Detailed information for compound 798810

Basic information

Technical information
  • TDR Targets ID: 798810
  • Name: 3-(carbamothioylamino)-1-(oxolan-2-ylmethyl)t hiourea
  • MW: 234.342 | Formula: C7H14N4OS2
  • H donors: 4 H acceptors: 0 LogP: -0.09 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(NNC(=S)N)NCC1CCCO1
  • InChi: 1S/C7H14N4OS2/c8-6(13)10-11-7(14)9-4-5-2-1-3-12-5/h5H,1-4H2,(H3,8,10,13)(H2,9,11,14)
  • InChiKey: PSXCQNVBSVUPLZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(carbamothioylamino)-1-(tetrahydrofuran-2-ylmethyl)thiourea
  • 3-(carbamothioylamino)-1-(2-tetrahydrofuranylmethyl)thiourea
  • 1-(tetrahydrofurfuryl)-3-(thiocarbamoylamino)thiourea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0005 0.0005
Echinococcus granulosus microtubule associated protein 2 0.0669 0.1558 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0005 0.0034
Loa Loa (eye worm) hypothetical protein 0.0099 0.0169 0.1175
Loa Loa (eye worm) MBCTL1 0.0112 0.0203 0.1406
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.027 0.0588 0.4076
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.027 0.0588 0.4076
Echinococcus granulosus expressed conserved protein 0.029 0.0635 0.4075
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0539 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0099 0.0169 0.1088
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0328 0.0727 0.5045
Toxoplasma gondii hypothetical protein 0.0053 0.0059 0.0412
Brugia malayi AMP-binding enzyme family protein 0.0099 0.017 0.1179
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0621 0.1442 1
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.028 0.061 0.1915
Schistosoma mansoni hypothetical protein 0.0345 0.0768 0.4934
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0539 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0331 0.0736 0.5102
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0621 0.1442 0.4525
Echinococcus multilocularis polycomb protein SCMH1 0.0099 0.0169 0.0169
Brugia malayi RNA binding protein 0.0063 0.0083 0.0579
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0044 0.0308
Loa Loa (eye worm) hypothetical protein 0.0074 0.0109 0.0757
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0612 0.142 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0267 0.1715
Loa Loa (eye worm) hypothetical protein 0.0074 0.0109 0.0757
Schistosoma mansoni hypothetical protein 0.0047 0.0044 0.0286
Schistosoma mansoni importin beta-1 0.0031 0.0004 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0267 0.1715
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0389 0.0876 0.5621
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.0034
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.1558 0.1558
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1337 0.3187 1
Onchocerca volvulus Putative GMP reductase 0.027 0.0588 1
Mycobacterium ulcerans transcriptional regulator 0.1337 0.3187 1
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0083 0.0579
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0099 0.017 0.0534
Echinococcus granulosus GPCR family 2 0.0031 0.0005 0.0034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0267 0.1715
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0621 0.1442 1
Plasmodium vivax importin-beta 2, putative 0.0031 0.0004 0.0029
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0621 0.1442 0.4525
Entamoeba histolytica acyl-CoA synthetase, putative 0.0099 0.017 0.25
Echinococcus granulosus geminin 0.0345 0.0768 0.4934
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1337 0.3187 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.0736 0.5102
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0329 0.5602
Brugia malayi Bromodomain containing protein 0.0038 0.0022 0.0156
Echinococcus granulosus polycomb protein SCMH1 0.0099 0.0169 0.1088
Schistosoma mansoni hypothetical protein 0.0599 0.1389 0.8918
Mycobacterium ulcerans TetR family transcriptional regulator 0.1337 0.3187 1
Loa Loa (eye worm) IMP dehydrogenase 1 0.0621 0.1442 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0389 0.0876 0.0876
Leishmania major mitochondrial DNA polymerase beta 0.0331 0.0736 0.5102
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0099 0.0169 0.1088
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0329 0.611
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0028
Mycobacterium ulcerans hypothetical protein 0.0174 0.0354 0.1111
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0612 0.142 1
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0004 0.0028
Brugia malayi mbt repeat family protein 0.0099 0.0169 0.1175
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0005 0.0037
Schistosoma mansoni hypothetical protein 0.0067 0.0094 0.0601
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.0034
Loa Loa (eye worm) hypothetical protein 0.0074 0.0109 0.0757
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0017 0.0107
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.017 0.1179
Onchocerca volvulus Huntingtin homolog 0.0119 0.0218 0.3716
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0112 0.0203 0.0203
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0068 0.0468
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0329 0.611
Onchocerca volvulus 0.0037 0.0019 0.0315
Echinococcus multilocularis protein dispatched 1 0.0151 0.0297 0.0297
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0099 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0252 0.4669
Onchocerca volvulus Huntingtin homolog 0.0119 0.0218 0.3716
Entamoeba histolytica acyl-coA synthetase, putative 0.0099 0.017 0.25
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.017 0.0534
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0329 0.611
