Detailed information for compound 865853

Basic information

Technical information
  • TDR Targets ID: 865853
  • Name: 2-(4-bromophenyl)-N-[4-[(4-methylpyrimidin-2- yl)sulfamoyl]phenyl]quinoline-4-carboxamide
  • MW: 574.448 | Formula: C27H20BrN5O3S
  • H donors: 2 H acceptors: 6 LogP: 4.92 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: Brc1ccc(cc1)c1nc2ccccc2c(c1)C(=O)Nc1ccc(cc1)S(=O)(=O)Nc1nccc(n1)C
  • InChi: 1S/C27H20BrN5O3S/c1-17-14-15-29-27(30-17)33-37(35,36)21-12-10-20(11-13-21)31-26(34)23-16-25(18-6-8-19(28)9-7-18)32-24-5-3-2-4-22(23)24/h2-16H,1H3,(H,31,34)(H,29,30,33)
  • InChiKey: KKXAXNFZGLWQIA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(4-bromophenyl)-N-[4-[(4-methyl-2-pyrimidinyl)sulfamoyl]phenyl]-4-quinolinecarboxamide
  • 2-(4-bromophenyl)-N-[4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl]cinchoninamide
  • ZINC01217977
  • IVK/8088791
  • 2-(4-bromophenyl)-N-(4-{[(4-methyl-2-pyrimidinyl)amino]sulfonyl}phenyl)-4-quinolinecarboxamide
  • EU-0039894
  • CBMicro_032717
  • BIM-0032829.P001
  • MLS000572245
  • SMR000194206

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Staphylococcus aureus (strain N315) Probable nicotinate-nucleotide adenylyltransferase Starlite/ChEMBL No references
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei nicotinamide/nicotinic acid mononucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva hypothetical protein, conserved Get druggable targets OG5_131883 All targets in OG5_131883
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi nicotinamide/nicotinic acid mononucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum hypothetical protein Get druggable targets OG5_131883 All targets in OG5_131883
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Babesia bovis cytidylyltransferase family protein Get druggable targets OG5_131883 All targets in OG5_131883
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii Predicted nucleotidyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic Get druggable targets OG5_131883 All targets in OG5_131883
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC Get druggable targets OG5_131883 All targets in OG5_131883
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi hypothetical protein, conserved Probable nicotinate-nucleotide adenylyltransferase   189 aa 200 aa 20.5 %
Entamoeba histolytica nicotinamide nucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 204 aa 24.5 %
Giardia lamblia Nicotinamide-nucleotide adenylyltransferase Probable nicotinate-nucleotide adenylyltransferase   189 aa 247 aa 20.6 %
Giardia lamblia Nicotinamide-nucleotide adenylyltransferase Probable nicotinate-nucleotide adenylyltransferase   189 aa 153 aa 24.2 %
Trichomonas vaginalis nicotinamide mononucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 205 aa 19.0 %
Entamoeba histolytica NMN adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 204 aa 24.5 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trichomonas vaginalis nicotinamide mononucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 210 aa 23.8 %
Plasmodium knowlesi cytoskeleton associated protein, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 170 aa 23.5 %
Trypanosoma brucei variant surface glycoprotein (VSG, atypical), putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 171 aa 20.5 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma cruzi hypothetical protein, conserved Probable nicotinate-nucleotide adenylyltransferase   189 aa 200 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0241 0.0236
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0345 0.4429 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0241 0.0533
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0006 0.0021 0.0038
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0322 0.6518
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0396 0.0392
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0193 0.0188
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0728 0.0724
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0241 0.0236
Loa Loa (eye worm) hypothetical protein 0.0016 0.015 0.0145
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0243 0.0374
Schistosoma mansoni hypothetical protein 0.0205 0.2608 0.4088
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0158 0.1996 0.1992
Schistosoma mansoni lamin 0.0033 0.0369 0.0572
Schistosoma mansoni cpg binding protein 0.0037 0.0422 0.0655
Entamoeba histolytica recQ family helicase, putative 0.0006 0.0021 0.0341
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0025 0.0402
Loa Loa (eye worm) hypothetical protein 0.0012 0.0101 0.0096
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0005 0.0005 0.0097
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0193 0.0188
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0101 0.1208
Loa Loa (eye worm) hypothetical protein 0.0006 0.0025 0.002
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0172 0.0167
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0188
Entamoeba histolytica hypothetical protein 0.0042 0.0495 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0101 0.0096
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0085 0.008
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0101 0.0096
Loa Loa (eye worm) hypothetical protein 0.0146 0.1844 0.184
Trichomonas vaginalis helicase, putative 0.0008 0.0047 0.0958
