Detailed information for compound 875399

Basic information

Technical information
  • TDR Targets ID: 875399
  • Name: N-[5-[ethyl-(2-methylphenyl)sulfamoyl]-1,3,4- thiadiazol-2-yl]-2-methylpropanamide
  • MW: 368.474 | Formula: C15H20N4O3S2
  • H donors: 1 H acceptors: 5 LogP: 2.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1nnc(s1)NC(=O)C(C)C)c1ccccc1C
  • InChi: 1S/C15H20N4O3S2/c1-5-19(12-9-7-6-8-11(12)4)24(21,22)15-18-17-14(23-15)16-13(20)10(2)3/h6-10H,5H2,1-4H3,(H,16,17,20)
  • InChiKey: SDMQJSINJVBMLG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[5-[ethyl-(2-methylphenyl)sulfamoyl]-1,3,4-thiadiazol-2-yl]-2-methyl-propanamide
  • N-[5-[ethyl-(2-methylphenyl)sulfamoyl]-1,3,4-thiadiazol-2-yl]-2-methyl-propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi tubulin alpha-2 chain 0.005 0.0299 0.0299
Loa Loa (eye worm) tubulin alpha chain 0.005 0.0299 0.0299
Echinococcus granulosus peroxidasin 0.0033 0.0073 0.0273
Brugia malayi Peroxidasin 0.0033 0.0073 0.0073
Loa Loa (eye worm) beta-tubulin 0.005 0.0299 0.0299
Trypanosoma brucei epsilon tubulin 0.005 0.0299 0.3161
Echinococcus granulosus tubulin beta 4A class IVa 0.005 0.0299 0.1119
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0073 0.0073
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0073 0.0073
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0073 0.0073
Echinococcus multilocularis roundabout 2 0.0033 0.0073 0.0273
Echinococcus granulosus roundabout 2 0.0058 0.0408 0.1529
Trypanosoma brucei tubulin gamma chain 0.005 0.0299 0.3161
Echinococcus granulosus geminin 0.0171 0.1938 0.7265
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0059 0.0426 0.1596
Loa Loa (eye worm) hypothetical protein 0.0069 0.0554 0.0554
Brugia malayi Tubulin gamma chain 0.005 0.0299 0.0299
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0933 1
Loa Loa (eye worm) tubulin beta-4 chain 0.005 0.0299 0.0299
Schistosoma mansoni dihydrofolate reductase 0.0182 0.2083 0.5182
Echinococcus granulosus epidermal growth factor receptor 0.0159 0.1777 0.6662
Brugia malayi Furin-like cysteine rich region family protein 0.0159 0.1777 0.1777
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0033 0.0073 0.0273
Echinococcus multilocularis Tubulin beta 2C chain 0.005 0.0299 0.1119
Leishmania major alpha tubulin 0.005 0.0299 0.2554
Trypanosoma brucei epsilon tubulin 0.005 0.0299 0.3161
Echinococcus granulosus Tubulin beta 2C chain 0.005 0.0299 0.1119
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.0299 0.3161
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0114 0.0429
Loa Loa (eye worm) hypothetical protein 0.0306 0.3752 0.3752
Echinococcus granulosus Tubulin alpha 1 chain 0.005 0.0299 0.1119
Schistosoma mansoni alpha tubulin 0.005 0.0299 0.0625
Entamoeba histolytica tubulin alpha chain, putative 0.005 0.0299 0.2249
Echinococcus granulosus insulin receptor 0.0059 0.0426 0.1596
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0033 0.0073 0.0273
Loa Loa (eye worm) alpha-tubulin 0.005 0.0299 0.0299
Leishmania major beta tubulin 0.005 0.0299 0.2554
Echinococcus multilocularis tubulin beta 1 chain 0.005 0.0299 0.1119
Echinococcus granulosus tubulin subunit TubB 0.005 0.0299 0.1119
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.007 0.0564 1
Echinococcus granulosus tubulin alpha chain 0.005 0.0299 0.1119
Schistosoma mansoni hypothetical protein 0.0069 0.0554 0.1277
Echinococcus granulosus peroxisome assembly protein 26 0.005 0.0299 0.1119
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0073 0.0073
Leishmania major alpha tubulin 0.005 0.0299 0.2554
Schistosoma mansoni septate junction protein 0.0033 0.0073 0.0048
Schistosoma mansoni tyrosine kinase 0.0159 0.1777 0.4401
Echinococcus multilocularis 0.0045 0.0238 0.0891
