Detailed information for compound 84939

Basic information

Technical information
  • TDR Targets ID: 84939
  • Name: N-[5-[(E)-2-(6-chloroquinolin-2-yl)ethenyl]na phthalen-2-yl]-1,1,1-trifluoromethanesulfonam ide
  • MW: 462.872 | Formula: C22H14ClF3N2O2S
  • H donors: 1 H acceptors: 3 LogP: 6.55 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)ccc(n2)/C=C/c1cccc2c1ccc(c2)NS(=O)(=O)C(F)(F)F
  • InChi: 1S/C22H14ClF3N2O2S/c23-17-6-11-21-16(12-17)5-8-18(27-21)7-4-14-2-1-3-15-13-19(9-10-20(14)15)28-31(29,30)22(24,25)26/h1-13,28H/b7-4+
  • InChiKey: CTINILPLIOIULZ-QPJJXVBHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[5-[(E)-2-(6-chloro-2-quinolyl)vinyl]-2-naphthyl]-1,1,1-trifluoro-methanesulfonamide
  • N-[5-[(E)-2-(6-chloro-2-quinolyl)vinyl]-2-naphthyl]-1,1,1-trifluoromethanesulfonamide
  • N-[5-[(E)-2-(6-chloroquinolin-2-yl)ethenyl]naphthalen-2-yl]-1,1,1-trifluoro-methanesulfonamide
  • AIDS-209747
  • AIDS209747
  • Methanesulfonamide, N-[5-[(E)-2-(6-chloro-2-quinolinyl)ethenyl]-2-naphthalenyl]-1,1,1-trifluoro-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) Human herpes virus 5 capsid protein P40 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0077 0.0242 0.4966
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0211 0.0825 0.2567
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0104 0.0358 1
Onchocerca volvulus 0.0077 0.0242 0.4966
Loa Loa (eye worm) hypothetical protein 0.0049 0.0122 0.0534
Trypanosoma cruzi hexose transporter 0.017 0.0645 0.8726
Echinococcus multilocularis mitogen activated protein kinase 0.0067 0.0197 0.0561
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0197 0.0862
Schistosoma mansoni lysyl-tRNA synthetase 0.0122 0.0438 0.1364
Loa Loa (eye worm) hypothetical protein 0.0031 0.0041 0.0181
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0168 0.0638 0.0928
Schistosoma mansoni hypothetical protein 0.004 0.008 0.0249
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0081 0.0353
Schistosoma mansoni sugar transporter 0.0077 0.0242 0.0753
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0026 0.0349
Trichomonas vaginalis glucose transporter, putative 0.0077 0.0242 0.1058
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0126 0.1039
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0026 0.0113
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0071 0.003
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Schistosoma mansoni alpha glucosidase 0.004 0.0081 0.0251
Schistosoma mansoni lysyl-tRNA synthetase 0.0122 0.0438 0.1364
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Chlamydia trachomatis lysine--tRNA ligase 0.0122 0.0438 1
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0031 0.0041 0.0181
Giardia lamblia Hexose transporter 0.0077 0.0242 0.3896
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0031 0.0041 0.0118
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0168 0.0638 0.1817
Echinococcus granulosus solute carrier family 22 0.0077 0.0242 0.0753
Brugia malayi AMP-binding enzyme family protein 0.005 0.0126 0.0553
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Mycobacterium tuberculosis Conserved hypothetical protein 0.0027 0.0026 0.0719
Echinococcus multilocularis lysyl tRNA synthetase 0.0122 0.0438 0.1248
Trypanosoma brucei THT1 - hexose transporter, putative 0.017 0.0645 0.8726
Brugia malayi Sugar transporter family protein 0.0548 0.2285 1
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0645 0.2822
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0031 0.0041 0.0024
Echinococcus multilocularis dna polymerase eta 0.0049 0.0122 0.0348
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0031 0.0041 0.034
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0027 0.0026 0.0349
Schistosoma mansoni alpha-glucosidase 0.0155 0.0579 0.1803
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0168 0.0638 0.2791
Leishmania major myo-inositol/proton symporter (MIT) 0.0077 0.0242 0.3273
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0168 0.0638 0.0599
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0311
Loa Loa (eye worm) hypothetical protein 0.005 0.0126 0.0553
Plasmodium falciparum calcium-dependent protein kinase 5 0.0168 0.0638 0.0599
Echinococcus granulosus sterol regulatory element binding protein 0.009 0.0298 0.0926
Echinococcus granulosus dna polymerase eta 0.0049 0.0122 0.038
Brugia malayi mbt repeat family protein 0.0053 0.0136 0.0595
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0168 0.0638 0.1985
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0164 0.0621 0.1933
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0081 0.0353
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0126 0.353
