TDR Targets

Basic information

Technical information

TDR Targets ID: 836999
Name: N-(2,4-dimethylphenyl)-2-[3-[(4-methoxyphenyl )methyl]-4-oxopyrido[2,3-d]pyrimidin-2-yl]sul fanylacetamide
MW: 460.548 | Formula: C25H24N4O3S
H donors: 1 H acceptors: 3 LogP: 4.18 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)Cn1c(SCC(=O)Nc2ccc(cc2C)C)nc2c(c1=O)cccn2
InChi: 1S/C25H24N4O3S/c1-16-6-11-21(17(2)13-16)27-22(30)15-33-25-28-23-20(5-4-12-26-23)24(31)29(25)14-18-7-9-19(32-3)10-8-18/h4-13H,14-15H2,1-3H3,(H,27,30)
InChiKey: PSGDIPRYPAMZOH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,4-dimethylphenyl)-2-[3-[(4-methoxyphenyl)methyl]-4-oxo-pyrido[2,3-d]pyrimidin-2-yl]sulfanyl-acetamide
N-(2,4-dimethylphenyl)-2-[[3-[(4-methoxyphenyl)methyl]-4-oxo-2-pyrido[2,3-d]pyrimidinyl]thio]acetamide
N-(2,4-dimethylphenyl)-2-[[4-keto-3-(4-methoxybenzyl)pyrido[2,3-d]pyrimidin-2-yl]thio]acetamide
N-(2,4-dimethylphenyl)-2-[3-[(4-methoxyphenyl)methyl]-4-oxo-pyrido[2,3-d]pyrimidin-2-yl]sulfanyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0084	0.0919	0.3201
Echinococcus multilocularis	RUN	0.0019	0.0114	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0323	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0013	0.004	0.0072
Echinococcus granulosus	neuropeptide receptor	0.0159	0.1856	0.1856
Schistosoma mansoni	single-minded	0.0015	0.0066	0.0066
Brugia malayi	F/Y-rich N-terminus family protein	0.0017	0.009	0.0164
Loa Loa (eye worm)	cytochrome P450	0.001	0.0003	0.0005
Toxoplasma gondii	heat shock protein 90, putative	0.0013	0.004	0.0301
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0013	0.004	0.004
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.0075	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0958	0.1736
Schistosoma mansoni	serine/threonine protein kinase	0.0226	0.2696	0.2696
Echinococcus granulosus	tar DNA binding protein	0.0126	0.1442	0.1442
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0015	0.0066	0.1155
Loa Loa (eye worm)	TK/FAK protein kinase	0.025	0.2998	0.5432
Schistosoma mansoni	hypothetical protein	0.001	0.0003	0.0003
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0015	0.0066	0.0222
Brugia malayi	RNA binding protein	0.0126	0.1442	0.2612
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0013	0.004	0.5
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0071	0.0071
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0013	0.004	0.0128
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0432	0.0783
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.024	0.2863	0.2863
Trypanosoma brucei	heat shock protein, putative	0.0013	0.004	0.0128
Leishmania major	basic transcription factor 3a, putative	0.0035	0.0312	0.1079
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0312	0.1079
Echinococcus granulosus	RUN	0.0019	0.0114	0.0114
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0114	0.0114
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0312	0.1079
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0014	0.005	0.005
Trypanosoma cruzi	heat shock protein 85, putative	0.0013	0.004	0.0128
Echinococcus granulosus	aryl hydrocarbon receptor	0.0052	0.052	0.052
Onchocerca volvulus	Protein cycle homolog	0.0036	0.0326	0.5586
Schistosoma mansoni	hypothetical protein	0.0811	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0323	0.0586
Leishmania major	protein kinase, putative	0.0016	0.0078	0.0261
Echinococcus granulosus	cpg binding protein	0.006	0.0625	0.0625
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0013	0.004	1
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0016	0.0071	0.1167
Brugia malayi	hypothetical protein	0.0036	0.0323	0.0586
Trypanosoma cruzi	heat shock protein 85, putative	0.0013	0.004	0.0128
Mycobacterium tuberculosis	Two component sensory transduction histidine kinase MtrB	0.0013	0.004	0.5355
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0071	0.0071
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Treponema pallidum	chemotaxis histidine kinase (cheA)	0.0013	0.004	0.5
Leishmania major	mitochondrial DNA topoisomerase II	0.0013	0.004	0.0128
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0071	0.0239
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Echinococcus multilocularis	tar DNA binding protein	0.0126	0.1442	0.1442
Wolbachia endosymbiont of Brugia malayi	membrane associated signal transduction histidine kinase	0.0013	0.004	0.5
Schistosoma mansoni	transcription factor btf3	0.0035	0.0312	0.0312
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.024	0.2863	1
Trichomonas vaginalis	heat shock protein, putative	0.0013	0.004	0.0189
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0432	0.0783
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0013	0.004	0.0189
Brugia malayi	Endoplasmin precursor	0.0013	0.004	0.0072
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0093	0.0093
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Mycobacterium tuberculosis	Two component sensor kinase MprB	0.0013	0.004	0.5355
Mycobacterium tuberculosis	Two component sensor histidine kinase PrrB	0.0013	0.004	0.5355