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0933 1
Echinococcus multilocularis tyrosine protein kinase otk 0.0033 0.0073 0.0273
Brugia malayi beta-tubulin, identical 0.005 0.0299 0.0299
Schistosoma mansoni septate junction protein 0.0033 0.0073 0.0048
Echinococcus multilocularis tubulin alpha 0.005 0.0299 0.1119
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0225 0.2667 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0555 0.2082
Echinococcus multilocularis roundabout 2 0.0058 0.0408 0.1529
Echinococcus granulosus tubulin alpha 0.005 0.0299 0.1119
Echinococcus multilocularis hypothetical protein 0.005 0.0299 0.1119
Echinococcus multilocularis tubulin subunit TubB 0.005 0.0299 0.1119
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.0299 0.3161
Trypanosoma brucei beta tubulin 0.005 0.0299 0.3161
Leishmania major dihydrofolate reductase-thymidylate synthase 0.007 0.0564 0.5663
Echinococcus granulosus epidermal growth factor receptor 0.0091 0.0858 0.3217
Echinococcus granulosus tubulin alpha 1C chain 0.005 0.0299 0.1119
Chlamydia trachomatis dihydrofolate reductase 0.0182 0.2083 0.5
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0225 0.2667 1
Entamoeba histolytica tubulin gamma chain 0.005 0.0299 0.2249
Loa Loa (eye worm) tubulin alpha 2 0.0028 0.0005 0.0005
Echinococcus multilocularis tubulin alpha chain 0.005 0.0299 0.1119
Schistosoma mansoni tyrosine kinase 0.0078 0.0679 0.1596
Echinococcus granulosus GPCR family 2 0.0032 0.0054 0.0202
Trypanosoma brucei alpha tubulin 0.005 0.0299 0.3161
Brugia malayi alpha-tubulin 0.005 0.0299 0.0299
Entamoeba histolytica tubulin family protein 0.005 0.0299 0.2249
Schistosoma mansoni roundabout 0.0033 0.0073 0.0048
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.007 0.0564 0.6017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0114 0.0429
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0933 1
Echinococcus granulosus Tubulin beta 2C chain 0.005 0.0299 0.1119
Echinococcus granulosus tubulin gamma 1 chain 0.005 0.0299 0.1119
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0059 0.0426 0.1596
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0933 0.3498
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0555 0.5385
Trypanosoma cruzi beta tubulin, putative 0.005 0.0299 0.2554
Echinococcus granulosus contactin 0.0033 0.0073 0.0273
Echinococcus granulosus lachesin 0.0033 0.0073 0.0273
Echinococcus multilocularis dihydrofolate reductase 0.0182 0.2083 0.7809
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0028 0.0005 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0054 0.0054
Echinococcus multilocularis tubulin, beta 4A class IVa 0.005 0.0299 0.1119
Schistosoma mansoni tubulin subunit beta 0.005 0.0299 0.0625
Echinococcus granulosus tyrosine protein kinase otk 0.0033 0.0073 0.0273
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0073 0.0073
Schistosoma mansoni cell adhesion molecule 0.0033 0.0073 0.0048
Onchocerca volvulus 0.0306 0.3752 0.39
Echinococcus multilocularis peroxisome assembly protein 26 0.005 0.0299 0.1119
Echinococcus multilocularis Tubulin alpha 1 chain 0.005 0.0299 0.1119
Echinococcus multilocularis roundabout 2 0.0033 0.0073 0.0273
Trypanosoma brucei alpha tubulin 0.005 0.0299 0.3161
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0555 0.5567
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1254 0.1254
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0033 0.0073 0.007
Schistosoma mansoni hypothetical protein 0.0171 0.1938 0.4812
Loa Loa (eye worm) hypothetical protein 0.0058 0.0408 0.0408
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0033 0.0073 0.0048
Leishmania major beta tubulin 0.005 0.0299 0.2554
Trypanosoma cruzi epsilon tubulin, putative 0.005 0.0299 0.2554
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0054 0.0202
