TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.328 | Formula: C17H18FNO4
H donors: 1 H acceptors: 2 LogP: 2.12 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COC(=C1C(=NC(=C(C1c1cccc(c1)F)C(=O)OC)C)C)O
InChi: 1S/C17H18FNO4/c1-9-13(16(20)22-3)15(11-6-5-7-12(18)8-11)14(10(2)19-9)17(21)23-4/h5-8,15,20H,1-4H3
InChiKey: ZDHFNLIPGGBHIS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0139	0.1604	0.1604
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0078	0.0842	0.2836
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1604	0.158
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0154	0.0154
Echinococcus multilocularis	neurogenic locus notch protein	0.0022	0.0132	0.0104
Entamoeba histolytica	presenilin 1 peptidase, putative	0.0218	0.2596	1
Brugia malayi	Presenilin spe-4	0.0076	0.0818	0.0818
Brugia malayi	hypothetical protein	0.0106	0.1194	0.1194
Onchocerca volvulus		0.0022	0.0132	0.0659
Brugia malayi	hypothetical protein	0.0076	0.0818	0.0818
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0033	0.0033
Echinococcus multilocularis	slit 2 protein	0.0022	0.0132	0.0104
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0246	0.2948	0.2929
Loa Loa (eye worm)	animal heme peroxidase	0.0139	0.1604	0.158
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1604	0.158
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Trichomonas vaginalis	Nicastrin precursor, putative	0.0106	0.1194	0.4274
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0018	0.0092	0.0092
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0127	0.1459	0.1435
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0022	0.0132	0.0132
Schistosoma mansoni	notch	0.0022	0.0132	0.0132
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Brugia malayi	Peroxidasin	0.0139	0.1604	0.1604
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Onchocerca volvulus		0.0041	0.0376	0.221
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1194	0.1169
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0154	0.0299
Trypanosoma cruzi	Nicastrin, putative	0.0039	0.035	0.0694
Brugia malayi	hypothetical protein	0.0106	0.1194	0.1194
Brugia malayi	Animal haem peroxidase family protein	0.0139	0.1604	0.1604
Schistosoma mansoni	hypothetical protein	0.0106	0.1194	0.1194
Brugia malayi	EGF-like domain containing protein	0.0022	0.0132	0.0132
Brugia malayi	Calcium binding EGF domain containing protein	0.0022	0.0132	0.0132
Brugia malayi	EGF-like domain containing protein	0.0022	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0154	0.0126
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0005
Echinococcus granulosus	slit 2 protein	0.0022	0.0132	0.0104
Echinococcus multilocularis	Mastin	0.0014	0.0033	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0052
Onchocerca volvulus		0.0033	0.0278	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0154	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0154	0.0154
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.008	0.139
Echinococcus granulosus	Polycystic kidney disease protein	0.0041	0.0376	0.0349
Onchocerca volvulus		0.0033	0.0278	0.1587
Onchocerca volvulus		0.0033	0.0278	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0033	0.0033
Trypanosoma cruzi	Nicastrin, putative	0.0039	0.035	0.0694
Echinococcus granulosus	Nicastrin	0.0106	0.1194	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Onchocerca volvulus		0.0023	0.0154	0.0801
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0376	0.0349
Schistosoma mansoni	slit	0.0022	0.0132	0.0132
Toxoplasma gondii	hypothetical protein	0.0033	0.0278	0.0672
Onchocerca volvulus	Putative cubilin	0.0022	0.0132	0.0659
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0154	0.003
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0013	0.0028	0.0028
Leishmania major	protein kinase ck2 regulatory subunit, putative	0.0078	0.0842	0.303
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0251
Brugia malayi	EGF-like domain containing protein	0.0022	0.0132	0.0132
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0022	0.0132	0.0132
Schistosoma mansoni	notch	0.0022	0.0132	0.0132
Echinococcus multilocularis	enteropeptidase	0.0014	0.0033	0.0005
Brugia malayi	Presenilin spe-4	0.0076	0.0818	0.0818
Trypanosoma cruzi	Aph-1 protein, putative	0.0314	0.3811	1
