c1-3-4-13-26-21-22-19(14-16-9-6-5-7-10-16)20(24)23(21)17-11-8-12-18(15-17)25-2/h5-12,14-15H,3-4,13H2,1-2H3/b19-14+
  • InChiKey: QLGDHORISZTIQP-XMHGGMMESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0212 0.0381 0.0755
Schistosoma mansoni smad1 5 8 and 0.0017 0.0007 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0044 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0025 0.0415
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0049 0.2951
Trichomonas vaginalis esterase, putative 0.0073 0.0115 0.2354
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.0152 0.0255
Schistosoma mansoni smad1 5 8 and 0.0017 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.005
Brugia malayi Smad1 0.0017 0.0007 0.0033
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.003 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0044 0.0827
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0115 0.0062
Loa Loa (eye worm) hypothetical protein 0.0073 0.0115 0.1201
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0036 0.0031
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0036 0.0035
Schistosoma mansoni Smad4 0.0017 0.0007 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0029 0.0519
Loa Loa (eye worm) Smad1 0.0017 0.0007 0.0075
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0013 0.0512
Brugia malayi MH1 domain containing protein 0.0017 0.0007 0.0033
Echinococcus multilocularis tumor protein p63 0.0761 0.1435 0.1434
Loa Loa (eye worm) beta-lactamase 0.0073 0.0115 0.1201
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0059 0.0087 0.1919
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0044 0.0827
Onchocerca volvulus 0.0258 0.047 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0112 0.0188 0.0334
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0005 0.0004
Mycobacterium ulcerans TetR family transcriptional regulator 0.2417 0.4616 1
Echinococcus granulosus tumor protein p63 0.0761 0.1435 0.1434
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0007 0.0075
Schistosoma mansoni microtubule-associated protein tau 0.522 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0005 0.0004
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0036 0.2062
Mycobacterium tuberculosis Probable reductase 0.0212 0.0381 0.0755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0049 0.0932
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.017 0.0301 0.0474
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2417 0.4616 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.041 0.4289
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.017 0.0301 1
Mycobacterium tuberculosis Conserved protein 0.0073 0.0115 0.0173
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2417 0.4616 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.017 0.0301 0.03
Brugia malayi Probable ClpP-like protease 0.017 0.0301 0.3125
Brugia malayi intermediate filament protein 0.0029 0.003 0.0276
Brugia malayi Pre-SET motif family protein 0.0033 0.0036 0.0339
Loa Loa (eye worm) hypothetical protein 0.0073 0.0115 0.1201
Echinococcus multilocularis lamin dm0 0.0029 0.003 0.0029
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0212 0.0381 0.0755
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0426
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0005 0.0001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0115 0.0173
Echinococcus multilocularis Smad4 0.0017 0.0007 0.0006
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.017 0.0301 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.003 0.0531
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0007 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0115 0.744
Entamoeba histolytica hypothetical protein 0.0117 0.0198 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0188 0.1965
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0112 0.0188 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0025 0.0415
Mycobacterium ulcerans transcriptional regulator 0.2417 0.4616 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0072 0.0751
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0018 0.0881
Echinococcus multilocularis peptidase Clp (S14 family) 0.0112 0.0188 0.0187
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0004 0.0042
Schistosoma mansoni intermediate filament proteins 0.0029 0.003 0.0025
Loa Loa (eye worm) hypothetical protein 0.017 0.0301 0.3154
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0236 0.0426 0.0855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0068 0.1347
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.017 0.0301 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.0174 0.1786
Schistosoma mansoni cellular tumor antigen P53 0.0111 0.0188 0.0183
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.017 0.0301 0.058
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0005 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0044 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0029 0.0519
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0068 0.0672
Loa Loa (eye worm) transcription factor SMAD2 0.0255 0.0464 0.4863
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0115 0.011
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0068 0.4256
Mycobacterium tuberculosis Conserved protein 0.0073 0.0115 0.0173
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.0152 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.017 0.0301 1
Brugia malayi MH1 domain containing protein 0.0017 0.0007 0.0033
Echinococcus multilocularis smad 0.0017 0.0007 0.0006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0072 0.0712
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0115 0.0173
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.017 0.0301 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0019 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0025 0.0413
Entamoeba histolytica hypothetical protein 0.0117 0.0198 1
Loa Loa (eye worm) glutathione reductase 0.0093 0.0152 0.1595
