Detailed information for compound 80117

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 231.29 | Formula: C14H17NO2
  • H donors: 1 H acceptors: 2 LogP: 3.01 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCc1ccc(cc1OCCCCC#N)O
  • InChi: 1S/C14H17NO2/c1-2-6-12-7-8-13(16)11-14(12)17-10-5-3-4-9-15/h2,7-8,11,16H,1,3-6,10H2
  • InChiKey: YGVAUQCHPKUHQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0935 0.1181
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0318 0.0318
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.104 0.104
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.011 0.011
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0422 0.0663
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Loa Loa (eye worm) hypothetical protein 0.0037 0.0422 0.0663
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0414 0.1131
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.104 0.1632
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0016 0.0024
Echinococcus granulosus nAChR subunit 0.0021 0.0186 0.0186
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0318 0.0318
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0056 0.0055
Loa Loa (eye worm) hypothetical protein 0.003 0.0318 0.0499
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.6693 0.6693
Loa Loa (eye worm) hypothetical protein 0.0036 0.0414 0.0649
Echinococcus granulosus glycine receptor subunit alpha 1 0.0039 0.0456 0.0456
Schistosoma mansoni acetylcholine receptor subunit beta 0.0018 0.0141 0.0141
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0039 0.0456 0.0456
Toxoplasma gondii endonuclease IV APN 0.0075 0.0996 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0602 0.0945
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0056 0.0055
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0399 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0078 0.104 0.1632
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0209 0.2999 0.4707
Schistosoma mansoni hypothetical protein 0.0016 0.011 0.011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0078 0.104 0.104
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.6693 0.6693
Loa Loa (eye worm) hypothetical protein 0.0312 0.4527 0.7105
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0018 0.0141 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0078 0.104 0.1632
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0039 0.0456 0.0456
Onchocerca volvulus 0.0028 0.0292 0.0374
Loa Loa (eye worm) hypothetical protein 0.0041 0.0488 0.0767
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0935 0.2702
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Schistosoma mansoni nuclear hormone receptor 0.0078 0.104 0.104
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.0422 0.0422
Echinococcus multilocularis glycine receptor subunit beta 0.0039 0.0456 0.0456
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0078 0.104 0.104
Loa Loa (eye worm) hypothetical protein 0.0041 0.0488 0.0767
Mycobacterium leprae Probable lipase LipE 0.0071 0.0935 0.9352
Loa Loa (eye worm) hypothetical protein 0.0078 0.104 0.1632
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0018 0.0141 0.0141
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.6693 0.6693
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0422 0.058
Echinococcus multilocularis nAChR subunit 0.0039 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0191 0.2729 0.4283
Onchocerca volvulus 0.0039 0.0456 0.0634
Brugia malayi Cation transporter family protein 0.0039 0.0456 0.0716
Brugia malayi PAS domain containing protein 0.0048 0.0585 0.0918
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.008 0.0803
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0422 0.0422
Onchocerca volvulus 0.0071 0.0935 0.1391
Leishmania major cytochrome p450-like protein 0.0012 0.0051 0.0147
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0041 0.0488 0.0767
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0414 0.0649
Loa Loa (eye worm) LGC-31 protein 0.0039 0.0456 0.0716
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0762 0.0762
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Mycobacterium ulcerans hypothetical protein 0.002 0.0167 0.1221
Mycobacterium leprae conserved hypothetical protein 0.002 0.0167 0.1174
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0039 0.0456 0.0716
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0414 0.0414
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0078 0.104 0.1632
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0021 0.0186 0.0292
Brugia malayi excitatory GABA receptor EXP-1A 0.0039 0.0456 0.0716
Echinococcus granulosus GPCR family 2 0.0016 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0078 0.104 0.1632
Mycobacterium ulcerans hypothetical protein 0.0071 0.0935 0.9355
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0456 0.0716
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Loa Loa (eye worm) hypothetical protein 0.0078 0.104 0.1632
