Detailed information for compound 801872

Basic information

Technical information
  • TDR Targets ID: 801872
  • Name: 3-(4-methoxyphenyl)-5-methyl-4-oxo-N-[4-(trif luoromethyl)phenyl]pyridazino[5,4-b]indole-1- carboxamide
  • MW: 492.449 | Formula: C26H19F3N4O3
  • H donors: 1 H acceptors: 2 LogP: 4.97 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)n1nc(C(=O)Nc2ccc(cc2)C(F)(F)F)c2c(c1=O)n(C)c1c2cccc1
  • InChi: 1S/C26H19F3N4O3/c1-32-20-6-4-3-5-19(20)21-22(24(34)30-16-9-7-15(8-10-16)26(27,28)29)31-33(25(35)23(21)32)17-11-13-18(36-2)14-12-17/h3-14H,1-2H3,(H,30,34)
  • InChiKey: UNLNOEWCWIIBDI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-methoxyphenyl)-5-methyl-4-oxo-N-[4-(trifluoromethyl)phenyl]-1-pyridazino[5,4-b]indolecarboxamide
  • 4-keto-3-(4-methoxyphenyl)-5-methyl-N-[4-(trifluoromethyl)phenyl]pyridazino[5,4-b]indole-1-carboxamide
  • EU-0026461

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major 4-coumarate:coa ligase-like protein 0.001 0.0155 0.0178
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0501 0.5892
Loa Loa (eye worm) hypothetical protein 0.0021 0.0501 0.0468
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0155 0.0137
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0159 0.0125
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.001 0.0155 0.0122
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0501 0.3817
Schistosoma mansoni importin beta-1 0.0032 0.0817 0.0817
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.1368 0.1338
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0501 0.0501
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0159 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0064 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0501 0.5892
Loa Loa (eye worm) hypothetical protein 0.001 0.0155 0.0122
Trypanosoma brucei unspecified product 0.0021 0.0501 0.5892
Echinococcus granulosus son of sevenless 1 0.0007 0.0076 0.0041
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.001 0.0155 0.0137
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0159 0.0125
Schistosoma mansoni regulator of G protein signaling 0.001 0.0159 0.0159
Plasmodium falciparum DNA repair protein REV1, putative 0.0007 0.0064 0.0158
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0064 0.022
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.001 0.0155 0.1404
Entamoeba histolytica hypothetical protein 0.0007 0.0076 0.0263
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.0076 0.0041
Echinococcus multilocularis dna polymerase eta 0.0021 0.0501 0.0468
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0501 0.5892
Brugia malayi RasGEF domain containing protein 0.0007 0.0076 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0501 0.5892
Echinococcus granulosus importin 5 0.0006 0.0047 0.0013
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0159 0.0159
Trichomonas vaginalis antibiotic synthetase, putative 0.001 0.0155 0.091
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0076 0.0238
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0197 0.5789 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0153 0.0119
Brugia malayi DIX domain containing protein 0.001 0.0159 0.0196
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.001 0.0155 0.0122
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0076 0.0041
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0501 0.0501
Trypanosoma brucei acetyl-CoA synthetase, putative 0.001 0.0155 0.1404
Plasmodium vivax DNA repair protein REV1, putative 0.0007 0.0064 0.0506
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0159 0.0146
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.001 0.0155 0.0144
Leishmania major DNA polymerase kappa, putative 0.0021 0.0501 0.0747
Schistosoma mansoni importin-beta 2 0.0006 0.0047 0.0047
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.1235 0.7071
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0501 0.5892
Loa Loa (eye worm) hypothetical protein 0.0007 0.0064 0.003
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0501 0.0468
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0501 0.0712
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0153 0.0119
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.0076 0.0041
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.1235 0.7071
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0076 0.0263
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.1368 0.1338
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0007 0.0076 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0159 0.0125
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0076 0.0076
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0501 0.0708
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0501 0.0689
Plasmodium vivax importin-beta 2, putative 0.0032 0.0817 0.6608
Echinococcus granulosus ras GTP exchange factor 0.0007 0.0076 0.0041
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0097 0.0063
Loa Loa (eye worm) hypothetical protein 0.0197 0.5789 0.5775
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0159 0.0159
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0159 0.0125
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0211 0.6198 1
Brugia malayi AMP-binding enzyme family protein 0.001 0.0155 0.019
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.001 0.0155 0.0144
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0817 0.4581
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.001 0.0155 0.019
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0155 0.0144
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0637 0.4967