Trypanosoma brucei	heat shock protein, putative	0.0013	0.004	0.0128
Trypanosoma cruzi	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0084	0.0919	0.3201
Mycobacterium leprae	Possible regulatory protein	0.0015	0.0066	1
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0013	0.004	0.5355
Schistosoma mansoni	hypothetical protein	0.0342	0.4141	0.4141
Echinococcus granulosus	Smad4	0.0016	0.0075	0.0075
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.1442	0.1442
Trichomonas vaginalis	receptor histidine kinase, putative	0.0013	0.004	0.0189
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0015	0.0066	0.1155
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0071	0.0239
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0016	0.0075	0.0075
Trypanosoma brucei	heat shock protein, putative	0.0013	0.004	0.0128
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0016	0.0071	0.1167
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0052	0.052	0.052
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0226	0.2696	0.2696
Schistosoma mansoni	neuropeptide receptor	0.0159	0.1856	0.1856
Echinococcus granulosus	smad	0.0016	0.0075	0.0075
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0013	0.004	1
Mycobacterium tuberculosis	Conserved protein	0.0013	0.004	0.5355
Entamoeba histolytica	protein kinase domain containing protein	0.0088	0.097	1
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0312	1
Loa Loa (eye worm)	ICD-1 protein	0.0035	0.0312	0.0565
Echinococcus multilocularis	dnaJ subfamily B	0.0811	1	1
Toxoplasma gondii	heat shock protein HSP90	0.0013	0.004	0.0301
Schistosoma mansoni	smad	0.0016	0.0075	0.0075
Brugia malayi	Muscleblind-like protein	0.0452	0.552	1
Echinococcus granulosus	dual specificity	0.0088	0.097	0.097
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Leishmania major	DNA topoisomerase ii	0.0013	0.004	0.0128
Brugia malayi	PAS domain containing protein	0.0015	0.0066	0.012
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.1442	0.1442
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0016	0.007	0.007
Schistosoma mansoni	loxhd1	0.0019	0.0114	0.0114
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0015	0.0066	0.0222
Echinococcus granulosus	c-Jun N-terminal kinases	0.0226	0.2696	0.2696
Echinococcus multilocularis	heat shock protein 90	0.0013	0.004	0.004
Brugia malayi	MH2 domain containing protein	0.0016	0.0075	0.0135
Echinococcus granulosus	heat shock protein 90	0.0013	0.004	0.004
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0226	0.2696	0.4883
Echinococcus multilocularis	smad	0.0016	0.0075	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0312	1
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0071	1
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Trichomonas vaginalis	mismatch repair protein Mlh1C (mutL homolog)	0.0013	0.004	0.0189
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0075	0.0075
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0432	0.0432
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0036	0.0326	0.0591
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0016	0.0075	0.0075
Brugia malayi	Protein kinase domain containing protein	0.025	0.2998	0.5432
Leishmania major	hypothetical protein, conserved	0.0013	0.004	0.0128
Schistosoma mansoni	polycystin 1-related	0.0019	0.0114	0.0114
Loa Loa (eye worm)	Smad1	0.0016	0.0075	0.0135
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0013	0.004	0.0189
Trypanosoma cruzi	Heat shock protein 83, putative	0.0013	0.004	0.0128
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0071	0.0071
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0016	0.007	0.007
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0013	0.004	0.0128
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0108	0.122	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0159	0.1856	0.1856
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0013	0.004	0.5355
Brugia malayi	Smad1	0.0016	0.0075	0.0135
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0432	0.0432
Echinococcus multilocularis	neuropeptide receptor	0.0159	0.1856	0.1856
Brugia malayi	Cytochrome P450 family protein	0.0048	0.0469	0.085
Entamoeba histolytica	protein kinase, putative	0.0088	0.097	1
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0036	0.0323	0.0586
Echinococcus multilocularis	cpg binding protein	0.006	0.0625	0.0625
Trichomonas vaginalis	receptor histidine kinase, putative	0.0013	0.004	0.0189
Echinococcus multilocularis	geminin	0.0342	0.4141	0.4141
Brugia malayi	kinase, mitochondrial precursor	0.024	0.2863	0.5187
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0029	0.0233	1
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0013	0.004	0.0678
Echinococcus granulosus	cytochrome P450 2K1	0.001	0.0003	0.0003
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0071	0.0561
Mycobacterium tuberculosis	Probable two component sensor kinase	0.0013	0.004	0.5355
Brugia malayi	hypothetical protein	0.0019	0.0114	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0114	0.0207
Brugia malayi	hypothetical protein	0.0036	0.0326	0.0591