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0067 0.0197 0.2666
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0081 0.1092
Onchocerca volvulus Putative transporter 0.0077 0.0242 0.4966
Plasmodium falciparum calcium-dependent protein kinase 3 0.0168 0.0638 0.0599
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0242 0.1058
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0077 0.0242 0.1988
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0164 0.0621 0.2717
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0081 0.0353
Brugia malayi Sugar transporter family protein 0.0077 0.0242 0.1058
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0053 0.0166
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.0122 0.1651
Onchocerca volvulus 0.0077 0.0242 0.4966
Trypanosoma cruzi hexose transporter, putative 0.0077 0.0242 0.3273
Leishmania major threonyl-tRNA synthetase, putative 0.0031 0.0041 0.0559
Echinococcus granulosus solute carrier family 22 0.0077 0.0242 0.0753
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0077 0.0242 0.1988
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0311
Schistosoma mansoni patched 1 0.009 0.0298 0.0926
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0191 0.0739 0.1081
Brugia malayi Major Facilitator Superfamily protein 0.0077 0.0242 0.1058
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0191 0.0739 1
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0077 0.0242 0.0753
Onchocerca volvulus 0.0077 0.0242 0.4966
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0164 0.0621 0.1933
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0031 0.0041 0.0262
Brugia malayi CHE-14 protein 0.009 0.0298 0.1303
Toxoplasma gondii sugar transporter ST3 0.0077 0.0242 0.0327
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0031 0.0041 0.0506
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0368 0.161
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0107 0.0373 0.1632
Schistosoma mansoni hypothetical protein 0.0034 0.0053 0.0166
Echinococcus granulosus mitogen activated protein kinase 3 0.0067 0.0197 0.0613
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0077 0.0242 0.0201
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0164 0.0621 0.2717
Brugia malayi lysyl-tRNA synthetase 0.0122 0.0438 0.1918
Trichomonas vaginalis sugar transporter, putative 0.017 0.0645 0.2822
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0058 0.0049
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Schistosoma mansoni hypothetical protein 0.0087 0.0284 0.0883
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0191 0.0739 1
Echinococcus multilocularis solute carrier family 22 0.0077 0.0242 0.0689
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0168 0.0638 0.1985
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0191 0.0739 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0211 0.0825 0.2349
Onchocerca volvulus 0.0055 0.0144 0.0774
Plasmodium vivax hexose transporter 0.0548 0.2285 0.2253
Brugia malayi glycyl-tRNA synthetase 0.0031 0.0041 0.0181
Onchocerca volvulus 0.0077 0.0242 0.4966
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0126 0.1711
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0081 0.0353
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0197 0.0862
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0242 0.1058
Entamoeba histolytica protein kinase, putative 0.0168 0.0638 0.7811
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0213 0.0831 0.2585
Loa Loa (eye worm) major facilitator superfamily transporter 0.0077 0.0242 0.1058
Giardia lamblia Sugar-proton symporter 0.0077 0.0242 0.3896
Brugia malayi Glycosyl hydrolases family 31 protein 0.018 0.0688 0.301
Trypanosoma brucei glucose transporter, putative 0.017 0.0645 0.8726
Loa Loa (eye worm) major facilitator superfamily transporter 0.0077 0.0242 0.1058
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0168 0.0638 0.1985
Toxoplasma gondii sugar transporter ST2 0.0077 0.0242 0.0327
Echinococcus granulosus mitogen activated protein kinase 0.0067 0.0197 0.0613
Brugia malayi major facilitator superfamily protein 0.0077 0.0242 0.1058
Brugia malayi Cam kinase protein 1 0.0168 0.0638 0.2791
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0136 0.0423
Schistosoma mansoni glucose transporter 0.0077 0.0242 0.0753
Leishmania major DNA polymerase eta, putative 0.0035 0.0058 0.0788
Giardia lamblia Prolyl-tRNA synthetase 0.0164 0.0621 1
Leishmania major hypothetical protein, conserved 0.0027 0.0026 0.0349
Onchocerca volvulus 0.0077 0.0242 0.4966
Loa Loa (eye worm) glutaminase 0.0302 0.1217 0.5325
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0031 0.0041 0.0181
Leishmania major protein kinase, putative 0.0168 0.0638 0.863
