Detailed information for compound 80680

Basic information

Technical information
  • TDR Targets ID: 80680
  • Name: 1-azabicyclo[2.2.2]octan-7-yl-bis(4-methoxyph enyl)methanol
  • MW: 353.455 | Formula: C22H27NO3
  • H donors: 1 H acceptors: 1 LogP: 3.48 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(C1C[C@@H]2CCN1CC2)(c1ccc(cc1)OC)O
  • InChi: 1S/C22H27NO3/c1-25-19-7-3-17(4-8-19)22(24,18-5-9-20(26-2)10-6-18)21-15-16-11-13-23(21)14-12-16/h3-10,16,21,24H,11-15H2,1-2H3
  • InChiKey: JGEWXQANFULTPF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • bis(4-methoxyphenyl)-quinuclidin-2-yl-methanol
  • bis(4-methoxyphenyl)-(2-quinuclidinyl)methanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0076 0.0087
Echinococcus granulosus son of sevenless 1 0.0007 0.0028 0.0023
Trichomonas vaginalis glucose-6-phosphate translocase, putative 0.0062 0.0709 0.2008
Leishmania major hypothetical protein, conserved 0.0035 0.0383 1
Trichomonas vaginalis Hexuronate transporter, putative 0.0062 0.0709 0.2008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.0006
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0008 0.0009
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0076 0.0087
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.1376 0.1369
Schistosoma mansoni dishevelled 0.0009 0.0061 0.0069
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0076 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0076 0.0098
Schistosoma mansoni loxhd1 0.0019 0.0187 0.0214
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0028 0.5
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.0028 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0076 0.0098
Loa Loa (eye worm) hypothetical protein 0.0007 0.0028 0.0029
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0061 0.0075
Schistosoma mansoni cpg binding protein 0.0031 0.0333 0.0382
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0038 0.0035
Echinococcus granulosus dnaJ subfamily B 0.0422 0.5142 0.5899
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0076 0.0087
Brugia malayi DIX domain containing protein 0.0009 0.0061 0.0075
Trichomonas vaginalis helicase, putative 0.0007 0.003 0.0006
Schistosoma mansoni polycystin 1-related 0.0019 0.0187 0.0214
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0076 0.0098
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0076 0.0078
Brugia malayi Augmenter of liver regeneration 0.0035 0.0383 0.054
Echinococcus granulosus geminin 0.0184 0.221 0.253
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0006 0.0017 0.0039
Brugia malayi quiescin Q6 0.0006 0.0017 0.0013
Echinococcus granulosus cpg binding protein 0.0031 0.0333 0.0373
Trypanosoma cruzi hypothetical protein 0.0007 0.0028 0.0305
Echinococcus granulosus Protein son of sevenless 0.0007 0.0028 0.0023
Schistosoma mansoni hypothetical protein 0.0184 0.221 0.2537
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0061 0.006
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0076 0.0068
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0076 0.0304
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.224 1
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0383 0.5893
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0076 0.0098
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0015 0.0018
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0076 0.0078
Loa Loa (eye worm) glutaminase 2 0.0282 0.3419 0.4908
Brugia malayi hypothetical protein 0.0009 0.0061 0.0075
Schistosoma mansoni glutaminase 0.0282 0.3419 0.3925
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0013
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0108 0.0143
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0028 0.0029
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0383 1
Schistosoma mansoni quiescin q6-related sulfhydryl oxidase 0.0006 0.0017 0.0019
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0062 0.0709 0.5
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0024 0.0028
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0008 0.0009
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0076 0.0068
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0061 0.0234
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0028 0.5
Schistosoma mansoni hypothetical protein 0.0569 0.6958 0.7988
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.0028 0.0023
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.0569 0.6958 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0013
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.0028 0.002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0076 0.0098
Echinococcus multilocularis neuropeptide s receptor 0.0477 0.582 0.5817
Loa Loa (eye worm) hypothetical protein 0.001 0.0076 0.0098
Entamoeba histolytica hypothetical protein 0.0007 0.0028 0.5
Schistosoma mansoni nuclear hormone receptor 0.001 0.0076 0.0087
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0383 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0076 0.0098
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0721 0.0828
Brugia malayi Cytochrome P450 family protein 0.0013 0.0108 0.0143
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0383 1
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0383 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0076 0.0098
Schistosoma mansoni nuclear receptor 0.0005 0.0008 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0076 0.0098
Schistosoma mansoni hypothetical protein 0.0184 0.221 0.2537
Brugia malayi nuclear receptor RXR 0.0006 0.0015 0.001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0076 0.0087
Brugia malayi steroid hormone receptor 0.001 0.0076 0.0098
Echinococcus granulosus FTZ F1 alpha 0.001 0.0076 0.0078
Loa Loa (eye worm) hypothetical protein 0.001 0.0076 0.0098
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0076 0.0087
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0008 0.0009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0061 0.006
Brugia malayi Doublecortin family protein 0.0019 0.0187 0.0257
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0187 0.4629
Brugia malayi indoleamine 2,3-dioxygenase 0.0569 0.6958 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0076 0.0098
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0028 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0076 0.0078
Brugia malayi hypothetical protein 0.0009 0.0061 0.0075
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0007 0.0028 0.0089
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0076 0.0087
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0076 0.0087
Schistosoma mansoni lipoxygenase 0.0116 0.1376 0.158
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0076 0.0098
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0015 0.0007
Echinococcus granulosus neuropeptide s receptor 0.0477 0.582 0.6678
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0028 0.0032