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0126	0.1442	0.2612
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0114	0.0114
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0114	0.0114
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0071	0.0071
Schistosoma mansoni	cpg binding protein	0.006	0.0625	0.0625
Echinococcus multilocularis	muscleblind protein	0.0452	0.552	0.552
Trypanosoma cruzi	heat shock protein 85, putative	0.0013	0.004	0.0128
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0071	0.0129
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0013	0.004	0.0128
Echinococcus multilocularis		0.001	0.0003	0.0003
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0093	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0066	0.1155
Brugia malayi	Probable DNA topoisomerase II	0.0013	0.004	0.0072
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0075	0.0075
Mycobacterium leprae	Probable two component sensor kinase MprB	0.0013	0.004	0.5774
Echinococcus multilocularis	heat shock protein	0.0013	0.004	0.004
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0016	0.0078	0.0261
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0794	0.9783	0.9783
Echinococcus multilocularis	Smad4	0.0016	0.0075	0.0075
Schistosoma mansoni	cpg binding protein	0.006	0.0625	0.0625
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0121	0.1381	0.1381
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0013	0.004	0.5
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.0093	0.0169
Trichomonas vaginalis	guanylate cyclase, putative	0.0015	0.0066	0.1155
Trypanosoma brucei	heat shock protein, putative	0.0013	0.004	0.0128
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0432	0.0432
Schistosoma mansoni	hypothetical protein	0.0342	0.4141	0.4141
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0016	0.0075	0.0075
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0071	0.0239
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.0075	0.0135
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0013	0.004	1
Leishmania major	protein kinase, putative	0.0016	0.0078	0.0261
Schistosoma mansoni	tyrosine kinase	0.0247	0.2962	0.2962
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0071	0.0071
Leishmania major	developmentally regulated phosphoprotein-like protein	0.024	0.2863	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0015	0.0066	0.1155
Onchocerca volvulus		0.0019	0.0114	0.1955
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0071	0.0129
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0114	0.2743
Plasmodium vivax	basic transcription factor 3b, putative	0.0035	0.0312	1
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0013	0.004	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0016	0.0075	0.0075
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0078	0.0261
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0088	0.097	0.3379
Schistosoma mansoni	cpg binding protein	0.0057	0.0584	0.0584
Brugia malayi	Stress-activated protein kinase jnk-1	0.0226	0.2696	0.4883
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Schistosoma mansoni	aryl hydrocarbon receptor	0.0016	0.007	0.007
Loa Loa (eye worm)	cytochrome P450 family protein	0.0048	0.0469	0.085
Loa Loa (eye worm)	transcription factor SMAD2	0.0237	0.2829	0.5125
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0432	0.0432
Brugia malayi	Cytochrome P450 family protein	0.001	0.0003	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0066	0.012
Loa Loa (eye worm)	hypothetical protein	0.0452	0.552	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0078	0.0261
Trypanosoma brucei	heat shock protein, putative	0.0013	0.004	0.0128
Trichomonas vaginalis	heat shock protein, putative	0.0013	0.004	0.0189
Onchocerca volvulus		0.0057	0.0584	1
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0075	0.0075
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0071	0.0071
Schistosoma mansoni	aryl hydrocarbon receptor nuclear translocator homolog (darnt)	0.0036	0.0326	0.0326
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0071	0.0129
Loa Loa (eye worm)	CYP4Cod1	0.001	0.0003	0.0005
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0013	0.004	0.0128
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0054	0.0548	0.0548
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0054	0.0548	0.0548
Plasmodium falciparum	basic transcription factor 3b, putative	0.0035	0.0312	1
Trichomonas vaginalis	endoplasmin, putative	0.0013	0.004	0.0189
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0013	0.004	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0114	0.0207
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.024	0.2863	0.2863
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0013	0.004	0.0128
Mycobacterium ulcerans	putative regultory protein	0.0013	0.004	1
Mycobacterium leprae	Probable two-component sensor kinase	0.0013	0.004	0.5774
Brugia malayi	MH1 domain containing protein	0.0016	0.0075	0.0135
Schistosoma mansoni	Smad4	0.0016	0.0075	0.0075
Echinococcus granulosus	transcription factor btf3	0.0035	0.0312	0.0312
