Detailed information for compound 836232

Basic information

Technical information
  • TDR Targets ID: 836232
  • Name: N-(2-bromophenyl)-3-methyl-2,4-dioxo-1,5-dihy dro-1,5-benzodiazepine-8-sulfonamide
  • MW: 424.269 | Formula: C16H14BrN3O4S
  • H donors: 3 H acceptors: 4 LogP: 1.97 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2cc(ccc2NC(=O)C1C)S(=O)(=O)Nc1ccccc1Br
  • InChi: 1S/C16H14BrN3O4S/c1-9-15(21)18-13-7-6-10(8-14(13)19-16(9)22)25(23,24)20-12-5-3-2-4-11(12)17/h2-9,20H,1H3,(H,18,21)(H,19,22)
  • InChiKey: DDVFFNMGMVANQJ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(2-bromophenyl)-2,4-diketo-3-methyl-1,5-dihydro-1,5-benzodiazepine-8-sulfonamide
  • E145-0034
  • NCGC00120602-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.8889 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0284 0.0413
Trichomonas vaginalis set domain proteins, putative 0.0286 0.6871 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0285 0.0415
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0925 0.1865
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0925 0.1865
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0192 0.4457 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0722 0.105
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Loa Loa (eye worm) hypothetical protein 0.0057 0.0986 0.1649
Leishmania major malate dehydrogenase, putative 0.0192 0.4457 0.5015
Giardia lamblia PHD finger protein 15 0.0035 0.0436 0.2407
Echinococcus multilocularis lactate dehydrogenase protein 0.0192 0.4457 0.4457
Brugia malayi hypothetical protein 0.0043 0.0648 0.1083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0925 0.1347
Entamoeba histolytica malate dehydrogenase, putative 0.0075 0.1447 0.3067
Schistosoma mansoni hypothetical protein 0.0035 0.0436 0.0979
Onchocerca volvulus 0.006 0.1065 0.0977
Loa Loa (eye worm) hypothetical protein 0.006 0.1081 0.1808
Schistosoma mansoni L-lactate dehydrogenase 0.0192 0.4457 1
Schistosoma mansoni malate dehydrogenase 0.0192 0.4457 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0116 0.0168
Giardia lamblia Malate dehydrogenase 0.0075 0.1447 1
Echinococcus multilocularis L lactate dehydrogenase 0.0117 0.2543 0.2543
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0827
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0685 0.1146
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0192 0.4457 0.7453
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0685 0.1538
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0436 0.0979
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0116 0.013
Echinococcus multilocularis malate dehydrogenase 0.0075 0.1447 0.1447
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0925 0.1041
Loa Loa (eye worm) hypothetical protein 0.0049 0.0795 0.133
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0075 0.1447 0.1447
Entamoeba histolytica malate dehydrogenase, putative 0.0192 0.4457 1
Echinococcus granulosus cytosolic malate dehydrogenase 0.0075 0.1447 0.1447
Plasmodium vivax malate dehydrogenase, putative 0.0192 0.4457 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0116 0.013
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.079 0.079
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Loa Loa (eye worm) hypothetical protein 0.0085 0.1724 0.2883
Schistosoma mansoni hypothetical protein 0.0018 0.0007 0.0016
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0925 0.1041
Plasmodium falciparum malate dehydrogenase 0.0192 0.4457 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0648 0.1453
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0436 0.073
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0849 0.0955
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0075 0.1447 0.1628
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0849 0.0955
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0285 0.0415
Leishmania major hypothetical protein, conserved 0.0018 0.0007 0.0008
Echinococcus granulosus malate dehydrogenase 0.0075 0.1447 0.1447
Onchocerca volvulus 0.0036 0.0458 0.0034
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0436 0.0738
Chlamydia trachomatis malate dehydrogenase 0.0075 0.1447 0.5
Trypanosoma brucei glycosomal malate dehydrogenase 0.0075 0.1447 0.1628
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.3961 0.4456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0284 0.0413
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0986 0.0986
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0925 0.1347
Echinococcus granulosus lactate dehydrogenase a 0.0192 0.4457 0.4457
Trypanosoma cruzi malate dehydrogenase, putative 0.0075 0.1447 0.1628
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.095 0.095
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0075 0.1447 0.1628
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3961 0.4456
Mycobacterium ulcerans hypothetical protein 0.0192 0.4461 1
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0075 0.1447 0.1628
Trypanosoma brucei malate dehydrogenase-related 0.0075 0.1447 0.1628
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0061 0.0138
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.095 0.1589
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0075 0.1447 0.3067
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0849 0.0955
Leishmania major malate dehydrogenase 0.0075 0.1447 0.1628
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0116 0.0194
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0646 0.0646
Mycobacterium ulcerans malate dehydrogenase 0.0075 0.1447 0.3064
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1883 0.4225
Leishmania major mitochondrial malate dehydrogenase 0.0075 0.1447 0.1628
