Detailed information for compound 871577

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 221.319 | Formula: C12H15NOS
  • H donors: 1 H acceptors: 1 LogP: 2.47 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(c1ccc(cc1)O)N1CCCCC1
  • InChi: 1S/C12H15NOS/c14-11-6-4-10(5-7-11)12(15)13-8-2-1-3-9-13/h4-7,14H,1-3,8-9H2
  • InChiKey: AXYKPBYGQHHZIY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0143 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0539 0.1697
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0142 0.024
Plasmodium vivax sphingomyelin synthase 1, putative 0.0024 0.0139 0.1734
Echinococcus granulosus histone deacetylase 1 0.0072 0.0723 0.0712
Echinococcus granulosus voltage gated potassium channel 0.0017 0.0058 0.0046
Leishmania major hypothetical protein, conserved 0.0078 0.0803 0.6421
Loa Loa (eye worm) RecQ helicase 0.0024 0.0143 0.0246
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0018 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0142 0.101
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0282 0.0887
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0021
Echinococcus multilocularis smad 0.0017 0.0061 0.005
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0143 0.1017
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0142 0.0243
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0282 0.0887
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0142 0.0243
Schistosoma mansoni alpha-glucosidase 0.0142 0.1586 0.1586
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0142 0.024
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.0701 0.253
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0965 0.0954
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0239
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0024 0.0139 0.0992
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0323 0.1002
Brugia malayi Inositol-1 0.0078 0.08 0.1473
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0239
Schistosoma mansoni Smad4 0.0017 0.0061 0.0061
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0282 0.0506
Loa Loa (eye worm) inositol-1 0.0078 0.08 0.1473
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0299 0.2295
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0142 0.101
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Trichomonas vaginalis glutaminase, putative 0.0269 0.3122 1
Plasmodium falciparum histone deacetylase, putative 0.0068 0.0678 0.8301
Echinococcus multilocularis histone deacetylase 6 0.0068 0.0678 0.0668
Brugia malayi MH2 domain containing protein 0.0253 0.293 0.5451
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0339 0.0339
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0282 0.2516
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0282 0.0871
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0012
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1241 1
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0463 0.0463
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0463 0.0463
Trichomonas vaginalis histone deacetylase, putative 0.0072 0.0723 0.2287
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1241 0.3952
Mycobacterium ulcerans lipase LipD 0.0035 0.0282 0.0701
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0416 0.0405
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0142 0.024
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0299 0.2295
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0965 0.0965
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0139 0.0411
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0011 0.0011
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1241 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1241 0.3952
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0477 0.087
Schistosoma mansoni inositol monophosphatase 0.0078 0.08 0.08
Entamoeba histolytica hypothetical protein 0.0024 0.0139 0.1122
Brugia malayi MH2 domain containing protein 0.0017 0.0061 0.0093
Brugia malayi MH1 domain containing protein 0.0017 0.0061 0.0093
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0139 0.0992
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0282 0.0701
Toxoplasma gondii histone deacetylase HDAC5 0.002 0.01 0.1245
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2604 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0011 0.0011
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0282 0.0506
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.08 0.6398
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.0087
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0058 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0106
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0282 0.0871
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0477 0.087
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0282 0.3514
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1241 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0061 0.0061
Loa Loa (eye worm) histone deacetylase 0.0068 0.0678 0.1245
Echinococcus multilocularis histone deacetylase 1 0.0072 0.0723 0.0712
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0072 0.0723 0.2287
Leishmania major histone deacetylase, putative 0.0072 0.0723 0.5764
Plasmodium falciparum histone deacetylase 1 0.0072 0.0723 0.8906
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0299 0.0923
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0282 0.0887
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0011 0.0011