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0114	0.0114
Schistosoma mansoni	pyruvate dehydrogenase	0.0226	0.2697	0.2697
Mycobacterium tuberculosis	Possible two component sensor kinase	0.0013	0.004	0.5355
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0066	0.1155
Loa Loa (eye worm)	MH2 domain-containing protein	0.0237	0.2829	0.5125
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0323	0.0586
Brugia malayi	MH1 domain containing protein	0.0016	0.0075	0.0135
Brugia malayi	Protein kinase domain containing protein	0.0088	0.097	0.1756
Mycobacterium tuberculosis	Possible two component sensor kinase TcrY	0.0013	0.004	0.5355
Brugia malayi	beta-NAC-like protein	0.0035	0.0312	0.0565
Trypanosoma brucei	heat shock protein, putative	0.0013	0.004	0.0128
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0013	0.004	0.0678
Trypanosoma cruzi	heat shock protein 90, putative	0.0013	0.004	0.0128
Brugia malayi	cytochrome P450	0.001	0.0003	0.0005
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0013	0.004	0.0301
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.005	0.005
Entamoeba histolytica	protein kinase, putative	0.0088	0.097	1
Mycobacterium ulcerans	DNA gyrase subunit B	0.0013	0.004	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0071	0.0561
Onchocerca volvulus		0.0019	0.0114	0.1955
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0015	0.0066	0.1155
Echinococcus granulosus	muscleblind protein	0.0452	0.552	0.552
Echinococcus multilocularis	protein tyrosine kinase	0.0247	0.2962	0.2962
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0014	0.005	0.005
Loa Loa (eye worm)	TAR-binding protein	0.0126	0.1442	0.2612
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.1442	0.1442
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.097	0.097
Schistosoma mansoni	cytochrome P450	0.001	0.0003	0.0003
Giardia lamblia	Pms1-like protein	0.0013	0.004	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0126	0.1442	0.2612
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0088	0.097	0.3379
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0014	0.005	0.005
Trichomonas vaginalis	guanylate cyclase, putative	0.0015	0.0066	0.1155
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0013	0.004	0.0128
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0088	0.097	0.1756
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0052	0.052	0.0941
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0071	0.0071
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0015	0.0066	0.1155
Schistosoma mansoni	pyruvate dehydrogenase	0.024	0.2863	0.2863
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0013	0.004	0.0678
Loa Loa (eye worm)	cytochrome P450 family protein	0.001	0.0003	0.0005
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0013	0.004	0.0072
Echinococcus granulosus	protein tyrosine kinase	0.0247	0.2962	0.2962
Echinococcus multilocularis	muscleblind protein 1	0.0452	0.552	0.552
Trypanosoma brucei	heat shock protein 90, putative	0.0013	0.004	0.0128
Trypanosoma brucei	heat shock protein 90, putative	0.0013	0.004	0.0128
Echinococcus multilocularis	transcription factor btf3	0.0035	0.0312	0.0312
Brugia malayi	CXXC zinc finger family protein	0.0057	0.0584	0.1059
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.1442	0.1442
Mycobacterium leprae	PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3	0.0013	0.004	0.5774
Trypanosoma cruzi	heat shock protein 90, putative	0.0013	0.004	0.0128
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0088	0.097	0.3379
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0015	0.0066	0.0222
Schistosoma mansoni	lipoxygenase	0.0019	0.0114	0.0114
Schistosoma mansoni	pyruvate dehydrogenase	0.0226	0.2697	0.2697
Trypanosoma brucei	transcription factor BTF3, putative	0.0035	0.0312	0.1079
Trypanosoma brucei	heat shock protein, putative	0.0013	0.004	0.0128
Echinococcus granulosus	heat shock protein	0.0013	0.004	0.004
Brugia malayi	TAR-binding protein	0.0126	0.1442	0.2612
Brugia malayi	heat shock protein 90	0.0013	0.004	0.0072
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0013	0.004	0.0189
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0013	0.004	1
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Schistosoma mansoni	lipoxygenase	0.0054	0.0548	0.0548
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.1442	0.1442
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0088	0.097	0.3379
Schistosoma mansoni	rab6-interacting	0.0019	0.0114	0.0114
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0013	0.004	0.0128
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0013	0.004	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0432	0.0432
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0013	0.004	0.5
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0057	0.0584	0.1059
Brugia malayi	MH2 domain containing protein	0.0016	0.0075	0.0135
Schistosoma mansoni	heat shock protein	0.0013	0.004	0.004
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0432	0.0432