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0082 0.1094 0.1094
Schistosoma mansoni cpg binding protein 0.0028 0.0292 0.0292
Echinococcus multilocularis Ankyrin 0.0016 0.0112 0.0112
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0039 0.0456 0.0716
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0039 0.0456 0.0716
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0078 0.104 0.104
Echinococcus granulosus single minded 2 0.0035 0.0399 0.0399
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0078 0.104 0.1632
Onchocerca volvulus 0.0021 0.0186 0.0206
Loa Loa (eye worm) hypothetical protein 0.0037 0.0422 0.0663
Loa Loa (eye worm) hypothetical protein 0.0078 0.104 0.1632
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0039 0.0456 0.0456
Brugia malayi hypothetical protein 0.0435 0.6372 1
Trichomonas vaginalis esterase, putative 0.0071 0.0935 0.2702
Schistosoma mansoni cpg binding protein 0.003 0.0316 0.0316
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0455 0.6669 1
Schistosoma mansoni hypothetical protein 0.0016 0.0102 0.0102
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0935 0.2702
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0056 0.0056
Loa Loa (eye worm) ACC-1 protein 0.0039 0.0456 0.0716
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0935 0.0935
Loa Loa (eye worm) hypothetical protein 0.0037 0.0422 0.0663
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0056 0.0055
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0102 0.0102
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0141 0.0221
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0102 0.0102
Echinococcus granulosus glycine receptor subunit alpha 1 0.0039 0.0456 0.0456
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.0422 0.0663
Leishmania major hypothetical protein, conserved 0.0071 0.0935 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0037 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Loa Loa (eye worm) hypothetical protein 0.0071 0.0935 0.1467
Onchocerca volvulus 0.0234 0.3359 0.5229
Brugia malayi conserved hypotetical protein 0.0037 0.0422 0.0663
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0318 0.0318
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0039 0.0456 0.0456
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0422 0.0422
Trichomonas vaginalis set domain proteins, putative 0.0233 0.3357 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0039 0.0456 0.0456
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0996 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0056 0.0055
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0935 0.2702
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0039 0.0456 0.0716
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0078 0.104 0.104
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0041 0.0488 0.0488
Onchocerca volvulus 0.0018 0.0141 0.0134
Onchocerca volvulus Putative nachr subunit 0.0039 0.0456 0.0634
Echinococcus multilocularis nAChR subunit 0.0021 0.0186 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0078 0.104 0.1632
Schistosoma mansoni thyroid hormone receptor 0.0078 0.104 0.104
Onchocerca volvulus 0.0078 0.104 0.1558
Onchocerca volvulus Netrin receptor homolog 0.0016 0.011 0.0084
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0685 0.6884
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0056 0.0055
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0935 0.2702
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0078 0.104 0.104
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0141 0.0221
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.104 0.104
Schistosoma mansoni nAChR subunit 0.0039 0.0456 0.0456
Echinococcus multilocularis ecdysone induced protein 78C 0.0078 0.104 0.104
Loa Loa (eye worm) hypothetical protein 0.0037 0.0422 0.0663
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0935 0.9355
Loa Loa (eye worm) hypothetical protein 0.016 0.2266 0.3557
Onchocerca volvulus Protein ultraspiracle homolog 0.0078 0.104 0.1558
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0292
Mycobacterium tuberculosis Conserved protein 0.0071 0.0935 0.1181
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0133 0.1864 0.1864
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.104 0.1632
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0292
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0102 0.0102
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0056 0.0203
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0488 0.0488
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0935 0.9355
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0039 0.0456 0.0456
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0184 0.0184
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0041 0.0488 0.0488
Brugia malayi Cation transporter family protein 0.0039 0.0456 0.0716
Loa Loa (eye worm) hypothetical protein 0.0435 0.6372 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0056 0.0203
