TDR Targets

Basic information

Technical information

TDR Targets ID: 862751
Name: N-(2-diethylaminoethyl)-4-[[3-[(4-fluoropheny l)methyl]imidazo[5,4-c]pyridin-2-yl]sulfanylm ethyl]benzamide
MW: 491.623 | Formula: C27H30FN5OS
H donors: 1 H acceptors: 3 LogP: 4.45 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CCNC(=O)c1ccc(cc1)CSc1nc2c(n1Cc1ccc(cc1)F)cncc2)CC
InChi: 1S/C27H30FN5OS/c1-3-32(4-2)16-15-30-26(34)22-9-5-21(6-10-22)19-35-27-31-24-13-14-29-17-25(24)33(27)18-20-7-11-23(28)12-8-20/h5-14,17H,3-4,15-16,18-19H2,1-2H3,(H,30,34)
InChiKey: HDWZTBJYHYIQEO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-diethylaminoethyl)-4-[[[3-[(4-fluorophenyl)methyl]-2-imidazo[5,4-c]pyridinyl]thio]methyl]benzamide
N-(2-diethylaminoethyl)-4-[[[3-(4-fluorobenzyl)imidazo[5,4-c]pyridin-2-yl]thio]methyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine protease, putative	0.0411	0.1157	0.3315
Leishmania major	cathepsin L-like protease	0.1155	0.3295	0.4037
Trypanosoma cruzi	cruzipain precursor, putative	0.1818	0.5203	0.519
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0375	0.0374
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0712	0.2024	0.2466
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.2833	0.8121	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1155	0.3295	0.3295
Echinococcus granulosus	dnaJ subfamily B	0.0462	0.1306	0.1306
Trypanosoma cruzi	major cysteine proteinase, putative	0.0411	0.1157	0.1132
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1155	0.3295	0.3986
Echinococcus multilocularis	isocitrate dehydrogenase	0.0018	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0139	0.0138
Entamoeba histolytica	cysteine protease, putative	0.0411	0.1157	0.3315
Echinococcus granulosus	cathepsin l1	0.1155	0.3295	0.3295
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0028	0.0028
Echinococcus multilocularis	cysteine protease	0.1155	0.3295	0.3295
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0302	0.0844	0.0843
Entamoeba histolytica	cysteine protease, putative	0.0712	0.2024	0.6025
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.013	0.013
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0411	0.1157	0.1156
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0411	0.1157	0.3455
Schistosoma mansoni	cathepsin F (C01 family)	0.1155	0.3295	0.3295
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0411	0.1157	0.1157
Echinococcus multilocularis	cpg binding protein	0.0034	0.0075	0.0075
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0028	0.0028
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1155	0.3295	0.3295
Echinococcus multilocularis	dnaJ subfamily B	0.0462	0.1306	0.1306
Trichomonas vaginalis	conserved hypothetical protein	0.0411	0.1157	0.1321
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0712	0.2024	0.2024
Toxoplasma gondii	cathepsin B	0.2833	0.8121	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1155	0.3295	0.3986
Brugia malayi	Cathepsin L-like precursor	0.0853	0.2429	0.2428
Echinococcus granulosus	GPCR family 2	0.0018	0.0028	0.0028
Onchocerca volvulus	Huntingtin homolog	0.0139	0.0375	0.1135
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0411	0.1157	0.1156
Entamoeba histolytica	cysteine proteinase, putative	0.0712	0.2024	0.6025
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1155	0.3295	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0411	0.1157	0.1321
Onchocerca volvulus	Cathepsin L homolog	0.1155	0.3295	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1155	0.3295	0.3295
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1155	0.3295	0.3986
Echinococcus multilocularis	lamin dm0	0.003	0.0064	0.0064
Trypanosoma cruzi	cysteine peptidase, putative	0.1155	0.3295	0.3276
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0411	0.1157	0.3455
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0712	0.2024	0.2001
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1155	0.3295	0.3986
Echinococcus granulosus	cathepsin L	0.0411	0.1157	0.1157
Echinococcus multilocularis	cathepsin b	0.3487	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0302	0.0844	0.0818
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0006	0.0006
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1818	0.5203	0.6395
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1818	0.5203	0.6395
Brugia malayi	hypothetical protein	0.0139	0.0375	0.0374
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0411	0.1157	0.3455
Schistosoma mansoni	hypothetical protein	0.0462	0.1306	0.1306
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.3487	1	1
Entamoeba histolytica	cysteine protease, putative	0.0712	0.2024	0.6025
