Detailed information for compound 812763

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 453.531 | Formula: C25H31N3O5
  • H donors: 1 H acceptors: 3 LogP: 2.28 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)CC(=O)N1CCC2(CC1)CCC(O2)CNC(=O)c1ccccn1)OC
  • InChi: 1S/C25H31N3O5/c1-31-19-6-7-22(32-2)18(15-19)16-23(29)28-13-10-25(11-14-28)9-8-20(33-25)17-27-24(30)21-5-3-4-12-26-21/h3-7,12,15,20H,8-11,13-14,16-17H2,1-2H3,(H,27,30)
  • InChiKey: TXXUEPUXWPQVSK-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Giardia lamblia Cysteine protease 0.0186 0.0835 0.2144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.1103 0.1103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Echinococcus multilocularis geminin 0.0197 0.0893 0.0877
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Giardia lamblia Cathepsin B precursor 0.0186 0.0835 0.2144
Schistosoma mansoni cathepsin B (C01 family) 0.0186 0.0835 0.0819
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Onchocerca volvulus Cathepsin L homolog 0.077 0.3901 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Echinococcus multilocularis cysteine protease 0.077 0.3901 0.389
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0206 0.0189
Echinococcus multilocularis cathepsin l cysteine peptidase 0.077 0.3901 0.389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0835 0.2015
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0062 0.0062
Onchocerca volvulus 0.077 0.3901 1
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.0835 0.2015
Brugia malayi calpain 5 0.0043 0.0083 0.0065
Schistosoma mansoni cathepsin F (C01 family) 0.0533 0.2658 0.2645
Plasmodium vivax serine-repeat antigen (SERA) 0.0186 0.0835 0.2105
Brugia malayi Cathepsin L-like precursor 0.0533 0.2658 0.2645
Plasmodium vivax calpain, putative 0.0061 0.018 0.0417
Loa Loa (eye worm) hypothetical protein 0.0186 0.0835 0.0835
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0206 0.0206
Brugia malayi Peroxidasin 0.0039 0.0062 0.0045
Giardia lamblia Hypothetical protein 0.0186 0.0835 0.2144
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0081 0.0282 0.027
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0186 0.0835 0.2105
Brugia malayi MH2 domain containing protein 0.0237 0.1103 0.1087
Brugia malayi Cathepsin L-like precursor 0.077 0.3901 0.389
Schistosoma mansoni cathepsin S (C01 family) 0.0186 0.0835 0.0819
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0186 0.0835 0.2141
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0345 0.0334
Plasmodium falciparum serine repeat antigen 7 0.0186 0.0835 0.2015
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Onchocerca volvulus Cathepsin L homolog 0.0186 0.0835 0.2105
Trypanosoma cruzi major cysteine proteinase, putative 0.0186 0.0835 0.0778
Brugia malayi Pre-SET motif family protein 0.0212 0.0972 0.0956
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0061 0.018 0.0307
Loa Loa (eye worm) cathepsin B 0.0726 0.367 0.367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0062 0.0185 0.0168
Giardia lamblia Cathepsin L precursor 0.0186 0.0835 0.2144
Loa Loa (eye worm) matrixin family protein 0.0049 0.0117 0.0117
Plasmodium vivax unspecified product 0.0237 0.1101 0.2789
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Brugia malayi Cathepsin L-like precursor 0.0533 0.2658 0.2645
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0186 0.0835 0.2105
Schistosoma mansoni peroxidasin 0.0039 0.0062 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Echinococcus multilocularis microtubule associated protein 2 0.0803 0.4072 0.4061
Loa Loa (eye worm) cysteine protease 0.077 0.3901 0.3901
Onchocerca volvulus Peroxidase homolog 0.0039 0.0062 0.0115
Plasmodium falciparum cysteine proteinase falcipain 2a 0.077 0.3901 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Onchocerca volvulus 0.077 0.3901 1
Brugia malayi RNA binding protein 0.0066 0.0206 0.0189
Loa Loa (eye worm) hypothetical protein 0.0123 0.0503 0.0503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Brugia malayi Hemopexin family protein 0.0031 0.0023 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0423 0.2078 0.5252
Trypanosoma cruzi cysteine peptidase, putative 0.0423 0.2078 0.2029
Giardia lamblia Cathepsin L precursor 0.0186 0.0835 0.2144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.0835 0.2015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0835 0.0819
Brugia malayi cathepsin L-like precursor 0.0533 0.2658 0.2645
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0423 0.2078 0.2064
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0186 0.0835 0.0819
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0062 0.0113
Echinococcus granulosus calpain 7 C02 family 0.0061 0.018 0.0168
Onchocerca volvulus Matrilysin homolog 0.0049 0.0117 0.0255
