Detailed information for compound 799222

Basic information

Technical information
  • TDR Targets ID: 799222
  • Name: ethyl 4-[[2-[(4-morpholin-4-yl-1,2,5-thiadiaz ol-3-yl)oxy]acetyl]amino]benzoate
  • MW: 392.43 | Formula: C17H20N4O5S
  • H donors: 1 H acceptors: 4 LogP: 1.88 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)NC(=O)COc1nsnc1N1CCOCC1
  • InChi: 1S/C17H20N4O5S/c1-2-25-17(23)12-3-5-13(6-4-12)18-14(22)11-26-16-15(19-27-20-16)21-7-9-24-10-8-21/h3-6H,2,7-11H2,1H3,(H,18,22)
  • InChiKey: HRPJNUMLYAEROZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 4-[[2-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]acetyl]amino]benzoate
  • 4-[[2-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-1-oxoethyl]amino]benzoic acid ethyl ester
  • 4-[[2-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]acetyl]amino]benzoic acid ethyl ester
  • ethyl 4-[2-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]ethanoylamino]benzoate
  • ZINC01444386
  • A3365/0142873

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis caspase 8 0.0017 0.0074 0.0074
Echinococcus granulosus lamin dm0 0.0026 0.0167 0.0167
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0441 0.0507
Schistosoma mansoni caspase-3 (C14 family) 0.0017 0.0074 0.0074
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0069 0.0069
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0072 0.0656 0.2665
Onchocerca volvulus Cell death protein 3 homolog 0.0058 0.0506 0.0397
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0069 0.0632
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0266 0.2212
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0069 0.0069
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0023 0.0023
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0859 0.9037 0.9037
Echinococcus granulosus lamin 0.0026 0.0167 0.0167
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0276 0.2309
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0063 0.0072
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0167 0.0167
Echinococcus multilocularis lamin 0.0026 0.0167 0.0167
Echinococcus granulosus phd:f box containing protein 0.0017 0.0069 0.0069
Entamoeba histolytica hypothetical protein 0.0072 0.0656 0.5922
Schistosoma mansoni caspase-7 (C14 family) 0.0017 0.0074 0.0074
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0067 0.062
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0334 0.1288
Trypanosoma brucei metacaspase MCA3 0.0017 0.0074 0.0388
Schistosoma mansoni importin beta-1 0.0089 0.0835 0.0835
Plasmodium falciparum metacaspase-like protein 0.0017 0.0074 0.0882
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0167 0.0167
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0201 0.1853
Schistosoma mansoni ran 0.0065 0.0585 0.0585
Trypanosoma cruzi metacaspase, putative 0.0017 0.0074 0.0388
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0069 0.0069
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0565 0.0565
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0276 0.0276
Onchocerca volvulus 0.0233 0.2372 0.2585
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0074 0.0175
Loa Loa (eye worm) hypothetical protein 0.0128 0.1251 0.1251
Brugia malayi RNA, U transporter 1 0.0253 0.2582 0.2968
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0276 0.1039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0201 0.0201
Echinococcus granulosus neutral alpha glucosidase AB 0.0112 0.1085 0.1085
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0074 0.0175
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0069 0.0069
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0266 0.0306
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0036 0.0276 0.0276
Trichomonas vaginalis alpha-glucosidase, putative 0.0112 0.1085 0.4501
Schistosoma mansoni hypothetical protein 0.0949 1 1
Brugia malayi jmjC domain containing protein 0.0017 0.0069 0.0079
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0159 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0074 0.0175
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0112 0.1085 1
Schistosoma mansoni lamin 0.0026 0.0167 0.0167
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0525 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0132 0.0132
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0525 0.0525
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0276 0.0276
Trichomonas vaginalis ran, putative 0.0065 0.0585 0.2362
Brugia malayi Glycosyl hydrolases family 31 protein 0.0112 0.1085 0.1248
Echinococcus multilocularis importin 5 0.0017 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0464 0.4832 0.4832
Loa Loa (eye worm) hypothetical protein 0.0089 0.0835 0.0835
Loa Loa (eye worm) beta-lactamase 0.0035 0.0266 0.0266
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0276 0.0317
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0525 0.4673
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0266 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0023
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0074 0.0083
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0432 0.4746
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.032 0.032
Trypanosoma brucei importin beta-1 subunit, putative 0.0089 0.0835 0.7624
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0069 0.0069
Onchocerca volvulus 0.0029 0.0201 0.004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0441 0.0507
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0074 0.0175
Toxoplasma gondii HEAT repeat-containing protein 0.0089 0.0835 0.7696
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0276 0.2309
Trypanosoma cruzi importin beta-1 subunit, putative 0.0072 0.0656 0.5922
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0565 0.0565
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0069 0.0632
Brugia malayi MH2 domain containing protein 0.0126 0.1235 0.142
Trypanosoma cruzi metacaspase, putative 0.0017 0.0074 0.0388
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0525 0.0525
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0334 0.1288
Loa Loa (eye worm) hypothetical protein 0.0026 0.0162 0.0162