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1155	0.3295	0.3295
Entamoeba histolytica	cysteine proteinase 1, putative	0.0712	0.2024	0.6025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1155	0.3295	0.3986
Schistosoma mansoni	hypothetical protein	0.0018	0.0028	0.0028
Entamoeba histolytica	cysteine protease, putative	0.0712	0.2024	0.6025
Plasmodium falciparum	serine repeat antigen 6	0.0411	0.1157	0.3455
Leishmania major	cathepsin L-like protease	0.1818	0.5203	0.6395
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0411	0.1157	0.1157
Schistosoma mansoni	intermediate filament proteins	0.003	0.0064	0.0064
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.013	0.013
Echinococcus granulosus	neuropeptide s receptor	0.1063	0.3032	0.3032
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0411	0.1157	0.3455
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3487	1	1
Loa Loa (eye worm)	hypothetical protein	0.0411	0.1157	0.1156
Onchocerca volvulus		0.0032	0.007	0.021
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0411	0.1157	0.1156
Plasmodium falciparum	serine repeat antigen 1	0.0411	0.1157	0.3455
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0712	0.2024	0.2402
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0028	0.0028
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0064	0.0064
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0411	0.1157	0.3455
Brugia malayi	Cathepsin L-like precursor	0.1155	0.3295	0.3295
Trypanosoma cruzi	cysteine protease, putative	0.0712	0.2024	0.2001
Loa Loa (eye worm)	MH2 domain-containing protein	0.0274	0.0766	0.0765
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.007	0.0069
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0097	0.0069
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0097	0.0085
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0006	0.0006
Leishmania major	cathepsin L-like protease	0.1155	0.3295	0.4037
Echinococcus granulosus	cysteine protease	0.0712	0.2024	0.2024
Echinococcus multilocularis	cathepsin b	0.3487	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.1155	0.3295	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0712	0.2024	0.2466
Brugia malayi	isocitrate dehydrogenase	0.0018	0.0028	0.0027
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0015	0.0019	0.0019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1155	0.3295	0.3986
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1155	0.3295	0.3986
Plasmodium falciparum	serine repeat antigen 3	0.0411	0.1157	0.3455
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0411	0.1157	0.1321
Trypanosoma brucei	cysteine peptidase C (CPC)	0.2833	0.8121	1
Entamoeba histolytica	hypothetical protein	0.0411	0.1157	0.3315
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0411	0.1157	0.3455
Brugia malayi	cathepsin F-like cysteine proteinase	0.0411	0.1157	0.1156
Plasmodium vivax	serine-repeat antigen (SERA)	0.0411	0.1157	0.3455
Schistosoma mansoni	smad1 5 8 and	0.0019	0.0031	0.0031
Entamoeba histolytica	cysteine protease, putative	0.0712	0.2024	0.6025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1155	0.3295	0.3986
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.013	0.013
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.3487	1	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0069	0.0175	0.0175
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0019	0.0031	0.0031
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0037	0.0084	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.1155	0.3295	0.3295
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0028	0.0028
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1155	0.3295	0.3986
Brugia malayi	Cathepsin L-like precursor	0.1155	0.3295	0.3295
Echinococcus granulosus	cpg binding protein	0.0034	0.0075	0.0075
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0411	0.1157	0.1321
Brugia malayi	intermediate filament protein	0.003	0.0064	0.0064
Brugia malayi	CXXC zinc finger family protein	0.0032	0.007	0.0069
Onchocerca volvulus		0.1155	0.3295	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1818	0.5203	0.6395
Entamoeba histolytica	cysteine protease, putative	0.0712	0.2024	0.6025
Echinococcus granulosus	mothers against decapentaplegic 6	0.0008	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0853	0.2429	0.2906
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0062	0.0154	0.0155
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0853	0.2429	0.2428
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0024	0.0023
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0411	0.1157	0.1321