Plasmodium falciparum histone deacetylase 2 0.0068 0.0678 0.8301
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0282 0.0871
Trypanosoma cruzi histone deacetylase, putative 0.0068 0.0678 0.54
Toxoplasma gondii histone deacetylase HDAC1 0.0068 0.0678 0.8445
Plasmodium vivax histone deacetylase, putative 0.0068 0.0678 0.8445
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0143 0.1017
Brugia malayi histone deacetylase 1 (HD1) 0.0072 0.0723 0.1328
Schistosoma mansoni DNA helicase recq5 0.0024 0.0143 0.0143
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0299 0.0923
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0803 0.6421
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0236 0.042
Echinococcus granulosus histone deacetylase 3 0.0072 0.0723 0.0712
Entamoeba histolytica hypothetical protein 0.0024 0.0139 0.1122
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1241 0.3952
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0046 0.0416 0.0756
Plasmodium vivax sphingomyelin synthase 2, putative 0.0024 0.0139 0.1734
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0139 0.0411
Brugia malayi Histone deacetylase family protein 0.0068 0.0678 0.1245
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.1985 0.6346
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0243
Loa Loa (eye worm) glutaminase 0.0269 0.3122 0.5809
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0049
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0339 0.0328
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0578 0.0567
Trichomonas vaginalis inositol monophosphatase, putative 0.0078 0.08 0.2536
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0143 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0539 0.1697
Loa Loa (eye worm) hypothetical protein 0.0024 0.0143 0.0246
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0061 0.005
Trypanosoma brucei glucosidase, putative 0.0037 0.0299 0.2295
Trypanosoma cruzi histone deacetylase, putative 0.002 0.01 0.0671
Loa Loa (eye worm) hypothetical protein 0.0035 0.0279 0.05
Schistosoma mansoni spingomyelin synthetase-related 0.0024 0.0139 0.0139
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0299 0.0288
Loa Loa (eye worm) transcription factor SMAD2 0.0253 0.293 0.5451
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0142 0.024
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1867 0.1858
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0061 0.005
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.08 0.2536
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1241 0.3952
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0578 0.0578
Trypanosoma cruzi histone deacetylase 1, putative 0.0072 0.0723 0.5764
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0578 0.458
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0578 0.1669
Onchocerca volvulus 0.0024 0.0142 0.101
Schistosoma mansoni hypothetical protein 0.0035 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0106
Trypanosoma brucei histone deacetylase 4 0.0068 0.0678 0.54
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0299 0.0288
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0024 0.0139 0.0967
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0049 0.0071
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0279 0.05
Brugia malayi MH2 domain containing protein 0.0017 0.0061 0.0093
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0477 0.087
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0061 0.005
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0011 0.0011
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0058 0.0058
Entamoeba histolytica hypothetical protein 0.004 0.0339 0.2734
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1867 0.1858
Echinococcus multilocularis geminin 0.0175 0.1978 0.1969
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0299 0.0536
Schistosoma mansoni kinase 0.0058 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0506
Brugia malayi hypothetical protein 0.004 0.0339 0.0612
Echinococcus granulosus inositol monophosphatase 1 0.0078 0.08 0.079
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0965 0.178
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0243
Loa Loa (eye worm) hypothetical protein 0.0453 0.5366 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0299 0.2407
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0024 0.0139 0.0239
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0299 0.0923
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0017 0.0058 0.0087
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0339 0.0328
Trichomonas vaginalis histone deacetylase, putative 0.0072 0.0723 0.2287
Entamoeba histolytica hypothetical protein 0.0024 0.0139 0.1122
Loa Loa (eye worm) MH2 domain-containing protein 0.0253 0.293 0.5451
Trypanosoma cruzi histone deacetylase, putative 0.0068 0.0678 0.54
Echinococcus granulosus sphingomyelin synthase protein 1 0.0024 0.0139 0.0128
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1241 0.2296
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0416 0.0405
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1241 0.3952
Schistosoma mansoni alpha glucosidase 0.0037 0.0299 0.0299
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0142 0.024
Onchocerca volvulus 0.0035 0.0282 0.2161
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0323 0.1002
Toxoplasma gondii histone deacetylase HDAC3 0.0072 0.0723 0.8999
Brugia malayi Histone deacetylase 1 0.0072 0.0723 0.1328
Loa Loa (eye worm) hypothetical protein 0.0016 0.0049 0.0071
