TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 265.335 | Formula: C11H15N5OS
H donors: 1 H acceptors: 4 LogP: 2.25 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1CCCCC1)Nc1sc2n(n1)c(nn2)C
InChi: 1S/C11H15N5OS/c1-7-13-14-11-16(7)15-10(18-11)12-9(17)8-5-3-2-4-6-8/h8H,2-6H2,1H3,(H,12,15,17)
InChiKey: GDYBMVNBXGXUCT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	vivapain-2	0.0017	0.0119	0.2259
Loa Loa (eye worm)	hypothetical protein	0.001	0.0022	0.0037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.081	0.1511
Giardia lamblia	Rrm3p helicase	0.0057	0.07	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0119	0.0222
Schistosoma mansoni	rab6-interacting	0.0019	0.0158	0.0158
Trichomonas vaginalis	DNA helicase recq1, putative	0.002	0.0171	0.032
Echinococcus granulosus	RUN	0.0019	0.0158	0.0158
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0158	0.2996
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0119	0.0222
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.001	0.0025	0.0047
Brugia malayi	steroid hormone receptor	0.001	0.0022	0.0041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0119	0.0222
Trichomonas vaginalis	hypothetical protein	0.0045	0.0527	0.0984
Echinococcus granulosus	cathepsin l1	0.0011	0.0038	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0527	0.0984
Echinococcus multilocularis	eukaryotic translation initiation factor 4E	0.0376	0.5359	0.5359
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0022	0.0022
Onchocerca volvulus		0.0017	0.0119	0.1923
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0119	0.0222
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0022	0.0022
Leishmania major	cathepsin L-like protease	0.0017	0.0119	0.0123
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0119	0.0222
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0022	0.0041
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0022	0.0037
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-3	0.0045	0.0527	0.0984
Echinococcus granulosus	lamin	0.0027	0.0269	0.0269
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0045	0.0527	0.0984
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.081	0.1511
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.0054	0.0097
Schistosoma mansoni	eukaryotic translation initiation factor 4e	0.0376	0.5359	0.5359
Echinococcus granulosus	lamin dm0	0.0027	0.0269	0.0269
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0158	0.0291
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0119	0.0222
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0171	0.3248
Entamoeba histolytica	hypothetical protein	0.0045	0.0527	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0038	0.0067
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0045	0.0527	0.0984
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0376	0.5359	1
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0057	0.07	0.1307
Leishmania major	eukaryotic translation initiation factor-like protein	0.0376	0.5359	1
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0038	0.0071
Mycobacterium ulcerans	thymidine phosphorylase	0.0636	0.9153	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0119	0.0222
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-4	0.0045	0.0527	0.0984
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0045	0.0527	0.0984
Leishmania major	hypothetical protein, conserved	0.0045	0.0527	0.0893
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0.0038	0.0038
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0171	0.032
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0045	0.0527	0.0984
Onchocerca volvulus		0.0017	0.0119	0.1923
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0158	0.0158
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0022	0.0022
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0119	0.0219
Echinococcus granulosus	eukaryotic translation initiation factor 4E	0.0376	0.5359	0.5359
Plasmodium falciparum	eukaryotic translation initiation factor 4E	0.0045	0.0527	1
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0119	0.1923
Entamoeba histolytica	recQ family helicase, putative	0.001	0.0019	0.0036
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0045	0.0527	0.0984
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0022	0.0022
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0158	0.0158
Onchocerca volvulus		0.0017	0.0119	0.1923
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0022	0.0022
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0022	0.0022
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-3	0.0045	0.0527	0.0984
Onchocerca volvulus		0.0017	0.0119	0.1923
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0609	0.1137
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0022	0.0022
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0022	0.0037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0119	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0269	0.0499
Leishmania major	cathepsin L-like protease	0.0017	0.0119	0.0123
Loa Loa (eye worm)	translation initiation factor 4E	0.0376	0.5359	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0119	0.0222
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0022	0.0022
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0119	0.0119
Schistosoma mansoni	DNA helicase recq1	0.002	0.0171	0.0171
Toxoplasma gondii	hypothetical protein	0.0045	0.0527	0.0951
Entamoeba histolytica	eukaryotic initiation factor 4E, putative	0.0045	0.0527	0.0984
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-1	0.0376	0.5359	1
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0054	0.0101
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0022	0.0041
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.081	0.1511
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0022	0.0041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0119	0.0222
Leishmania major	eukaryotic translation initiation factor eIF-4E, putative	0.0376	0.5359	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0022	0.0041