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0168 0.0638 0.0928
Loa Loa (eye worm) hypothetical protein 0.005 0.0126 0.0553
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0168 0.0638 0.1817
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0081 0.0353
Mycobacterium ulcerans sugar transporter 0.0077 0.0242 0.1988
Loa Loa (eye worm) hypothetical protein 0.0168 0.0638 0.2791
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0071 0.003
Trichomonas vaginalis sugar transporter, putative 0.017 0.0645 0.2822
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0168 0.0638 0.0599
Echinococcus granulosus lysosomal alpha glucosidase 0.018 0.0688 0.2141
Echinococcus multilocularis tumor protein p63 0.0373 0.1526 0.4347
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0031 0.0041 0.0559
Loa Loa (eye worm) hypothetical protein 0.0133 0.0487 0.2132
Loa Loa (eye worm) MBCTL1 0.006 0.0168 0.0734
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0081 0.0353
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Loa Loa (eye worm) hypothetical protein 0.009 0.0298 0.1303
Echinococcus granulosus solute carrier family 22 0.0077 0.0242 0.0753
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Echinococcus granulosus tumor protein p63 0.0373 0.1526 0.475
Brugia malayi jmjC domain containing protein 0.0065 0.0189 0.0828
Leishmania major glucose transporter, lmgt2 0.017 0.0645 0.8726
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0126 0.1692
Leishmania major glucose transporter/membrane transporter D2, putative 0.017 0.0645 0.8726
Trypanosoma brucei glucosidase, putative 0.004 0.0081 0.1092
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0189 0.0589
Trypanosoma brucei glucose transporter 2A 0.017 0.0645 0.8726
Trypanosoma brucei protein kinase, putative 0.0067 0.0197 0.2666
Loa Loa (eye worm) hypothetical protein 0.0055 0.0144 0.0632
Schistosoma mansoni glucose transport protein 0.0548 0.2285 0.7113
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0126 0.1549
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0222 0.0972
Brugia malayi Niemann-Pick C1 protein precursor 0.0209 0.0816 0.3573
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0122 0.0438 0.3602
Schistosoma mansoni protein kinase 0.0168 0.0638 0.1985
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0067 0.0197 0.2666
Loa Loa (eye worm) sugar transporter 0.0548 0.2285 1
Brugia malayi Major Facilitator Superfamily protein 0.0077 0.0242 0.1058
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0548 0.2285 0.651
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Echinococcus multilocularis synaptic vesicle 2 protein 0.0077 0.0242 0.0689
Brugia malayi AMP-binding enzyme family protein 0.005 0.0126 0.0553
Toxoplasma gondii transporter, major facilitator family protein 0.0077 0.0242 0.0327
Onchocerca volvulus 0.0053 0.0136 0.0412
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.009 0.0298 0.1303
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.0197 0.2666
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0081 0.0353
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0168 0.0638 0.0599
Plasmodium falciparum calcium-dependent protein kinase 2 0.0168 0.0638 0.0599
Brugia malayi Major Facilitator Superfamily protein 0.0077 0.0242 0.1058
Brugia malayi hypothetical protein 0.004 0.008 0.035
Echinococcus granulosus Protein patched homolog 1 0.009 0.0298 0.0926
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Echinococcus multilocularis solute carrier family 22 0.0077 0.0242 0.0689
Leishmania major hypothetical protein, conserved 0.0027 0.0026 0.0349
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.083 0.351 1
Echinococcus granulosus Niemann Pick C1 protein 0.0209 0.0816 0.2542
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0168 0.0478
Giardia lamblia Glycyl-tRNA synthetase 0.0031 0.0041 0.0666
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0168 0.0522
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0168 0.0638 0.1817
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0311
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0067 0.02 0.0877
Schistosoma mansoni transcription factor LCR-F1 0.004 0.008 0.0249
Trypanosoma brucei THT1 - hexose transporter, putative 0.017 0.0645 0.8726
Trypanosoma brucei glucose transporter, putative 0.017 0.0645 0.8726
Schistosoma mansoni glucose transport protein 0.0548 0.2285 0.7113
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0122 0.0438 0.1918
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0242 0.1058
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0168 0.0638 0.2791
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0645 0.2822
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Mycobacterium ulcerans hypothetical protein 0.0027 0.0026 0.0212