Echinococcus granulosus importin subunit beta 1 0.0089 0.0835 0.0835
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0565 0.0565
Schistosoma mansoni importin-beta 2 0.0017 0.0067 0.0067
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0065 0.0585 0.0673
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1085 1
Schistosoma mansoni hypothetical protein 0.0178 0.178 0.178
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0065 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0042 0.0334 0.0334
Schistosoma mansoni hypothetical protein 0.0041 0.032 0.032
Brugia malayi jmjC domain containing protein 0.0064 0.0565 0.0649
Plasmodium falciparum transportin 0.0017 0.0067 0.0806
Echinococcus multilocularis geminin 0.0178 0.178 0.178
Echinococcus granulosus GTP binding nuclear protein Ran 0.0065 0.0585 0.0585
Echinococcus granulosus translational activator gcn1 0.0017 0.0067 0.0067
Trichomonas vaginalis alpha-glucosidase, putative 0.0112 0.1085 0.4501
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0058 0.0506 0.0506
Echinococcus granulosus transportin 1 0.0017 0.0067 0.0067
Trypanosoma brucei glycosyl hydrolase-like protein 0.0042 0.0334 0.2862
Trypanosoma cruzi metacaspase 5, putative 0.0017 0.0074 0.0388
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0074 0.0175
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0525 0.4835
Echinococcus granulosus GPCR family 2 0.0016 0.0063 0.0063
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0069 0.0069
Trypanosoma brucei importin beta-1 subunit, putative 0.0089 0.0835 0.7624
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1385 0.1385
Onchocerca volvulus 0.0041 0.032 0.018
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0074 0.0175
Brugia malayi intermediate filament protein 0.0026 0.0167 0.0192
Brugia malayi vesicular acetylcholine transporter unc-17 0.0827 0.8698 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.207 0.207
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0063 0.0063
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0266 0.0266
Onchocerca volvulus 0.0035 0.0266 0.0116
Entamoeba histolytica Ran family GTPase 0.0065 0.0585 0.5248
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0074 0.0175
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0112 0.1085 1
Brugia malayi hypothetical protein 0.0041 0.032 0.0368
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1385 0.1385
Echinococcus multilocularis lysosomal alpha glucosidase 0.0506 0.5284 0.5284
Leishmania major GTP-binding protein, putative 0.0065 0.0585 0.5248
Echinococcus granulosus caspase 2 0.0058 0.0506 0.0506
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2372 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0074 0.0175
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0266 0.0995
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0266 0.0995
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0037 0.0037
Brugia malayi beta-lactamase 0.0035 0.0266 0.0305
Loa Loa (eye worm) hypothetical protein 0.0052 0.0441 0.0441
Onchocerca volvulus 0.0464 0.4832 0.5469
Brugia malayi Importin beta-1 subunit 0.0089 0.0835 0.096
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0276 0.1039
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Entamoeba histolytica HEAT repeat domain containing protein 0.0017 0.0067 0.0327
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0065 0.0585 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0266 0.0995
Loa Loa (eye worm) hypothetical protein 0.0464 0.4832 0.4832
Brugia malayi hypothetical protein 0.0033 0.0239 0.0275
Brugia malayi hypothetical protein 0.0464 0.4832 0.5556
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0069 0.0339
Leishmania major hypothetical protein, conserved 0.0051 0.0432 0.379
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0276 0.2309
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0018
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0069 0.0637
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0063 0.0063
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0276 0.0276
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1385 0.1385
Brugia malayi hypothetical protein 0.0051 0.0432 0.0496
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0112 0.1085 0.4501
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0017 0.0067 0.0327
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0071 0.0052
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0334 0.1288
Loa Loa (eye worm) hypothetical protein 0.0017 0.0069 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0266 0.0995
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0159 0.0183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1385 0.1385
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0072 0.0656 0.2665
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0266 0.2212
Trichomonas vaginalis alpha-glucosidase, putative 0.0112 0.1085 0.4501
Schistosoma mansoni lozenge 0.0058 0.0508 0.0508
Loa Loa (eye worm) runx1 0.0058 0.0508 0.0508
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0441 0.0441
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0112 0.1085 0.1085
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0042 0.0334 0.2862
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0069 0.0069
Leishmania major glycosyl hydrolase-like protein 0.0042 0.0334 0.2862
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0266 0.0266
Trypanosoma cruzi metacaspase, putative 0.0017 0.0074 0.0388
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0017 0.0074 0.0074
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.0742 0.6732
Trypanosoma brucei Metacaspase-4 0.0017 0.0074 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0074 0.0175
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0069 0.0339
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0334 0.1288
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0074 0.0175
Echinococcus granulosus caspase 8 0.0017 0.0074 0.0074
Brugia malayi kap beta 3 protein 0.0017 0.0067 0.0077
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0065 0.0585 0.5248