Echinococcus multilocularis hemicentin 1 0.0033 0.0073 0.0273
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0933 1
Brugia malayi Blistered cuticle protein 3 0.0034 0.0081 0.0081
Brugia malayi Tubulin alpha-2 chain 0.005 0.0299 0.0299
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0054 0.0202
Leishmania major beta tubulin 0.005 0.0299 0.2554
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0033 0.0073 0.0273
Leishmania major beta tubulin 0.005 0.0299 0.2554
Leishmania major beta tubulin 0.005 0.0299 0.2554
Loa Loa (eye worm) tubulin alpha chain 0.005 0.0299 0.0299
Echinococcus granulosus transcription factor Dp 1 0.004 0.0163 0.061
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0033 0.0073 0.0273
Leishmania major alpha tubulin 0.005 0.0299 0.2554
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.0034 0.0081 0.0816
Echinococcus multilocularis tubulin alpha 3 chain 0.005 0.0299 0.1119
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0182 0.2083 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0073 0.0073
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0933 0.3498
Echinococcus multilocularis tubulin alpha 1C chain 0.005 0.0299 0.1119
Echinococcus multilocularis tubulin subunit beta 0.005 0.0299 0.1119
Schistosoma mansoni alpha tubulin 0.005 0.0299 0.0625
Trichomonas vaginalis tubulin gamma chain, putative 0.005 0.0299 0.3161
Trichomonas vaginalis tubulin epsilon chain, putative 0.005 0.0299 0.3161
Leishmania major beta tubulin 0.005 0.0299 0.2554
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0073 0.0073
Echinococcus granulosus tubulin alpha chain 0.005 0.0299 0.1119
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0054 0.0202
Schistosoma mansoni alpha tubulin 0.005 0.0299 0.0625
Loa Loa (eye worm) hypothetical protein 0.0058 0.0408 0.0408
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0033 0.0073 0.0073
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0985 0.0985
Echinococcus multilocularis epidermal growth factor receptor 0.0159 0.1777 0.6662
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0114 0.0155
Brugia malayi Protein kinase domain containing protein 0.0059 0.0426 0.0426
Leishmania major alpha tubulin 0.005 0.0299 0.2554
Echinococcus granulosus tubulin subunit beta 0.005 0.0299 0.1119
Echinococcus multilocularis tubulin epsilon chain 0.005 0.0299 0.1119
Schistosoma mansoni titin 0.0033 0.0073 0.0048
Trichomonas vaginalis tubulin alpha chain, putative 0.005 0.0299 0.3161
Trypanosoma brucei alpha tubulin 0.005 0.0299 0.3161
Echinococcus granulosus tubulin epsilon chain 0.005 0.0299 0.1119
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0933 1
Entamoeba histolytica tubulin alpha-1 chain 0.005 0.0299 0.2249
Echinococcus multilocularis Tubulin alpha 1 chain 0.005 0.0299 0.1119
Schistosoma mansoni cell adhesion molecule 0.0043 0.021 0.0399
Brugia malayi Tubulin alpha chain 0.005 0.0299 0.0299
Schistosoma mansoni tyrosine kinase 0.0091 0.0858 0.2054
Leishmania major beta tubulin 0.005 0.0299 0.2554
Leishmania major beta tubulin 0.005 0.0299 0.2554
Trypanosoma brucei polo-like protein kinase 0.0097 0.0933 1
Brugia malayi Tubulin beta-1 chain 0.005 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0033 0.0073 0.0073
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0043 0.021 0.0788
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0091 0.0858 0.3217
Trypanosoma cruzi tubulin gamma chain 0.005 0.0299 0.2554
Trypanosoma cruzi alpha tubulin, putative 0.005 0.0299 0.2554
Echinococcus granulosus Tubulin alpha 1 chain 0.005 0.0299 0.1119
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0554 0.0554
Schistosoma mansoni tubulin subunit beta 0.005 0.0299 0.0625
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0933 1