Onchocerca volvulus 0.0031 0.0789 0.1249
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0817 0.0785
Schistosoma mansoni bromodomain containing protein 0.0006 0.0034 0.0034
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0076 0.0263
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0097 0.0063
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0218 0.6403 0.639
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.001 0.0155 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0077 0.0246
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0789 0.0758
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.1235 0.1205
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0076 0.0041
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0637 0.4967
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.1121 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.4518 0.4499
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0159 0.0125
Onchocerca volvulus 0.001 0.0155 0.014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0637 0.4967
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.001 0.0155 0.0144
Echinococcus granulosus Protein son of sevenless 0.0007 0.0076 0.0041
Schistosoma mansoni cpg binding protein 0.0032 0.0842 0.0842
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.4518 0.704
Brugia malayi acetyl-Coenzyme A synthetase 2 0.001 0.0155 0.019
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.001 0.0155 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0501 0.5892
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0047 0.0013
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.001 0.0155 0.0144
Toxoplasma gondii hypothetical protein 0.001 0.0159 0.0666
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1368 0.1368
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.001 0.0155 0.0144
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0077 0.0246
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0501 0.5892
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0077 0.0246
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.1368 0.1338
Brugia malayi RasGEF domain containing protein 0.0007 0.0076 0.0065
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.001 0.0155 0.0149
Loa Loa (eye worm) hypothetical protein 0.0007 0.0076 0.0041
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0007 0.0076 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0064 0.022
Trichomonas vaginalis antibiotic synthetase, putative 0.001 0.0155 0.091
Echinococcus multilocularis Protein son of sevenless 0.0007 0.0076 0.0041
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0501 0.0712
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0211 0.6198 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0076 0.0076
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.001 0.0155 0.0137
Brugia malayi N-terminal motif family protein 0.0197 0.5789 0.9036
Echinococcus granulosus long chain fatty acid transport protein 4 0.0211 0.6198 0.6185
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0007 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0338 1 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0218 0.6403 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0637 0.0934
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0076 0.0041
Brugia malayi AMP-binding enzyme family protein 0.001 0.0155 0.019
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0076 0.0263
Leishmania major DNA damage repair protein, putative 0.0007 0.0064 0.0028
Onchocerca volvulus 0.001 0.0155 0.014
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.1368 0.2094
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0338 1 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.1235 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.1822 0.1822
Echinococcus granulosus importin subunit beta 1 0.0032 0.0817 0.0785
Echinococcus granulosus translational activator gcn1 0.0006 0.0047 0.0013
Brugia malayi AMP-binding enzyme family protein 0.0218 0.6403 1
Echinococcus granulosus cpg binding protein 0.0032 0.0842 0.081
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.1235 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0501 0.4222
Brugia malayi AMP-binding enzyme family protein 0.001 0.0155 0.019
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.0076 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.1368 0.1338
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0064 0.0064
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.001 0.0155 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0077 0.0246
Onchocerca volvulus 0.001 0.0155 0.014
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0501 0.0733
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0007 0.0064 0.0101
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0501 0.0689
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0064 0.022
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0076 0.0263
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0077 0.0246
Mycobacterium ulcerans fatty-acid-CoA ligase 0.001 0.0155 0.0144
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0159 0.0125
Loa Loa (eye worm) hypothetical protein 0.001 0.0155 0.0122
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0076 0.0263
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0159 0.0196
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0077 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0077 0.0246
Brugia malayi kap beta 3 protein 0.0006 0.0047 0.002
Brugia malayi RasGEF domain containing protein 0.0007 0.0076 0.0065