Echinococcus multilocularis zinc finger protein 0.0024 0.014 0.014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.095 0.095
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0458 0.1027
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0191 0.0215
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0172 0.0288
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0685 0.0685
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0827
Leishmania major glycosomal malate dehydrogenase 0.0075 0.1447 0.1628
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0626 0.0626
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0116 0.013
Trypanosoma cruzi ISWI complex protein 0.0018 0.0007 0.0008
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0642 0.0722
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0458 0.0458
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0111 0.0125
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1382 0.1382
Brugia malayi Bromodomain containing protein 0.0038 0.051 0.0852
Trypanosoma brucei ISWI complex protein 0.0018 0.0007 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0986 0.0986
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0925 0.1041
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.8889 1
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0075 0.1447 0.1628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0932
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.095 0.1589
Schistosoma mansoni zinc finger protein 0.0018 0.0007 0.0016
Trichomonas vaginalis malate dehydrogenase, putative 0.0036 0.0466 0.0678
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0231 0.0231
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0648 0.0648
Entamoeba histolytica hypothetical protein 0.0043 0.0648 0.1225
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.4461 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0925 0.1041
Brugia malayi lactate dehydrogenase. 0.0192 0.4457 0.7453
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0116 0.5
Plasmodium falciparum phd finger protein, putative 0.0035 0.0436 0.0738
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Echinococcus granulosus cytosolic malate dehydrogenase 0.0075 0.1447 0.1447
Loa Loa (eye worm) hypothetical protein 0.0052 0.0854 0.1428
Trypanosoma brucei cytosolic malate dehydrogenase 0.0075 0.1447 0.1628
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0648 0.0648
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0192 0.4457 0.4457
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0642 0.0722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0932
Brugia malayi Bromodomain containing protein 0.0046 0.072 0.1203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.095 0.2132
Brugia malayi jmjC domain containing protein 0.0045 0.0685 0.1146
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0458 0.0788
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0075 0.1447 0.242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0437 0.0636
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0075 0.1447 0.3064
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0075 0.1447 0.1628
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0925 0.1041
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0827
Plasmodium vivax SET domain protein, putative 0.0036 0.0458 0.0788
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.095 0.095
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0075 0.1447 0.2106
Echinococcus multilocularis tumor protein p63 0.0408 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0365 0.0531
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0685 0.1538
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0436 0.0436
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0849 0.0955
Schistosoma mansoni ap endonuclease 0.0023 0.0116 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0284 0.0413
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.008 0.0134
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0925 0.1547
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1398 0.2338
Giardia lamblia GTOR 0.0054 0.0925 0.608
Trypanosoma cruzi ISWI complex protein 0.0018 0.0007 0.0008
Echinococcus granulosus L lactate dehydrogenase B chain 0.0192 0.4457 0.4457
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0116 0.0116
Toxoplasma gondii hypothetical protein 0.0059 0.1042 0.2134
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1382 0.1382
Trichomonas vaginalis malate dehydrogenase, putative 0.0036 0.0466 0.0678
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0116 0.013
Brugia malayi Pre-SET motif family protein 0.0036 0.0458 0.0766
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0357 0.0519
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0925 0.1041
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0925 0.0925
Plasmodium vivax lactate dehydrogenase 0.0192 0.4457 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2491 0.2491
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.598 1
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0075 0.1447 0.242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0357 0.0519
Schistosoma mansoni hypothetical protein 0.0025 0.0172 0.0387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0986 0.2212
Schistosoma mansoni hypothetical protein 0.0043 0.0648 0.1453
Entamoeba histolytica hypothetical protein 0.0043 0.0648 0.1225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0932
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0116 0.0116
Echinococcus granulosus lactate dehydrogenase a 0.0192 0.4457 0.4457
Entamoeba histolytica hypothetical protein 0.0043 0.0648 0.1225
Schistosoma mansoni malate dehydrogenase 0.0075 0.1447 0.3247