Echinococcus granulosus	neurogenic locus notch protein	0.0022	0.0132	0.0104
Echinococcus multilocularis	Nicastrin	0.0106	0.1194	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Onchocerca volvulus		0.0022	0.0132	0.0659
Brugia malayi	Muscle positioning protein 4	0.0022	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0005
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0078	0.0842	0.5162
Onchocerca volvulus		0.0033	0.0278	0.1587
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0154	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0005
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0041	0.0376	0.0349
Brugia malayi	hypothetical protein	0.0041	0.0376	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0052
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0033	0.0033
Echinococcus granulosus	ankyrin repeat protein	0.0181	0.2141	0.2119
Onchocerca volvulus		0.0051	0.0507	0.3036
Brugia malayi	Presenilin family protein	0.0218	0.2596	0.2596
Echinococcus multilocularis	neurogenic locus notch protein	0.0022	0.0132	0.0104
Brugia malayi	casein kinase II, putaitve	0.0023	0.0147	0.0147
Schistosoma mansoni	notch	0.0022	0.0132	0.0132
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0033	0.0033
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0033	0.0278	0.0672
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0078	0.0842	0.2836
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1604	0.158
Brugia malayi	Blistered cuticle protein 3	0.0139	0.1604	0.1604
Leishmania major	hypothetical protein, conserved	0.0051	0.0507	0.1699
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0014	0.0033	0.0005
Echinococcus granulosus	protein jagged 1	0.0022	0.0132	0.0104
Onchocerca volvulus		0.0014	0.0033	0.0029
Brugia malayi	Trypsin family protein	0.0014	0.0033	0.0033
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.0018	0.0092	0.0064
Brugia malayi	hypothetical protein	0.0041	0.0376	0.0376
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0014	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0052
Schistosoma mansoni	hypothetical protein	0.0014	0.0033	0.0033
Echinococcus granulosus	transient receptor potential cation channel	0.0185	0.2187	0.2165
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0376	0.0349
Loa Loa (eye worm)	doublecortin family protein	0.0041	0.0376	0.0349
Schistosoma mansoni	loxhd1	0.0041	0.0376	0.0376
Brugia malayi	EGF-like domain containing protein	0.0022	0.0132	0.0132
Onchocerca volvulus		0.0014	0.0033	0.0029
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0033	0.0033
Brugia malayi	hypothetical protein	0.0076	0.0818	0.0818
Brugia malayi	Trypsin-like protease protein 5	0.0014	0.0033	0.0033
Echinococcus granulosus	lipoxygenase domain containing protein	0.0041	0.0376	0.0349
Echinococcus granulosus	neurogenic locus notch protein	0.0022	0.0132	0.0104
Giardia lamblia	Casein kinase II beta chain	0.0078	0.0842	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0033	0.0278	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Schistosoma mansoni	egf-like domain protein	0.0013	0.0028	0.0028
Brugia malayi	PAN domain containing protein	0.0033	0.0278	0.0278
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0806	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0154	1
Onchocerca volvulus		0.0018	0.0092	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Trypanosoma cruzi	Aph-1 protein, putative	0.0314	0.3811	1
Echinococcus granulosus	transmembrane protease serine 3	0.0014	0.0033	0.0005
Brugia malayi	hypothetical protein	0.0076	0.0818	0.0818
Plasmodium falciparum	cysteine repeat modular protein 1	0.0051	0.0507	0.5607
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0092	0.0064
Echinococcus granulosus	notch	0.0022	0.0132	0.0104
Schistosoma mansoni	lipoxygenase	0.0246	0.2948	0.2948
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0005
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0033	0.0033
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0041	0.0376	0.0349
Brugia malayi	Calcium binding EGF domain containing protein	0.0022	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1604	0.158
Leishmania major	phospholipase c-like protein	0.0018	0.0092	0.0052
Schistosoma mansoni	laminin gamma-3 chain	0.0022	0.0132	0.0132
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Schistosoma mansoni	hypothetical protein	0.0014	0.0033	0.0033