Schistosoma mansoni tubulin subunit beta 0.005 0.0299 0.0625
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0073 0.0073
Echinococcus granulosus neuroglian 0.0033 0.0073 0.0273
Echinococcus multilocularis lachesin 0.0033 0.0073 0.0273
Loa Loa (eye worm) hypothetical protein 0.005 0.0299 0.0299
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0768 1 1
Schistosoma mansoni tyrosine kinase 0.0091 0.0858 0.2054
Schistosoma mansoni hypothetical protein 0.0171 0.1938 0.4812
Echinococcus multilocularis beta tubulin 0.005 0.0299 0.1119
Schistosoma mansoni tyrosine kinase 0.0059 0.0426 0.095
Leishmania major alpha tubulin 0.005 0.0299 0.2554
Echinococcus granulosus neuroglian 0.0039 0.0156 0.0583
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0933 1
Leishmania major beta tubulin 0.005 0.0299 0.2554
Schistosoma mansoni kinase 0.0322 0.3969 1
Trichomonas vaginalis tubulin gamma chain, putative 0.005 0.0299 0.3161
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0933 0.0933
Schistosoma mansoni cell adhesion molecule 0.0033 0.0073 0.0048
Schistosoma mansoni tubulin subunit alpha 0.005 0.0299 0.0625
Echinococcus granulosus tubulin alpha 3 chain 0.005 0.0299 0.1119
Echinococcus multilocularis epidermal growth factor receptor 0.0091 0.0858 0.3217
Trichomonas vaginalis tubulin epsilon chain, putative 0.005 0.0299 0.3161
Leishmania major alpha tubulin 0.005 0.0299 0.2554
Entamoeba histolytica tubulin family protein 0.005 0.0299 0.2249
Loa Loa (eye worm) hypothetical protein 0.0033 0.0073 0.0073
Schistosoma mansoni cell adhesion molecule 0.0033 0.0073 0.0048
Echinococcus granulosus Tubulin alpha 1 chain 0.005 0.0299 0.1119
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0033 0.0073 0.0073
Loa Loa (eye worm) tubulin beta-2A chain 0.005 0.0299 0.0299
Echinococcus multilocularis tubulin alpha chain 0.005 0.0299 0.1119
Echinococcus multilocularis Tubulin beta 2C chain 0.005 0.0299 0.1119
Trichomonas vaginalis tubulin, putative 0.005 0.0299 0.3161
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.0299 0.3161
Echinococcus granulosus tubulin alpha chain 0.005 0.0299 0.1119
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0054 0.0054
Trypanosoma brucei beta tubulin 0.005 0.0299 0.3161
Schistosoma mansoni neuroglian 0.0033 0.0073 0.0048
Echinococcus multilocularis GPCR, family 2 0.0032 0.0054 0.0202
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0182 0.2083 0.5
Leishmania major beta tubulin 0.005 0.0299 0.2554
Echinococcus multilocularis tubulin alpha 1C chain 0.005 0.0299 0.1119
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0033 0.0073 0.0273
Schistosoma mansoni nephrin 0.0039 0.0156 0.026
Trypanosoma brucei beta tubulin 0.005 0.0299 0.3161
Echinococcus granulosus tubulin alpha chain 0.005 0.0299 0.1119
Echinococcus multilocularis Tubulin beta 2C chain 0.005 0.0299 0.1119
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.0299 0.3161
Schistosoma mansoni tyrosine kinase 0.0059 0.0426 0.095
Echinococcus granulosus hemicentin 1 0.0033 0.0073 0.0273
Leishmania major epsilon tubulin, putative 0.005 0.0299 0.2554
Trypanosoma brucei alpha tubulin 0.005 0.0299 0.3161
Loa Loa (eye worm) hypothetical protein 0.0033 0.0073 0.0073
Loa Loa (eye worm) blistered cuticle protein 3 0.0034 0.0081 0.0081
Echinococcus granulosus beta tubulin 0.005 0.0299 0.1119
Echinococcus multilocularis neuroglian 0.0033 0.0073 0.0273
Trichomonas vaginalis tubulin alpha chain, putative 0.005 0.0299 0.3161
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0033 0.0073 0.0048
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0933 0.0933
Loa Loa (eye worm) hypothetical protein 0.0028 0.0005 0.0005
Leishmania major alpha tubulin 0.005 0.0299 0.2554
Echinococcus granulosus roundabout 2 0.0033 0.0073 0.0273