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0122 0.0438 0.593
Leishmania major DNA polymerase eta, putative 0.0049 0.0122 0.1651
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0126 0.353
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0164 0.0621 0.1769
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0031 0.0041 0.034
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Trypanosoma brucei glucose transporter, putative 0.017 0.0645 0.8726
Schistosoma mansoni glucose transport protein 0.0548 0.2285 0.7113
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0026 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0081 0.1092
Loa Loa (eye worm) hypothetical protein 0.0034 0.0053 0.0233
Schistosoma mansoni alpha-glucosidase 0.0155 0.0579 0.1803
Onchocerca volvulus 0.0077 0.0242 0.4966
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0126 0.1039
Loa Loa (eye worm) hypothetical protein 0.005 0.0126 0.0553
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0122 0.0438 0.593
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0126 0.1039
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.0688 0.196
Schistosoma mansoni protein kinase 0.0168 0.0638 0.1985
Entamoeba histolytica hypothetical protein 0.004 0.008 0.0978
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0189 0.0589
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.018 0.0688 0.301
Schistosoma mansoni glycyl-tRNA synthetase 0.0031 0.0041 0.0129
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0168 0.0638 0.863
Trichomonas vaginalis conserved hypothetical protein 0.0548 0.2285 1
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0126 0.1549
Onchocerca volvulus 0.0077 0.0242 0.4966
Echinococcus multilocularis calcium dependent protein kinase 0.0157 0.0591 0.1682
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0053 0.0233
Trichomonas vaginalis glutaminase, putative 0.0302 0.1217 0.5325
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0144 0.045
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Onchocerca volvulus 0.0077 0.0242 0.4966
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0031 0.0041 0.0559
Echinococcus granulosus glycyl tRNA synthetase 0.0031 0.0041 0.0129
Echinococcus multilocularis mitogen activated protein kinase 3 0.0067 0.0197 0.0561
Schistosoma mansoni sugar transporter 0.0077 0.0242 0.0753
Entamoeba histolytica hypothetical protein 0.004 0.008 0.0978
Schistosoma mansoni hypothetical protein 0.0087 0.0284 0.0883
Trypanosoma brucei glucose transporter, putative 0.017 0.0645 0.8726
Echinococcus multilocularis Niemann Pick C1 protein 0.0299 0.1207 0.3437
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0077 0.0242 0.0689
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0548 0.2285 0.7113
Echinococcus granulosus microtubule associated protein 2 0.0761 0.3212 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0053 0.0152
Brugia malayi hypothetical protein 0.0077 0.0242 0.1058
Loa Loa (eye worm) glutaminase 2 0.0302 0.1217 0.5325
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Echinococcus multilocularis solute carrier family 22 0.0077 0.0242 0.0689
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0077 0.0242 0.6751
Giardia lamblia Kinase, CMGC MAPK 0.0067 0.0197 0.3174
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0189 0.0589
Schistosoma mansoni microtubule-associated protein tau 0.0761 0.3212 1
Toxoplasma gondii protein kinase, putative 0.1548 0.6627 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0058 0.0788
Loa Loa (eye worm) hypothetical protein 0.0209 0.0816 0.3573
Plasmodium falciparum proline--tRNA ligase 0.0191 0.0739 0.0701
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0081 0.0353
Echinococcus multilocularis Niemann Pick C1 protein 0.0209 0.0816 0.2326
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0067 0.0197 0.2666
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0053 0.0152
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Brugia malayi MAP kinase sur-1 0.0067 0.0197 0.0862
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0067 0.0197 0.2666
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0168 0.0638 0.1985
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.0189 0.0589
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Echinococcus granulosus calcium dependent protein kinase 0.0157 0.0591 0.1838
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0126 0.1549
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0311
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0062 0.1736
Loa Loa (eye worm) hypothetical protein 0.0053 0.0136 0.0595
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0168 0.0734