Schistosoma mansoni	lipoxygenase	0.0172	0.2019	0.2019
Brugia malayi	Calcium binding EGF domain containing protein	0.0013	0.0028	0.0028
Brugia malayi	PAN domain containing protein	0.0033	0.0278	0.0278
Echinococcus granulosus	presenilin enhancer 2	0.0204	0.2428	0.2407
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0507	0.0507
Trypanosoma brucei	Nicastrin, putative	0.0039	0.035	0.0694
Loa Loa (eye worm)	animal heme peroxidase	0.0139	0.1604	0.158
Toxoplasma gondii	microneme protein MIC17A	0.0033	0.0278	0.0672
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0218	0.2596	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Brugia malayi	Cadherin domain containing protein	0.0022	0.0132	0.0132
Echinococcus multilocularis	presenilin	0.0218	0.2596	0.2575
Brugia malayi	Csnk2b protein	0.0078	0.0842	0.0842
Brugia malayi	EGF-like domain containing protein	0.0022	0.0132	0.0132
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0014	0.0033	0.0005
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0154	0.0299
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0018	0.0092	0.0064
Onchocerca volvulus	Chorion peroxidase homolog	0.0139	0.1604	1
Schistosoma mansoni	septate junction protein	0.0022	0.0132	0.0132
Loa Loa (eye worm)	Notch2	0.0022	0.0132	0.0104
Onchocerca volvulus		0.0139	0.1604	1
Echinococcus granulosus	fibropellin Ia	0.0022	0.0132	0.0104
Onchocerca volvulus		0.0014	0.0033	0.0029
Schistosoma mansoni	hypothetical protein	0.0022	0.0132	0.0132
Schistosoma mansoni	hypothetical protein	0.0022	0.0132	0.0132
Onchocerca volvulus		0.0033	0.0278	0.1587
Echinococcus granulosus	RUN	0.0041	0.0376	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.0018	0.0092	0.0064
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0218	0.2596	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0376	0.0376
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0154	1
Brugia malayi	PAN domain containing protein	0.0033	0.0278	0.0278
Trichomonas vaginalis	Nicastrin precursor, putative	0.0106	0.1194	0.4274
Schistosoma mansoni	hypothetical protein	0.0051	0.0507	0.0507
Plasmodium vivax	multidomain scavenger receptor, putative	0.0041	0.0376	0.3901
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1604	0.158
Echinococcus multilocularis	presenilin enhancer 2	0.0204	0.2428	0.2407
Brugia malayi	notch-like transmembrane receptor	0.0022	0.0132	0.0132
Echinococcus multilocularis	notch	0.0022	0.0132	0.0104
Brugia malayi	Animal haem peroxidase family protein	0.0139	0.1604	0.1604
Loa Loa (eye worm)	gamma-secretase subunit pen-2	0.0204	0.2428	0.2407
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0154	0.003
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0013	0.0028	0.0028
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0033	0.0033
Onchocerca volvulus	Peroxidasin homolog	0.0139	0.1604	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Onchocerca volvulus		0.0041	0.0376	0.221
Brugia malayi	Animal haem peroxidase family protein	0.0139	0.1604	0.1604
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.008	0.0013
Loa Loa (eye worm)	blistered cuticle protein 3	0.0139	0.1604	0.158
Brugia malayi	GCC2 and GCC3 family protein	0.0022	0.0132	0.0132
Schistosoma mansoni	notch	0.0022	0.0132	0.0132
Loa Loa (eye worm)	TK/ROR protein kinase	0.0051	0.0507	0.048
Echinococcus multilocularis	transient receptor potential cation channel	0.0185	0.2191	0.2169
Brugia malayi	Doublecortin family protein	0.0041	0.0376	0.0376
Brugia malayi	Trypsin family protein	0.0014	0.0033	0.0033
Brugia malayi	PAN domain containing protein	0.0033	0.0278	0.0278
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0033	0.0005
Schistosoma mansoni	polycystin 1-related	0.0041	0.0376	0.0376
Toxoplasma gondii	casein kinase ii regulatory subunit protein	0.0078	0.0842	0.2185
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0154	1
Toxoplasma gondii	kringle domain-containing protein	0.0051	0.0507	0.1285
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1604	0.158
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.008	0.0013
Echinococcus granulosus	protein jagged 2	0.0022	0.0132	0.0104
Toxoplasma gondii	microneme protein MIC17C	0.0033	0.0278	0.0672
Loa Loa (eye worm)	PAN domain-containing protein	0.0033	0.0278	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1604	0.158