Trichomonas vaginalis alpha-glucosidase, putative 0.0112 0.1085 0.4501
Loa Loa (eye worm) hypothetical protein 0.0051 0.0432 0.0432
Echinococcus granulosus vesicular acetylcholine transporter 0.0827 0.8698 0.8698
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0506 0.5284 0.5284
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0266 0.2582
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0565 0.0565
Onchocerca volvulus 0.0035 0.0266 0.0116
Echinococcus multilocularis neutral alpha glucosidase AB 0.0112 0.1085 0.1085
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0017 0.0074 0.0074
Plasmodium vivax importin-beta 2, putative 0.0089 0.0835 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0042 0.0334 0.2862
Brugia malayi Pre-SET motif family protein 0.0029 0.0201 0.0231
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0334 0.1288
Schistosoma mansoni alpha-glucosidase 0.0436 0.4532 0.4532
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0065 0.0585 0.0585
Trichomonas vaginalis importin beta-1, putative 0.0072 0.0656 0.2665
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0334 0.1288
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0432 0.379
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1385 0.1385
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0565 0.0565
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0525 0.0525
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0201 0.0201
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0069 0.0069
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0159 0.0539
Loa Loa (eye worm) hypothetical protein 0.0026 0.0167 0.0167
Schistosoma mansoni hypothetical protein 0.0016 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0016 0.0063 0.0063
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0112 0.1085 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0276 0.2309
Trichomonas vaginalis sucrase-isomaltase, putative 0.0112 0.1085 0.4501
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0201 0.0201
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0432 0.5169
Trichomonas vaginalis alpha-glucosidase, putative 0.0112 0.1085 0.4501
Loa Loa (eye worm) hypothetical protein 0.0041 0.032 0.032
Trypanosoma brucei metacaspase 0.0017 0.0074 0.0388
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1385 0.1385
Brugia malayi beta-lactamase family protein 0.0035 0.0266 0.0305
Brugia malayi Glycosyl hydrolases family 31 protein 0.0506 0.5284 0.6075
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0069 0.0069
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0565 0.0565
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1235 0.1235
Brugia malayi Cell death protein 3 precursor 0.0058 0.0506 0.0581
Echinococcus multilocularis caspase 0.0017 0.0074 0.0074
Mycobacterium leprae Probable lipase LipE 0.0035 0.0266 0.5
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0065 0.0585 0.5392
Plasmodium vivax JmjC domain containing protein 0.0017 0.0069 0.0016
Echinococcus multilocularis snurportin 1 0.0949 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0018
Trypanosoma cruzi metacaspase 5, putative 0.0017 0.0074 0.0388
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0065 0.0585 0.5248
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0023 0.0023
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0525 0.1274
Plasmodium vivax SET domain protein, putative 0.0029 0.0201 0.1742
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0276 0.4714
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0565 0.0565
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0276 0.0276
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0432 0.5169
Plasmodium falciparum metacaspase 1 0.0017 0.0074 0.0882
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0074 0.0175
Echinococcus multilocularis caspase 2 0.0058 0.0506 0.0506
Schistosoma mansoni ran 0.0065 0.0585 0.0585
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0069 0.0069
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0525 1
Echinococcus multilocularis lamin dm0 0.0026 0.0167 0.0167
Echinococcus granulosus bloom syndrome protein 0.0025 0.0159 0.0159
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0069 0.0069
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0432 0.3978
Trypanosoma brucei metacaspase MCA2 0.0017 0.0074 0.0388
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0565 0.0565
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.032 0.032
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0276 0.1039
Leishmania major importin beta-1 subunit, putative 0.0072 0.0656 0.5922
Echinococcus granulosus intermediate filament protein 0.0026 0.0167 0.0167
Echinococcus multilocularis importin subunit beta 1 0.0089 0.0835 0.0835
Echinococcus multilocularis musashi 0.0026 0.0167 0.0167
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0069 0.0069
Plasmodium vivax metacaspase 1, putative 0.0017 0.0074 0.0083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1385 0.1385
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0334 0.0384
Echinococcus multilocularis Protein lozenge 0.0058 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0069 0.0069
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0266 0.0266
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0334 0.2862
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0016 0.0063 0.0063
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0017 0.0067 0.0327
Schistosoma mansoni vesicular acetylcholine transporter 0.0827 0.8698 0.8698
Leishmania major alpha glucosidase II subunit, putative 0.0112 0.1085 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0042 0.0334 0.0196
Loa Loa (eye worm) RecQ helicase 0.0025 0.0159 0.0159
Toxoplasma gondii ABC1 family protein 0.0035 0.0266 0.2448
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0074 0.0175
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0017 0.0074 0.0074
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0063 0.0063
Brugia malayi Pre-SET motif family protein 0.0205 0.207 0.238
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Schistosoma mansoni alpha glucosidase 0.0112 0.1085 0.1085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0201 0.0201
