TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 290.381 | Formula: C15H18N2O2S
H donors: 1 H acceptors: 2 LogP: 2.8 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COCCCNC(=O)c1csc(n1)c1cccc(c1)C
InChi: 1S/C15H18N2O2S/c1-11-5-3-6-12(9-11)15-17-13(10-20-15)14(18)16-7-4-8-19-2/h3,5-6,9-10H,4,7-8H2,1-2H3,(H,16,18)
InChiKey: IPSJHQHTYSEGAV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.005	0.0314	0.0299
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0043	0.0193	0.013
Brugia malayi	Animal haem peroxidase family protein	0.0055	0.0404	0.0404
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0173	0.2469	0.2469
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0132	0.1745	0.2302
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0267	0.411	0.411
Echinococcus multilocularis	peroxidasin	0.0055	0.0404	0.0425
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0173	0.2469	0.5811
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0742	0.0559
Brugia malayi	hypothetical protein	0.0055	0.0404	0.0404
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0173	0.2469	0.2321
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0069	0.0649	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0404	0.0215
Onchocerca volvulus	Peroxidase homolog	0.0055	0.0404	0.0538
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0267	0.411	0.411
Loa Loa (eye worm)	hypothetical protein	0.0267	0.411	0.3994
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0082	0.087	0.087
Loa Loa (eye worm)	animal heme peroxidase	0.0055	0.0404	0.0215
Brugia malayi	nuclear hormone receptor family member odr-7	0.0082	0.087	0.087
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0173	0.2469	0.3316
Plasmodium vivax	multidomain scavenger receptor, putative	0.0062	0.0524	0.6032
Echinococcus granulosus	epidermal growth factor receptor	0.0156	0.2169	0.496
Loa Loa (eye worm)	animal heme peroxidase	0.0055	0.0404	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0404	0.0215
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0043	0.0193	0.0222
Brugia malayi	intermediate filament protein	0.0056	0.0429	0.0429
Onchocerca volvulus		0.0144	0.196	0.4511
Loa Loa (eye worm)	ShTK domain-containing protein	0.0267	0.411	0.3994
Loa Loa (eye worm)	hypothetical protein	0.0082	0.087	0.0691
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0173	0.2469	0.3316
Echinococcus granulosus	lamin dm0	0.0056	0.0429	0.0787
Onchocerca volvulus		0.0062	0.0524	0.0845
Schistosoma mansoni	sodium/chloride dependent transporter	0.0253	0.3862	0.5267
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0173	0.2469	0.3316
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0173	0.2469	0.3316
Schistosoma mansoni	lipoxygenase	0.0238	0.3617	0.4923
Echinococcus multilocularis	Polycystic kidney disease protein	0.0062	0.0524	0.0593
Onchocerca volvulus		0.0074	0.0742	0.1401
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0173	0.2469	0.5679
Schistosoma mansoni	hypothetical protein	0.0149	0.2048	0.2726
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0404	0.0215
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0173	0.2469	0.2469
Schistosoma mansoni	nuclear receptor	0.0082	0.087	0.1078
Brugia malayi	hypothetical protein	0.0043	0.0193	0.0193
Schistosoma mansoni	intermediate filament proteins	0.0056	0.0429	0.046
Loa Loa (eye worm)	hypothetical protein	0.0173	0.2469	0.2321
Echinococcus multilocularis	nuclear receptor nhr 48	0.0082	0.087	0.1078
Loa Loa (eye worm)	animal heme peroxidase	0.0055	0.0404	0.0215
Brugia malayi	Animal haem peroxidase family protein	0.0055	0.0404	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0404	0.0215
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0742	0.0843
Schistosoma mansoni	hypothetical protein	0.0062	0.0524	0.0593
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0173	0.2469	0.2321
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0185	0.2672	0.3601
Loa Loa (eye worm)	hypothetical protein	0.0173	0.2469	0.2321
Loa Loa (eye worm)	hypothetical protein	0.0173	0.2469	0.2321
Schistosoma mansoni	tyrosinase precursor	0.0267	0.411	0.5614
Brugia malayi	hypothetical protein	0.0144	0.196	0.196
Brugia malayi	Peroxidasin	0.0055	0.0404	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0082	0.087	0.0691
Echinococcus granulosus	slit 2 protein	0.007	0.0671	0.1369
Brugia malayi	hypothetical protein	0.0091	0.1041	0.1041
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0173	0.2469	0.2469
Echinococcus granulosus	geminin	0.0177	0.254	0.585
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0173	0.2469	0.3316