Brugia malayi Niemann-Pick C1 protein precursor 0.0308 0.068 0.4717
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0083 0.0536
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0621 0.1442 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.0493 0.3417
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0099 0.0169 0.2883
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0083 0.0536
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0005 0.0037
Loa Loa (eye worm) hypothetical protein 0.0074 0.0109 0.0757
Loa Loa (eye worm) hypothetical protein 0.0232 0.0494 0.3425
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.017 0.1176
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0112 0.0203 0.1406
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0351 0.651
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0329 0.611
Plasmodium falciparum importin beta, putative 0.0031 0.0004 0.0029
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.0311 0.2157
Onchocerca volvulus 0.0099 0.017 0.2893
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.017 0.0534
Toxoplasma gondii IMP dehydrogenas 0.0621 0.1442 1
Entamoeba histolytica hypothetical protein 0.0074 0.011 0.1619
Loa Loa (eye worm) hypothetical protein 0.0162 0.0324 0.2247
Echinococcus multilocularis geminin 0.0345 0.0768 0.0768
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0539 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0112 0.0203 0.0203
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0005 0.0037
Loa Loa (eye worm) hypothetical protein 0.0099 0.017 0.1179
Entamoeba histolytica hypothetical protein 0.0074 0.011 0.1619
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0342 0.0761 0.2389
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0267 0.1715
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.0354 0.1111
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0311 0.2157
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0099 0.017 0.0534
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0621 0.1442 0.4525
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0094 0.0649
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0083 0.0536
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.1558 1
Onchocerca volvulus 0.0047 0.0044 0.0757
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0074 0.0109 0.5
Loa Loa (eye worm) hypothetical protein 0.0308 0.068 0.4717
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0043 0.0296
Echinococcus granulosus Niemann Pick C1 protein 0.0441 0.1002 0.6436
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0005 0.0005
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0099 0.017 0.0534
Echinococcus granulosus Protein patched homolog 1 0.0132 0.0252 0.1615
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0308 0.068 1
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0539 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0004 0.0028
Echinococcus multilocularis SAM and MBT domain containing protein 0.0099 0.0169 0.0169
Schistosoma mansoni myelin transcription factor 1 myt1 0.0112 0.0203 0.1301
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.017 0.1179
Loa Loa (eye worm) hypothetical protein 0.0074 0.0109 0.0757
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0539 1
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0083 0.0579
Loa Loa (eye worm) hypothetical protein 0.0041 0.0028 0.0197
Echinococcus granulosus snurportin 1 0.0328 0.0727 0.467
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0621 0.1442 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.0539 0.3737
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0005 0.0034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.017 0.1176
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1337 0.3187 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0043 0.0296
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0621 0.1442 0.9257
Schistosoma mansoni hypothetical protein 0.0128 0.024 0.154
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0229
Schistosoma mansoni hypothetical protein 0.0128 0.024 0.154
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0329 0.611
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.0736 0.5102
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.0494 0.3171
Loa Loa (eye worm) hypothetical protein 0.0071 0.0101 0.0703
Brugia malayi follicle stimulating hormone receptor 0.0231 0.0493 0.3417
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0017 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0539 1
Echinococcus granulosus importin subunit beta 1 0.0031 0.0004 0.0026
Loa Loa (eye worm) hypothetical protein 0.0119 0.0218 0.1515
Schistosoma mansoni sex comb on midleg homolog 0.0099 0.0169 0.1088
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0043 0.0296
Loa Loa (eye worm) hypothetical protein 0.0067 0.0094 0.0649
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0112 0.0203 0.1301
Brugia malayi hypothetical protein 0.0119 0.0218 0.1515
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0099 0.017 0.0534
Schistosoma mansoni bromodomain containing protein 0.0063 0.0083 0.0535
Schistosoma mansoni sex comb on midleg homolog 0.0099 0.0169 0.1088
Schistosoma mansoni hypothetical protein 0.0128 0.024 0.154
Loa Loa (eye worm) hypothetical protein 0.0119 0.0218 0.1515
Schistosoma mansoni survival motor neuron protein 0.0047 0.0044 0.0286
Plasmodium vivax acyl-CoA synthetase, putative 0.0074 0.0109 0.0769
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0267 0.1715
Loa Loa (eye worm) GMP reductase 0.027 0.0588 0.4076
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.028 0.061 0.1915
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0099 0.017 0.0534
