Detailed information for compound 810300

Basic information

Technical information
  • TDR Targets ID: 810300
  • Name: BIM-0017079.P001
  • MW: 247.29 | Formula: C14H17NO3
  • H donors: 1 H acceptors: 1 LogP: 2.39 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCC1)NCc1ccc2c(c1)OCO2
  • InChi: 1S/C14H17NO3/c16-14(11-3-1-2-4-11)15-8-10-5-6-12-13(7-10)18-9-17-12/h5-7,11H,1-4,8-9H2,(H,15,16)
  • InChiKey: PLEKNUDTGJZQKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • CBMicro_016980
  • N-(1,3-benzodioxol-5-ylmethyl)cyclopentanecarboxamide
  • Oprea1_613346
  • T5613283
  • ZINC00253657

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Zinc knuckle family protein 0.0014 0.0051 0.0175
Echinococcus multilocularis RNA directed DNA polymerase 0.0014 0.0051 0.0051
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0051 0.0175
Schistosoma mansoni beta-14-galactosyltransferase 0.0038 0.0205 0.0205
Schistosoma mansoni cpg binding protein 0.0023 0.0111 0.0111
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.021 0.1295 0.1295
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0009 0.002 0.002
Trypanosoma brucei unspecified product 0.0137 0.0832 0.2126
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0009 0.002 0.002
Brugia malayi thymidylate synthase 0.0226 0.1399 0.5687
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0009 0.0021 0.0011
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.0111 0.0416
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0009 0.002 0.0044
Echinococcus multilocularis thymidine kinase 0.158 1 1
Echinococcus multilocularis transfer RNA-Ile 0.158 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0023 0.0112 0.0112
Entamoeba histolytica hypothetical protein 0.021 0.1295 1
Brugia malayi hypothetical protein 0.0014 0.0051 0.0175
Echinococcus granulosus ribonuclease H1 0.0123 0.0744 0.0744
Echinococcus multilocularis Ribosomal protein L34a 0.0028 0.0141 0.0141
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.021 0.1295 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0014 0.0052 0.0256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0023 0.0112 0.0112
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0026 0.0129 0.0403
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0051 0.0175
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0051 0.0051
Trypanosoma brucei hypothetical protein, conserved 0.0137 0.0832 0.2126
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0014 0.0051 0.0247
Trypanosoma cruzi thymidine kinase, putative 0.0147 0.0894 0.3235
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0051 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0044 0.0242 0.0824
Loa Loa (eye worm) deoxynucleoside kinase 0.021 0.1295 0.5261
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0226 0.1399 0.1399
Brugia malayi DNA polymerase family B containing protein 0.0009 0.002 0.0046
Echinococcus granulosus thymidylate kinase 0.0138 0.084 0.084
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.021 0.1295 0.1295
Echinococcus granulosus RNA directed DNA polymerase 0.0014 0.0051 0.0051
Schistosoma mansoni beta-14-galactosyltransferase 0.001 0.0027 0.0027
Schistosoma mansoni cpg binding protein 0.0025 0.0119 0.0119
Schistosoma mansoni thymidylate kinase 0.0138 0.084 0.084
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0009 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0138 0.084 0.084
Echinococcus multilocularis thymidine kinase 0.158 1 1
Trichomonas vaginalis thymidine kinase, putative 0.0147 0.0894 0.6857
Schistosoma mansoni beta-14-galactosyltransferase 0.001 0.0027 0.0027
Mycobacterium ulcerans thymidylate synthase 0.0226 0.1399 0.0631
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0051 0.0051
Toxoplasma gondii hypothetical protein 0.001 0.0027 0.0026
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0014 0.0051 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0023 0.0112 0.0112
Schistosoma mansoni beta-14-galactosyltransferase 0.001 0.0027 0.0027
Brugia malayi CXXC zinc finger family protein 0.0023 0.0111 0.0418
Echinococcus multilocularis ribonuclease H1 0.0123 0.0744 0.0744
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0054 0.0308 0.1064
Plasmodium vivax DNA polymerase alpha, putative 0.0026 0.0129 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0646 0.4914
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0051 0.0051
Giardia lamblia Deoxynucleoside kinase 0.1094 0.6912 1
Trypanosoma cruzi ribonuclease H1, putative 0.0123 0.0744 0.268
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0014 0.0051 0.0247
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0014 0.0052 0.0086