Schistosoma mansoni histone deacetylase 1 2 3 0.002 0.01 0.01
Leishmania major hypothetical protein, conserved 0.0035 0.0282 0.2161
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0282 0.0887
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1241 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0282 0.0506
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0018 0.0021
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0049
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0139 0.0992
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0143 0.1779
Schistosoma mansoni histone deacetylase 4 5 0.0068 0.0678 0.0678
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0018 0.0021
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0058 0.0046
Schistosoma mansoni hypothetical protein 0.004 0.0339 0.0339
Onchocerca volvulus 0.0035 0.0282 0.2161
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0282 0.0271
Trypanosoma cruzi histone deacetylase 1, putative 0.0072 0.0723 0.5764
Trichomonas vaginalis histone deacetylase, putative 0.0072 0.0723 0.2287
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0078 0.08 0.9965
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0011 0.0011
Echinococcus granulosus smad 0.0017 0.0061 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1241 0.3952
Giardia lamblia Histone deacetylase 0.0072 0.0723 0.5282
Loa Loa (eye worm) hypothetical protein 0.0047 0.043 0.0781
Brugia malayi histone deacetylase 11 0.002 0.01 0.0165
Brugia malayi beta-lactamase family protein 0.0035 0.0282 0.0506
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0282 0.2161
Echinococcus multilocularis Smad4 0.0017 0.0061 0.005
Brugia malayi Histone deacetylase family protein 0.0068 0.0678 0.1245
Loa Loa (eye worm) hypothetical protein 0.0183 0.2079 0.3861
Loa Loa (eye worm) hypothetical protein 0.0047 0.043 0.0781
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1241 0.1241
Echinococcus granulosus Smad4 0.0017 0.0061 0.005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0965 0.178
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0046 0.0416 0.0756
Entamoeba histolytica hypothetical membrane-spanning protein 0.0024 0.0139 0.1122
Loa Loa (eye worm) hypothetical protein 0.0051 0.0477 0.087
Schistosoma mansoni histone deacetylase 4 5 0.0068 0.0678 0.0678
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0282 0.0282
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0282 0.0871
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0803 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0106
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0024 0.0139 0.0239
Mycobacterium ulcerans hypothetical protein 0.0035 0.0282 0.0701
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0506
Onchocerca volvulus 0.0096 0.1017 0.8172
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0803 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0965 0.0954
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0183 0.2079 0.3861
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0453 0.5366 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0506
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0049
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0058 0.0058
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0299 0.0923
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.08 0.6398
Trypanosoma brucei histone deacetylase 1 0.0072 0.0723 0.5764
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1241 0.2296
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0282 0.0887
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0282 0.2161
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0143 0.1152
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0143 0.0246
Echinococcus granulosus GPCR family 2 0.0016 0.0049 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0142 0.0243
Trypanosoma brucei histone deacetylase, putative 0.0068 0.0678 0.54
Mycobacterium ulcerans glutaminase 0.0269 0.3122 1
Schistosoma mansoni hypothetical protein 0.0175 0.1978 0.1978
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0018 0.0145
Trypanosoma brucei histone deacetylase 2 0.002 0.01 0.0671
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0068 0.0046
Loa Loa (eye worm) Smad1 0.0017 0.0061 0.0093
Brugia malayi Smad1 0.0017 0.0061 0.0093
Brugia malayi Sphingomyelin synthase-related 1 0.0024 0.0139 0.0239
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0143 0.0132
Trichomonas vaginalis esterase, putative 0.0035 0.0282 0.0871
Schistosoma mansoni smad1 5 8 and 0.0017 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0078 0.0803 0.1479
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0282 0.0871
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0139 0.0411
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0965 0.0954
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0106
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0142 0.024
Mycobacterium leprae Probable lipase LipE 0.0035 0.0282 0.2516
Echinococcus multilocularis GPCR, family 2 0.0016 0.0049 0.0038
Loa Loa (eye worm) hypothetical protein 0.0041 0.035 0.0632
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1867 0.1858
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0282 0.0271
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0143 0.0132
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0078 0.08 0.6451
Plasmodium vivax histone deacetylase 1, putative 0.0072 0.0723 0.8999
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0049 0.0038