Giardia lamblia Cathepsin L precursor 0.0186 0.0835 0.2144
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0186 0.0835 0.2105
Schistosoma mansoni calpain-7 (C02 family) 0.0061 0.018 0.0162
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0062 0.0062
Brugia malayi Papain family cysteine protease containing protein 0.0423 0.2078 0.2064
Plasmodium vivax unspecified product 0.0423 0.2078 0.5306
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0123 0.0503 0.0487
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Entamoeba histolytica cysteine proteinase 1, putative 0.0423 0.2078 0.5327
Giardia lamblia Cysteine protease 0.0186 0.0835 0.2144
Giardia lamblia Cathepsin L precursor 0.0186 0.0835 0.2144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1932 1 1
Onchocerca volvulus 0.077 0.3901 1
Schistosoma mansoni peptidylglycine monooxygenase 0.0123 0.0503 0.0487
Echinococcus multilocularis cathepsin b 0.1932 1 1
Echinococcus multilocularis calpain 5 0.0061 0.018 0.0162
Schistosoma mansoni cathepsin C 0.0186 0.0835 0.0819
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0835 0.2015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Plasmodium vivax vivapain-1 0.0423 0.2078 0.5306
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0062 0.5
Schistosoma mansoni cathepsin s 0.0237 0.1101 0.1085
Brugia malayi fibroinase precursor 0.0186 0.0835 0.0819
Trypanosoma cruzi cysteine peptidase, putative 0.077 0.3901 0.3863
Echinococcus multilocularis cathepsin L 0.0186 0.0835 0.0819
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0062 0.0045
Loa Loa (eye worm) calpain family protein 1 0.012 0.0486 0.0486
Echinococcus multilocularis cysteine protease 0.077 0.3901 0.389
Schistosoma mansoni peroxidasin 0.0039 0.0062 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.018 0.0119
Giardia lamblia Cathepsin B precursor 0.0186 0.0835 0.2144
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0231 0.1073 0.1057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Loa Loa (eye worm) hypothetical protein 0.0533 0.2658 0.2658
Leishmania major kinesin, putative 0.0043 0.0083 0.0056
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Giardia lamblia Cathepsin B precursor 0.0726 0.367 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0062 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0307
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0835 0.0819
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0061 0.018 0.0119
Onchocerca volvulus 0.077 0.3901 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.0835 0.0835
Onchocerca volvulus 0.0039 0.0062 0.0115
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0835 0.0819
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0835 0.2015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.0835 0.2015
Echinococcus granulosus survival motor neuron protein 1 0.0257 0.1206 0.1195
Echinococcus granulosus calpain A 0.0177 0.0786 0.0775
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0726 0.367 0.363
Schistosoma mansoni calpain-7 (C02 family) 0.0061 0.018 0.0162
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0186 0.0835 0.2141
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0835 0.2015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0423 0.2078 0.5252
Echinococcus multilocularis cathepsin l cysteine peptidase 0.077 0.3901 0.389
Echinococcus granulosus microtubule associated protein 2 0.0803 0.4072 0.4065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.0835 0.2144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0186 0.0835 0.2105
Brugia malayi hypothetical protein 0.0257 0.1206 0.119
Giardia lamblia Cathepsin L-like protease 0.0186 0.0835 0.2144
Echinococcus granulosus cathepsin l1 0.077 0.3901 0.3894
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0389 0.0389
Brugia malayi cathepsin F-like cysteine proteinase 0.0186 0.0835 0.0819
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0835 0.2015
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0423 0.2078 0.2064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Onchocerca volvulus Chorion peroxidase homolog 0.0039 0.0062 0.0115
Entamoeba histolytica cysteine proteinase, putative 0.077 0.3901 1
Giardia lamblia Hypothetical protein 0.0186 0.0835 0.2144
Plasmodium falciparum cysteine proteinase falcipain 3 0.077 0.3901 1
Schistosoma mansoni pyruvate kinase 0.0039 0.0062 0.0044
Trypanosoma cruzi cruzipain precursor, putative 0.077 0.3901 0.3863
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0186 0.0835 0.2105
Brugia malayi Cathepsin L-like precursor 0.077 0.3901 0.389
Onchocerca volvulus Peroxidase homolog 0.0039 0.0062 0.0115
Echinococcus granulosus cathepsin b 0.1932 1 1
Loa Loa (eye worm) matrixin family protein 0.0054 0.014 0.014
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0186 0.0835 0.0819