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.0996 1
Schistosoma mansoni hypothetical protein 0.0016 0.0102 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.104 0.1632
Schistosoma mansoni cpg binding protein 0.003 0.0316 0.0316
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0039 0.0456 0.0716
Loa Loa (eye worm) acetylcholine receptor protein 0.0018 0.0141 0.0221
Schistosoma mansoni acetylcholine receptor-related 0.0018 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0037 0.0422 0.0663
Onchocerca volvulus 0.0213 0.3055 0.4748
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0488 0.0767
Schistosoma mansoni nAChR subunit 0.0039 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Loa Loa (eye worm) hypothetical protein 0.0037 0.0422 0.0663
Schistosoma mansoni nAChR subunit 0.0039 0.0456 0.0456
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0456 0.0716
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0292
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0414 0.0414
Loa Loa (eye worm) ACC-1 protein 0.0039 0.0456 0.0716
Loa Loa (eye worm) hypothetical protein 0.0071 0.0935 0.1467
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0039 0.0456 0.0716
Loa Loa (eye worm) hypothetical protein 0.0037 0.0422 0.0663
Brugia malayi hypothetical protein 0.0018 0.0141 0.0221
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0039 0.0456 0.0456
Brugia malayi photoreceptor-specific nuclear receptor 0.0078 0.104 0.1632
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.104 0.1632
Brugia malayi tailless protein 0.0037 0.0422 0.0663
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0935 0.1181
Schistosoma mansoni thyroid hormone receptor 0.0078 0.104 0.104
Onchocerca volvulus 0.0039 0.0456 0.0634
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0935 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0935 0.0935
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0051 0.0147
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0039 0.0456 0.0456
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0935 0.1467
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0414 0.0414
Loa Loa (eye worm) beta-lactamase 0.0071 0.0935 0.1467
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0371 0.0582
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0039 0.0456 0.0456
Onchocerca volvulus 0.003 0.0318 0.0415
Schistosoma mansoni coup transcription factor 0.0078 0.104 0.104
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0051 0.008
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0056 0.0203
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0021 0.0186 0.0186
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0056 0.0055
Schistosoma mansoni neurotransmitter gated ion channel 0.0018 0.0141 0.0141
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0318 0.3194
Loa Loa (eye worm) hypothetical protein 0.0033 0.0371 0.0582
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0037 0.0422 0.0663
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0318 0.0318
Mycobacterium tuberculosis Conserved protein 0.0071 0.0935 0.1181
Schistosoma mansoni single-minded 0.0048 0.0585 0.0585
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0078 0.104 0.1632
Loa Loa (eye worm) hypothetical protein 0.0037 0.0422 0.0663
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0762 0.0762
Echinococcus granulosus nAChR subunit 0.0039 0.0456 0.0456
Brugia malayi Cation transporter family protein 0.0039 0.0456 0.0716
Loa Loa (eye worm) runx1 0.0055 0.0686 0.1077
Echinococcus granulosus neuropeptide s receptor 0.0457 0.6693 0.6693
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0762 0.0916
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0602 0.0945
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0112 0.0112
Schistosoma mansoni nAChR subunit 0.0039 0.0456 0.0456
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0039 0.0456 0.0716
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0021 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0292
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0414 0.3861
Schistosoma mansoni neurotransmitter gated ion channel 0.0021 0.0186 0.0186
Echinococcus multilocularis Protein lozenge 0.0055 0.0686 0.0686
Loa Loa (eye worm) hypothetical protein 0.0071 0.0935 0.1467
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0056 0.0056
Brugia malayi ecdysteroid receptor 0.0078 0.104 0.1632
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0118 0.0118
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0167 0.1221
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.0422 0.0663
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0039 0.0456 0.0456
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0414 0.0414
Mycobacterium ulcerans lipase LipD 0.0071 0.0935 0.9355
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0292 0.0459
Onchocerca volvulus 0.0435 0.6372 1
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0935 0.9333
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0078 0.104 0.1632