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0173	0.2469	0.3316
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0404	0.0215
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0173	0.2469	0.5679
Loa Loa (eye worm)	hypothetical protein	0.0082	0.087	0.0691
Echinococcus granulosus	thyroid hormone receptor alpha	0.0082	0.087	0.1846
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0173	0.2469	0.3316
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0253	0.3862	0.3741
Echinococcus granulosus	sodium and chloride dependent glycine	0.0043	0.0193	0.0222
Echinococcus granulosus	FTZ F1 alpha	0.0173	0.2469	0.5679
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0742	0.0559
Schistosoma mansoni	tyrosine kinase	0.005	0.0314	0.0299
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0173	0.2469	0.3316
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0404	0.0215
Schistosoma mansoni	slit	0.007	0.0671	0.0799
Brugia malayi	nuclear hormone receptor	0.0173	0.2469	0.2469
Onchocerca volvulus	Peroxidasin homolog	0.0055	0.0404	0.0538
Brugia malayi	Animal haem peroxidase family protein	0.0055	0.0404	0.0404
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0446	0.7242	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0404	0.0215
Schistosoma mansoni	jun-related protein	0.0149	0.2048	0.2726
Brugia malayi	Furin-like cysteine rich region family protein	0.0156	0.2169	0.2169
Brugia malayi	beta-lactamase family protein	0.0074	0.0742	0.0742
Loa Loa (eye worm)	hypothetical protein	0.0173	0.2469	0.2321
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0043	0.0193	0.013
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0183	0.2648	0.6109
Loa Loa (eye worm)	glutaminase	0.0285	0.4439	0.433
Echinococcus granulosus	mitogen activated protein kinase 11	0.0132	0.1745	0.3942
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0043	0.0193	0.013
Schistosoma mansoni	nuclear receptor nhr-48	0.0082	0.087	0.1078
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0173	0.2469	0.3316
Plasmodium vivax	hypothetical protein, conserved	0.0074	0.0742	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0043	0.0193	0.013
Echinococcus multilocularis	slit 2 protein	0.007	0.0671	0.0799
Onchocerca volvulus		0.0055	0.0404	0.0538
Schistosoma mansoni	lamin	0.0056	0.0429	0.046
Echinococcus granulosus	carboxylesterase 5A	0.014	0.1888	0.4287
Echinococcus granulosus	RUN	0.0062	0.0524	0.1016
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0524	0.0337
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0043	0.0193	0.0222
Brugia malayi	Nuclear hormone receptor E75	0.0082	0.087	0.087
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0069	0.0649	0.0465
Schistosoma mansoni	nuclear hormone receptor	0.0082	0.087	0.1078
Brugia malayi	P38 map kinase family protein 2	0.0132	0.1745	0.1745
Onchocerca volvulus		0.0055	0.0404	0.0538
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0156	0.2169	0.2015
Loa Loa (eye worm)	hypothetical protein	0.0082	0.087	0.0691
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0069	0.0649	0.0649
Echinococcus granulosus	lipoxygenase domain containing protein	0.0062	0.0524	0.1016
Brugia malayi	Blistered cuticle protein 3	0.0055	0.0404	0.0404
Loa Loa (eye worm)	steroid hormone receptor	0.0173	0.2469	0.2321
Loa Loa (eye worm)	nuclear hormone receptor	0.0082	0.087	0.0691
Brugia malayi	nuclear receptor NHR-88	0.0173	0.2469	0.2469
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0091	0.1041	0.1318
Loa Loa (eye worm)	hypothetical protein	0.0082	0.087	0.0691
Mycobacterium leprae	conserved hypothetical protein	0.0074	0.0742	0.5
Onchocerca volvulus	Peroxidasin homolog	0.0055	0.0404	0.0538
Loa Loa (eye worm)	hypothetical protein	0.046	0.7488	0.7439
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0082	0.087	0.1078
Schistosoma mansoni	lamin	0.0056	0.0429	0.046
Schistosoma mansoni	sodium/chloride dependent transporter	0.0043	0.0193	0.013
Loa Loa (eye worm)	animal heme peroxidase	0.0055	0.0404	0.0215
Brugia malayi	EGF-like domain containing protein	0.007	0.0671	0.0671
Onchocerca volvulus		0.0074	0.0742	0.1401
Brugia malayi	hypothetical protein	0.0062	0.0524	0.0524
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0082	0.087	0.1078
Schistosoma mansoni	tyrosine kinase	0.0083	0.0892	0.1108
Loa Loa (eye worm)	carboxylesterase	0.014	0.1888	0.1729
Onchocerca volvulus	Bile acid receptor homolog	0.0173	0.2469	0.5811
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0267	0.411	0.411
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0074	0.0742	0.0898