Loa Loa (eye worm) fibroinase 0.077 0.3901 0.3901
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Trypanosoma brucei calpain-like protein, putative 0.0061 0.018 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Echinococcus granulosus cathepsin l1 0.0533 0.2658 0.265
Onchocerca volvulus 0.0031 0.0023 0.0014
Loa Loa (eye worm) hypothetical protein 0.0186 0.0835 0.0835
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0062 0.0113
Giardia lamblia Cathepsin B precursor 0.0726 0.367 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0186 0.0835 0.0819
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Giardia lamblia Cathepsin B precursor 0.0186 0.0835 0.2144
Loa Loa (eye worm) hypothetical protein 0.012 0.0486 0.0486
Plasmodium vivax vivapain-2 0.077 0.3901 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0835 0.2015
Onchocerca volvulus 0.0241 0.1125 0.2852
Echinococcus granulosus cathepsin b 0.1932 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0835 0.2015
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0119
Trypanosoma cruzi cruzipain precursor, putative 0.0237 0.1101 0.1046
Plasmodium falciparum serine repeat antigen 8 0.0186 0.0835 0.2015
Brugia malayi Papain family cysteine protease containing protein 0.0423 0.2078 0.2064
Brugia malayi calpain family protein 1 0.0162 0.0711 0.0694
Entamoeba histolytica cysteine protease, putative 0.0186 0.0835 0.2141
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Echinococcus multilocularis cathepsin b 0.1932 1 1
Onchocerca volvulus 0.077 0.3901 1
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0061 0.0176 0.0158
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.0835 0.0819
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0423 0.2078 0.2029
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0186 0.0835 0.2015
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0162 0.0711 0.0694
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0423 0.2078 0.2064
Entamoeba histolytica cysteine proteinase, putative 0.0423 0.2078 0.5327
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0186 0.0835 0.2015
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1932 1 1
Loa Loa (eye worm) hypothetical protein 0.0257 0.1206 0.1206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0835 0.2015
Plasmodium falciparum serine repeat antigen 6 0.0186 0.0835 0.2015
Trypanosoma brucei cysteine peptidase C (CPC) 0.0726 0.367 0.9397
Loa Loa (eye worm) hypothetical protein 0.0162 0.0711 0.0711
Echinococcus granulosus cysteine protease 0.0423 0.2078 0.2069
Giardia lamblia Cysteine protease 0.0186 0.0835 0.2144
Echinococcus granulosus calpain 5 0.0061 0.018 0.0168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Toxoplasma gondii cathepsin CPL 0.077 0.3901 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0176 0.0784 0.0773
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.077 0.3901 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1932 1 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0186 0.0835 0.2105
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0206 0.0189
Chlamydia trachomatis pyruvate kinase 0.0039 0.0062 0.5
Loa Loa (eye worm) ctsf protein 0.077 0.3901 0.3901
Echinococcus multilocularis hypothetical protein 0.0061 0.018 0.0162
Onchocerca volvulus Cathepsin L homolog 0.077 0.3901 1
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0062 0.0062
Plasmodium falciparum serine repeat antigen 4 0.0186 0.0835 0.2015
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0062 0.0044
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Brugia malayi Cathepsin L-like precursor 0.077 0.3901 0.389
Onchocerca volvulus 0.0052 0.0133 0.0297
Loa Loa (eye worm) hypothetical protein 0.0186 0.0835 0.0835
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0176 0.0784 0.0767
Onchocerca volvulus Peroxidasin homolog 0.0039 0.0062 0.0115
Onchocerca volvulus 0.0101 0.0389 0.0957
Onchocerca volvulus Cathepsin F homolog 0.077 0.3901 1
Echinococcus granulosus calpain 0.0061 0.018 0.0168
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0186 0.0835 0.2144
Onchocerca volvulus 0.077 0.3901 1
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0062 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0423 0.2078 0.5252
Schistosoma mansoni Mername-AA248 (C02 family) 0.0061 0.018 0.0162
Echinococcus granulosus cathepsin l cysteine peptidase 0.077 0.3901 0.3894
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0186 0.0835 0.2015
Echinococcus granulosus cathepsin L 0.0423 0.2078 0.2069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0835 0.2015
Echinococcus multilocularis calpain 0.0061 0.018 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Entamoeba histolytica hypothetical protein 0.0186 0.0835 0.2141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Giardia lamblia Cathepsin L precursor 0.0186 0.0835 0.2144
