TDR Targets

Basic information

Technical information

TDR Targets ID: 797805
Name: ethyl 1-(4-ethylamino-6-piperidin-1-yl-1,3,5- triazin-2-yl)-5-methyltriazole-4-carboxylate
MW: 360.414 | Formula: C16H24N8O2
H donors: 1 H acceptors: 6 LogP: 2.67 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1nnn(c1C)c1nc(NCC)nc(n1)N1CCCCC1
InChi: 1S/C16H24N8O2/c1-4-17-14-18-15(23-9-7-6-8-10-23)20-16(19-14)24-11(3)12(21-22-24)13(25)26-5-2/h4-10H2,1-3H3,(H,17,18,19,20)
InChiKey: PTTZWMAPUPTDKB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 1-[4-ethylamino-6-(1-piperidyl)-1,3,5-triazin-2-yl]-5-methyl-triazole-4-carboxylate
1-[4-ethylamino-6-(1-piperidyl)-1,3,5-triazin-2-yl]-5-methyl-4-triazolecarboxylic acid ethyl ester
1-(4-ethylamino-6-piperidino-s-triazin-2-yl)-5-methyl-triazole-4-carboxylic acid ethyl ester
ethyl 1-(4-ethylamino-6-piperidin-1-yl-1,3,5-triazin-2-yl)-5-methyl-1,2,3-triazole-4-carboxylate
SMR000027611
ethyl 1-[4-(ethylamino)-6-piperidin-1-yl-1,3,5-triazin-2-yl]-5-methyl-1H-1,2,3-triazole-4-carboxylate
ZINC01074277
A2996/0126256
MLS000045654