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0251
Brugia malayi	PAN domain containing protein	0.0033	0.0278	0.0278
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0033	0.0033
Onchocerca volvulus		0.0139	0.1604	1
Brugia malayi	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4	0.0017	0.0079	0.0079
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0806	1	1
Brugia malayi	Delta serrate ligand family protein	0.0022	0.0132	0.0132
Onchocerca volvulus	Neurogenic locus notch homolog	0.0022	0.0136	0.0681
Brugia malayi	Calcium binding EGF domain containing protein	0.0022	0.0132	0.0132
Onchocerca volvulus	Dual oxidase homolog	0.0139	0.1604	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0033	0.0033
Brugia malayi	Cadherin domain containing protein	0.0022	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0092	0.0064
Toxoplasma gondii	PAN domain-containing protein	0.0033	0.0278	0.0672
Echinococcus multilocularis	neural cadherin	0.0022	0.0132	0.0104
Echinococcus granulosus	nicalin	0.0039	0.035	0.0323
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0154	1
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0218	0.2596	1
Trypanosoma brucei	Aph-1 protein, putative	0.0314	0.3811	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Schistosoma mansoni	hypothetical protein	0.0022	0.0132	0.0132
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0154	1
Toxoplasma gondii	ck2 beta subunit	0.0078	0.0842	0.2185
Echinococcus multilocularis	glycoprotein Antigen 5	0.0014	0.0033	0.0005
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0033	0.0033
Echinococcus granulosus	protein jagged 1	0.0022	0.0132	0.0104
Trypanosoma cruzi	presenilin-like aspartic peptidase, putative	0.0218	0.2596	0.6733
Brugia malayi	Kringle domain containing protein	0.0051	0.0507	0.0507
Loa Loa (eye worm)	animal heme peroxidase	0.0139	0.1604	0.158
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0078	0.0842	0.2015
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Schistosoma mansoni	subfamily A22A unassigned peptidase (A22 family)	0.0218	0.2596	0.2596
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0017	0.0079	0.0079
Onchocerca volvulus		0.0022	0.0132	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1604	0.158
Brugia malayi	Animal haem peroxidase family protein	0.0139	0.1604	0.1604
Onchocerca volvulus		0.0033	0.0278	0.1587
Echinococcus multilocularis	neurogenic locus protein delta	0.0022	0.0132	0.0104
Echinococcus multilocularis	RUN	0.0041	0.0376	0.0349
Schistosoma mansoni	hypothetical protein	0.0022	0.0132	0.0132
Onchocerca volvulus	Peroxidase homolog	0.0139	0.1604	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.008	0.3883
Leishmania major	hypothetical protein, conserved	0.0061	0.0633	0.2201
Plasmodium falciparum	casein kinase II beta chain	0.0078	0.0842	1
Brugia malayi	Fibulin-1 precursor	0.0013	0.0028	0.0028
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0078	0.0842	0.2015
Toxoplasma gondii	subtilisin SUB12	0.0033	0.0278	0.0672
Onchocerca volvulus		0.0018	0.0092	0.0406
Echinococcus granulosus	delta-like protein 1	0.0022	0.0132	0.0104
Toxoplasma gondii	microneme protein MIC17B	0.0033	0.0278	0.0672
Brugia malayi	PAN domain containing protein	0.0033	0.0278	0.0278
Loa Loa (eye worm)	trypsin family protein	0.0014	0.0033	0.0005
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0022	0.0132	0.0104
Loa Loa (eye worm)	Csnk2b protein	0.0078	0.0842	0.0816
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0033	0.0033
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Toxoplasma gondii	phosphoinositide phospholipase PIPLC	0.0018	0.0092	0.0172
Echinococcus multilocularis	protein jagged 1	0.0022	0.0132	0.0104
Echinococcus granulosus	gamma secretase subunit aph 1	0.0806	1	1
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0033	0.0278	0.0672
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.0181	0.2141	0.2141
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1604	0.158
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0022	0.0132	0.0659
Echinococcus multilocularis	neurogenic locus protein delta	0.0022	0.0132	0.0104
Echinococcus granulosus	Mastin	0.0014	0.0033	0.0005
Onchocerca volvulus		0.0022	0.0132	0.0659
Brugia malayi	Trypsin family protein	0.0014	0.0033	0.0033