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0209 0.0816 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0104 0.0358 0.5587
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0077 0.0242 1
Echinococcus multilocularis expressed conserved protein 0.0197 0.0761 0.2169
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0136 0.0387
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0191 0.0739 1
Trypanosoma brucei sugar transporter, putative 0.0077 0.0242 0.3273
Entamoeba histolytica hypothetical protein 0.0122 0.0438 0.5367
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Mycobacterium ulcerans integral membrane transport protein 0.0077 0.0242 0.1988
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0081 0.0989
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0081 0.0353
Plasmodium falciparum calcium-dependent protein kinase 4 0.0168 0.0638 0.0599
Trypanosoma brucei glucose transporter 1E 0.017 0.0645 0.8726
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0081 0.023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0053 0.0233
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Trypanosoma cruzi glucose transporter, putative 0.0077 0.0242 0.3273
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0104 0.0358 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0126 0.1039
Loa Loa (eye worm) sugar transporter 0.0077 0.0242 0.1058
Leishmania major glucose transporter, lmgt1 0.017 0.0645 0.8726
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0638 0.2791
Entamoeba histolytica protein kinase, putative 0.0168 0.0638 0.7811
Trypanosoma cruzi hexose transporter, putative 0.017 0.0645 0.8726
Trichomonas vaginalis glucose transporter, putative 0.017 0.0645 0.2822
Echinococcus multilocularis sterol regulatory element binding protein 0.009 0.0298 0.0848
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Schistosoma mansoni DNA polymerase eta 0.0049 0.0122 0.038
Giardia lamblia Threonyl-tRNA synthetase 0.0031 0.0041 0.0666
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0638 0.1985
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.008 0.0249
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0081 0.0353
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0548 0.2285 0.651
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0081 0.1092
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0164 0.0621 0.2717
Schistosoma mansoni hypothetical protein 0.0087 0.0284 0.0883
Loa Loa (eye worm) hypothetical protein 0.0106 0.0368 0.161
Trypanosoma brucei THT1 - hexose transporter, putative 0.017 0.0645 0.8726
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0071 0.1985
Onchocerca volvulus 0.0077 0.0242 0.4966
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Toxoplasma gondii facilitative glucose transporter GT1 0.0548 0.2285 0.3423
Schistosoma mansoni sugar transporter 0.0077 0.0242 0.0753
Chlamydia trachomatis proline--tRNA ligase 0.0058 0.016 0.2978
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Trichomonas vaginalis sugar transporter, putative 0.017 0.0645 0.2822
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0062 0.1736
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0058 0.016 0.1311
Trichomonas vaginalis sugar transport protein, putative 0.0077 0.0242 0.1058
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0885 0.3751 0.3725
Echinococcus multilocularis GPCR, family 2 0.0034 0.0053 0.0152
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0071 0.0584
Plasmodium falciparum lysine--tRNA ligase 0.0122 0.0438 0.0399
Trypanosoma cruzi sugar transporter, putative 0.0077 0.0242 0.3273
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0126 0.1711
Loa Loa (eye worm) hypothetical protein 0.006 0.0168 0.0734
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0067 0.0197 0.0259
Treponema pallidum prolyl-tRNA synthetase 0.0058 0.016 1
Echinococcus granulosus solute carrier family 22 0.0077 0.0242 0.0753
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0122 0.0438 0.6932
Loa Loa (eye worm) hypothetical protein 0.0122 0.0438 0.1918
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0081 0.0353
Schistosoma mansoni hypothetical protein 0.0072 0.0222 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0298 0.1303
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0548 0.2285 0.7113
Loa Loa (eye worm) hypothetical protein 0.0072 0.0222 0.0972
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0026 0.0349
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0368 0.161
Trypanosoma cruzi hexose transporter, putative 0.017 0.0645 0.8726
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0077 0.0242 0.3273
Echinococcus multilocularis solute carrier family 22 0.0077 0.0242 0.0689