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0119	0.0219
Leishmania major	hypothetical protein, conserved	0.0045	0.0527	0.0893
Schistosoma mansoni	lipoxygenase	0.0019	0.0158	0.0158
Brugia malayi	Bloom's syndrome protein homolog	0.002	0.0171	0.032
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0038	0.0067
Leishmania major	eukaryotic translation initiation factor, putative	0.0045	0.0527	0.0893
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0064	0.0064
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0022	0.0041
Treponema pallidum	ATP-dependent DNA helicase	0.001	0.0025	0.5
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0045	0.0527	0.0984
Plasmodium vivax	translation initiation factor 4E, putative	0.0045	0.0527	1
Echinococcus granulosus	eukaryotic translation initiation factor 4E type	0.0045	0.0527	0.0527
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0019	0.0019
Entamoeba histolytica	translation initiation factor 4e, putative	0.0045	0.0527	0.0984
Loa Loa (eye worm)	hypothetical protein	0.001	0.0022	0.0037
Echinococcus multilocularis	microtubule associated protein 2	0.0694	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0022	0.0022
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0171	0.032
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0022	0.0022
Loa Loa (eye worm)	eukaryotic translation initiation factor 4E type 3	0.0045	0.0527	0.0981
Leishmania major	eukaryotic translation initiation factor-like	0.0376	0.5359	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.0119	0.2259
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0119	0.0222
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0158	0.0158
Leishmania major	eukaryotic translation initiation factor 4e, putative	0.0045	0.0527	0.0893
Echinococcus multilocularis	lamin dm0	0.0027	0.0269	0.0269
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.001	0.0025	0.0047
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0376	0.5359	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0119	0.0222
Trypanosoma cruzi	eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative	0.0045	0.0527	0.0984
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0045	0.0527	0.0984
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0022	0.0041
Loa Loa (eye worm)	hypothetical protein	0.001	0.0025	0.0043
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.081	0.1511
Plasmodium vivax	ATP-dependent DNA helicase Q1, putative	0.001	0.0019	0.0369
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0022	0.0022
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0119	0.0119
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0022	0.0037
Loa Loa (eye worm)	hypothetical protein	0.001	0.0022	0.0037
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0022	0.0022
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0376	0.5359	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0119	0.0222
Giardia lamblia	Hypothetical protein	0.0045	0.0527	0.6729
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0022	0.0022
Trypanosoma cruzi	cruzipain precursor, putative	0.0064	0.081	0.1511
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.0376	0.5359	1
Entamoeba histolytica	hypothetical protein, conserved	0.0057	0.07	0.1307
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0045	0.0527	0.0984
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0158	0.2996
Onchocerca volvulus		0.0017	0.0119	0.1923
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0171	0.032
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.081	0.1511
Loa Loa (eye worm)	hypothetical protein	0.001	0.0025	0.0043
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	0.0636	0.9153	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0022	0.0037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0119	0.0222
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0119	0.0222
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0.0038	0.0071
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0054	0.0101
Mycobacterium ulcerans	anthranilate phosphoribosyltransferase	0.0179	0.2493	0.268
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0045	0.0527	0.0984
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0038	0.0071
Echinococcus multilocularis	RUN	0.0019	0.0158	0.0158
Giardia lamblia	Hypothetical protein	0.0045	0.0527	0.6729
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0119	0.0222
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0171	0.032
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0022	0.0037
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0022	0.0037
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0057	0.07	0.07
Loa Loa (eye worm)	hypothetical protein	0.001	0.0022	0.0037
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0055	0.067	0.067
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0158	0.0291
Trypanosoma brucei	Eukaryotic translation initiation factor 4E type 5	0.0045	0.0527	0.0984
Onchocerca volvulus		0.0017	0.0119	0.1923
Brugia malayi	translation initiation factor 4E	0.0376	0.5359	1
Leishmania major	cathepsin L-like protease	0.0064	0.081	0.1424
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0376	0.5359	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0022	0.0041
Echinococcus granulosus	cathepsin l1	0.0017	0.0119	0.0119
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0119	0.0119
Brugia malayi	intermediate filament protein	0.0027	0.0269	0.0502
Loa Loa (eye worm)	ctsf protein	0.0017	0.0119	0.0219
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0085	0.0156
Leishmania major	cathepsin L-like protease	0.0017	0.0119	0.0123
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0376	0.5359	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0119	0.0222
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0171	0.0284
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0057	0.07	0.1307
Loa Loa (eye worm)	hypothetical protein	0.001	0.0022	0.0037
Schistosoma mansoni	lipoxygenase	0.0055	0.067	0.067
Loa Loa (eye worm)	hypothetical protein	0.001	0.0022	0.0037