Brugia malayi	hypothetical protein	0.0082	0.087	0.087
Loa Loa (eye worm)	doublecortin family protein	0.0062	0.0524	0.0337
Schistosoma mansoni	laminin gamma-3 chain	0.007	0.0671	0.0799
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0173	0.2469	0.5679
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0173	0.2469	0.2321
Echinococcus granulosus	acetylcholinesterase	0.014	0.1888	0.4287
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0161	0.2254	0.5163
Onchocerca volvulus		0.0062	0.0524	0.0845
Schistosoma mansoni	hypothetical protein	0.0273	0.4216	0.5763
Onchocerca volvulus	Peroxidase homolog	0.0055	0.0404	0.0538
Echinococcus granulosus	transcription factor Dp 1	0.004	0.0141	0.0098
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0082	0.087	0.1846
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0084	0.0907	0.1935
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0082	0.087	0.1078
Brugia malayi	laminin alpha chain	0.0052	0.0361	0.0361
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0173	0.2469	0.5679
Echinococcus granulosus	ecdysone induced protein 78C	0.0173	0.2469	0.5679
Brugia malayi	hypothetical protein	0.0082	0.087	0.087
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.014	0.1888	0.2503
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0091	0.1041	0.2257
Echinococcus multilocularis	acetylcholinesterase	0.014	0.1888	0.2503
Schistosoma mansoni	tyrosine kinase	0.0156	0.2169	0.2896
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0082	0.087	0.1729
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0173	0.2469	0.5679
Loa Loa (eye worm)	ShTK domain-containing protein	0.0267	0.411	0.3994
Schistosoma mansoni	coup transcription factor	0.0173	0.2469	0.3316
Echinococcus granulosus	neurogenic locus notch protein	0.0052	0.0361	0.0624
Brugia malayi	ecdysone receptor	0.0082	0.087	0.087
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0043	0.0193	0.0222
Onchocerca volvulus		0.0267	0.411	1
Echinococcus granulosus	sodium and chloride dependent glycine	0.0043	0.0193	0.0222
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0062	0.0524	0.0593
Brugia malayi	Animal haem peroxidase family protein	0.0055	0.0404	0.0404
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0173	0.2469	0.2321
Echinococcus multilocularis	geminin	0.0177	0.254	0.3416
Brugia malayi	Nuclear hormone receptor-like 1	0.0091	0.1041	0.1041
Brugia malayi	conserved hypotetical protein	0.0082	0.087	0.087
Schistosoma mansoni	tyrosinase precursor	0.0267	0.411	0.5614
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0074	0.0742	0.0742
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0043	0.0193	0.0222
Schistosoma mansoni	cell polarity protein	0.0052	0.0361	0.0364
Echinococcus multilocularis	lamin	0.0056	0.0429	0.046
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0238	0.3617	0.4923
Loa Loa (eye worm)	TK/INSR protein kinase	0.005	0.0314	0.0123
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0043	0.0193	0.013
Brugia malayi	bZIP transcription factor family protein	0.0183	0.2648	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0411	0.0222
Brugia malayi	nuclear hormone receptor	0.0082	0.087	0.087
Brugia malayi	orphan nuclear receptor NR2E1	0.0082	0.087	0.087
Echinococcus multilocularis	musashi	0.0056	0.0429	0.046
Brugia malayi	beta-lactamase	0.0074	0.0742	0.0742
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0043	0.0193	0.013
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0043	0.0193	0.0193
Echinococcus multilocularis	neurogenic locus notch protein	0.0052	0.0361	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0404	0.0215
Brugia malayi	hypothetical protein	0.0038	0.01	0.01
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0273	0.4216	0.5763
Schistosoma mansoni	thyroid hormone receptor	0.0446	0.7242	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0074	0.0742	0.1538
Onchocerca volvulus	Protein ultraspiracle homolog	0.0173	0.2469	0.5811
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0043	0.0193	0.013
Echinococcus granulosus	lipoxygenase domain containing protein	0.0062	0.0524	0.1016
Echinococcus granulosus	lamin	0.0056	0.0429	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0742	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0742	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0267	0.411	0.3994
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0173	0.2469	0.2469
Loa Loa (eye worm)	DR-78	0.0082	0.087	0.0691
Schistosoma mansoni	tyrosine kinase	0.005	0.0314	0.0299
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0173	0.2469	0.3316