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0329 0.611
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0329 0.611
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0004 0.0004
Leishmania major guanosine monophosphate reductase 0.0621 0.1442 1
Echinococcus multilocularis snurportin 1 0.0328 0.0727 0.0727
Loa Loa (eye worm) mbt repeat family protein 0.0099 0.0169 0.1175
Mycobacterium ulcerans hypothetical protein 0.0099 0.017 0.0534
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0083 0.0536
Brugia malayi Importin beta-1 subunit 0.0031 0.0004 0.0028
Trypanosoma cruzi GMP reductase 0.0621 0.1442 1
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0621 0.1442 1
Echinococcus granulosus Niemann Pick C1 protein 0.0308 0.068 0.4367
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0083 0.0579
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0099 0.017 0.0534
Brugia malayi AMP-binding enzyme family protein 0.0099 0.017 0.1179
Trypanosoma brucei GMP reductase 0.0621 0.1442 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.011 0.0707
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0311 0.2157
Echinococcus granulosus tar DNA binding protein 0.0063 0.0083 0.0536
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0099 0.0312
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.011 0.0707
Schistosoma mansoni patched 1 0.0132 0.0252 0.1615
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.011 0.011
Trypanosoma cruzi GMP reductase 0.0621 0.1442 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0112 0.0203 0.1406
Brugia malayi hypothetical protein 0.0074 0.011 0.0764
Entamoeba histolytica acyl-CoA synthetase, putative 0.0099 0.017 0.25
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0342 0.0761 0.2389
Schistosoma mansoni hypothetical protein 0.0128 0.024 0.154
Entamoeba histolytica hypothetical protein 0.0074 0.011 0.1619
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0099 0.017 0.0534
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0621 0.1442 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0004 0.0028
Brugia malayi mbt repeat family protein 0.0099 0.0169 0.1175
Echinococcus granulosus histone acetyltransferase MYST2 0.0112 0.0203 0.1301
Brugia malayi CHE-14 protein 0.0132 0.0252 0.1745
Schistosoma mansoni hypothetical protein 0.0345 0.0768 0.4934
Brugia malayi AMP-binding enzyme family protein 0.0099 0.017 0.1179
Loa Loa (eye worm) hypothetical protein 0.0099 0.017 0.1176
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0132 0.0252 0.1745
Entamoeba histolytica hypothetical protein 0.0074 0.011 0.1619
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.0034
Brugia malayi TAR-binding protein 0.0063 0.0083 0.0579
Schistosoma mansoni hypothetical protein 0.0074 0.011 0.0707
Plasmodium falciparum acyl-CoA synthetase 0.0074 0.0109 0.0769
Echinococcus multilocularis expressed conserved protein 0.029 0.0635 0.0635
Echinococcus multilocularis sterol regulatory element binding protein 0.0132 0.0252 0.0252
Echinococcus multilocularis Niemann Pick C1 protein 0.0441 0.1002 0.1002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0267 0.1853
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0621 0.1442 0.1442
Leishmania major inosine-5-monophosphate dehydrogenase 0.0621 0.1442 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0267 0.0267
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0074 0.0109 0.0343
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0099 0.0312
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0621 0.1442 0.9257
Brugia malayi GMP reductase 0.027 0.0588 0.4076
Echinococcus multilocularis GPCR, family 2 0.0031 0.0005 0.0005
Echinococcus multilocularis Niemann Pick C1 protein 0.0308 0.068 0.068
Brugia malayi RNA, U transporter 1 0.0087 0.0142 0.0984
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0037
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.0539 0.3737
Loa Loa (eye worm) hypothetical protein 0.0132 0.0252 0.1745
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0313 0.0692 0.4442
Echinococcus multilocularis protein patched 0.0132 0.0252 0.0252
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0612 0.142 0.4455
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0083 0.0536
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0099 0.017 0.0534
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.017 0.1179
Brugia malayi Bromodomain containing protein 0.0075 0.0112 0.0775
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.017 0.0534
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0075 0.0479
Brugia malayi hypothetical protein 0.0232 0.0494 0.3425
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.0034
Echinococcus granulosus sterol regulatory element binding protein 0.0132 0.0252 0.1615
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.0494 0.0494
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0109 0.0343
Onchocerca volvulus 0.0099 0.0169 0.2883
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.017 0.1176
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0157
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0267 0.1853
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0099 0.017 0.1179
Loa Loa (eye worm) hypothetical protein 0.0099 0.017 0.1179
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0043 0.0296
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0351 0.651
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0075 0.0075
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0099 0.0312
Schistosoma mansoni hypothetical protein 0.0328 0.0727 0.467
Loa Loa (eye worm) RNA binding protein 0.0063 0.0083 0.0579

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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