Trypanosoma brucei ingi protein (ORF1) 0.0137 0.0832 0.2126
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0051 0.0051
Schistosoma mansoni beta-14-galactosyltransferase 0.0006 0.0001 0.0001
Loa Loa (eye worm) UDP-Galactose:b-N-acetylglucosamine b1,4-galactosyltransferase 4 0.001 0.0027 0.0073
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0049 0.0276 0.0276
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0032 0.0167 0.0167
Echinococcus multilocularis cpg binding protein 0.0025 0.0119 0.0119
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0006 0.0001 0.0001
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0226 0.1399 0.2988
Brugia malayi beta-1,4-galactosyltransferase VII 0.001 0.0027 0.0075
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0009 0.002 0.002
Onchocerca volvulus 0.0014 0.0051 0.0228
Trypanosoma brucei thymidine kinase 0.0147 0.0894 0.2288
Schistosoma mansoni hypothetical protein 0.0014 0.0051 0.0051
Brugia malayi MH2 domain containing protein 0.0058 0.0334 0.1331
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0023 0.0112 0.0112
Brugia malayi Deoxynucleoside kinase family protein 0.021 0.1295 0.5262
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0051 0.0051
Leishmania major hypothetical protein, conserved 0.0054 0.0308 0.1064
Echinococcus granulosus dihydrofolate reductase 0.0392 0.2454 0.2454
Brugia malayi Zinc knuckle family protein 0.0014 0.0051 0.0175
Entamoeba histolytica hypothetical protein 0.021 0.1295 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0434 0.2723 1
Loa Loa (eye worm) transcription factor SMAD2 0.0058 0.0334 0.1329
Trypanosoma brucei ribonuclease H1 0.0123 0.0744 0.1896
Brugia malayi RNase H family protein 0.0123 0.0744 0.3009
Trichomonas vaginalis conserved hypothetical protein 0.021 0.1295 1
Brugia malayi DNA polymerase alpha catalytic subunit 0.0026 0.0129 0.0492
Schistosoma mansoni beta-14-galactosyltransferase 0.001 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.021 0.1295 1
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0014 0.0051 0.0082
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0032 0.0167 0.0167
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0138 0.084 0.0818
Onchocerca volvulus Putative thymidylate kinase 0.0138 0.084 0.5947
Mycobacterium tuberculosis Conserved hypothetical protein 0.0093 0.0554 0.0521
Giardia lamblia CDC8 0.0138 0.084 0.119
Echinococcus multilocularis thymidylate kinase 0.0138 0.084 0.084
Trichomonas vaginalis reverse transcriptases, putative 0.0014 0.0051 0.0247
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0014 0.0051 0.0082
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0014 0.0051 0.0046
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0014 0.0051 0.0051
Echinococcus granulosus thymidylate synthase 0.0226 0.1399 0.1399
Trypanosoma cruzi thymidine kinase, putative 0.0147 0.0894 0.3235
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0434 0.2723 1
Brugia malayi DNA polymerase delta catalytic subunit 0.0009 0.002 0.0046
Echinococcus multilocularis thymidylate synthase 0.0226 0.1399 0.1399
Echinococcus granulosus beta 14 galactosyltransferase 7 0.001 0.0027 0.0027
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0054 0.0308 0.1064
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0009 0.002 0.002
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.021 0.1295 1
Entamoeba histolytica hypothetical protein 0.021 0.1295 1
Loa Loa (eye worm) dihydrofolate reductase 0.0392 0.2454 1
Schistosoma mansoni cpg binding protein 0.0025 0.0119 0.0119
Trypanosoma cruzi thymidylate kinase, putative 0.0138 0.084 0.3035
Echinococcus granulosus KRAB A domain containing protein 0.0014 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.021 0.1295 1
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0051 0.0051
Echinococcus granulosus Metazoa galactosyltransferase 0.0038 0.0205 0.0205
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0051 0.0051
Treponema pallidum thymidylate kinase (tmk) 0.0138 0.084 1
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.021 0.1295 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0108 0.0646 0.2318
Schistosoma mansoni beta-14-galactosyltransferase 0.001 0.0027 0.0027
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0009 0.0009
Loa Loa (eye worm) galactosyltransferase 0.001 0.0027 0.0073
Loa Loa (eye worm) beta-1,4-galactosyltransferase VII 0.001 0.0027 0.0073
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0138 0.084 1
Brugia malayi Galactosyltransferase family protein 0.0038 0.0205 0.0803
Echinococcus multilocularis Metazoa galactosyltransferase 0.0032 0.0167 0.0167