Leishmania major beta tubulin 0.005 0.0299 0.2554
Leishmania major beta tubulin 0.005 0.0299 0.2554
Echinococcus multilocularis Tubulin alpha 1 chain 0.005 0.0299 0.1119
Schistosoma mansoni tubulin subunit alpha 0.005 0.0299 0.0625
Echinococcus multilocularis geminin 0.0171 0.1938 0.7265
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.021
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0034 0.0081 0.0081
Leishmania major beta tubulin 0.005 0.0299 0.2554
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0985 0.0985
Echinococcus granulosus Tubulin beta 2C chain 0.005 0.0299 0.1119
Leishmania major alpha tubulin 0.005 0.0299 0.2554
Brugia malayi Dihydrofolate reductase 0.0182 0.2083 0.2083
Echinococcus granulosus roundabout 2 0.0033 0.0073 0.0273
Loa Loa (eye worm) hypothetical protein 0.0033 0.0073 0.0073
Schistosoma mansoni tyrosine kinase 0.0078 0.0679 0.1596
Leishmania major gamma-tubulin 0.005 0.0299 0.2554
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0555 0.1281
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0073 0.0073
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0182 0.2083 0.5
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0555 0.5929
Trypanosoma brucei epsilon tubulin 0.005 0.0299 0.3161
Echinococcus multilocularis tubulin alpha chain 0.005 0.0299 0.1119
Echinococcus multilocularis neuroglian 0.0039 0.0156 0.0583
Leishmania major alpha tubulin 0.005 0.0299 0.2554
Echinococcus granulosus tubulin beta 1 chain 0.005 0.0299 0.1119
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0054 0.0202
Schistosoma mansoni tyrosine kinase 0.0047 0.0252 0.0506
Schistosoma mansoni nephrin 0.0033 0.0073 0.0048
Echinococcus multilocularis tubulin gamma 1 chain 0.005 0.0299 0.1119
Trypanosoma brucei beta tubulin 0.005 0.0299 0.3161
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0555 0.0555
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1254 0.1254
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0985 0.0985
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.0299 0.3161
Leishmania major alpha tubulin 0.005 0.0299 0.2554
Brugia malayi Tubulin alpha-2 chain 0.005 0.0299 0.0299
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0933 0.0966
Echinococcus multilocularis hemicentin 1 0.0033 0.0073 0.0273
Loa Loa (eye worm) BEN-1 protein 0.005 0.0299 0.0299
Echinococcus multilocularis tubulin alpha chain 0.005 0.0299 0.1119
Brugia malayi Prion-like- 0.0033 0.0073 0.0073
Onchocerca volvulus Dual oxidase homolog 0.0034 0.0081 0.0079
Leishmania major beta tubulin 0.005 0.0299 0.2554
Schistosoma mansoni hypothetical protein 0.0036 0.0114 0.0155
Loa Loa (eye worm) alpha-tubulin 0.005 0.0299 0.0299
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.007 0.0564 0.5663
Loa Loa (eye worm) hypothetical protein 0.0033 0.0073 0.0073
Brugia malayi hypothetical protein 0.0306 0.3752 0.3752
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0555 0.5567
Trypanosoma cruzi epsilon tubulin, putative 0.005 0.0299 0.2554
Echinococcus granulosus tubulin alpha 1C chain 0.005 0.0299 0.1119
Loa Loa (eye worm) tubulin beta-1 chain 0.005 0.0299 0.0299
Echinococcus granulosus beta tubulin 0.005 0.0299 0.1119
Leishmania major alpha tubulin 0.005 0.0299 0.2554
Trichomonas vaginalis tubulin epsilon chain, putative 0.005 0.0299 0.3161
Schistosoma mansoni tubulin subunit beta 0.005 0.0299 0.0625
Loa Loa (eye worm) hypothetical protein 0.0101 0.0985 0.0985
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0933 0.2245
Echinococcus granulosus tubulin alpha chain 0.005 0.0299 0.1119
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0555 0.2082
Loa Loa (eye worm) hypothetical protein 0.0033 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0033 0.0073 0.0073