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0036 0.2062
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2412 0.4607 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0255 0.0464 0.4863
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0036 0.2062
Brugia malayi hypothetical protein 0.0117 0.0198 0.2044
Loa Loa (eye worm) hypothetical protein 0.0033 0.0036 0.038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.003 0.0531
Echinococcus granulosus intermediate filament protein 0.0029 0.003 0.0029
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0059 0.0087 0.1919
Trichomonas vaginalis set domain proteins, putative 0.0258 0.047 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0005 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0036 0.2062
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0068 0.4256
Mycobacterium ulcerans lipase LipD 0.0073 0.0115 0.0173
Trypanosoma brucei trypanothione reductase 0.0093 0.0152 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0051 0.0072 0.0751
Schistosoma mansoni smad1 5 8 and 0.0017 0.0007 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0115 0.2354
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.017 0.0301 0.058
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.0152 0.4392
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0068 0.4256
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0036 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0068 0.1347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0025 0.0413
Brugia malayi MH2 domain containing protein 0.0017 0.0007 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0036 0.0032
Brugia malayi MH2 domain containing protein 0.0017 0.0007 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0115 0.2354
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0115 0.2354
Plasmodium falciparum glutathione reductase 0.0093 0.0152 0.4392
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0036 0.0035
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0115 0.0173
Echinococcus multilocularis musashi 0.0029 0.003 0.0029
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0115 0.0173
Brugia malayi Thioredoxin reductase 0.0093 0.0152 0.1559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0068 0.1347
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0068 0.0067
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0212 0.0381 0.0755
Plasmodium falciparum thioredoxin reductase 0.0093 0.0152 0.4392
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0115 0.0173
Entamoeba histolytica hypothetical protein 0.0117 0.0198 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0036 0.2062
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0036 0.0332
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0115 0.1164
Loa Loa (eye worm) hypothetical protein 0.0073 0.0115 0.1201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0025 0.0415
Brugia malayi hypothetical protein 0.0511 0.0955 1
Toxoplasma gondii hypothetical protein 0.0059 0.0087 0.1919
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0036 0.0652
Brugia malayi MH2 domain containing protein 0.0255 0.0464 0.4841
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0005 0.0008
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0236 0.0426 0.0855
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0117 0.0198 0.0197
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0115 0.0173
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0036 0.2062
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0034 0.0033
Plasmodium vivax SET domain protein, putative 0.0033 0.0036 0.0025
Brugia malayi Pre-SET motif family protein 0.0227 0.041 0.4265
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0036 0.2062
Schistosoma mansoni hypothetical protein 0.0117 0.0198 0.0194
Schistosoma mansoni lamin 0.0029 0.003 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0049 0.0932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0049 0.0932
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0005 0.0004
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0115 0.1201
Brugia malayi beta-lactamase family protein 0.0073 0.0115 0.1164
Loa Loa (eye worm) hypothetical protein 0.0029 0.003 0.0317
Echinococcus granulosus GPCR family 2 0.0016 0.0005 0.0004
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0005 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0044 0.0827
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0036 0.2062
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0068 0.0067
Mycobacterium leprae Probable lipase LipE 0.0073 0.0115 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0044 0.0827
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0115 0.2354
Echinococcus granulosus peptidase Clp S14 family 0.0112 0.0188 0.0187
Echinococcus granulosus Smad4 0.0017 0.0007 0.0006
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0115 0.744
Loa Loa (eye worm) hypothetical protein 0.0073 0.0115 0.1201
Onchocerca volvulus 0.0111 0.0188 0.3581
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0036 0.0032
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.017 0.0301 1
Toxoplasma gondii thioredoxin reductase 0.0093 0.0152 0.4392
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0036 0.2062
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0306
Brugia malayi beta-lactamase family protein 0.0073 0.0115 0.1164
Echinococcus granulosus thioredoxin glutathione reductase 0.0093 0.0153 0.0152
Brugia malayi beta-lactamase 0.0073 0.0115 0.1164
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0115 0.744
Echinococcus multilocularis GPCR, family 2 0.0016 0.0005 0.0004
Mycobacterium ulcerans beta-lactamase 0.0073 0.0115 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0049 0.0932
Echinococcus multilocularis thioredoxin glutathione reductase 0.0093 0.0153 0.0152