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0061 0.006
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.001
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0007 0.0028 0.0305
Onchocerca volvulus 0.0007 0.0028 0.0089
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0061 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0076 0.0068
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0015 0.0008
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0061 0.0052
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0028 0.5
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0187 0.0257
Loa Loa (eye worm) hypothetical protein 0.001 0.0076 0.0098
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0108 0.248
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0061 0.0052
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0076 0.0068
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0038 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0075
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0076 0.0078
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0076 0.0098
Schistosoma mansoni zinc finger protein 0.0005 0.0008 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0709 0.2008
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0312 0.0438
Brugia malayi Cytochrome P450 family protein 0.0013 0.0108 0.0143
Loa Loa (eye worm) quiescin Q6 0.0006 0.0017 0.0013
Brugia malayi RasGEF domain containing protein 0.0007 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.0076 0.0098
Schistosoma mansoni hypothetical protein 0.0019 0.0187 0.0214
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0076 0.0098
Brugia malayi N-terminal motif family protein 0.0186 0.224 0.3211
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0028 0.5
Brugia malayi hypothetical protein 0.0062 0.0709 0.1008
Giardia lamblia Sugar transport family protein 0.0062 0.0709 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0477 0.582 0.5817
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0076 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.0006
Schistosoma mansoni rab6-interacting 0.0019 0.0187 0.0214
Onchocerca volvulus 0.003 0.0312 0.1363
Brugia malayi ecdysteroid receptor 0.001 0.0076 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.0006
Echinococcus multilocularis sulfhydryl oxidase 1 0.0006 0.0017 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0709 0.2008
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0028 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0076 0.0098
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0187 0.0205
Schistosoma mansoni coup transcription factor 0.001 0.0076 0.0087
Loa Loa (eye worm) hypothetical protein 0.0019 0.0187 0.0257
Echinococcus granulosus sulfhydryl oxidase 1 0.0006 0.0017 0.001
Trichomonas vaginalis Regulatory protein uhpC, putative 0.0062 0.0709 0.2008
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0187 0.0205
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.001
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.001
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.0028 0.002
Brugia malayi nuclear receptor NHR-88 0.001 0.0076 0.0098
Schistosoma mansoni dep domain containing protein 0.0009 0.0061 0.0069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0076 0.0078
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0187 0.0178
Echinococcus multilocularis RUN 0.0019 0.0187 0.0178
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.0569 0.6958 0.6956
Trichomonas vaginalis glutaminase, putative 0.0282 0.3419 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0187 0.0257
Toxoplasma gondii hypothetical protein 0.0009 0.0061 0.0701
Schistosoma mansoni rab6-interacting 0.0019 0.0187 0.0214
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0076 0.0078
Brugia malayi glutaminase DH11.1 0.0282 0.3419 0.4908
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0076 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0709 0.2008
Loa Loa (eye worm) hypothetical protein 0.001 0.0076 0.0098
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0061 0.006
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0038 0.003
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.001
Trichomonas vaginalis transport proetin, putative 0.0062 0.0709 0.2008
Onchocerca volvulus 0.0009 0.0061 0.0234
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0006 0.0017 0.0039
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0061 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0076 0.0098
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0061 0.0052
Brugia malayi N-terminal motif family protein 0.0007 0.0028 0.0029
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0076 0.0078
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0061 0.0052
Schistosoma mansoni thyroid hormone receptor 0.001 0.0076 0.0087
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0076 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.0006
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0383 0.5893
Mycobacterium ulcerans glutaminase 0.0282 0.3419 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0076 0.0068
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0075
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0061 0.006
Echinococcus granulosus ras GTP exchange factor 0.0007 0.0028 0.0023
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0061 0.0075
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0028 0.0032
Loa Loa (eye worm) Erv1/Alr family protein 0.0006 0.0017 0.0013
Onchocerca volvulus 0.0019 0.0187 0.0799
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0076 0.0068
Brugia malayi RasGEF domain containing protein 0.0007 0.0028 0.0029
Brugia malayi CXXC zinc finger family protein 0.003 0.0312 0.0438
Schistosoma mansoni cpg binding protein 0.0031 0.0333 0.0382
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0076 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0709 0.2008
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0061 0.0069
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0015 0.001
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0108 0.248
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0028 0.5
Echinococcus multilocularis Protein son of sevenless 0.0007 0.0028 0.002
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0061 0.0075
Schistosoma mansoni nuclear receptor 0.0005 0.0008 0.0009
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0028 0.0029
Onchocerca volvulus 0.001 0.0076 0.0304
Echinococcus multilocularis geminin 0.0184 0.221 0.2203
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.001
Brugia malayi nuclear hormone receptor 0.001 0.0076 0.0098
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0008 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0709 0.2008
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.0569 0.6958 0.7986
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.0028 0.0023