Onchocerca volvulus 0.0077 0.0242 0.4966
Plasmodium vivax calcium-dependent protein kinase, putative 0.0168 0.0638 0.0599
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0189 0.0539
Leishmania major glucose transporter, lmgt3 0.017 0.0645 0.8726
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0191 0.0739 1
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Brugia malayi mbt repeat family protein 0.0053 0.0136 0.0595
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0122 0.1651
Echinococcus granulosus GPCR family 2 0.0034 0.0053 0.0166
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0126 0.1039
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Plasmodium vivax proline--tRNA ligase, putative 0.0191 0.0739 0.0701
Plasmodium falciparum hexose transporter 0.0548 0.2285 0.2253
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0031 0.0041 0.0181
Brugia malayi major facilitator superfamily protein 0.0077 0.0242 0.1058
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.008 0.0228
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0548 0.2285 0.651
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Echinococcus multilocularis General substrate transporter 0.0471 0.1951 0.5557
Brugia malayi AMP-binding enzyme family protein 0.005 0.0126 0.0553
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Trypanosoma cruzi hexose transporter, putative 0.0093 0.0311 0.4203
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0031 0.0041 0.0181
Plasmodium vivax CDK-related protein kinase 6, putative 0.2324 1 1
Schistosoma mansoni hypothetical protein 0.0034 0.0053 0.0166
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0126 0.1039
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0164 0.0621 0.7604
Plasmodium falciparum calcium-dependent protein kinase 1 0.0168 0.0638 0.0599
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0062 0.1736
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0031 0.0041 0.0559
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0136 0.0423
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.0189 0.0539
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0548 0.2285 0.7113
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0168 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0242 0.1058
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0077 0.0242 0.6751
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0062 0.1736
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Leishmania major hypothetical protein, conserved 0.0077 0.0242 0.3273
Onchocerca volvulus 0.0077 0.0242 0.4966
Brugia malayi hypothetical protein 0.0077 0.0242 0.1058
Loa Loa (eye worm) hypothetical protein 0.0164 0.0621 0.2717
Schistosoma mansoni glutaminase 0.0302 0.1217 0.3788
Mycobacterium ulcerans glutaminase 0.0302 0.1217 1
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0031 0.0041 0.0181
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.0688 0.196
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0031 0.0041 0.0559
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0197 0.0613
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0136 0.0595
Entamoeba histolytica hypothetical protein 0.004 0.008 0.0978
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0164 0.0621 0.1933
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0168 0.0638 0.2791
Onchocerca volvulus 0.0077 0.0242 0.4966
Schistosoma mansoni hypothetical protein 0.0324 0.1313 0.4088
Schistosoma mansoni sugar transporter 0.0077 0.0242 0.0753
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0168 0.0522
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0168 0.0638 0.1817
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0126 0.1039
Echinococcus granulosus lysyl tRNA synthetase 0.0122 0.0438 0.1364
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0368 0.161
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0136 0.0423
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0081 0.0989
Trypanosoma brucei glucose transporter, putative 0.017 0.0645 0.8726
Echinococcus granulosus expressed conserved protein 0.0197 0.0761 0.237
Echinococcus granulosus Niemann Pick C1 protein 0.0299 0.1207 0.3756
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0067 0.0197 0.2666
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0885 0.3751 0.5644
Trypanosoma brucei glucose transporter, putative 0.017 0.0645 0.8726
Mycobacterium ulcerans hypothetical protein 0.005 0.0126 0.1039
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0027 0.0026 0.0349
Onchocerca volvulus 0.0104 0.0359 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0164 0.0621 1
Brugia malayi hypothetical protein 0.0077 0.0242 0.1058
Trichomonas vaginalis myo-inositol transporter, putative 0.0077 0.0242 0.1058