Brugia malayi PHD-finger family protein 0.0035 0.0436 0.073
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0116 0.0194
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0569 0.1043
Echinococcus granulosus zinc finger protein 0.0024 0.014 0.014
Schistosoma mansoni ap endonuclease 0.0023 0.0116 0.026
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0436 0.0738
Loa Loa (eye worm) hypothetical protein 0.0046 0.0722 0.1207
Leishmania major cytosolic malate dehydrogenase 0.0075 0.1447 0.1628
Echinococcus granulosus malate dehydrogenase 0.0075 0.1447 0.1447
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0116 0.0168
Brugia malayi jmjC domain containing protein 0.0115 0.2491 0.4165
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0925 0.0925
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0075 0.1447 0.1447
Entamoeba histolytica hypothetical protein 0.0043 0.0648 0.1225
Loa Loa (eye worm) malate dehydrogenase 0.0075 0.1447 0.242
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0075 0.1447 0.1628
Toxoplasma gondii malate dehydrogenase MDH 0.0192 0.4457 1
Brugia malayi Pre-SET motif family protein 0.0251 0.598 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0932
Echinococcus multilocularis malate dehydrogenase 0.0075 0.1447 0.1447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0467 0.068
Echinococcus granulosus L lactate dehydrogenase 0.0117 0.2543 0.2543
Echinococcus granulosus lactate dehydrogenase protein 0.0192 0.4457 0.4457
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.1136 0.1278
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0925 0.1547
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2491 0.2491
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0436 0.0738
Schistosoma mansoni zinc finger protein 0.0024 0.014 0.0313
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0827
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.095 0.095
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0827
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0075 0.1447 0.2106
Echinococcus multilocularis peregrin 0.0038 0.051 0.051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0458 0.1027
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0075 0.1447 0.2106
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.8889 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0061 0.0138
Schistosoma mansoni malate dehydrogenase 0.0075 0.1447 0.3247
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0642 0.0722
Brugia malayi PHD-finger family protein 0.003 0.0305 0.051
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0646 0.0646
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0231 0.0231
Echinococcus multilocularis lactate dehydrogenase a 0.0192 0.4457 0.4457
Onchocerca volvulus 0.0286 0.6871 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0231 0.0519
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0075 0.1447 0.2106
Plasmodium falciparum L-lactate dehydrogenase 0.0192 0.4457 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0925 0.1347
Schistosoma mansoni bromodomain containing protein 0.0076 0.1493 0.335
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0061 0.0061
Leishmania major malate dehydrogenase, putative 0.0075 0.1447 0.1628
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0986 0.2212
Toxoplasma gondii lactate dehydrogenase LDH2 0.0192 0.4457 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1065 0.1781
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Plasmodium falciparum lactate dehydrogenase, putative 0.0075 0.1447 0.3067
Echinococcus granulosus peregrin 0.0038 0.051 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0932
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0925 0.2076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.095 0.2132
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0365 0.0531
Loa Loa (eye worm) hypothetical protein 0.0035 0.0436 0.073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0285 0.0415
Loa Loa (eye worm) malate dehydrogenase 0.0075 0.1447 0.242
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.8889 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0436 0.0436
Echinococcus multilocularis lactate dehydrogenase a 0.0192 0.4457 0.4457
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0075 0.1447 0.3067
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3961 0.4456
Schistosoma mansoni L-lactate dehydrogenase 0.0075 0.1447 0.3247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0285 0.0415
Schistosoma mansoni malate dehydrogenase 0.0075 0.1447 0.3247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0365 0.0531
Toxoplasma gondii lactate dehydrogenase LDH1 0.0192 0.4457 1
Echinococcus multilocularis lactate dehydrogenase a 0.0192 0.4457 0.4457
Brugia malayi Bromodomain containing protein 0.0091 0.1856 0.3104
Echinococcus granulosus jumonji domain containing protein 0.0049 0.079 0.079
Trypanosoma cruzi malate dehydrogenase, putative 0.0075 0.1447 0.1628
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Schistosoma mansoni cellular tumor antigen P53 0.006 0.1065 0.239
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.095 0.2132
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0075 0.1447 0.5
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0424 0.0424

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1413 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.3359 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.0918 uM PubChem BioAssay. Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in WT MEF Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 16.4816 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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