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0013	0.004	0.5355
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0013	0.004	0.0128
Trypanosoma brucei	DNA topoisomerase ii	0.0013	0.004	0.0128
Echinococcus multilocularis	dual specificity	0.0088	0.097	0.097
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0013	0.004	0.0189
Brugia malayi	Cytochrome P450 family protein	0.001	0.0003	0.0005
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.024	0.2863	0.2863
Loa Loa (eye worm)	hypothetical protein	0.0013	0.004	0.0072
Brugia malayi	hypothetical protein	0.0019	0.0114	0.0207
Entamoeba histolytica	hypothetical protein	0.0035	0.0312	0.2925
Loa Loa (eye worm)	endoplasmin	0.0013	0.004	0.0072
Loa Loa (eye worm)	hypothetical protein	0.024	0.2863	0.5187
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0013	0.004	0.004
Entamoeba histolytica	transcription factor BTF3, putative	0.0035	0.0312	0.2925
Schistosoma mansoni	endoplasmin	0.0013	0.004	0.004
Schistosoma mansoni	endoplasmin	0.0013	0.004	0.004
Trypanosoma brucei	heat shock protein, putative	0.0013	0.004	0.0128
Trypanosoma brucei	developmentally regulated phosphoprotein	0.024	0.2863	1
Trichomonas vaginalis	adenylate cyclase, putative	0.0015	0.0066	0.1155
Loa Loa (eye worm)	cytochrome P450 family protein	0.001	0.0003	0.0005
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0013	0.004	1
Toxoplasma gondii	NAC domain-containing protein	0.0035	0.0312	0.2535
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0013	0.004	1
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0084	0.0919	0.3201
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0013	0.004	1
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0013	0.004	0.0189
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Schistosoma mansoni	DNA topoisomerase II	0.0013	0.004	0.004
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0114	0.0114
Wolbachia endosymbiont of Brugia malayi	signal transduction histidine kinase and receiver	0.0013	0.004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0452	0.552	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0114	0.0114
Schistosoma mansoni	rab6-interacting	0.0019	0.0114	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0958	0.1736
Mycobacterium tuberculosis	Probable sensor protein KdpD	0.0013	0.004	0.5355
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0097	0.1085	0.8888
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0114	0.0207
Echinococcus granulosus	geminin	0.0342	0.4141	0.4141
Trypanosoma brucei	Heat shock protein 83, putative	0.0013	0.004	0.0128
Brugia malayi	Doublecortin family protein	0.0019	0.0114	0.0207
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0014	0.005	0.005
Loa Loa (eye worm)	heat shock protein 90	0.0013	0.004	0.0072
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0114	0.0114
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0016	0.0078	0.0261
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0013	0.004	0.0301
Mycobacterium tuberculosis	Two component sensor histidine kinase TrcS	0.0013	0.004	0.5355
Mycobacterium leprae	TWO COMPONENT SENSOR HISTIDINE KINASE PRRB	0.0013	0.004	0.5774
Mycobacterium tuberculosis	Possible two component system response sensor kinase membrane associated PhoR	0.0013	0.004	0.5355
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Mycobacterium ulcerans	two component sensor kinase MprB	0.0013	0.004	1
Onchocerca volvulus		0.0052	0.0516	0.8837
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0036	0.0326	0.0591
Schistosoma mansoni	heat shock protein	0.0013	0.004	0.004
Toxoplasma gondii	pyruvate dehydrogenase kinase, putative	0.0084	0.0919	0.7522
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0071	0.0239
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0036	0.0326	0.0591
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0066	0.1155
Loa Loa (eye worm)	RNA binding protein	0.0126	0.1442	0.2612
Brugia malayi	MH2 domain containing protein	0.0237	0.2829	0.5125
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0312	1
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0114	0.2743
Trichomonas vaginalis	sensor histidine kinase, putative	0.0013	0.004	0.0189
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.0071	0.0239
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128
Echinococcus granulosus	mothers against decapentaplegic 5	0.0016	0.0075	0.0075
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0432	0.0432
Entamoeba histolytica	hypothetical protein	0.0088	0.097	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0323	0.0586
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0013	0.004	0.0072
Loa Loa (eye worm)	TOPoisomerase family member	0.0013	0.004	0.0072
Mycobacterium tuberculosis	Two component sensor kinase [second part]	0.0013	0.004	0.5355
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0516	0.0935
Brugia malayi	hypothetical protein	0.0052	0.0516	0.0935
Brugia malayi	Cytochrome P450 family protein	0.001	0.0003	0.0005
Leishmania major	heat shock protein 83-1	0.0013	0.004	0.0128

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 836999