Loa Loa (eye worm) hypothetical protein 0.0032 0.0361 0.0357
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0481 0.0476
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0277 0.0614
Schistosoma mansoni blooms syndrome DNA helicase 0.0006 0.0025 0.0031
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0193 0.0188
Echinococcus multilocularis GPCR, family 2 0.0019 0.0193 0.0188
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0057 0.0052
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0345 0.4429 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0147 0.2897
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0241 0.4816
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0147 0.2966
Schistosoma mansoni hypothetical protein 0.0205 0.2608 0.4088
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0025 0.0402
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0005 0.0005 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0495 1
Toxoplasma gondii exonuclease III APE 0.0023 0.0241 0.2966
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0047 0.0958
Loa Loa (eye worm) RecQ helicase 0.0029 0.0322 0.0318
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0193 0.0188
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0101 0.0217
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.02 0.0442
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0085 0.008
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0728 0.0724
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0322 0.0318
Echinococcus multilocularis cpg binding protein 0.0037 0.0422 0.0418
Onchocerca volvulus 0.0033 0.0369 0.1829
Echinococcus multilocularis transcription factor btf3 0.0042 0.0495 0.049
Schistosoma mansoni ap endonuclease 0.0023 0.0241 0.037
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0345 0.4429 1
Brugia malayi Muscleblind-like protein 0.018 0.2292 0.2289
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0241 0.4866
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0025 0.0402
Schistosoma mansoni hypothetical protein 0.0041 0.0481 0.0747
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0101 0.1208
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0241 0.4866
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0047 0.0958
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0083 0.0078
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0322 0.0318
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0241 0.4816
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0495 1
Schistosoma mansoni lamin 0.0033 0.0369 0.0572
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0005 0.0005 0.0097
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0101 0.0096
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0101 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0137
Echinococcus granulosus intermediate filament protein 0.0033 0.0369 0.0364
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0369 0.0364
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0241 0.4816
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0101 0.4072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.001 0.0008
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0241 0.0533
Leishmania major basic transcription factor 3a, putative 0.0042 0.0495 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0047 0.0958
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0047 0.0958
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0495 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0197 0.2419
Schistosoma mansoni DNA helicase recq5 0.0012 0.0101 0.0151
Echinococcus multilocularis geminin 0.0205 0.2608 0.2604
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.08 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0047 0.0958
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0005 0.0005 0.0097
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0193 0.0188
Echinococcus granulosus cpg binding protein 0.0037 0.0422 0.0418
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0101 0.0096
Brugia malayi intermediate filament protein 0.0033 0.0369 0.0364
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0047 0.0958
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0193 0.0188
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0241 0.0236
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0495 0.049
Schistosoma mansoni hypothetical protein 0.0019 0.0193 0.0296
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0047 0.0958
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0369 0.0364
Schistosoma mansoni intermediate filament proteins 0.0033 0.0369 0.0572
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0147 0.2897
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0495 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0369 0.0364
Trichomonas vaginalis Phospholipase C precursor, putative 0.0005 0.0005 0.0097
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0005 0.0005 0.0097
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0241 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0193 0.0188
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0322 0.6518
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0047 0.0958
Loa Loa (eye worm) hypothetical protein 0.006 0.0728 0.0724
Schistosoma mansoni hypothetical protein 0.0019 0.0193 0.0296
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0057 0.0052