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0153 0.0119
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0076 0.0076
Brugia malayi AMP-binding enzyme family protein 0.001 0.0155 0.019
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0149 0.0181
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0155 0.0144
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0155 0.0137
Leishmania major fatty acid transporter protein-like protein 0.0208 0.6115 1
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0155 0.0144
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0064 0.022
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0155 0.0144
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.1121 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0304 0.334
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0077 0.0246
Schistosoma mansoni bromodomain containing protein 0.0006 0.0034 0.0034
Entamoeba histolytica acyl-coA synthetase, putative 0.001 0.0155 0.1006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.1235 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0501 0.0733
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0159 0.0125
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0076 0.0263
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0155 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0304 0.334
Mycobacterium ulcerans hypothetical protein 0.001 0.0155 0.0144
Schistosoma mansoni FFA transport protein 0.0211 0.6198 0.6198
Loa Loa (eye worm) oxidoreductase 0.001 0.0155 0.0122
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0064 0.0101
Brugia malayi N-terminal motif family protein 0.0007 0.0076 0.0065
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.001 0.0155 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0077 0.0246
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.001 0.0155 0.0144
Mycobacterium ulcerans acetyl-CoA synthetase 0.001 0.0155 0.0144
Schistosoma mansoni dishevelled 0.001 0.0159 0.0159
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0076 0.0263
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0064 0.022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0817 0.0785
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0501 0.0712
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.001 0.0155 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0077 0.0246
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.001 0.0155 0.0144
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0159 0.0125
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0208 0.6115 1
Schistosoma mansoni cpg binding protein 0.0031 0.0789 0.0789
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.0076 0.0041
Leishmania major DNA polymerase eta, putative 0.0007 0.0064 0.0028
Echinococcus multilocularis transportin 1 0.0006 0.0047 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0501 0.5892
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.1368 0.1338
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0077 0.0246
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0208 0.6115 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0501 0.0712
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1368 0.1368
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0501 0.5892
Trypanosoma cruzi hypothetical protein 0.0007 0.0076 0.0018
Trypanosoma brucei unspecified product 0.0015 0.0304 0.334
Schistosoma mansoni cpg binding protein 0.0032 0.0842 0.0842
Leishmania major DNA polymerase eta, putative 0.0021 0.0501 0.0747
Trypanosoma cruzi hypothetical protein 0.0007 0.0076 0.0018
Brugia malayi hypothetical protein 0.001 0.0159 0.0196
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0155 0.0144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1368 0.1368
Echinococcus multilocularis cpg binding protein 0.0032 0.0842 0.081
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.001 0.0155 0.0144
Brugia malayi polk-prov protein 0.0007 0.0064 0.0047
Schistosoma mansoni zinc finger protein 0.0006 0.0034 0.0034
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0501 0.0468
Leishmania major acetyl-CoA synthetase, putative 0.001 0.0155 0.0178
Entamoeba histolytica acyl-CoA synthetase, putative 0.001 0.0155 0.1006
Brugia malayi N-terminal motif family protein 0.0007 0.0076 0.0065
Schistosoma mansoni DNA polymerase eta 0.0021 0.0501 0.0501
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0501 0.0747
Echinococcus multilocularis son of sevenless 1 0.0007 0.0076 0.0041
Echinococcus multilocularis importin 5 0.0006 0.0047 0.0013
Onchocerca volvulus 0.001 0.0155 0.014
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0155 0.0144
Echinococcus multilocularis translational activator gcn1 0.0006 0.0047 0.0013
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.001 0.0155 0.0137
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0501 0.3817
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0159 0.0125
Loa Loa (eye worm) hypothetical protein 0.001 0.0155 0.0122
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0159 0.0125
Echinococcus granulosus dna polymerase kappa 0.0021 0.0501 0.0468
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.001 0.0155 0.0178
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.001 0.0155 0.0643
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0817 1
Leishmania major 4-coumarate:coa ligase-like protein 0.001 0.0155 0.0178
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.001 0.0155 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0501 0.5892
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.001 0.0155 0.1006
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0501 0.5892