Trypanosoma cruzi hexose transporter, putative 0.017 0.0645 0.8726
Schistosoma mansoni hypothetical protein 0.0034 0.0053 0.0166
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0031 0.0041 0.1154
Onchocerca volvulus 0.0077 0.0242 0.4966
Echinococcus multilocularis glycyl tRNA synthetase 0.0031 0.0041 0.0118
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0081 0.0251
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0197 0.0862
Onchocerca volvulus 0.0077 0.0242 0.4966
Brugia malayi jmjC domain containing protein 0.0065 0.0189 0.0828
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0122 0.0438 0.3602
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0168 0.0478
Plasmodium vivax sugar transporter, putative 0.0077 0.0242 0.0201
Schistosoma mansoni hypothetical protein 0.0548 0.2285 0.7113
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0053 0.0233
Plasmodium falciparum protein kinase 7 0.1548 0.6627 0.6613
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0189 0.0589
Trypanosoma brucei glucose transporter, putative 0.017 0.0645 0.8726
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.0197 0.2666
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0242 0.1058
Leishmania major lysyl-tRNA synthetase, putative 0.0122 0.0438 0.593
Entamoeba histolytica hypothetical protein 0.004 0.008 0.0978
Toxoplasma gondii glycyl-tRNA synthetase 0.0031 0.0041 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0026 0.0113
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0311
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.0071 0.0751
Brugia malayi glutaminase DH11.1 0.0302 0.1217 0.5325
Trichomonas vaginalis glucose transporter, putative 0.017 0.0645 0.2822
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0053 0.0166
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0197 0.0862
Echinococcus granulosus Threonyl tRNA synthetase C 0.0031 0.0041 0.0129
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0126 0.1692
Echinococcus multilocularis protein dispatched 1 0.0103 0.0353 0.1005
Onchocerca volvulus 0.0077 0.0242 0.4966
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0189 0.0828
Brugia malayi Sugar transporter family protein 0.0077 0.0242 0.1058
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0031 0.0041 0.0506
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0136 0.0412
Trichomonas vaginalis sugar transporter, putative 0.0077 0.0242 0.1058
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0122 0.0534
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0136 0.0423
Giardia lamblia Lysyl-tRNA synthetase 0.0122 0.0438 0.7059
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0136 0.0387
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0548 0.2285 0.651
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0136 0.0423
Echinococcus granulosus synaptic vesicle 2 protein 0.0077 0.0242 0.0753
Schistosoma mansoni protein kinase 0.0168 0.0638 0.1985
Loa Loa (eye worm) hypothetical protein 0.0077 0.0242 0.1058
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0081 0.0083
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0126 0.1711
Loa Loa (eye worm) hypothetical protein 0.0164 0.0621 0.2717
Schistosoma mansoni hypothetical protein 0.0034 0.0053 0.0166
Toxoplasma gondii lysine-tRNA ligase 0.0122 0.0438 0.0625
Echinococcus multilocularis protein patched 0.009 0.0298 0.0848
Echinococcus multilocularis microtubule associated protein 2 0.0761 0.3212 0.9152
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0067 0.0197 0.0862
Loa Loa (eye worm) hypothetical protein 0.011 0.0385 0.1687
Plasmodium vivax lysine--tRNA ligase, putative 0.0122 0.0438 0.0399
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0027 0.0026 0.0349
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0548 0.2285 0.7113
Toxoplasma gondii sugar transporter ST1 0.0077 0.0242 0.0327
Schistosoma mansoni hypothetical protein 0.0087 0.0284 0.0883
Trypanosoma brucei glucose transporter, putative 0.017 0.0645 0.8726
Echinococcus granulosus General substrate transporter 0.0471 0.1951 0.6072
Plasmodium falciparum mitogen-activated protein kinase 2 0.0885 0.3751 0.3725
Echinococcus granulosus Sugar transporter ERD6 protein 0.0077 0.0242 0.0753
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0168 0.0638 0.0928

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.2 nM Inhibitory concentration against HCMV protease. ChEMBL. 15055990
IC50 (functional) = 3.2 nM Inhibitory concentration against HCMV protease. ChEMBL. 15055990
IC50 (functional) > 50 nM Inhibitory concentration against elastase ChEMBL. 15055990

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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