Echinococcus granulosus survival motor neuron protein 1 0.0773 1 1
Schistosoma mansoni cpg binding protein 0.0035 0.0396 0.0615
Loa Loa (eye worm) hypothetical protein 0.018 0.2292 0.2289
Schistosoma mansoni transcription factor btf3 0.0042 0.0495 0.0769
Echinococcus multilocularis muscleblind protein 0.018 0.2292 0.2289
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0101 0.0096
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0495 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0369 0.0364
Echinococcus multilocularis lamin 0.0033 0.0369 0.0364
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0495 0.1107
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0047 0.0958
Echinococcus granulosus muscleblind protein 0.018 0.2292 0.2289
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0085 0.008
Brugia malayi beta-NAC-like protein 0.0042 0.0495 0.049
Schistosoma mansoni hypothetical protein 0.0158 0.1996 0.3127
Echinococcus granulosus lamin 0.0033 0.0369 0.0364
Echinococcus multilocularis lamin dm0 0.0033 0.0369 0.0364
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0172 0.0167
Schistosoma mansoni cpg binding protein 0.0037 0.0422 0.0655
Brugia malayi CXXC zinc finger family protein 0.0035 0.0396 0.0392
Echinococcus multilocularis musashi 0.0033 0.0369 0.0364
Schistosoma mansoni hypothetical protein 0.0494 0.6372 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0147 0.2897
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.015 0.0145
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0101 0.0096
Treponema pallidum ATP-dependent DNA helicase 0.0006 0.0025 0.0045
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0057 0.0052
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0025 0.0248
Echinococcus granulosus GPCR family 2 0.0019 0.0193 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0047 0.0958
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.015 0.0145
Onchocerca volvulus 0.0158 0.1996 1
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0005 0.0005 0.0097
Loa Loa (eye worm) hypothetical protein 0.0041 0.0481 0.0476
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0047 0.0958
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0047 0.0958
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0005 0.0005 0.0097
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0241 0.0236
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0902 0.141
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0345 0.4429 1
Schistosoma mansoni DNA helicase recq1 0.0012 0.0101 0.0151
Echinococcus multilocularis muscleblind protein 1 0.018 0.2292 0.2289
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0047 0.0958
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0057 0.0052
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0241 0.4816
Loa Loa (eye worm) hypothetical protein 0.018 0.2292 0.2289
Echinococcus granulosus bloom syndrome protein 0.0029 0.0322 0.0318
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0495 0.6158
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0147 0.2897
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0728 0.0724
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0047 0.0958
Schistosoma mansoni ap endonuclease 0.0023 0.0241 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0047 0.0958
Onchocerca volvulus 0.0035 0.0396 0.1967
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0495 1
Echinococcus multilocularis survival motor neuron protein 1 0.0773 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0241 1
Schistosoma mansoni survival motor neuron protein 0.0158 0.1996 0.3127
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0495 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0241 0.0533
Echinococcus granulosus dnaJ subfamily B 0.0494 0.6372 0.6371
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0495 0.1107
Echinococcus granulosus transcription factor btf3 0.0042 0.0495 0.049
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0241 0.0533
Onchocerca volvulus 0.0033 0.0369 0.1829
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0005 0.0005 0.0097
Treponema pallidum hypothetical protein 0.0345 0.4429 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0241 0.4816
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0137
Schistosoma mansoni hypothetical protein 0.0019 0.0193 0.0296
Echinococcus granulosus geminin 0.0205 0.2608 0.2604
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0047 0.0958
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0047 0.0958
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.6372 0.6371
Echinococcus granulosus lamin dm0 0.0033 0.0369 0.0364
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0345 0.4429 0.5
Loa Loa (eye worm) hypothetical protein 0.0773 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0057 0.0082
Schistosoma mansoni hypothetical protein 0.0019 0.0193 0.0296

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 3.343 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 5.836 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
IC50 (functional) 7.03 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 20.9 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay - Set 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.005 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 47.7548 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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