Detailed information for compound 798810

Basic information

Technical information
  • TDR Targets ID: 798810
  • Name: 3-(carbamothioylamino)-1-(oxolan-2-ylmethyl)t hiourea
  • MW: 234.342 | Formula: C7H14N4OS2
  • H donors: 4 H acceptors: 0 LogP: -0.09 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(NNC(=S)N)NCC1CCCO1
  • InChi: 1S/C7H14N4OS2/c8-6(13)10-11-7(14)9-4-5-2-1-3-12-5/h5H,1-4H2,(H3,8,10,13)(H2,9,11,14)
  • InChiKey: PSXCQNVBSVUPLZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(carbamothioylamino)-1-(tetrahydrofuran-2-ylmethyl)thiourea
  • 3-(carbamothioylamino)-1-(2-tetrahydrofuranylmethyl)thiourea
  • 1-(tetrahydrofurfuryl)-3-(thiocarbamoylamino)thiourea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0075 0.0112 0.0775
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0005 0.0037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.017 0.1176
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0329 0.611
Loa Loa (eye worm) hypothetical protein 0.0308 0.068 0.4717
Loa Loa (eye worm) hypothetical protein 0.0119 0.0218 0.1515
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0099 0.0312
Onchocerca volvulus Huntingtin homolog 0.0119 0.0218 0.3716
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0017 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0329 0.611
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.0736 0.5102
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0329 0.611
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0351 0.651
Schistosoma mansoni myelin transcription factor 1 myt1 0.0112 0.0203 0.1301
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0621 0.1442 1
Schistosoma mansoni hypothetical protein 0.0128 0.024 0.154
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0044 0.0308
Echinococcus multilocularis geminin 0.0345 0.0768 0.0768
Loa Loa (eye worm) hypothetical protein 0.0232 0.0494 0.3425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0267 0.1715
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.0494 0.3171
Brugia malayi follicle stimulating hormone receptor 0.0231 0.0493 0.3417
Brugia malayi Niemann-Pick C1 protein precursor 0.0308 0.068 0.4717
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0389 0.0876 0.0876
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0621 0.1442 0.9257
Echinococcus granulosus histone acetyltransferase MYST2 0.0112 0.0203 0.1301
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.011 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0252 0.4669
Brugia malayi AMP-binding enzyme family protein 0.0099 0.017 0.1179
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0099 0.0312
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0005 0.0005
Plasmodium falciparum importin beta, putative 0.0031 0.0004 0.0029
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0099 0.017 0.0534
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0351 0.651
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0112 0.0203 0.1406
Schistosoma mansoni hypothetical protein 0.0128 0.024 0.154
Onchocerca volvulus 0.0037 0.0019 0.0315
Brugia malayi Bromodomain containing protein 0.0038 0.0022 0.0156
Plasmodium falciparum acyl-CoA synthetase 0.0074 0.0109 0.0769
Entamoeba histolytica hypothetical protein 0.0074 0.011 0.1619
Schistosoma mansoni sex comb on midleg homolog 0.0099 0.0169 0.1088
Trypanosoma cruzi GMP reductase 0.0621 0.1442 1
Onchocerca volvulus 0.0099 0.0169 0.2883
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0083 0.0579
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0004 0.0028
Entamoeba histolytica hypothetical protein 0.0074 0.011 0.1619
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.0034
Onchocerca volvulus Huntingtin homolog 0.0119 0.0218 0.3716
Brugia malayi hypothetical protein 0.0074 0.011 0.0764
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.0354 0.1111
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1337 0.3187 1
Schistosoma mansoni hypothetical protein 0.0599 0.1389 0.8918
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.017 0.1176
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0099 0.017 0.0534
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0157
Brugia malayi mbt repeat family protein 0.0099 0.0169 0.1175
Entamoeba histolytica acyl-CoA synthetase, putative 0.0099 0.017 0.25
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0099 0.017 0.0534
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0612 0.142 0.4455
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0099 0.0312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0267 0.1715
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0099 0.0169 0.1088
Loa Loa (eye worm) hypothetical protein 0.0112 0.0203 0.1406
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0099 0.0169 0.2883
Echinococcus multilocularis expressed conserved protein 0.029 0.0635 0.0635
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0267 0.1853
Onchocerca volvulus Putative GMP reductase 0.027 0.0588 1
Brugia malayi mbt repeat family protein 0.0099 0.0169 0.1175
Schistosoma mansoni hypothetical protein 0.0128 0.024 0.154
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.028 0.061 0.1915
Schistosoma mansoni sex comb on midleg homolog 0.0099 0.0169 0.1088
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0389 0.0876 0.5621
Echinococcus granulosus microtubule associated protein 2 0.0669 0.1558 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0043 0.0296
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0043 0.0296
Mycobacterium ulcerans transcriptional regulator 0.1337 0.3187 1
Trypanosoma cruzi GMP reductase 0.0621 0.1442 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0099 0.0169 0.0169
Echinococcus multilocularis histone acetyltransferase MYST2 0.0112 0.0203 0.0203