Schistosoma mansoni	Smad4	0.0019	0.0031	0.0031
Onchocerca volvulus		0.1155	0.3295	1
Plasmodium falciparum	serine repeat antigen 9	0.0411	0.1157	0.3455
Loa Loa (eye worm)	MH2 domain-containing protein	0.0019	0.0031	0.003
Entamoeba histolytica	cysteine proteinase, putative	0.1155	0.3295	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0411	0.1157	0.1157
Brugia malayi	MH1 domain containing protein	0.0019	0.0031	0.003
Plasmodium falciparum	serine repeat antigen 7	0.0411	0.1157	0.3455
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1155	0.3295	0.3986
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.013	0.013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0411	0.1157	0.1321
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0411	0.1157	0.1157
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0019	0.0031	0.0031
Trypanosoma cruzi	cruzipain precursor, putative	0.0302	0.0844	0.0818
Loa Loa (eye worm)	inositol-1	0.0042	0.0097	0.0096
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0411	0.1157	0.3315
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1818	0.5203	0.6395
Onchocerca volvulus	Cathepsin F homolog	0.1155	0.3295	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0411	0.1157	0.1321
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1155	0.3295	0.3986
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1155	0.3295	0.3295
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1517	0.4336	0.432
Entamoeba histolytica	cysteine protease, putative	0.0411	0.1157	0.3315
Plasmodium vivax	unspecified product	0.0411	0.1157	0.3455
Leishmania major	cysteine peptidase A (CPA)	0.1155	0.3295	0.4037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1155	0.3295	0.3986
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1155	0.3295	0.3986
Schistosoma mansoni	cathepsin s	0.0302	0.0844	0.0844
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1155	0.3295	0.3986
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0411	0.1157	0.1321
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1155	0.3295	0.3986
Onchocerca volvulus		0.1155	0.3295	1
Leishmania major	cathepsin L-like protease	0.1155	0.3295	0.4037
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0064	0.0064
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0712	0.2024	0.2402
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0712	0.2024	0.2024
Loa Loa (eye worm)	Smad1	0.0019	0.0031	0.003
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0411	0.1157	0.1157
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0411	0.1157	0.3455
Plasmodium vivax	serine-repeat antigen (SERA)	0.0411	0.1157	0.3455
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0411	0.1157	0.1321
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0411	0.1157	0.1321
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0008	0.0001	0.0001
Onchocerca volvulus	Huntingtin homolog	0.0139	0.0375	0.1135
Brugia malayi	Cathepsin L-like precursor	0.0853	0.2429	0.2428
Echinococcus granulosus	cathepsin l1	0.0853	0.2429	0.2429
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0024	0.0023
Schistosoma mansoni	cathepsin S (C01 family)	0.0411	0.1157	0.1157
Plasmodium falciparum	serine repeat antigen 8	0.0411	0.1157	0.3455
Brugia malayi	MH2 domain containing protein	0.0019	0.0031	0.003
Brugia malayi	Cathepsin L-like precursor	0.1155	0.3295	0.3295
Leishmania major	cathepsin L-like protease	0.1155	0.3295	0.4037
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1155	0.3295	0.3986
Onchocerca volvulus		0.1155	0.3295	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1155	0.3295	0.3295
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1818	0.5203	0.6395
Giardia lamblia	Cathepsin B precursor	0.2833	0.8121	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0139	0.0138
Echinococcus granulosus	intermediate filament protein	0.003	0.0064	0.0064
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0028	0.0028
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3487	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0411	0.1157	0.3455
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1155	0.3295	0.3986
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Brugia malayi	Cathepsin L-like precursor	0.1155	0.3295	0.3295
Trypanosoma cruzi	cysteine proteinase, putative	0.0712	0.2024	0.2001
Loa Loa (eye worm)	hypothetical protein	0.0411	0.1157	0.1156
Brugia malayi	Papain family cysteine protease containing protein	0.0411	0.1157	0.1156
Brugia malayi	Cathepsin L-like precursor	0.0302	0.0844	0.0843
Plasmodium falciparum	serine repeat antigen 4	0.0411	0.1157	0.3455