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0051 0.008
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0018 0.0141 0.0141
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0935 0.9352
Onchocerca volvulus 0.0071 0.0935 0.1391
Brugia malayi Steroid receptor seven-up type 2 0.0078 0.104 0.1632
Toxoplasma gondii ABC1 family protein 0.0071 0.0935 0.9388
Loa Loa (eye worm) hypothetical protein 0.0361 0.526 0.8254
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0078 0.104 0.104
Echinococcus granulosus bloom syndrome protein 0.0021 0.0184 0.0184
Leishmania major protein kinase, putative 0.0012 0.0056 0.0203
Schistosoma mansoni netrin receptor unc5 0.0016 0.011 0.011
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.2081 0.3265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0078 0.104 0.1632
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0039 0.0456 0.0456
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0488 0.0767
Mycobacterium ulcerans beta-lactamase 0.0071 0.0935 0.9355
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0184 0.044
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0078 0.104 0.104
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0318 0.0318
Schistosoma mansoni nAChR subunit 0.0039 0.0456 0.0456
Brugia malayi Uncoordinated protein 44 0.0016 0.011 0.0172
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0017 0.0017
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0078 0.104 0.104
Brugia malayi hypothetical protein 0.0018 0.0141 0.0221
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0056 0.0203
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0051 0.0147
Brugia malayi nuclear hormone receptor 0.0037 0.0422 0.0663
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0175 0.2482 0.2482
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0602 0.0945
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0456 0.0716
Schistosoma mansoni hypothetical protein 0.0221 0.3166 0.3166
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0039 0.0456 0.0716
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.0422 0.0663
Loa Loa (eye worm) hypothetical protein 0.0078 0.104 0.1632
Plasmodium vivax SET domain protein, putative 0.003 0.0318 0.258
Loa Loa (eye worm) hypothetical protein 0.0078 0.104 0.1632
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Onchocerca volvulus 0.0018 0.0141 0.0134
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0399 0.3684
Loa Loa (eye worm) hypothetical protein 0.0037 0.0422 0.0663
Echinococcus granulosus glycine receptor subunit beta 0.0039 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0292
Brugia malayi Death domain containing protein 0.0016 0.011 0.0172
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0056 0.0203
Echinococcus multilocularis jun protein 0.0272 0.3926 0.3926
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0167 0.0175
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.0422 0.0663
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0422 0.0663
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Loa Loa (eye worm) hypothetical protein 0.0016 0.0102 0.016
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0021 0.0186 0.0292
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0056 0.0055
Brugia malayi Protein kinase domain containing protein 0.0016 0.011 0.0172
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0078 0.104 0.1632
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0078 0.104 0.104
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0146 0.1465
Onchocerca volvulus 0.0037 0.0422 0.058
Echinococcus multilocularis GPCR, family 2 0.0016 0.0102 0.0102
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0585 0.0585
Mycobacterium ulcerans epimerase 0.002 0.0167 0.1221
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0318 0.0318
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0141 0.0221
Loa Loa (eye worm) GABA receptor subunit 0.0021 0.0186 0.0292
Loa Loa (eye worm) hypothetical protein 0.0037 0.0422 0.0663
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Brugia malayi hypothetical protein 0.0041 0.0488 0.0767
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0762 0.7652
Mycobacterium tuberculosis Conserved protein 0.0071 0.0935 0.1181
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.101 0.101
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0039 0.0456 0.0716
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0039 0.0456 0.0716
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0039 0.0456 0.0716
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.104 0.104
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0051 0.0147
Echinococcus granulosus ecdysone induced protein 78C 0.0078 0.104 0.104
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0935 0.0935
Echinococcus granulosus jun protein 0.0272 0.3926 0.3926
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0039 0.0456 0.0456
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0102 0.016