Onchocerca volvulus 0.0186 0.0835 0.2105
Trypanosoma cruzi kinesin, putative 0.0043 0.0083 0.0021
Loa Loa (eye worm) hypothetical protein 0.0237 0.1101 0.1101
Echinococcus multilocularis pyruvate kinase 0.0039 0.0062 0.0044
Onchocerca volvulus Peroxidasin homolog 0.0039 0.0062 0.0115
Echinococcus granulosus peroxidasin 0.0039 0.0062 0.0051
Entamoeba histolytica cysteine protease, putative 0.0186 0.0835 0.2141
Schistosoma mansoni calpain (C02 family) 0.0061 0.018 0.0162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0345 0.0328
Schistosoma mansoni hypothetical protein 0.0197 0.0893 0.0877
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0062 0.0062
Onchocerca volvulus 0.0533 0.2658 0.6799
Trypanosoma cruzi cysteine protease, putative 0.0423 0.2078 0.2029
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0206 0.0189
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Brugia malayi calpain family protein 1 0.0162 0.0711 0.0694
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.077 0.3901 0.3901
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0119
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0186 0.0835 0.2015
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0345 0.0328
Trypanosoma brucei calpain-like protein, putative 0.0061 0.018 0.0307
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0186 0.0835 0.2105
Trypanosoma brucei antigen, putative 0.0061 0.018 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.0835 0.2015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Brugia malayi TAR-binding protein 0.0066 0.0206 0.0189
Schistosoma mansoni hypothetical protein 0.0197 0.0893 0.0877
Plasmodium falciparum serine repeat antigen 5 0.0186 0.0835 0.2015
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0018
Schistosoma mansoni pyruvate kinase 0.0039 0.0062 0.0044
Brugia malayi Cathepsin L-like precursor 0.077 0.3901 0.389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0533 0.2658 0.6763
Brugia malayi cathepsin L precursor 0.0186 0.0835 0.0819
Echinococcus multilocularis survival motor neuron protein 1 0.0257 0.1206 0.119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.0835 0.2015
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.077 0.3901 1
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0062 0.0062
Brugia malayi calpain 7 0.0061 0.018 0.0162
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0345 0.0334
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0176 0.0784 0.0767
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0835 0.2015
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0062 0.5
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Loa Loa (eye worm) hypothetical protein 0.077 0.3901 0.3901
Loa Loa (eye worm) blistered cuticle protein 3 0.0039 0.0062 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.0835 0.2144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0345 0.0328
Schistosoma mansoni calpain C (C02 family) 0.0061 0.018 0.0162
Trypanosoma cruzi cysteine proteinase, putative 0.0423 0.2078 0.2029
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0206 0.0189
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0237 0.1101 0.1101
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0062 0.0045
Loa Loa (eye worm) hypothetical protein 0.0231 0.1073 0.1073
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0062 0.0045
Plasmodium vivax unspecified product 0.0186 0.0835 0.2105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0533 0.2658 0.6763
Loa Loa (eye worm) hypothetical protein 0.0186 0.0835 0.0835
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0237 0.1101 0.1085
Trypanosoma cruzi cysteine peptidase, putative 0.077 0.3901 0.3863
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Plasmodium vivax vivapain-2 0.077 0.3901 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0186 0.0835 0.0819
Entamoeba histolytica cysteine protease, putative 0.077 0.3901 1
Brugia malayi Papain family cysteine protease containing protein 0.077 0.3901 0.389
Leishmania major cysteine peptidase A (CPA) 0.077 0.3901 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0835 0.0819
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0726 0.367 0.3658
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.1103 0.1103
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0119
Trypanosoma cruzi cysteine peptidase, putative 0.077 0.3901 0.3863
Brugia malayi Cathepsin L-like precursor 0.077 0.3901 0.389
Plasmodium falciparum serine repeat antigen 9 0.0186 0.0835 0.2015
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0062 0.0045
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0062 0.0113
Entamoeba histolytica protein kinase, putative 0.0043 0.0083 0.0213