Brugia malayi	Papain family cysteine protease containing protein	0.0712	0.2024	0.2023
Entamoeba histolytica	cysteine protease, putative	0.0712	0.2024	0.6025
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0018	0.0028	0.0028
Echinococcus granulosus	cathepsin L	0.0712	0.2024	0.2024
Loa Loa (eye worm)	hypothetical protein	0.0853	0.2429	0.2428
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0008	0.0001	0.0001
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0015	0.0019	0.0019
Brugia malayi	MH2 domain containing protein	0.0274	0.0766	0.0765
Entamoeba histolytica	cysteine protease, putative	0.0712	0.2024	0.6025
Brugia malayi	fibroinase precursor	0.0411	0.1157	0.1156
Echinococcus multilocularis	lamin	0.003	0.0064	0.0064
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.2833	0.8121	0.8115
Entamoeba histolytica	cysteine protease, putative	0.0712	0.2024	0.6025
Entamoeba histolytica	cysteine proteinase, putative	0.0712	0.2024	0.6025
Onchocerca volvulus	Cathepsin L homolog	0.0411	0.1157	0.351
Schistosoma mansoni	smad	0.0008	0.0001	0.0001
Onchocerca volvulus		0.0853	0.2429	0.7369
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0411	0.1157	0.1321
Loa Loa (eye worm)	hypothetical protein	0.003	0.0063	0.0062
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1818	0.5203	0.6395
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0097	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0028	0.0027
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0411	0.1157	0.3455
Schistosoma mansoni	cathepsin F (C01 family)	0.1155	0.3295	0.3295
Brugia malayi	Papain family cysteine protease containing protein	0.1155	0.3295	0.3295
Schistosoma mansoni	cathepsin B (C01 family)	0.0411	0.1157	0.1157
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0411	0.1157	0.1321
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0411	0.1157	0.3315
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.0028	0.0027
Brugia malayi	MH1 domain containing protein	0.001	0.0007	0.0006
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0411	0.1157	0.1321
Echinococcus multilocularis	neuropeptide receptor A26	0.1063	0.3032	0.3032
Plasmodium vivax	vivapain-3	0.0712	0.2024	0.6109
Trypanosoma cruzi	cysteine proteinase, putative	0.0712	0.2024	0.2001
Entamoeba histolytica	cysteine protease, putative	0.0712	0.2024	0.6025
Loa Loa (eye worm)	transcription factor SMAD2	0.0274	0.0766	0.0765
Schistosoma mansoni	hypothetical protein	0.0039	0.0088	0.0088
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1155	0.3295	0.3986
Trypanosoma cruzi	major cysteine proteinase, putative	0.1074	0.3065	0.3045
Toxoplasma gondii	cathepsin CPC2	0.0411	0.1157	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0853	0.2429	0.2428
Entamoeba histolytica	cysteine protease, putative	0.0712	0.2024	0.6025
Giardia lamblia	Cathepsin B precursor	0.2833	0.8121	1
Brugia malayi	Smad1	0.0019	0.0031	0.003
Entamoeba histolytica	cysteine protease, putative	0.0411	0.1157	0.3315
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0097	0.0069
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0028	0.0028
Loa Loa (eye worm)	MH1 domain-containing protein	0.0019	0.0031	0.003
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0411	0.1157	0.1157
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0712	0.2024	0.6109
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0411	0.1157	0.1321
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0037	0.0084	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1818	0.5203	0.519
Onchocerca volvulus		0.003	0.0064	0.0193
Brugia malayi	MH1 domain containing protein	0.0019	0.0031	0.003
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0028	0.0027
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0017
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1155	0.3295	0.3986
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1155	0.3295	0.3986
Loa Loa (eye worm)	ctsf protein	0.1155	0.3295	0.3295
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0018	0.0028	0.0028
Brugia malayi	Cathepsin L-like precursor	0.1155	0.3295	0.3295
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.2833	0.8121	1
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0005	0.0004
Plasmodium vivax	unspecified product	0.0302	0.0844	0.2496
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0853	0.2429	0.2906
Trypanosoma cruzi	cysteine peptidase, putative	0.1818	0.5203	0.519
Plasmodium falciparum	serine repeat antigen 5	0.0411	0.1157	0.3455
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0411	0.1157	0.1321
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1155	0.3295	0.3986