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0139 0.0239
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1241 0.3952
Schistosoma mansoni smad 0.0017 0.0061 0.0061
Entamoeba histolytica histone deacetylase, putative 0.0072 0.0723 0.5826
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0506
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0106
Schistosoma mansoni alpha-glucosidase 0.0142 0.1586 0.1586
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0299 0.0923
Schistosoma mansoni histone deacetylase 0.0072 0.0723 0.0723
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0578 0.7196
Echinococcus granulosus histone deacetylase 7 0.0068 0.0678 0.0668
Loa Loa (eye worm) histone deacetylase 7A 0.0068 0.0678 0.1245
Brugia malayi hypothetical protein 0.005 0.0466 0.0849
Mycobacterium ulcerans beta-lactamase 0.0035 0.0282 0.0701
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0282 0.0887
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0061 0.005
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0803 1
Echinococcus multilocularis inositol monophosphatase 1 0.0078 0.08 0.079
Entamoeba histolytica hypothetical protein 0.004 0.0339 0.2734
Brugia malayi beta-lactamase family protein 0.0035 0.0282 0.0506
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0021
Schistosoma mansoni histone deacetylase 0.0072 0.0723 0.0723
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0072 0.0723 0.2287
Toxoplasma gondii histone deacetylase HDAC4 0.002 0.01 0.1245
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0578 0.1669
Echinococcus granulosus histone deacetylase 6 0.0068 0.0678 0.0668
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0142 0.101
Schistosoma mansoni hypothetical protein 0.0175 0.1978 0.1978
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0139 0.0239
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0139 0.0992
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0282 0.0701
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0299 0.0536
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0143 0.0246
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.0701 1
Trypanosoma brucei polo-like protein kinase 0.0114 0.1241 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0578 0.0567
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0299 0.2295
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0143 0.0246
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0143 0.1022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0143 0.1779
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0021
Echinococcus granulosus histone deacetylase 8 0.002 0.01 0.0089
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0061 0.0093
Brugia malayi glutaminase DH11.1 0.0269 0.3122 0.5809
Trichomonas vaginalis hypothetical protein 0.0024 0.0139 0.0411
Mycobacterium tuberculosis Conserved protein 0.0035 0.0282 0.0887
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0299 0.0923
Toxoplasma gondii ABC1 family protein 0.0035 0.0282 0.3514
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.0165
Brugia malayi histone deacetylase 3 (HD3) 0.0072 0.0723 0.1328
Entamoeba histolytica hypothetical protein 0.004 0.0339 0.2734
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0078 0.08 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0299 0.0923
Toxoplasma gondii hypothetical protein 0.0024 0.0139 0.1734
Echinococcus granulosus bloom syndrome protein 0.0024 0.0143 0.0132
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0139 0.0992
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0299 0.3719
Echinococcus multilocularis histone deacetylase 6 0.0068 0.0678 0.0668
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0239
Schistosoma mansoni hypothetical protein 0.0035 0.0279 0.0279
Loa Loa (eye worm) histone deacetylase 11 0.002 0.01 0.0165
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0578 0.2048
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0282 0.0282
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0061 0.0093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0239
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0024 0.0139 0.0128
Plasmodium vivax histone deacetylase 2, putative 0.0068 0.0678 0.8445
Mycobacterium ulcerans hypothetical protein 0.0024 0.0142 0.024
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0049 0.0038
Mycobacterium tuberculosis Conserved protein 0.0035 0.0282 0.0887
Schistosoma mansoni histone deacetylase hda2 0.002 0.01 0.01
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0142 0.0334
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0278 0.0267
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.08 0.2536
Loa Loa (eye worm) glutaminase 2 0.0269 0.3122 0.5809
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0578 0.0578
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0049 0.0071
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0803 0.6421
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0282 0.0887
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0965 0.0954
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0049 0.0071
Echinococcus granulosus histone deacetylase 6 0.0068 0.0678 0.0668
Echinococcus granulosus histone deacetylase 6 0.0068 0.0678 0.0668
Schistosoma mansoni glutaminase 0.0269 0.3122 0.3122
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0139 0.0411
Entamoeba histolytica hypothetical protein 0.0024 0.0139 0.1122
Onchocerca volvulus Histone deacetylase 10 homolog 0.002 0.01 0.0671
Leishmania major histone deacetylase, putative 0.0072 0.0723 0.5764