Plasmodium vivax	hypothetical protein, conserved	0.0045	0.0527	1
Loa Loa (eye worm)	fibroinase	0.0017	0.0119	0.0219
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0057	0.07	0.1307
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E type 5, putative	0.0045	0.0527	0.0984
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E type 5, putative	0.0045	0.0527	0.0984
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.001	0.0025	0.0479
Leishmania major	cathepsin L-like protease	0.0064	0.081	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0057	0.0103
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0119	0.0222
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0025	0.0011
Toxoplasma gondii	cathepsin CPL	0.0017	0.0119	0.0187
Entamoeba histolytica	eukaryotic initiation factor 4E, putative	0.0045	0.0527	0.0984
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0038	0.0071
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0119	0.0222
Leishmania major	cathepsin L-like protease	0.0064	0.081	0.1424
Schistosoma mansoni	hypothetical protein	0.0057	0.07	0.07
Schistosoma mansoni	lamin	0.0027	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0262	0.0485
Loa Loa (eye worm)	eukaryotic translation initiation factor 4E-1	0.0045	0.0527	0.0981
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0376	0.5359	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0022	0.0037
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0022	0.0022
Onchocerca volvulus		0.0017	0.0119	0.1923
Mycobacterium leprae	Probable anthranilate phosphoribosyltransferase TrpD	0.0179	0.2493	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0038	0.0067
Echinococcus multilocularis	cysteine protease	0.0017	0.0119	0.0119
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0055	0.067	0.067
Loa Loa (eye worm)	hypothetical protein	0.002	0.0171	0.0316
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0119	0.0119
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0057	0.07	0.1307
Onchocerca volvulus	Putative eukaryotic translation initiation factor 4e	0.0045	0.0527	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0022	0.0041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0119	0.0222
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0022	0.0041
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0269	0.0269
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0022	0.0022
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0022	0.0022
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0158	0.0158
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.002	0.0171	0.0316
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.0728	0.1359
Echinococcus multilocularis	lamin	0.0027	0.0269	0.0269
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0022	0.0037
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0054	0.0097
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0158	0.0158
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0171	0.0284
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0045	0.0527	0.0984
Loa Loa (eye worm)	cysteine protease	0.0017	0.0119	0.0219
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0119	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0057	0.0103
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.081	0.1511
Schistosoma mansoni	polycystin 1-related	0.0019	0.0158	0.0158
Trypanosoma cruzi	eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative	0.0045	0.0527	0.0984
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0119	0.0222
Schistosoma mansoni	hypothetical protein	0.0019	0.0158	0.0158
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0171	0.032
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0269	0.0499
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0022	0.0022
Leishmania major	cathepsin L-like protease	0.0017	0.0119	0.0123
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0054	0.0101
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0022	0.0022
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0054	0.0097
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.0119	0.2259
Schistosoma mansoni	DNA helicase recq5	0.002	0.0171	0.0171
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.002	0.0171	0.3248
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0045	0.0527	0.0984
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0119	0.0222
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0022	0.0022
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0119	0.0222
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0022	0.0041
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0057	0.07	0.1307
Leishmania major	cathepsin L-like protease	0.0017	0.0119	0.0123
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0045	0.0527	0.0984
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.002	0.0171	0.0171
Entamoeba histolytica	recQ family DNA helicase	0.001	0.0025	0.0047
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.081	0.1511
Schistosoma mansoni	lamin	0.0027	0.0269	0.0269
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0057	0.07	0.1307
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0119	0.0222
Brugia malayi	Eukaryotic translation initiation factor 4E type 3, putative	0.0045	0.0527	0.0984
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.002	0.0171	0.0171
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0119	0.0119
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0022	0.0022
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.081	0.1511
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0119	0.0222
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0085	0.0159
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0022	0.0022
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0376	0.5359	1
Giardia lamblia	hypothetical protein	0.0045	0.0527	0.6729
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.081	0.1511
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0119	0.0222
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0119	0.0222
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.07	0.1307