Loa Loa (eye worm)	nuclear factor I	0.001	0.0007	0.0006
Schistosoma mansoni	smad	0.0019	0.0031	0.0031
Schistosoma mansoni	Smad4	0.0008	0.0001	0.0001
Brugia malayi	Cathepsin L-like precursor	0.1155	0.3295	0.3295
Echinococcus granulosus	lamin dm0	0.003	0.0064	0.0064
Schistosoma mansoni	smad1 5 8 and	0.0019	0.0031	0.0031
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0712	0.2024	0.2024
Schistosoma mansoni	hypothetical protein	0.0018	0.0028	0.0028
Entamoeba histolytica	cysteine proteinase, putative	0.0712	0.2024	0.6025
Schistosoma mansoni	hypothetical protein	0.0018	0.0028	0.0028
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0028	0.0028
Schistosoma mansoni	hypothetical protein	0.0018	0.0028	0.0028
Brugia malayi	cathepsin L precursor	0.0411	0.1157	0.1156
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1818	0.5203	0.6395
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0088	0.0087
Schistosoma mansoni	lamin	0.003	0.0064	0.0064
Onchocerca volvulus		0.1155	0.3295	1
Entamoeba histolytica	cysteine proteinase, putative	0.0712	0.2024	0.6025
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0018	0.0017
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0064	0.0064
Echinococcus granulosus	lamin	0.003	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.003	0.0064	0.0064
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3487	1	1
Echinococcus multilocularis	smad	0.0019	0.0031	0.0031
Brugia malayi	cathepsin F-like cysteine proteinase	0.0302	0.0844	0.0843
Onchocerca volvulus		0.0411	0.1157	0.351
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0411	0.1157	0.1156
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0006	0.0005
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0139	0.0138
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0844	0.0843
Plasmodium vivax	vivapain-2	0.1155	0.3295	1
Schistosoma mansoni	cpg binding protein	0.0034	0.0075	0.0075
Entamoeba histolytica	cysteine protease, putative	0.0712	0.2024	0.6025
Toxoplasma gondii	cathepsin CPL	0.1155	0.3295	0.4037
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0411	0.1157	0.3455
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1155	0.3295	0.3986
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1155	0.3295	1
Echinococcus granulosus	mothers against decapentaplegic 2	0.0008	0.0001	0.0001
Loa Loa (eye worm)	fibroinase	0.1155	0.3295	0.3295
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.013	0.013
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0028	0.0028
Echinococcus granulosus	Smad4	0.0019	0.0031	0.0031
Brugia malayi	Papain family cysteine protease containing protein	0.0411	0.1157	0.1156
Schistosoma mansoni	Smad4	0.0008	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0411	0.1157	0.1321
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0411	0.1157	0.1395
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0042	0.0097	0.5
Echinococcus multilocularis	cathepsin L	0.0411	0.1157	0.1157
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0411	0.1157	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0375	0.0374
Brugia malayi	MH1 domain containing protein	0.001	0.0007	0.0006
Echinococcus granulosus	smad	0.0019	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0019	0.0018
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0411	0.1157	0.3455
Trypanosoma cruzi	cysteine peptidase, putative	0.1818	0.5203	0.519
Echinococcus multilocularis	musashi	0.003	0.0064	0.0064
Plasmodium falciparum	serine repeat antigen 2	0.0411	0.1157	0.3455
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0028	0.0027
Entamoeba histolytica	cysteine proteinase, putative	0.0853	0.2429	0.729
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1818	0.5203	0.6395
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0042	0.0097	0.0085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0411	0.1157	0.1321
Schistosoma mansoni	smad1 5 8 and	0.0019	0.0031	0.0031
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0028	0.0027
Schistosoma mansoni	lamin	0.003	0.0064	0.0064
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0042	0.0097	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0712	0.2024	0.2001
Brugia malayi	MH2 domain containing protein	0.0019	0.0031	0.003
Leishmania major	cathepsin L-like protease	0.1155	0.3295	0.4037
Trichomonas vaginalis	conserved hypothetical protein	0.0411	0.1157	0.1321
Brugia malayi	cathepsin L-like precursor	0.0853	0.2429	0.2428
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0019	0.0031	0.0031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0411	0.1157	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0411	0.1157	0.1156