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0243
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0068 0.0849
Brugia malayi MH1 domain containing protein 0.0017 0.0061 0.0093
Trichomonas vaginalis histone deacetylase, putative 0.0072 0.0723 0.2287
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0143 0.1022
Trichomonas vaginalis histone deacetylase, putative 0.0072 0.0723 0.2287
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1241 0.1231
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0049 0.0038
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0299 0.0923
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.08 0.6398
Loa Loa (eye worm) histone deacetylase 1 0.0072 0.0723 0.1328
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0506
Loa Loa (eye worm) hypothetical protein 0.0072 0.0723 0.1328
Echinococcus multilocularis histone deacetylase 3 0.0072 0.0723 0.0712
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0142 0.1141
Loa Loa (eye worm) histone deacetylase 3 0.0072 0.0723 0.1328
Brugia malayi hypothetical protein 0.0078 0.0803 0.1479
Entamoeba histolytica hypothetical protein 0.004 0.0339 0.2734
Leishmania major histone deacetylase, putative 0.0068 0.0678 0.54
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0299 0.0923
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0142 0.1141
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0143 0.0246
Giardia lamblia Kinase, PLK 0.0114 0.1241 1
Trypanosoma cruzi histone deacetylase, putative 0.0068 0.0678 0.54
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0078 0.08 0.2397
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0011 0.0011
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0072 0.0723 0.2287
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0024 0.0139 0.0967
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0965 0.0965
Schistosoma mansoni DNA helicase recq1 0.0024 0.0143 0.0143
Trypanosoma cruzi histone deacetylase, putative 0.002 0.01 0.0671
Brugia malayi Cytochrome P450 family protein 0.0032 0.0236 0.042
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0024 0.0139 0.0967
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.08 0.6398
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0142 0.024
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0299 0.2407
Onchocerca volvulus 0.0035 0.0282 0.2161
Toxoplasma gondii histone deacetylase HDAC2 0.0072 0.0723 0.8999
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0239
Echinococcus granulosus histone deacetylase 0.0068 0.0678 0.0668
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0018 0.0021
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0803 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0282 0.0887
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0139 0.0992
Echinococcus multilocularis histone deacetylase 7 0.0068 0.0678 0.0668
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0965 0.0965
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0803 0.6421
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1241 0.1231
Trypanosoma brucei inositol phosphorylceramide synthase 0.0024 0.0139 0.0992
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0139 0.0411
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0506
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1241 1
Leishmania major histone deacetylase, putative 0.0068 0.0678 0.54
Trypanosoma brucei histone deacetylase 3 0.0068 0.0678 0.54
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0049 0.0038
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0143 0.0132
Echinococcus multilocularis histone deacetylase 0.0068 0.0678 0.0668
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0143 0.0423
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0142 0.1141
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0143 0.1022
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0282 0.2161
Echinococcus multilocularis histone deacetylase 6 0.0068 0.0678 0.0668
Echinococcus granulosus geminin 0.0175 0.1978 0.1969
Plasmodium vivax histone deacetylase, putative 0.002 0.01 0.1245
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0278 0.0267
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0068 0.5
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1867 0.3465
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0142 0.0334
Entamoeba histolytica hypothetical protein 0.0024 0.0139 0.1122
Schistosoma mansoni inositol monophosphatase 0.0078 0.08 0.08
Echinococcus multilocularis histone deacetylase 8 0.002 0.01 0.0089
Trichomonas vaginalis histone deacetylase, putative 0.0072 0.0723 0.2287
Brugia malayi beta-lactamase 0.0035 0.0282 0.0506
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0578 0.1669
Schistosoma mansoni histone deacetylase hda2 0.0068 0.0678 0.0678
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0143 0.0423
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1867 0.3465
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0143 0.0423
Schistosoma mansoni smad1 5 8 and 0.0017 0.0061 0.0061
Echinococcus multilocularis voltage gated potassium channel 0.0017 0.0058 0.0046

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 1.0418 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: Confirmation Assay for Identification of Novel General Anesthetics. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2323, AID2385, AID485281] ChEMBL. No reference
Potency (functional) 18.8876 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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