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0159 0.0539
Schistosoma mansoni caspase-7 (C14 family) 0.0058 0.0506 0.0506
Schistosoma mansoni hypothetical protein 0.0016 0.0063 0.0063
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0276 0.0276
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0266 0.0266
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0276 0.0276
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0037 0.0043
Loa Loa (eye worm) hypothetical protein 0.0017 0.0069 0.0069
Leishmania major metacaspase, putative 0.0017 0.0074 0.0388
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0525 1
Schistosoma mansoni hypothetical protein 0.0035 0.0266 0.0266
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0949 1 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0742 0.0742
Brugia malayi jmjC domain containing protein 0.0017 0.0069 0.0079
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0102 0.0102
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.019 0.019
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0276 0.0276
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0132 0.0132
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0065 0.0585 0.6744
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0074 0.0679
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0074 0.0175
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0069 0.0069
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.0742 0.6732
Plasmodium falciparum importin beta, putative 0.0089 0.0835 1
Echinococcus granulosus caspase 0.0017 0.0074 0.0074
Brugia malayi jmjC domain containing protein 0.0017 0.0069 0.0079
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0266 0.0305
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0276 0.2309
Trichomonas vaginalis esterase, putative 0.0035 0.0266 0.0995
Echinococcus granulosus lysosomal alpha glucosidase 0.0506 0.5284 0.5284
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0334 0.1288
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0432 0.379
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0276 0.0276
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0074 0.0175
Brugia malayi jmjC domain containing protein 0.0017 0.0069 0.0079
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0069 0.0069
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0525 0.0525
Brugia malayi beta-lactamase family protein 0.0035 0.0266 0.0305
Leishmania major hypothetical protein, conserved 0.0035 0.0266 0.2212
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0266 0.0995
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0074 0.0175
Schistosoma mansoni hypothetical protein 0.0178 0.178 0.178
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0167 0.0192
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0063 0.0063
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0063 0.0063
Trypanosoma cruzi metacaspase, putative 0.0017 0.0074 0.0388
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0432 0.379
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.23 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0112 0.1085 0.4501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0201
Onchocerca volvulus 0.0293 0.3009 0.3331
Leishmania major hypothetical protein, conserved 0.0017 0.0069 0.0339
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0069 0.0069
Schistosoma mansoni intermediate filament proteins 0.0026 0.0167 0.0167
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0017 0.0074 0.0085
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0065 0.0585 0.5248
Echinococcus multilocularis GPCR, family 2 0.0016 0.0063 0.0063
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.1385 0.1593
Schistosoma mansoni alpha-glucosidase 0.0436 0.4532 0.4532
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0063 0.0072
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0065 0.0585 0.7006
Trichomonas vaginalis hypothetical protein 0.0017 0.0067 0.0147
Brugia malayi jmjC domain containing protein 0.0064 0.0565 0.0649
Echinococcus multilocularis vesicular acetylcholine transporter 0.0827 0.8698 0.8698
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0069 0.0339
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1235 0.1235
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0074 0.0679
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0067 0.062
Echinococcus multilocularis lysosomal alpha glucosidase 0.0506 0.5284 0.5284
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1085 1
Schistosoma mansoni lamin 0.0026 0.0167 0.0167
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.1385 0.1385
Loa Loa (eye worm) kap beta 3 protein 0.0017 0.0067 0.0067
Trypanosoma brucei metacaspase 5, putative 0.0017 0.0074 0.0388
Trypanosoma brucei glucosidase, putative 0.0112 0.1085 1
Echinococcus multilocularis translational activator gcn1 0.0017 0.0067 0.0067
Echinococcus granulosus importin 5 0.0017 0.0067 0.0067
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0112 0.1085 0.4501
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0334 0.1288
Leishmania major hypothetical protein, conserved 0.0017 0.0067 0.0327
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0069 0.0069
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0827 0.8698 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0266 0.2212
Echinococcus granulosus geminin 0.0178 0.178 0.178
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0023 0.0132 0.0132
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0126 0.151
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0069 0.0821
Loa Loa (eye worm) importin-beta domain-containing protein 0.0017 0.0067 0.0067
Echinococcus multilocularis transportin 1 0.0017 0.0067 0.0067
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0266 0.0266
Onchocerca volvulus 0.0035 0.0266 0.0116
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0074 0.0679
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0827 0.8698 0.8698

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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