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0023 0.0112 0.0112
Schistosoma mansoni thymidylate kinase 0.0138 0.084 0.084
Trichomonas vaginalis conserved hypothetical protein 0.021 0.1295 1
Schistosoma mansoni hypothetical protein 0.0611 0.3842 0.3842
Leishmania major thymidylate kinase-like protein 0.0138 0.084 0.3035
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0392 0.2454 0.1822
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0433 0.2712 1
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0014 0.0051 0.0051
Schistosoma mansoni phenylalanine decarboxylase 0.001 0.0027 0.0027
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0014 0.0051 0.0046
Schistosoma mansoni thymidine kinase 0.158 1 1
Schistosoma mansoni dihydrofolate reductase 0.0392 0.2454 0.2454
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0014 0.0051 0.0051
Giardia lamblia DNA polymerase alpha subunit A 0.0027 0.0136 0.0169
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0226 0.1399 0.1397
Echinococcus multilocularis beta 1,4 N acetylgalactosaminyltransferase 0.001 0.0027 0.0027
Echinococcus granulosus thymidine phosphorylase 0.1533 0.9699 0.9699
Schistosoma mansoni beta-14-galactosyltransferase 0.001 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.021 0.1295 1
Loa Loa (eye worm) galactosyltransferase 0.0038 0.0205 0.0801
Entamoeba histolytica Thymidylate kinase, putative 0.0138 0.084 0.6432
Brugia malayi RNase H family protein 0.0123 0.0744 0.3009
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0051 0.0175
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0434 0.2723 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0058 0.0334 0.1329
Trypanosoma brucei ingi protein (ORF1) 0.0137 0.0832 0.2126
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0023 0.0112 0.0423
Schistosoma mansoni beta-14-galactosyltransferase 34-related 0.001 0.0027 0.0027
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0009 0.002 0.002
Schistosoma mansoni phosphoglucomutase 0.0123 0.0744 0.0744
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0023 0.0112 0.0425
Echinococcus granulosus Ribosomal protein L34a 0.0028 0.0141 0.0141
Echinococcus granulosus thymidine kinase 0.158 1 1
Trypanosoma brucei thymidylate kinase, putative 0.0138 0.084 0.2147
Trichomonas vaginalis thymidylate kinase, putative 0.0138 0.084 0.6432
Leishmania major thymidine kinase, putative 0.0147 0.0894 0.3235
Entamoeba histolytica thymidine kinase, putative 0.0147 0.0894 0.6857
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0009 0.002 0.0046
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0009 0.002 0.002
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0392 0.2454 0.8624
Toxoplasma gondii ribonuclease HI protein 0.0123 0.0744 0.268
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0392 0.2454 0.249
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.021 0.1295 0.1295
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0051 0.0175
Loa Loa (eye worm) thymidylate kinase 0.0138 0.084 0.34
Echinococcus granulosus beta 14 N acetylgalactosaminyltransferase 0.001 0.0027 0.0027
Mycobacterium ulcerans thymidine phosphorylase 0.1533 0.9699 1
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0009 0.002 0.002
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0051 0.0175
Schistosoma mansoni hypothetical protein 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.096
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0051 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.021 0.1295 1
Brugia malayi RNase H family protein 0.0123 0.0744 0.3009
Brugia malayi hypothetical protein 0.0014 0.0051 0.0175
Trichomonas vaginalis thymidine kinase, putative 0.0147 0.0894 0.6857
Entamoeba histolytica hypothetical protein 0.021 0.1295 1
Brugia malayi hypothetical protein 0.0014 0.0051 0.0175
Echinococcus granulosus cpg binding protein 0.0025 0.0119 0.0119
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.021 0.1295 1
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0433 0.2712 0.2112
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0051 0.0175
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0137 0.0832 0.2126
Onchocerca volvulus 0.0014 0.0051 0.0228
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0014 0.0052 0.0121
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1533 0.9699 1
Brugia malayi Dihydrofolate reductase 0.0392 0.2454 1
Onchocerca volvulus 0.0023 0.0111 0.0659
Plasmodium vivax thymidylate kinase, putative 0.0138 0.084 0.3035
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0014 0.0051 0.0228
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0014 0.0052 0.0121
Trypanosoma cruzi thymidylate kinase, putative 0.0138 0.084 0.3035