Onchocerca volvulus		0.003	0.0064	0.0193
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0018	0.0028	0.0028
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0411	0.1157	0.3455
Brugia malayi	Papain family cysteine protease containing protein	0.0712	0.2024	0.2023
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0411	0.1157	0.3455
Echinococcus granulosus	inositol monophosphatase 1	0.0042	0.0097	0.0097
Echinococcus granulosus	neuropeptide receptor A26	0.1063	0.3032	0.3032
Loa Loa (eye worm)	cysteine protease	0.1155	0.3295	0.3295
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0411	0.1157	0.1156
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2833	0.8121	0.8121
Loa Loa (eye worm)	hypothetical protein	0.001	0.0007	0.0006
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0019	0.0031	0.0031
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0411	0.1157	0.1157
Plasmodium vivax	unspecified product	0.0712	0.2024	0.6109
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.013	0.013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1155	0.3295	0.3986
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1818	0.5203	0.6395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1155	0.3295	0.3986
Schistosoma mansoni	cpg binding protein	0.0034	0.0075	0.0075
Onchocerca volvulus		0.1155	0.3295	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0411	0.1157	0.1157
Leishmania major	cathepsin L-like protease	0.1818	0.5203	0.6395
Entamoeba histolytica	cysteine protease, putative	0.0411	0.1157	0.3315
Toxoplasma gondii	cathepsin CPC1	0.0411	0.1157	0.1395
Entamoeba histolytica	cysteine proteinase 2	0.0712	0.2024	0.6025
Loa Loa (eye worm)	hypothetical protein	0.0411	0.1157	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0844	0.0843
Echinococcus multilocularis	Smad4	0.0019	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0853	0.2429	0.2428
Entamoeba histolytica	cysteine protease, putative	0.0411	0.1157	0.3315
Loa Loa (eye worm)	cathepsin B	0.2833	0.8121	0.812
Giardia lamblia	Cathepsin B precursor	0.2833	0.8121	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0018	0.0028	0.0027
Onchocerca volvulus		0.1155	0.3295	1
Schistosoma mansoni	inositol monophosphatase	0.0042	0.0097	0.0097
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1155	0.3295	0.3986
Leishmania major	cathepsin L-like protease	0.1818	0.5203	0.6395
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0302	0.0844	0.0843
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1155	0.3295	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1818	0.5203	0.6395
Echinococcus multilocularis	neuropeptide s receptor	0.1063	0.3032	0.3032
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0411	0.1157	0.1156
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.013	0.013
Schistosoma mansoni	inositol monophosphatase	0.0042	0.0097	0.0097
Echinococcus granulosus	cathepsin b	0.3487	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0411	0.1157	0.1156
Echinococcus granulosus	cathepsin L cysteine protease	0.0712	0.2024	0.2024
Echinococcus granulosus	cathepsin b	0.3487	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0853	0.2429	0.2429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0088	0.0087
Echinococcus multilocularis	inositol monophosphatase 1	0.0042	0.0097	0.0097
Echinococcus multilocularis	cysteine protease	0.1155	0.3295	0.3295
Entamoeba histolytica	cysteine protease, putative	0.0712	0.2024	0.6025
Loa Loa (eye worm)	hypothetical protein	0.0411	0.1157	0.1156
Entamoeba histolytica	cysteine protease, putative	0.1155	0.3295	1
Loa Loa (eye worm)	hypothetical protein	0.0411	0.1157	0.1156
Schistosoma mansoni	cpg binding protein	0.0032	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0844	0.0843
Echinococcus multilocularis	cathepsin L cysteine protease	0.1155	0.3295	0.3295
Plasmodium vivax	vivapain-2	0.1155	0.3295	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1818	0.5203	0.6395
Echinococcus granulosus	mothers against decapentaplegic 5	0.0019	0.0031	0.0031
Schistosoma mansoni	cathepsin C	0.0411	0.1157	0.1157
Plasmodium vivax	vivapain-1	0.0712	0.2024	0.6109
Brugia malayi	Inositol-1	0.0042	0.0097	0.0096
Entamoeba histolytica	cysteine protease, putative	0.0712	0.2024	0.6025
Echinococcus multilocularis	cathepsin L	0.0712	0.2024	0.2024
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0139	0.0138
Brugia malayi	cathepsin L-like cysteine proteinase	0.0411	0.1157	0.1156
Onchocerca volvulus	Cathepsin L homolog	0.1155	0.3295	1
Loa Loa (eye worm)	hypothetical protein	0.1155	0.3295	0.3295

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 862751