Echinococcus multilocularis	protein jagged 2	0.0022	0.0132	0.0104
Schistosoma mansoni	peroxidasin	0.0139	0.1604	0.1604
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1604	0.158
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0154	0.0126
Echinococcus granulosus	protein jagged 2	0.0022	0.0132	0.0104
Onchocerca volvulus		0.0014	0.0033	0.0029
Loa Loa (eye worm)	animal heme peroxidase	0.0139	0.1604	0.158
Toxoplasma gondii	microneme protein, putative	0.0033	0.0278	0.0672
Brugia malayi	Trypsin family protein	0.0014	0.0033	0.0033
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0246	0.2948	0.2929
Echinococcus multilocularis	ankyrin repeat protein	0.0181	0.2141	0.2119
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0033	0.0033
Echinococcus granulosus	neural cadherin	0.0022	0.0132	0.0104
Brugia malayi	Animal haem peroxidase family protein	0.0139	0.1604	0.1604
Echinococcus granulosus	neurogenic locus notch protein 4	0.0022	0.0132	0.0104
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0078	0.0842	0.5162
Plasmodium falciparum	LCCL domain-containing protein	0.0041	0.0376	0.3901
Echinococcus multilocularis	casein kinase ii subunit beta	0.0078	0.0842	0.0816
Plasmodium vivax	casein kinase II beta chain, putative	0.0078	0.0842	1
Toxoplasma gondii	hypothetical protein	0.0076	0.0818	0.2123
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1604	0.158
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0005
Schistosoma mansoni	cell polarity protein	0.0022	0.0132	0.0132
Onchocerca volvulus		0.0014	0.0033	0.0029
Echinococcus granulosus	enteropeptidase	0.0014	0.0033	0.0005
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.008	0.5
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Brugia malayi	PAN domain containing protein	0.0033	0.0278	0.0278
Toxoplasma gondii	microneme protein MIC4	0.0033	0.0278	0.0672
Onchocerca volvulus	Peroxidase homolog	0.0139	0.1604	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0005
Brugia malayi	Variant SH3 domain containing protein	0.0127	0.1459	0.1459
Toxoplasma gondii	hypothetical protein	0.0061	0.0633	0.1625
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0033	0.0033
Brugia malayi	Presenilin spe-4	0.0076	0.0818	0.0818
Onchocerca volvulus		0.0033	0.0278	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0251
Brugia malayi	hypothetical protein	0.0014	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1604	0.158
Echinococcus multilocularis	transmembrane protease serine 3	0.0014	0.0033	0.0005
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0806	1	1
Toxoplasma gondii	PAN domain-containing protein	0.0033	0.0278	0.0672
Schistosoma mansoni	rab6-interacting	0.0041	0.0376	0.0376
Schistosoma mansoni	notch	0.0022	0.0132	0.0132
Toxoplasma gondii	PAN domain-containing protein	0.0033	0.0278	0.0672
Trypanosoma cruzi	hypothetical protein, conserved	0.0051	0.0507	0.1115
Onchocerca volvulus		0.0014	0.0033	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0154	0.0126
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0154	1
Onchocerca volvulus		0.0022	0.0132	0.0659
Echinococcus granulosus	glycoprotein Antigen 5	0.0014	0.0033	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0507	0.048
Echinococcus granulosus	casein kinase ii subunit beta	0.0078	0.0842	0.0816
Brugia malayi	EGF-like domain containing protein	0.0022	0.0132	0.0132
Leishmania major	presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative	0.0218	0.2596	1
Trypanosoma brucei	Presenilin enhancer-2 subunit of gamma secretase, putative	0.0061	0.0633	0.1454
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0154	0.003
Brugia malayi	EGF-like domain containing protein	0.0022	0.0132	0.0132
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Echinococcus multilocularis	protein jagged 1	0.0022	0.0132	0.0104
Trypanosoma brucei	Casein kinase II subunit beta, putative	0.0078	0.0842	0.2015
Loa Loa (eye worm)	PAN domain-containing protein	0.0033	0.0278	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Echinococcus granulosus	neurogenic locus protein delta	0.0022	0.0132	0.0104
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0154	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0251
Toxoplasma gondii	hypothetical protein	0.0033	0.0278	0.0672
Toxoplasma gondii	EGF family domain-containing protein	0.0022	0.0132	0.0279