Schistosoma mansoni hypothetical protein 0.0345 0.0768 0.4934
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0005 0.0034
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.017 0.1179
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0074 0.0109 0.5
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0132 0.0252 0.1745
Echinococcus multilocularis protein patched 0.0132 0.0252 0.0252
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0621 0.1442 0.9257
Loa Loa (eye worm) RNA binding protein 0.0063 0.0083 0.0579
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0539 1
Brugia malayi RNA, U transporter 1 0.0087 0.0142 0.0984
Loa Loa (eye worm) hypothetical protein 0.0099 0.017 0.1179
Trypanosoma brucei GMP reductase 0.0621 0.1442 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0083 0.0536
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.028 0.061 0.1915
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.0034
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0621 0.1442 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0267 0.0267
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.017 0.1179
Loa Loa (eye worm) hypothetical protein 0.0099 0.0169 0.1175
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0005 0.0034
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0621 0.1442 1
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0539 1
Leishmania major inosine-5-monophosphate dehydrogenase 0.0621 0.1442 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0083 0.0083
Schistosoma mansoni importin beta-1 0.0031 0.0004 0.0026
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0621 0.1442 0.4525
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.017 0.1176
Mycobacterium ulcerans hypothetical protein 0.0174 0.0354 0.1111
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0329 0.611
Loa Loa (eye worm) hypothetical protein 0.0099 0.017 0.1176
Schistosoma mansoni bromodomain containing protein 0.0063 0.0083 0.0535
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.017 0.1179
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0099 0.0312
Brugia malayi RNA binding protein 0.0063 0.0083 0.0579
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.0539 0.3737
Schistosoma mansoni hypothetical protein 0.0047 0.0044 0.0286
Loa Loa (eye worm) hypothetical protein 0.0099 0.017 0.1179
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0612 0.142 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.017 0.0534
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.0736 0.5102
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0028
Echinococcus multilocularis Niemann Pick C1 protein 0.0308 0.068 0.068
Entamoeba histolytica acyl-coA synthetase, putative 0.0099 0.017 0.25
Echinococcus granulosus Niemann Pick C1 protein 0.0308 0.068 0.4367
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0621 0.1442 0.1442
Loa Loa (eye worm) hypothetical protein 0.0041 0.0028 0.0197
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.017 0.1179
Schistosoma mansoni survival motor neuron protein 0.0047 0.0044 0.0286
Loa Loa (eye worm) hypothetical protein 0.0074 0.0109 0.0757
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0311 0.2157
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0229
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.1558 1
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1337 0.3187 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0313 0.0692 0.4442
Loa Loa (eye worm) hypothetical protein 0.0067 0.0094 0.0649
Entamoeba histolytica hypothetical protein 0.0074 0.011 0.1619
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.0494 0.0494
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0539 1
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0005 0.0037
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.027 0.0588 0.4076
Brugia malayi AMP-binding enzyme family protein 0.0099 0.017 0.1179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0267 0.1715
Brugia malayi hypothetical protein 0.0119 0.0218 0.1515
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0099 0.017 0.0534
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0267 0.1715
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0004 0.0004
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0328 0.0727 0.5045
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0099 0.017 0.0534
Toxoplasma gondii IMP dehydrogenas 0.0621 0.1442 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.011 0.0707
Echinococcus granulosus expressed conserved protein 0.029 0.0635 0.4075
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0308 0.068 1
Brugia malayi CHE-14 protein 0.0132 0.0252 0.1745
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0621 0.1442 1
Schistosoma mansoni hypothetical protein 0.0128 0.024 0.154
Brugia malayi GMP reductase 0.027 0.0588 0.4076
Echinococcus granulosus Niemann Pick C1 protein 0.0441 0.1002 0.6436
Mycobacterium ulcerans TetR family transcriptional regulator 0.1337 0.3187 1
Brugia malayi TAR-binding protein 0.0063 0.0083 0.0579
Onchocerca volvulus 0.0047 0.0044 0.0757
Echinococcus multilocularis snurportin 1 0.0328 0.0727 0.0727
Echinococcus granulosus geminin 0.0345 0.0768 0.4934
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0329 0.611
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0043 0.0296
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0083 0.0536
Toxoplasma gondii hypothetical protein 0.0053 0.0059 0.0412
Echinococcus multilocularis protein dispatched 1 0.0151 0.0297 0.0297
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.027 0.0588 0.4076
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0083 0.0536
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0267 0.1853