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0187 0.0205
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0028 0.0032
Trichomonas vaginalis glucarate, hexuronate transporter, putative 0.0062 0.0709 0.2008
Echinococcus granulosus RUN 0.0019 0.0187 0.0205
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0061 0.0075
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0076 0.0098
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0076 0.0098
Trichomonas vaginalis glucarate, hexuronate transporter, putative 0.0062 0.0709 0.2008
Schistosoma mansoni thyroid hormone receptor 0.001 0.0076 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.0006
Echinococcus multilocularis microtubule associated protein 2 0.0711 0.8711 0.871
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0061 0.0069
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0008 0.0009
Echinococcus multilocularis son of sevenless 1 0.0007 0.0028 0.002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0076 0.0098
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0076 0.0098
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0038 0.003
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0028 0.0029
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0108 0.248
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0186 0.224 0.3211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0076 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0076 0.0098
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.003 0.0006
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0028 0.0032
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0383 0.054
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.1376 0.1572
Echinococcus granulosus neuropeptide receptor A26 0.0477 0.582 0.6678
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0062 0.0709 0.5
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0187 0.4629
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0076 0.0098
Onchocerca volvulus 0.0019 0.0187 0.0799
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0076 0.0098
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0076 0.0304
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0383 0.0431
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0061 0.0069
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0187 0.0178
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0038 0.0035
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0061 0.006
Trypanosoma cruzi hypothetical protein 0.0007 0.0028 0.0305
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0006 0.0017 0.0039
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0187 0.0178
Brugia malayi hypothetical protein 0.0019 0.0187 0.0257
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0028 0.5
Schistosoma mansoni lipoxygenase 0.0081 0.0946 0.1087
Schistosoma mansoni microtubule-associated protein tau 0.0711 0.8711 1
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0059 0.0073
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0028 0.5
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0028 0.5
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0383 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.0006
Chlamydia trachomatis hexose phosphate transporter 0.0062 0.0709 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0709 0.2008
Brugia malayi N-terminal motif family protein 0.0007 0.0028 0.0029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0015 0.0018
Schistosoma mansoni hypothetical protein 0.0422 0.5142 0.5903
Brugia malayi hypothetical protein 0.0006 0.0015 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0076 0.0098
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0108 0.0143
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0028 0.5
Trichomonas vaginalis Regulatory protein uhpC, putative 0.0062 0.0709 0.2008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0076 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0076 0.0098
Loa Loa (eye worm) glutaminase 0.0282 0.3419 0.4908
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.0006
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0061 0.0075
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0639 1
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0383 0.0375
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0076 0.0068
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0015 0.001
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0383 1
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0076 0.0098
Loa Loa (eye worm) hypothetical protein 0.001 0.0076 0.0098
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0108 0.0143
Schistosoma mansoni cpg binding protein 0.003 0.0312 0.0359
Schistosoma mansoni dishevelled 0.0009 0.0061 0.0069
Loa Loa (eye worm) hypothetical protein 0.0009 0.0062 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0709 0.2008
Echinococcus granulosus microtubule associated protein 2 0.0711 0.8711 1
Brugia malayi Erv1 / Alr family protein 0.0006 0.0017 0.0013
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0028 0.5
Echinococcus multilocularis cpg binding protein 0.0031 0.0333 0.0325
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0028 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0015 0.001
Brugia malayi hypothetical protein 0.0006 0.0015 0.001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0076 0.0087
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0061 0.0052
Loa Loa (eye worm) hypothetical protein 0.0007 0.0028 0.0029
Echinococcus multilocularis dnaJ subfamily B 0.0422 0.5142 0.5138
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0028 0.0032
Schistosoma mansoni hypothetical protein 0.0569 0.6958 0.7988
Brugia malayi hypothetical protein 0.0019 0.0187 0.0257
Brugia malayi RasGEF domain containing protein 0.0007 0.0028 0.0029

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0.54 Local anesthetic activity using modification of the guinea pig intracutaneous wheal method. ChEMBL. 7359531
Dose (functional) = 5 mg kg-1 Concentration of the compound required to reverse ouabain induced arrhythmia in dogs ChEMBL. 7359531
Duration of reversal (functional) = 14 min Duration of the reversal of ouabain induced arrhythmia was measured ChEMBL. 7359531
Heart rate (functional) = 168 min-1 Heart rate of the dog was measured after drug administration to dogs ChEMBL. 7359531
Heart rate (functional) = 240 min-1 Heart rate of the dog was measured after ouabain administration to dogs ChEMBL. 7359531
No. of dogs reverted (functional) = 1 Number of dogs reverted ouabain induced arrhythmia ChEMBL. 7359531
No. of dogs used (functional) = 1 Number of dogs used ouabain induced arrhythmia ChEMBL. 7359531
Ouabain (functional) = 60 ug kg-1 Concentration of ouabain required to induce arrhythmia in dogs ChEMBL. 7359531

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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