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.0299 0.3161
Echinococcus granulosus tubulin alpha 3 chain 0.005 0.0299 0.1119
Echinococcus multilocularis tubulin alpha 3 chain 0.005 0.0299 0.1119
Trichomonas vaginalis tubulin epsilon chain, putative 0.005 0.0299 0.3161
Echinococcus granulosus twitchin 0.004 0.0164 0.0615
Loa Loa (eye worm) tubulin alpha-2 chain 0.005 0.0299 0.0299
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0555 0.5567
Trichomonas vaginalis tubulin gamma chain, putative 0.005 0.0299 0.3161
Schistosoma mansoni tubulin subunit beta 0.005 0.0299 0.0625
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.007 0.0564 1
Schistosoma mansoni tubulin subunit gamma 0.005 0.0299 0.0625
Schistosoma mansoni tubulin subunit beta 0.005 0.0299 0.0625
Loa Loa (eye worm) tubulin alpha 2 0.0028 0.0005 0.0005
Leishmania major beta tubulin 0.005 0.0299 0.2554
Brugia malayi tubulin alpha chain - mouse 0.005 0.0299 0.0299
Brugia malayi dihydrofolate reductase family protein 0.0182 0.2083 0.2083
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0933 1
Echinococcus multilocularis beta tubulin 0.005 0.0299 0.1119
Echinococcus multilocularis peroxidasin 0.0033 0.0073 0.0273
Echinococcus multilocularis insulin receptor 0.0059 0.0426 0.1596
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0555 0.0555
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.007 0.0564 1
Schistosoma mansoni tyrosine kinase 0.0078 0.0679 0.1596
Brugia malayi Tubulin beta chain 0.0028 0.0005 0.0005
Schistosoma mansoni tubulin subunit alpha 0.005 0.0299 0.0625
Loa Loa (eye worm) TK/EGFR protein kinase 0.0159 0.1777 0.1777
Echinococcus granulosus dihydrofolate reductase 0.0182 0.2083 0.7809
Echinococcus multilocularis tubulin alpha chain 0.005 0.0299 0.1119
Loa Loa (eye worm) TK/INSR protein kinase 0.0059 0.0426 0.0426
Echinococcus granulosus Tubulin beta 2C chain 0.005 0.0299 0.1119
Schistosoma mansoni tubulin subunit epsilon 0.005 0.0299 0.0625
Trypanosoma brucei beta tubulin 0.005 0.0299 0.3161
Leishmania major alpha tubulin 0.005 0.0299 0.2554
Brugia malayi MH2 domain containing protein 0.0121 0.1254 0.1254
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0054
Echinococcus granulosus alpha tubulin 0.005 0.0299 0.1119
Loa Loa (eye worm) dihydrofolate reductase 0.0182 0.2083 0.2083
Loa Loa (eye worm) tubulin beta chain 0.005 0.0299 0.0299
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0933 1
Loa Loa (eye worm) tubulin gamma chain 0.005 0.0299 0.0299
Onchocerca volvulus 0.0711 0.9233 0.9607
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0033 0.0073 0.0073
Echinococcus multilocularis Tubulin beta 2C chain 0.005 0.0299 0.1119
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0933 1
Echinococcus granulosus Tubulin beta 2C chain 0.005 0.0299 0.1119
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0073 0.0073
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.005 0.0299 0.3161
Giardia lamblia Kinase, PLK 0.0097 0.0933 1
Leishmania major beta tubulin 0.005 0.0299 0.2554
Onchocerca volvulus Tyrosine kinase homolog 0.0739 0.961 1
Loa Loa (eye worm) BEN-1 protein 0.005 0.0299 0.0299
Leishmania major beta tubulin 0.005 0.0299 0.2554
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0033 0.0073 0.0273
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0163 0.061
Brugia malayi hypothetical protein 0.0036 0.0114 0.0114
Echinococcus multilocularis Tubulin beta 2C chain 0.005 0.0299 0.1119
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0933 1
Leishmania major beta tubulin 0.005 0.0299 0.2554
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0054 0.0054
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.0299 0.3161

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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