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0076 0.0263
Echinococcus granulosus transportin 1 0.0006 0.0047 0.0013
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.001 0.0155 0.0137
Entamoeba histolytica hypothetical protein 0.0026 0.0637 0.5494
Loa Loa (eye worm) hypothetical protein 0.0007 0.0076 0.0041
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.001 0.0155 0.0149
Leishmania major 4-coumarate:coa ligase-like protein 0.001 0.0155 0.0178
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0159 0.0125
Plasmodium falciparum acetyl-CoA synthetase, putative 0.001 0.0155 0.1006
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0077 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0077 0.0246
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0155 0.0144
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0076 0.0076
Onchocerca volvulus 0.001 0.0159 0.0146
Echinococcus multilocularis snurportin 1 0.0338 1 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.001 0.0155 0.0643
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0076 0.0263
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.4387 0.4368
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.0064 0.022
Plasmodium vivax acetyl-CoA synthetase, putative 0.001 0.0155 0.1245
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0077 0.0246
Brugia malayi Importin beta-1 subunit 0.0032 0.0817 0.1229
Brugia malayi RNA, U transporter 1 0.009 0.2567 0.3977
Giardia lamblia DINP protein human, muc B family 0.0021 0.0501 0.413
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0076 0.0263
Trichomonas vaginalis helicase, putative 0.0007 0.0077 0.0246
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.1121 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0501 0.0468
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0007 0.0076 0.0238
Schistosoma mansoni acetyl-CoA synthetase 0.001 0.0155 0.0155
Trypanosoma brucei unspecified product 0.0015 0.0304 0.334
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0159 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0304 0.334
Echinococcus granulosus dna polymerase eta 0.0021 0.0501 0.0468
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0076 0.0263
Loa Loa (eye worm) AMP-binding enzyme family protein 0.001 0.0155 0.0122
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0501 0.5892
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0097 0.0063
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0501 0.0708
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.001 0.0159 0.0125
Onchocerca volvulus 0.001 0.0155 0.014
Brugia malayi AMP-binding enzyme family protein 0.001 0.0155 0.019
Schistosoma mansoni dishevelled 0.001 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.001 0.0155 0.0122
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.001 0.0155 0.0144
Toxoplasma gondii propionate-CoA ligase 0.001 0.0155 0.0643
Leishmania major DNA polymerase kappa, putative 0.0007 0.0064 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0077 0.0246
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0076 0.0238
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0077 0.0246
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.001 0.0155 0.0149
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0155 0.0144
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.0076 0.0041
Leishmania major acetyl-CoA synthetase, putative 0.001 0.0155 0.0178
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0155 0.0137
Brugia malayi CXXC zinc finger family protein 0.0031 0.0789 0.1185
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0155 0.0144
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0501 0.0468
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0501 0.5892
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0064 0.0101
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0155 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0501 0.5892
Leishmania major importin beta-1 subunit, putative 0.0026 0.0637 0.0973
Loa Loa (eye worm) hypothetical protein 0.001 0.0159 0.0125
Brugia malayi hypothetical protein 0.001 0.0159 0.0196
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0097 0.0063
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0211 0.6198 0.6185
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.4518 0.4518
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0076 0.0263
Loa Loa (eye worm) acetyltransferase 0.0155 0.4518 0.4499
Plasmodium vivax transportin, putative 0.0006 0.0047 0.0368
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0817 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0076 0.0263
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0159 0.0125
Brugia malayi AMP-binding enzyme family protein 0.001 0.0155 0.019
Entamoeba histolytica acyl-CoA synthetase, putative 0.001 0.0155 0.1006
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0155 0.0144
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0159 0.0125
Plasmodium falciparum importin beta, putative 0.0032 0.0817 0.7166
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0155 0.0137
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.001 0.0155 0.0137
Schistosoma mansoni dep domain containing protein 0.001 0.0159 0.0159
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0047 0.0013
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.1727 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0077 0.0246
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0501 0.0712

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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