Echinococcus granulosus glycine receptor subunit alpha 1 0.0039 0.0456 0.0456
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0078 0.104 0.104
Loa Loa (eye worm) hypothetical protein 0.0078 0.104 0.1632
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0292
Brugia malayi beta-lactamase family protein 0.0071 0.0935 0.1467
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0935 0.1181
Loa Loa (eye worm) hypothetical protein 0.0071 0.0935 0.1467
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0056 0.0203
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0935 0.2702
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0056 0.0055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.104 0.1632
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0039 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0041 0.0488 0.0767
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.000000000058884 0.00000000059134
Brugia malayi hypothetical protein 0.0213 0.3055 0.4794
Brugia malayi hypothetical protein 0.016 0.2266 0.3557
Echinococcus granulosus Ankyrin 0.0016 0.0112 0.0112
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.011 0.011
Brugia malayi Pre-SET motif family protein 0.003 0.0318 0.0499
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0762 0.7525
Brugia malayi Nuclear hormone receptor-like 1 0.0078 0.104 0.1632
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.101 0.101
Loa Loa (eye worm) hypothetical protein 0.0209 0.2999 0.4707
Loa Loa (eye worm) hypothetical protein 0.0049 0.0602 0.0945
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0422 0.0422
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.011 0.0172
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0051 0.008
Brugia malayi nuclear receptor RXR 0.0041 0.0488 0.0767
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.104 0.1632
Entamoeba histolytica hypothetical protein 0.0076 0.101 1
Onchocerca volvulus Bile acid receptor homolog 0.0078 0.104 0.1558
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0422 0.0422
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0414 0.1131
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0078 0.104 0.1558
Brugia malayi ecdysone receptor 0.0037 0.0422 0.0663
Schistosoma mansoni hypothetical protein 0.0016 0.0102 0.0102
Brugia malayi hypothetical protein 0.0018 0.0141 0.0221
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0292
Brugia malayi nuclear hormone receptor 0.0078 0.104 0.1632
Loa Loa (eye worm) hypothetical protein 0.0037 0.0422 0.0663
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0935 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0293 0.0293
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.0422 0.0422
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0039 0.0456 0.0716
Loa Loa (eye worm) hypothetical protein 0.0017 0.0121 0.0189
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0018 0.0141 0.0221
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0078 0.104 0.104
Echinococcus granulosus cpg binding protein 0.003 0.0316 0.0316
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0039 0.0456 0.0456
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0456 0.0716
Schistosoma mansoni nAChR subunit 0.0039 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0041 0.0488 0.0767
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0018 0.0141 0.0221
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0056 0.0055
Schistosoma mansoni nAChR subunit 0.0039 0.0456 0.0456
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0039 0.0456 0.0456
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0935 0.1181
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.0996 0.1275
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0184 0.044
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0141 0.0221
Onchocerca volvulus 0.0035 0.0399 0.0543
Schistosoma mansoni nAChR subunit 0.0018 0.0141 0.0141
Brugia malayi nuclear receptor NHR-88 0.0037 0.0422 0.0663
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.0422 0.0663
Brugia malayi steroid hormone receptor 0.0078 0.104 0.1632
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0056 0.0088
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0414 0.4187
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.104 0.104
Brugia malayi bZIP transcription factor family protein 0.0272 0.3926 0.6161
Loa Loa (eye worm) hypothetical protein 0.0037 0.0422 0.0663
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0039 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0318 0.0318
Schistosoma mansoni nuclear receptor 0.0037 0.0422 0.0422
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0039 0.0456 0.0716
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.0422 0.0422
Loa Loa (eye worm) DR-78 0.0037 0.0422 0.0663
Brugia malayi Pre-SET motif family protein 0.0205 0.2935 0.4606
Loa Loa (eye worm) hypothetical protein 0.0071 0.0935 0.1467
Brugia malayi hypothetical protein 0.0076 0.101 0.1586