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Giardia lamblia Cathepsin L precursor 0.0186 0.0835 0.2144
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1932 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0186 0.0835 0.0819
Loa Loa (eye worm) calpain 5 0.0043 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.1932 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0186 0.0835 0.2015
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0186 0.0835 0.2105
Trypanosoma cruzi cysteine peptidase, putative 0.0237 0.1101 0.1046
Entamoeba histolytica cysteine proteinase, putative 0.0423 0.2078 0.5327
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.0835 0.0835
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0062 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0345 0.0328
Loa Loa (eye worm) hypothetical protein 0.0533 0.2658 0.2658
Entamoeba histolytica cysteine protease, putative 0.0186 0.0835 0.2141
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Echinococcus granulosus cathepsin L cysteine protease 0.0423 0.2078 0.2069
Onchocerca volvulus 0.0039 0.0062 0.0115
Echinococcus multilocularis cathepsin L 0.0423 0.2078 0.2064
Toxoplasma gondii cathepsin CPC2 0.0186 0.0835 0.2105
Brugia malayi Cathepsin L-like precursor 0.077 0.3901 0.389
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0081 0.0282 0.0265
Brugia malayi cathepsin Z-like cysteine proteinase 0.0186 0.0835 0.0819
Trypanosoma cruzi cysteine proteinase, putative 0.0423 0.2078 0.2029
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Brugia malayi hypothetical protein 0.0039 0.0062 0.0045
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0726 0.367 0.9397
Echinococcus granulosus pyruvate kinase 0.0039 0.0062 0.005
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.0835 0.0819
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0062 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Giardia lamblia Cathepsin L-like protease 0.0186 0.0835 0.2144
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Plasmodium falciparum serine repeat antigen 2 0.0186 0.0835 0.2015
Entamoeba histolytica cysteine proteinase, putative 0.0533 0.2658 0.6814
Toxoplasma gondii preprocathepsin c precursor, putative 0.0186 0.0835 0.2105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Toxoplasma gondii cathepsin CPC1 0.0186 0.0835 0.2105
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0176 0.0784 0.0767
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0018 0.0006
Schistosoma mansoni cathepsin F (C01 family) 0.077 0.3901 0.389
Brugia malayi Cathepsin L-like precursor 0.0237 0.1101 0.1085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0237 0.1101 0.1085
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0345 0.0328
Schistosoma mansoni microtubule-associated protein tau 0.0803 0.4072 0.4061
Onchocerca volvulus 0.077 0.3901 1
Giardia lamblia Cathepsin B precursor 0.0726 0.367 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0533 0.2658 0.2613
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0186 0.0835 0.2015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Trypanosoma brucei kinesin, putative 0.0043 0.0083 0.0056
Echinococcus multilocularis pyruvate kinase 0.0031 0.0019 0.0001
Onchocerca volvulus Dual oxidase homolog 0.0039 0.0062 0.0115
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0307
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0062 0.0062
Trichomonas vaginalis set domain proteins, putative 0.0241 0.1125 0.277
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0186 0.0835 0.2015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0031 0.0023 0.0006
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0307
Brugia malayi Matrixin family protein 0.0054 0.014 0.0122
Loa Loa (eye worm) hypothetical protein 0.0237 0.1101 0.1101
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0062 0.0113
Brugia malayi Blistered cuticle protein 3 0.0039 0.0062 0.0045
Loa Loa (eye worm) hypothetical protein 0.0237 0.1101 0.1101
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0231 0.1073 0.1063
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0186 0.0835 0.2105
Plasmodium vivax serine-repeat antigen (SERA) 0.0186 0.0835 0.2105
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Plasmodium vivax vivapain-3 0.0423 0.2078 0.5306
Plasmodium falciparum serine repeat antigen 3 0.0186 0.0835 0.2015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0423 0.2078 0.5252
Brugia malayi Cathepsin L-like cysteine proteinase 0.0533 0.2658 0.2645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Schistosoma mansoni hypothetical protein 0.0052 0.0133 0.0115
Loa Loa (eye worm) RNA binding protein 0.0066 0.0206 0.0206
Echinococcus granulosus tar DNA binding protein 0.0066 0.0206 0.0195
Schistosoma mansoni dopamine-beta-monooxygenase 0.0123 0.0503 0.0487