Brugia malayi	Presenilin-like protein At2g29900	0.0076	0.0818	0.0818
Echinococcus granulosus	tissue type plasminogen activator	0.0051	0.0507	0.048
Brugia malayi	gamma-secretase subunit pen-2	0.0204	0.2428	0.2428
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0022	0.0132	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Loa Loa (eye worm)	notch protein	0.0022	0.0132	0.0104
Onchocerca volvulus	Slit protein homolog	0.0022	0.0132	0.0659
Toxoplasma gondii	PAN domain-containing protein	0.0309	0.375	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1604	0.158
Schistosoma mansoni	casein kinase II beta subunit	0.0078	0.0842	0.0842
Toxoplasma gondii	PAN domain-containing protein	0.0033	0.0278	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0033	0.0033
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0154	0.5
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Loa Loa (eye worm)	PAN domain-containing protein	0.0033	0.0278	0.0251
Schistosoma mansoni	phospholipase C beta	0.0017	0.0079	0.0079
Echinococcus multilocularis	nicalin	0.0039	0.035	0.0323
Schistosoma mansoni	rab6-interacting	0.0041	0.0376	0.0376
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0154	1
Entamoeba histolytica	hypothetical protein	0.0039	0.035	0.083
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0052
Onchocerca volvulus	Peroxidasin homolog	0.0139	0.1604	1
Trypanosoma brucei	presenilin-like aspartic peptidase, putative	0.0218	0.2596	0.6733
Brugia malayi	PAN domain containing protein	0.0033	0.0278	0.0278
Onchocerca volvulus		0.0033	0.0278	0.1587
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0154	1
Schistosoma mansoni	notch	0.0022	0.0136	0.0136
Giardia lamblia	Casein kinase II beta chain	0.0023	0.0147	0.021
Loa Loa (eye worm)	casein kinase II	0.0023	0.0147	0.0119
Brugia malayi	PAN domain containing protein	0.0033	0.0278	0.0278
Echinococcus granulosus	lipoxygenase domain containing protein	0.0041	0.0376	0.0349
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Schistosoma mansoni	hypothetical protein	0.0022	0.0132	0.0132
Onchocerca volvulus		0.0139	0.1604	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0154	0.0299
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0051	0.0507	0.5607
Schistosoma mansoni	peroxidasin	0.0139	0.1604	0.1604
Echinococcus granulosus	peroxidasin	0.0139	0.1604	0.158
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0033	0.0033
Echinococcus multilocularis	Polycystic kidney disease protein	0.0041	0.0376	0.0349
Echinococcus multilocularis	Nicastrin	0.0106	0.1194	0.1169
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0014	0.0033	0.0005
Plasmodium vivax	casein kinase II beta chain, putative	0.0078	0.0842	1
Plasmodium falciparum	casein kinase II beta chain	0.0078	0.0842	1
Toxoplasma gondii	PAN domain-containing protein	0.0309	0.375	1
Trypanosoma cruzi	presenilin-like aspartic peptidase, putative	0.0218	0.2596	0.6733
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0251
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0078	0.0842	0.2836
Onchocerca volvulus		0.0033	0.0278	0.1587
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0033	0.0033
Schistosoma mansoni	hypothetical protein	0.0022	0.0132	0.0132
Echinococcus multilocularis	peroxidasin	0.0139	0.1604	0.158
Echinococcus granulosus	presenilin	0.0218	0.2596	0.2575
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0078	0.0842	0.2836
Loa Loa (eye worm)	Plcb4 protein	0.0017	0.0079	0.0051
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0014	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0079	0.0051
Echinococcus multilocularis	tissue type plasminogen activator	0.0051	0.0507	0.048
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1604	0.158
Brugia malayi	PAN domain containing protein	0.0033	0.0278	0.0278
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0154	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0104
Schistosoma mansoni	hypothetical protein	0.0022	0.0132	0.0132
Echinococcus multilocularis	fibropellin Ia	0.0022	0.0132	0.0104
Onchocerca volvulus		0.0033	0.0278	0.1587
Loa Loa (eye worm)	presenilin spe-4	0.0076	0.0818	0.0792
Loa Loa (eye worm)	PAN domain-containing protein	0.0033	0.0278	0.0251
Onchocerca volvulus		0.0033	0.0278	0.1587

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 797336