Schistosoma mansoni nuclear receptor 0.0037 0.0422 0.0422
Schistosoma mansoni neurotransmitter gated ion channel 0.0018 0.0141 0.0141
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.0996 0.1563
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0039 0.0456 0.0456
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0422 0.058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0078 0.104 0.1632
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.0422 0.0422
Brugia malayi hypothetical protein 0.0037 0.0422 0.0663
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0039 0.0456 0.0456
Brugia malayi CXXC zinc finger family protein 0.0028 0.0292 0.0459
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0078 0.104 0.1632
Onchocerca volvulus 0.0021 0.0186 0.0206
Loa Loa (eye worm) hypothetical protein 0.002 0.0167 0.0261
Loa Loa (eye worm) hypothetical protein 0.0037 0.0422 0.0663
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0039 0.0456 0.0456
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0422 0.0422
Onchocerca volvulus 0.0039 0.0456 0.0634
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.0422 0.0422
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.011 0.0172
Schistosoma mansoni nAChR subunit 0.0018 0.0141 0.0141
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0435 0.6372 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0056 0.0203
Leishmania major protein kinase, putative 0.0012 0.0056 0.0203
Echinococcus multilocularis microtubule associated protein 2 0.0678 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0078 0.104 0.104
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0056 0.0055
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0141 0.0141
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.101 0.101
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0039 0.0456 0.0456
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0078 0.104 0.1632
Entamoeba histolytica hypothetical protein 0.0076 0.101 1
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0422 0.0422
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0762 0.7525
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0039 0.0456 0.0456
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0167 0.0261
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0456 0.0716
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0021 0.0186 0.0292
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0018 0.0141 0.0221
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0078 0.104 0.104
Echinococcus granulosus death domain containing protein 0.0016 0.011 0.011
Brugia malayi nuclear receptor NHR-88 0.0078 0.104 0.1632
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.0422 0.0422
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0414 0.0414
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0102 0.016
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0272 0.3926 0.3926
Onchocerca volvulus 0.0037 0.0422 0.058
Chlamydia trachomatis endonuclease IV 0.0075 0.0996 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0056 0.0056
Brugia malayi nuclear receptor RXR 0.0037 0.0422 0.0663
Entamoeba histolytica hypothetical protein 0.0076 0.101 1
Brugia malayi hypothetical protein 0.0037 0.0422 0.0663
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0056 0.0056
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0039 0.0456 0.0456
Schistosoma mansoni lozenge 0.0055 0.0686 0.0686
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.011 0.011
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0039 0.0456 0.0716
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0102 0.016
Echinococcus multilocularis FTZ F1 alpha 0.0078 0.104 0.104
Echinococcus granulosus FTZ F1 alpha 0.0078 0.104 0.104
Schistosoma mansoni microtubule-associated protein tau 0.0678 1 1
Entamoeba histolytica hypothetical protein 0.0076 0.101 1
Brugia malayi hypothetical protein 0.0041 0.0488 0.0767
Loa Loa (eye worm) hypothetical protein 0.0075 0.0996 0.1563
Loa Loa (eye worm) RecQ helicase 0.0021 0.0184 0.0289
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0996 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.011 0.0172
Loa Loa (eye worm) hypothetical protein 0.0078 0.104 0.1632
Brugia malayi hypoxia-induced factor 1 0.0148 0.2081 0.3265
Brugia malayi Cytochrome P450 family protein 0.0012 0.0051 0.008
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0184 0.0289
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0414 0.4187
Echinococcus granulosus netrin receptor unc 5 0.0016 0.011 0.011
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.5875 0.5875
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0414 0.0414
Echinococcus granulosus glycine receptor subunit beta 0.0039 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0071 0.0935 0.1467
Loa Loa (eye worm) hypothetical protein 0.0078 0.104 0.1632
Schistosoma mansoni retinoic acid receptor RXR 0.0175 0.2482 0.2482
Schistosoma mansoni RAR-like nuclear receptor 0.0078 0.104 0.104