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	mitogen-activated protein kinase 1	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0275	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0002	0.0002
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0002	0.0002
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0443	0.1682	0.1682
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0021	0.0021
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.261	1	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0042	0.0042
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0016	0.0016
Echinococcus granulosus	sulfhydryl oxidase 1	0.0005	0.0002	0.0002
Schistosoma mansoni	cpg binding protein	0.0029	0.0092	0.0092
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0021	0.0021
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0443	0.1682	0.1682
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0021	0.0021
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0021	0.0021
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0021	0.0021
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0009	0.0009
Echinococcus granulosus	geminin	0.0338	0.128	0.128
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0021	0.0021
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0021	0.0021
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.0218	0.0218
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0275	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0443	0.1682	0.1682
Brugia malayi	hypothetical protein	0.0005	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0338	0.128	0.128
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0021	0.0021
Schistosoma mansoni	sodium/chloride dependent transporter	0.0444	0.1684	0.1684
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0443	0.1682	0.1682
Echinococcus granulosus	sodium and chloride dependent glycine	0.0443	0.1682	0.1682
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0021	0.0021
Brugia malayi	Erv1 / Alr family protein	0.0005	0.0002	0.0002
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0035	0.0114	0.0114
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0174	0.0174
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0021	0.0021
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0021	0.0021
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0021	0.0021
Brugia malayi	hypothetical protein	0.0443	0.1682	0.1682
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0824	0.3145	0.3145
Entamoeba histolytica	hypothetical protein	0.0043	0.0148	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0042	0.0042
Brugia malayi	MAP kinase sur-1	0.0062	0.0218	0.0218
Entamoeba histolytica	hypothetical protein	0.0043	0.0148	0.5
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0021	0.0021
Plasmodium falciparum	transporter, putative	0.0443	0.1682	1
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0275	0.0275
Echinococcus multilocularis	geminin	0.0338	0.128	0.128
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0015	0.0015
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0002	0.0002
Brugia malayi	steroid hormone receptor	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0443	0.1682	0.1682
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0148	0.0148
Loa Loa (eye worm)	hepatopoietin HPO2	0.0035	0.0114	0.0114
Brugia malayi	nuclear receptor NHR-88	0.001	0.0021	0.0021
Echinococcus multilocularis	muscleblind protein	0.0302	0.1141	0.1141
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0002	0.0002
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0021	0.0021
Brugia malayi	hypothetical protein	0.0005	0.0002	0.0002
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0218	1
Onchocerca volvulus		0.001	0.0021	0.0021
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0042	0.0042
Onchocerca volvulus	Sulfhydryl oxidase homolog	0.0005	0.0002	0.0002
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0009	0.0009
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0443	0.1682	0.1682
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0042	0.0042
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0021	0.0021
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0021	0.0021
Entamoeba histolytica	hypothetical protein	0.0043	0.0148	0.5
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0016	0.0042	0.0042
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0021	0.0021
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0217	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0002	0.0002
Onchocerca volvulus		0.261	1	1
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0443	0.1682	0.1682
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0002	0.0002
Schistosoma mansoni	sodium/chloride dependent transporter	0.0443	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.0218	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0021	0.0021
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0443	0.1682	0.1682
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0192	0.1126
Treponema pallidum	sodium- and chloride- dependent transporter	0.261	1	0.5
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.0218	1
Loa Loa (eye worm)	hypothetical protein	0.0443	0.1682	0.1682
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0275	0.0275
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0021	0.0021
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0021	0.0021
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0021	0.0021
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0443	0.1682	0.1682
Brugia malayi	ecdysteroid receptor	0.001	0.0021	0.0021
Onchocerca volvulus		0.0443	0.1682	0.1682
Brugia malayi	hypothetical protein	0.0043	0.0148	0.0148
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0443	0.1682	1
Echinococcus multilocularis	serotonin transporter	0.261	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0275	0.0275
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0021	0.0021
Loa Loa (eye worm)	serotonin transporter b	0.261	1	1
Loa Loa (eye worm)	solute carrier family 6 member 4	0.261	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0021	0.0021
Schistosoma mansoni	hypothetical protein	0.0016	0.0042	0.0042
Toxoplasma gondii	Erv1 / Alr family protein	0.0035	0.0114	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0443	0.1682	0.1682
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0021	0.0021
Plasmodium falciparum	amino acid transporter, putative	0.0443	0.1682	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0021	0.0021
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0021	0.0021
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0021	0.0021
Schistosoma mansoni	sodium/chloride dependent transporter	0.261	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0021	0.0021
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0443	0.1682	1
Loa Loa (eye worm)	hypothetical protein	0.261	1	1
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0035	0.0114	0.0664
Echinococcus granulosus	muscleblind protein	0.0302	0.1141	0.1141
Onchocerca volvulus		0.0029	0.0092	0.0092
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0218	1
Brugia malayi	TAR-binding protein	0.0076	0.0275	0.0275
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0035	0.0114	0.0114
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0443	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0002	0.0002
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0021	0.0021
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0218	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0443	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0016	0.0016
Toxoplasma gondii	Erv1 / Alr family protein	0.0035	0.0114	0.0664
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0035	0.0114	0.518
Echinococcus granulosus	sodium and chloride dependent glycine	0.0443	0.1682	0.1682
Brugia malayi	Augmenter of liver regeneration	0.0035	0.0114	0.0114
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0443	0.1682	0.1682