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0057	0.07	0.1219
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0022	0.0041
Brugia malayi	ecdysteroid receptor	0.001	0.0022	0.0041
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0022	0.0041
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0064	0.0064
Onchocerca volvulus		0.0027	0.0269	0.4891
Brugia malayi	cathepsin L-like precursor	0.0011	0.0038	0.0071
Entamoeba histolytica	hypothetical protein	0.0045	0.0527	0.0984
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0022	0.0022
Echinococcus granulosus	intermediate filament protein	0.0027	0.0269	0.0269
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0045	0.0527	0.0984
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0527	0.0984
Echinococcus granulosus	bloom syndrome protein	0.002	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0119	0.0219
Schistosoma mansoni	loxhd1	0.0019	0.0158	0.0158
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0527	0.0984
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0022	0.0022
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-4	0.0045	0.0527	0.0984
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0158	0.0291
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.0119	0.1923
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0158	0.0158
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.002	0.0171	0.0171
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0022	0.0041
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.081	0.1511
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.081	0.1511
Brugia malayi	hypothetical protein	0.0019	0.0158	0.0295
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0269	0.0502
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0045	0.0527	0.0984
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0119	0.0222
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-2	0.0045	0.0527	0.0984
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0057	0.07	0.1219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0119	0.0222
Onchocerca volvulus		0.0019	0.0158	0.2693
Echinococcus granulosus	thymidine phosphorylase	0.0636	0.9153	0.9153
Echinococcus multilocularis	thymidine phosphorylase	0.0636	0.9153	0.9153
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0022	0.0041
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0119	0.0119
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0022	0.0037
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0119	0.0119
Echinococcus multilocularis	bloom syndrome protein	0.002	0.0171	0.0171
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.0045	0.0527	0.0951
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0119	0.0123
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.081	0.1511
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0119	0.0222
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-4	0.0045	0.0527	0.0984
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.081	0.1511
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0119	0.0222
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0025	0.0025
Onchocerca volvulus		0.0019	0.0158	0.2693
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0022	0.0041
Echinococcus multilocularis	cysteine protease	0.0017	0.0119	0.0119
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0119	0.0222
Brugia malayi	Doublecortin family protein	0.0019	0.0158	0.0295
Schistosoma mansoni	rab6-interacting	0.0019	0.0158	0.0158
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.002	0.0171	0.0171
Brugia malayi	nuclear receptor NHR-88	0.001	0.0022	0.0041
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0038	0.0071
Echinococcus multilocularis	musashi	0.0027	0.0269	0.0269
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0171	0.032
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0269	0.0499
Onchocerca volvulus		0.0027	0.0269	0.4891
Loa Loa (eye worm)	hypothetical protein	0.001	0.0022	0.0037
Entamoeba histolytica	recQ family helicase, putative	0.002	0.0171	0.032
Schistosoma mansoni	coup transcription factor	0.001	0.0022	0.0022
Brugia malayi	eukaryotic translation initiation factor 4E-1	0.0045	0.0527	0.0984
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0054	0.0101
Onchocerca volvulus		0.0011	0.0038	0.0317
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0376	0.5359	1
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0119	0.1923
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0119	0.0222
Brugia malayi	nuclear hormone receptor	0.001	0.0022	0.0041
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.0119	0.2259
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0022	0.0022
Loa Loa (eye worm)	RecQ helicase	0.002	0.0171	0.0316
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0119	0.0119
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0022	0.0022
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0171	0.0221
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0045	0.0527	0.0984
Plasmodium vivax	vivapain-2	0.0017	0.0119	0.2259
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0119	0.0222
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0057	0.07	0.07
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0038	0.0071
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0022	0.0041
Brugia malayi	hypothetical protein	0.0019	0.0158	0.0295
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.081	0.1511
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0119	0.0222
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0045	0.0527	0.0984
Schistosoma mansoni	microtubule-associated protein tau	0.0694	1	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0022	0.0022
Plasmodium falciparum	eukaryotic translation initiation factor 4E, putative	0.0045	0.0527	1
Trypanosoma brucei	cytochrome P450, putative	0.0012	0.0054	0.0101
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0064	0.0117
Giardia lamblia	Translation elongation factor	0.0045	0.0527	0.6729

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 875385