Schistosoma mansoni hypothetical protein 0.0104 0.0174 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0025 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0025 0.0415
Echinococcus granulosus lamin dm0 0.0029 0.003 0.0029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0036 0.2062
Onchocerca volvulus 0.0073 0.0115 0.1921
Onchocerca volvulus 0.0104 0.0174 0.3268
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0036 0.2062
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0059 0.0087 0.1919
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0115 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0037 0.068
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0068 0.0711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0054 0.105
Echinococcus multilocularis microtubule associated protein 2 0.522 1 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0007 0.0006
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0236 0.0426 0.075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.003 0.0531
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0005 0.0004
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0005 0.0004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.003 0.0317
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.017 0.0301 1
Schistosoma mansoni survival motor neuron protein 0.0104 0.0174 0.0169
Mycobacterium tuberculosis Probable oxidoreductase 0.0236 0.0426 0.0855
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0049 0.2951
Leishmania major trypanothione reductase 0.0093 0.0152 1
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0036 0.2062
Giardia lamblia GTOR 0.0049 0.0068 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0068 0.4256
Echinococcus multilocularis lamin 0.0029 0.003 0.0029
Brugia malayi glutathione reductase 0.0093 0.0152 0.1559
Loa Loa (eye worm) intermediate filament protein 0.0029 0.003 0.0317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0035 0.0636
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0036 0.2062
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.017 0.0301 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0115 0.1201
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0005 0.005
Echinococcus granulosus lamin 0.0029 0.003 0.0029
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0115 0.0173
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0068 0.4256
Entamoeba histolytica hypothetical protein 0.0117 0.0198 1
Mycobacterium tuberculosis Conserved protein 0.0073 0.0115 0.0173
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0044 0.0306
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0212 0.0381 0.0755
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0036 0.2062
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0115 0.2354
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0117 0.0198 0.0197
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.0152 0.1595
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0041 0.0386
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0007 0.0006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0072 0.0712
Echinococcus granulosus smad 0.0017 0.0007 0.0006
Plasmodium vivax glutathione reductase, putative 0.0093 0.0152 0.4392
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0115 0.0114
Schistosoma mansoni lamin 0.0029 0.003 0.0025
Schistosoma mansoni hypothetical protein 0.0035 0.0041 0.0036
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0007 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0049 0.0932
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0007 0.0075
Schistosoma mansoni transcription factor LCR-F1 0.0117 0.0198 0.0194
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0036 0.0032
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0036 0.0035
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0036 0.2062
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0036 0.2062
Leishmania major hypothetical protein, conserved 0.0073 0.0115 0.744
Echinococcus multilocularis survival motor neuron protein 1 0.0511 0.0955 0.0954
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0036 0.0035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0036 0.2062
Schistosoma mansoni smad 0.0017 0.0007 0.0002
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0112 0.0188 0.0225
Toxoplasma gondii ABC1 family protein 0.0073 0.0115 0.2976
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0212 0.0381 0.065
Loa Loa (eye worm) hypothetical protein 0.0073 0.0115 0.1201
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0469 0.0874 0.1833
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0115 0.0173
Mycobacterium tuberculosis Probable dehydrogenase 0.0212 0.0381 0.0755
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0115 0.0173
Loa Loa (eye worm) hypothetical protein 0.0511 0.0955 1
Onchocerca volvulus 0.0033 0.0036 0.0137
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0036 0.0035
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.017 0.0301 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0044 0.0827
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0005 0.0004
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0115 0.0114
Onchocerca volvulus 0.0073 0.0115 0.1921
Schistosoma mansoni peptidase Clp (S14 family) 0.017 0.0301 0.0297
Onchocerca volvulus 0.0073 0.0115 0.1921
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0068 0.4256
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0049 0.2951
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0036 0.0025
Mycobacterium ulcerans hypothetical protein 0.0073 0.0115 0.0173
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0019 0.016
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0068 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0115 0.2976
Echinococcus granulosus survival motor neuron protein 1 0.0511 0.0955 0.0954
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0007 0.0002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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