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0056 0.0055
Onchocerca volvulus 0.0018 0.0141 0.0134
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0018 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0016 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0402 0.5875 0.5875
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.011 0.011
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0078 0.104 0.104
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0078 0.104 0.104
Onchocerca volvulus 0.0039 0.0456 0.0634
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0935 0.1181
Loa Loa (eye worm) hypothetical protein 0.0264 0.3815 0.5987
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0272 0.3926 0.3926
Brugia malayi beta-lactamase family protein 0.0071 0.0935 0.1467
Loa Loa (eye worm) hypothetical protein 0.0012 0.0056 0.0088
Schistosoma mansoni hypothetical protein 0.0033 0.0371 0.0371
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0399 0.0626
Schistosoma mansoni hypothetical protein 0.0076 0.101 0.101
Echinococcus granulosus nuclear factor of activated T cells 5 0.0082 0.1094 0.1094
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Onchocerca volvulus 0.0071 0.0935 0.1391
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0935 0.0935
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0414 0.1131
Onchocerca volvulus 0.0039 0.0456 0.0634
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0935 0.1181
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0039 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0175
Echinococcus granulosus dnaJ subfamily B 0.0402 0.5875 0.5875
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.0422 0.0663
Schistosoma mansoni jun-related protein 0.0221 0.3166 0.3166
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0414 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0456 0.0716
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0762 0.0762
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0762 0.7525
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0422 0.0422
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0141 0.0141
Brugia malayi beta-lactamase 0.0071 0.0935 0.1467
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0021 0.0186 0.0292
Brugia malayi hypothetical protein 0.012 0.1657 0.2601
Echinococcus multilocularis cpg binding protein 0.003 0.0316 0.0316
Brugia malayi Cytochrome P450 family protein 0.0012 0.0051 0.008
Brugia malayi nuclear receptor NHR-67 0.0037 0.0422 0.0663
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0039 0.0456 0.0456
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0935 0.1181
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0414 0.4187
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0935 1
Schistosoma mansoni zinc finger protein 0.0037 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0039 0.0456 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0078 0.104 0.1632
Loa Loa (eye worm) histone methyltransferase 0.001 0.0017 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0078 0.104 0.104
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.0221
Brugia malayi hypothetical protein 0.0018 0.0141 0.0221
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0414 0.4187
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0762 0.0762
Onchocerca volvulus 0.0039 0.0456 0.0634
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0039 0.0456 0.0716
Entamoeba histolytica hypothetical protein 0.0021 0.0186 0.1524
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0292
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.0422 0.0422
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0762 0.8072
Loa Loa (eye worm) steroid hormone receptor 0.0078 0.104 0.1632
Loa Loa (eye worm) hypothetical protein 0.0041 0.0488 0.0767
Echinococcus multilocularis glycine receptor subunit beta 0.0039 0.0456 0.0456
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2935 0.4606
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0935 0.1467
Mycobacterium ulcerans endonuclease IV 0.0075 0.0996 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0041 0.0488 0.0488
Brugia malayi hypothetical protein 0.0018 0.0141 0.0221

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 9 % Inhibition of [3H]-LTB4 binding to leukotriene B4 receptor from human peripheral neutrophils (PMN), at a concentration of 1 microM ChEMBL. 1316967
Inhibition (binding) = 9 % Inhibition of [3H]-LTB4 binding to leukotriene B4 receptor from human peripheral neutrophils (PMN), at a concentration of 1 microM ChEMBL. 1316967
Inhibition (binding) = 29 % Inhibition of binding of [3H]-LTB4 to the leukotriene B4 receptor of human peripheral neutrophils(PMN) at a concentration of 10 uM. ChEMBL. 1316967
Inhibition (binding) = 29 % Inhibition of binding of [3H]-LTB4 to the leukotriene B4 receptor of human peripheral neutrophils(PMN) at a concentration of 10 uM. ChEMBL. 1316967

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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