Brugia malayi dihydrofolate reductase family protein 0.0392 0.2454 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0009 0.0009
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.021 0.1295 0.185
Entamoeba histolytica hypothetical protein 0.021 0.1295 1
Echinococcus multilocularis thymidine phosphorylase 0.1533 0.9699 0.9699
Trichomonas vaginalis thymidine kinase, putative 0.0147 0.0894 0.6857
Trypanosoma brucei thymidylate kinase, putative 0.0138 0.084 0.2147
Schistosoma mansoni beta-14-galactosyltransferase 0.0038 0.0205 0.0205
Brugia malayi Galactosyltransferase family protein 0.001 0.0027 0.0075
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.158 1 1
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0014 0.0051 0.0046
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0434 0.2723 1
Giardia lamblia Hypothetical protein 0.021 0.1295 0.185
Brugia malayi hypothetical protein 0.0108 0.0646 0.2609
Schistosoma mansoni phosphoglucomutase 0.0123 0.0744 0.0744
Mycobacterium tuberculosis Hypothetical protein 0.0108 0.0646 0.0617
Trichomonas vaginalis reverse transcriptases, putative 0.0014 0.0051 0.0247
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0433 0.2712 0.2757
Loa Loa (eye worm) thymidylate synthase 0.0226 0.1399 0.5686
Trichomonas vaginalis conserved hypothetical protein 0.021 0.1295 1
Brugia malayi reverse transcriptase 0.0014 0.0051 0.0175
Chlamydia trachomatis dihydrofolate reductase 0.0392 0.2454 1
Plasmodium falciparum thymidylate kinase 0.0138 0.084 0.3035
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0051 0.0175
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0051 0.0175
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0012 0.004 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0023 0.0112 0.0112
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0014 0.0051 0.0082
Giardia lamblia Hypothetical protein 0.021 0.1295 0.185
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0051 0.0175
Onchocerca volvulus 0.0226 0.1399 1
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0014 0.0051 0.0051
Entamoeba histolytica hypothetical protein 0.021 0.1295 1
Brugia malayi reverse transcriptase 0.0014 0.0051 0.0175
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0014 0.0051 0.0051
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0051 0.0051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0023 0.0112 0.0112
Echinococcus multilocularis dihydrofolate reductase 0.0392 0.2454 0.2454
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0009 0.0021 0.0005
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0416 0.2604 0.2604
Toxoplasma gondii thymidylate kinase 0.0138 0.084 0.3035
Giardia lamblia Thymidine kinase 0.0147 0.0894 0.1269
Trichomonas vaginalis ribonuclease H1, putative 0.0123 0.0744 0.5681
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0051 0.0175
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0051 0.0175
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0434 0.2723 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0051 0.0175
Entamoeba histolytica hypothetical protein 0.021 0.1295 1
Echinococcus multilocularis Metazoa galactosyltransferase 0.0038 0.0205 0.0205
Echinococcus multilocularis beta 1,4 galactosyltransferase 7 0.001 0.0027 0.0027
Brugia malayi hypothetical protein 0.0014 0.0051 0.0175
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0434 0.2723 0.7074
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0009 0.002 0.002
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0044 0.0244 0.1623
Schistosoma mansoni protein kinase 0.0014 0.0051 0.0051
Trichomonas vaginalis DNA polymerase II, putative 0.0014 0.0052 0.0256
Brugia malayi thymidylate kinase 0.0138 0.084 0.3401
Giardia lamblia Reverse transcriptase/endonuclease 0.0014 0.0051 0.0046
Trypanosoma cruzi ribonuclease H1, putative 0.0123 0.0744 0.268
Schistosoma mansoni phosphoglucomutase 0.0123 0.0744 0.0744
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0032 0.0167 0.0167
Giardia lamblia Ribonuclease H 0.0123 0.0744 0.1051
Trichomonas vaginalis thymidylate kinase, putative 0.0138 0.084 0.6432
Leishmania major ribonuclease H1, putative 0.0123 0.0744 0.268
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0051 0.0175
Onchocerca volvulus Ribonuclease H1 homolog 0.0123 0.0744 0.5253
Trypanosoma brucei RNA helicase, putative 0.0611 0.3842 1
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0051 0.0117
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0014 0.0051 0.0051
Brugia malayi reverse transcriptase 0.0014 0.0051 0.0175

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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