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0443	0.1682	0.5
Schistosoma mansoni	cpg binding protein	0.0031	0.0099	0.0099
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0021	0.0021
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.0218	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0042	0.0042
Echinococcus granulosus	GPCR family 2	0.0016	0.0042	0.0042
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.0218	0.0218
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0443	0.1682	0.1682
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0002	0.0002
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.0218	0.0218
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0275	0.0275
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.0218	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0443	0.1682	0.1682
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0443	0.1682	0.1682
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0443	0.1682	0.1682
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0035	0.0114	0.0664
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Echinococcus granulosus	serotonin transporter	0.261	1	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0009	0.0009
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0035	0.0114	0.518
Brugia malayi	RNA binding protein	0.0076	0.0275	0.0275
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0275	0.0275
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0092	0.0092
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0443	0.1682	0.1682
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0021	0.0021
Loa Loa (eye worm)	norepinephrine transporter	0.261	1	1
Loa Loa (eye worm)	Erv1/Alr family protein	0.0005	0.0002	0.0002
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0021	0.0021
Plasmodium vivax	hypothetical protein, conserved	0.0443	0.1682	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0021	0.0021
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.0218	0.0218
Onchocerca volvulus		0.0443	0.1682	0.1682
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0021	0.0021
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0174	0.0174
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0443	0.1682	0.1682
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0016	0.0016
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0009	0.0009
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0021	0.0021
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0002	0.0002
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0443	0.1682	0.1682
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.0218	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0174	0.0174
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0021	0.0021
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0021	0.0021
Brugia malayi	nuclear hormone receptor	0.001	0.0021	0.0021
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0443	0.1682	0.1682
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0174	0.0174
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0443	0.1682	0.1682
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Schistosoma mansoni	hypothetical protein	0.0338	0.128	0.128
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0021	0.0021
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.0218	0.0218
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0021	0.0021
Onchocerca volvulus		0.0443	0.1682	0.1682
Echinococcus multilocularis	sulfhydryl oxidase 1	0.0005	0.0002	0.0002
Echinococcus granulosus	cpg binding protein	0.0031	0.0099	0.0099
Brugia malayi	nuclear receptor RXR	0.0005	0.0002	0.0002
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0035	0.0114	0.518
Schistosoma mansoni	coup transcription factor	0.001	0.0021	0.0021
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.261	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0113	0.0113
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0021	0.0021
Loa Loa (eye worm)	quiescin Q6	0.0005	0.0002	0.0002
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0021	0.0021
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0042	0.0042
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.261	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0275	0.0275
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.0218	0.5
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0443	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0113	0.0113
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0021	0.0021
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0443	0.1682	0.1682
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0443	0.1682	0.1682
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.0218	0.1281
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0275	0.0275
Schistosoma mansoni	hypothetical protein	0.0043	0.0148	0.0148
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0443	0.1682	0.1682
Echinococcus multilocularis	muscleblind protein 1	0.0302	0.1141	0.1141
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0042	0.0042
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0092	0.0092
Toxoplasma gondii	hypothetical protein	0.0443	0.1682	1
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0218	1
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0021	0.0021
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0002	0.0002
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0443	0.1682	1
Onchocerca volvulus	Sulfhydryl oxidase homolog	0.0005	0.0002	0.0002
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0042	0.0042
Plasmodium vivax	amine transporter, putative	0.0443	0.1682	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0443	0.1682	0.1682
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0021	0.0021
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0042	0.0042
Schistosoma mansoni	hypothetical protein	0.0016	0.0042	0.0042
Schistosoma mansoni	cpg binding protein	0.0031	0.0099	0.0099
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0148	0.0148
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0009	0.0009
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0218	1
Brugia malayi	Muscleblind-like protein	0.0302	0.1141	0.1141
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0021	0.0021
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0002	0.0002
Entamoeba histolytica	hypothetical protein	0.0043	0.0148	0.5
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0443	0.1682	0.1682
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0218	0.0218
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0218	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0021	0.0021
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0021	0.0021
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0275	0.0275
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0275	0.0275
Trypanosoma brucei	protein kinase, putative	0.0062	0.0218	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0113	0.0113
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0443	0.1682	0.1682
Echinococcus multilocularis	cpg binding protein	0.0031	0.0099	0.0099
Schistosoma mansoni	quiescin q6-related sulfhydryl oxidase	0.0005	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0302	0.1141	0.1141
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0021	0.0021
Toxoplasma gondii	hypothetical protein	0.0443	0.1682	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0148	0.0148
Brugia malayi	quiescin Q6	0.0005	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0443	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0302	0.1141	0.1141
Onchocerca volvulus	Sulfhydryl oxidase homolog	0.0005	0.0002	0.0002
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0002	0.0002
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0035	0.0114	0.518

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0029 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	95.2834 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1578860
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 797805