Schistosoma mansoni survival motor neuron protein 0.0052 0.0133 0.0115
Entamoeba histolytica cysteine proteinase, putative 0.077 0.3901 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.0835 0.0835
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.018 0.0119
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0307
Plasmodium falciparum cysteine proteinase falcipain 1 0.0423 0.2078 0.5252
Echinococcus multilocularis calpain 7 (C02 family) 0.0061 0.018 0.0162
Entamoeba histolytica cysteine proteinase, putative 0.0423 0.2078 0.5327
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0345 0.0345
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0206 0.0189
Entamoeba histolytica cysteine protease, putative 0.0186 0.0835 0.2141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.018 0.0119
Trypanosoma brucei calpain-like protein, putative 0.0061 0.018 0.0307
Entamoeba histolytica cysteine protease, putative 0.0186 0.0835 0.2141
Entamoeba histolytica cysteine proteinase 2 0.0423 0.2078 0.5327
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.0835 0.2144
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0206 0.0189
Giardia lamblia Cysteine protease 0.0186 0.0835 0.2144
Echinococcus granulosus pyruvate kinase 0.0039 0.0062 0.005
Onchocerca volvulus 0.0039 0.0062 0.0115
Trypanosoma brucei calpain-like protein, putative 0.0061 0.018 0.0307
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.018 0.0119
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.4119 0.4108
Echinococcus multilocularis cathepsin L cysteine protease 0.077 0.3901 0.389
Trypanosoma cruzi cysteine peptidase, putative 0.077 0.3901 0.3863
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0186 0.0835 0.0835
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0835 0.0819
Loa Loa (eye worm) hypothetical protein 0.0533 0.2658 0.2658
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0726 0.367 0.9397
Echinococcus granulosus cathepsin L cysteine proteinase 0.077 0.3901 0.3894
Echinococcus multilocularis peroxidasin 0.0039 0.0062 0.0045
Loa Loa (eye worm) calpain 0.0061 0.018 0.018
Entamoeba histolytica cysteine proteinase, putative 0.0423 0.2078 0.5327
Loa Loa (eye worm) calpain family protein 1 0.0162 0.0711 0.0711
Echinococcus multilocularis calpain family protein 1, d 0.012 0.0486 0.0469
Plasmodium falciparum cysteine proteinase falcipain 2b 0.077 0.3901 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1932 1 1
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0206 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0345 0.0328
Entamoeba histolytica calpain large subunit domain III containing protein 0.0043 0.0083 0.0213
Loa Loa (eye worm) hypothetical protein 0.0144 0.0614 0.0614
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0119
Plasmodium falciparum serine repeat antigen 1 0.0186 0.0835 0.2015
Giardia lamblia Cathepsin B precursor 0.0186 0.0835 0.2144
Loa Loa (eye worm) papain family cysteine protease containing protein 0.077 0.3901 0.3901
Echinococcus multilocularis pyruvate kinase 0.0039 0.0062 0.0044
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0133 0.0115
Echinococcus granulosus geminin 0.0197 0.0893 0.0882
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0206 0.0189
Giardia lamblia Cathepsin B precursor 0.0186 0.0835 0.2144
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0231 0.1073 0.1057
Giardia lamblia Encystation-specific protease 0.0186 0.0835 0.2144
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0186 0.0835 0.2105
Echinococcus granulosus cathepsin L 0.0186 0.0835 0.0824
Loa Loa (eye worm) hypothetical protein 0.0186 0.0835 0.0835
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.0835 0.0819
Brugia malayi cathepsin L-like cysteine proteinase 0.0186 0.0835 0.0819
Schistosoma mansoni cathepsin F (C01 family) 0.077 0.3901 0.389
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0186 0.0835 0.0819
Echinococcus granulosus calpain A 0.0061 0.018 0.0168
Trypanosoma cruzi major cysteine proteinase, putative 0.0186 0.0835 0.0778
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0062 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0231 0.1073 0.1057
Toxoplasma gondii cathepsin B 0.0726 0.367 0.9404
Onchocerca volvulus Matrix metalloproteinase homolog 0.0049 0.0117 0.0255
Trypanosoma cruzi kinesin, putative 0.0043 0.0083 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.0972 0.0972
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.018 0.0119
Entamoeba histolytica cysteine protease, putative 0.0186 0.0835 0.2141
Echinococcus multilocularis cathepsin L cysteine protease 0.077 0.3901 0.389
Echinococcus multilocularis calpain A 0.0177 0.0786 0.077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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