Leishmania major mitochondrial DNA polymerase beta 0.0331 0.0736 0.5102
Echinococcus multilocularis Niemann Pick C1 protein 0.0441 0.1002 0.1002
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0621 0.1442 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0075 0.0075
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0539 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0112 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0162 0.0324 0.2247
Echinococcus multilocularis sterol regulatory element binding protein 0.0132 0.0252 0.0252
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0329 0.611
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0099 0.017 0.0534
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.017 0.0534
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0043 0.0296
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.0034
Echinococcus granulosus importin subunit beta 1 0.0031 0.0004 0.0026
Onchocerca volvulus 0.0099 0.017 0.2893
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0094 0.0649
Schistosoma mansoni patched 1 0.0132 0.0252 0.1615
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.0034
Echinococcus multilocularis GPCR, family 2 0.0031 0.0005 0.0005
Loa Loa (eye worm) IMP dehydrogenase 1 0.0621 0.1442 1
Loa Loa (eye worm) mbt repeat family protein 0.0099 0.0169 0.1175
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0267 0.1715
Echinococcus granulosus snurportin 1 0.0328 0.0727 0.467
Echinococcus granulosus tar DNA binding protein 0.0063 0.0083 0.0536
Echinococcus granulosus polycomb protein SCMH1 0.0099 0.0169 0.1088
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0075 0.0479
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1337 0.3187 1
Schistosoma mansoni hypothetical protein 0.0328 0.0727 0.467
Loa Loa (eye worm) MBCTL1 0.0112 0.0203 0.1406
Entamoeba histolytica hypothetical protein 0.0074 0.011 0.1619
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0109 0.0343
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0099 0.017 0.0534
Brugia malayi hypothetical protein 0.0232 0.0494 0.3425
Mycobacterium ulcerans hypothetical protein 0.0099 0.017 0.0534
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0612 0.142 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0068 0.0468
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0329 0.5602
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0331 0.0736 0.5102
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.1558 0.1558
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0004 0.0028
Loa Loa (eye worm) hypothetical protein 0.0071 0.0101 0.0703
Loa Loa (eye worm) hypothetical protein 0.0074 0.0109 0.0757
Echinococcus granulosus sterol regulatory element binding protein 0.0132 0.0252 0.1615
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0112 0.0203 0.1301
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0083 0.0579
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0311 0.2157
Brugia malayi AMP-binding enzyme family protein 0.0099 0.017 0.1179
Echinococcus granulosus GPCR family 2 0.0031 0.0005 0.0034
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0083 0.0579
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0005 0.0005
Plasmodium vivax acyl-CoA synthetase, putative 0.0074 0.0109 0.0769
Plasmodium vivax importin-beta 2, putative 0.0031 0.0004 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0083 0.0536
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0099 0.017 0.0534
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0621 0.1442 0.4525
Loa Loa (eye worm) GMP reductase 0.027 0.0588 0.4076
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0342 0.0761 0.2389
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0539 1
Echinococcus multilocularis polycomb protein SCMH1 0.0099 0.0169 0.0169
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0004 0.0028
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.0539 0.3737
Schistosoma mansoni hypothetical protein 0.0074 0.011 0.0707
Loa Loa (eye worm) hypothetical protein 0.0132 0.0252 0.1745
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0017 0.0107
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0005 0.0037
Entamoeba histolytica acyl-CoA synthetase, putative 0.0099 0.017 0.25
Loa Loa (eye worm) hypothetical protein 0.0074 0.0109 0.0757
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.017 0.0534
Echinococcus granulosus Protein patched homolog 1 0.0132 0.0252 0.1615
Leishmania major guanosine monophosphate reductase 0.0621 0.1442 1
Schistosoma mansoni hypothetical protein 0.0345 0.0768 0.4934
Loa Loa (eye worm) hypothetical protein 0.0074 0.0109 0.0757
Loa Loa (eye worm) hypothetical protein 0.0074 0.0109 0.0757
Loa Loa (eye worm) hypothetical protein 0.0119 0.0218 0.1515
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.011 0.0707
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0083 0.0536
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0342 0.0761 0.2389
Brugia malayi Importin beta-1 subunit 0.0031 0.0004 0.0028
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.0493 0.3417
Echinococcus granulosus SAM and MBT domain containing protein 0.0099 0.0169 0.1088
Schistosoma mansoni hypothetical protein 0.0067 0.0094 0.0601
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0267 0.0267
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0074 0.0109 0.0343
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0621 0.1442 1
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0621 0.1442 0.4525
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0329 0.611
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.0311 0.2157

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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