Brugia malayi	Nuclear hormone receptor E75	0.0082	0.087	0.087
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0043	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.046	0.7488	0.7439
Schistosoma mansoni	retinoic acid receptor RXR	0.0276	0.4271	0.5839
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0082	0.087	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0253	0.3862	0.3741
Loa Loa (eye worm)	hypothetical protein	0.0173	0.2469	0.2321
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0183	0.2648	0.3567
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0056	0.0429	0.024
Echinococcus granulosus	pikachurin	0.0052	0.0361	0.0624
Onchocerca volvulus		0.0082	0.087	0.1729
Loa Loa (eye worm)	hypothetical protein	0.0178	0.256	0.2414
Schistosoma mansoni	nuclear receptor	0.0082	0.087	0.1078
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0082	0.087	0.1729
Loa Loa (eye worm)	acetylcholinesterase 1	0.014	0.1888	0.1729
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0132	0.1745	0.1582
Echinococcus granulosus	jun protein	0.0183	0.2648	0.6109
Onchocerca volvulus		0.0055	0.0404	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1041	0.0865
Loa Loa (eye worm)	serotonin transporter b	0.0253	0.3862	0.3741
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0043	0.0193	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0091	0.1041	0.1318
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0276	0.4271	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0742	0.0559
Brugia malayi	Protein kinase domain containing protein	0.005	0.0314	0.0314
Echinococcus multilocularis	acetylcholinesterase	0.014	0.1888	0.2503
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1041	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0404	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0742	0.0559
Brugia malayi	photoreceptor-specific nuclear receptor	0.0173	0.2469	0.2469
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0361	0.0171
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0253	0.3862	0.3862
Schistosoma mansoni	hypothetical protein	0.0177	0.254	0.3416
Loa Loa (eye worm)	hypothetical protein	0.0173	0.2469	0.2321
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0173	0.2469	0.3316
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0074	0.0742	0.0559
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0082	0.087	0.0691
Loa Loa (eye worm)	abnormal epIthelia family member	0.0052	0.0361	0.0171
Echinococcus granulosus	epidermal growth factor receptor	0.0084	0.0907	0.1935
Loa Loa (eye worm)	hypothetical protein	0.014	0.1888	0.1729
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0043	0.0193	0.013
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0069	0.0649	0.0769
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0062	0.0524	0.0593
Brugia malayi	tailless protein	0.0082	0.087	0.087
Echinococcus granulosus	serotonin transporter	0.0253	0.3862	0.9021
Loa Loa (eye worm)	hypothetical protein	0.0082	0.087	0.0691
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0742	0.0898
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0043	0.0193	0.013
Schistosoma mansoni	peroxidasin	0.0055	0.0404	0.0425
Echinococcus multilocularis	epidermal growth factor receptor	0.0084	0.0907	0.113
Onchocerca volvulus		0.0173	0.2469	0.5811
Echinococcus multilocularis	FTZ F1 alpha	0.0173	0.2469	0.3316
Loa Loa (eye worm)	hypothetical protein	0.0082	0.087	0.0691
Brugia malayi	ShTK domain containing protein	0.0267	0.411	0.411
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0082	0.087	0.1846
Schistosoma mansoni	loxhd1	0.0062	0.0524	0.0593
Onchocerca volvulus	Dual oxidase homolog	0.0055	0.0404	0.0538
Onchocerca volvulus		0.0267	0.411	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1041	0.0865
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0173	0.2469	0.2469
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0173	0.2469	0.2469
Echinococcus multilocularis	lamin dm0	0.0056	0.0429	0.046
Trichomonas vaginalis	glutaminase, putative	0.0285	0.4439	1
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0043	0.0193	0.013
Brugia malayi	nuclear receptor RXR	0.0091	0.1041	0.1041
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0082	0.087	0.0691
Loa Loa (eye worm)	hypothetical protein	0.007	0.0671	0.0488
Onchocerca volvulus		0.0082	0.087	0.1729
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0474	0.7741	1
Schistosoma mansoni	tyrosine kinase	0.0084	0.0907	0.113
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0173	0.2469	0.2321
Echinococcus multilocularis	jun protein	0.0183	0.2648	0.3567
Brugia malayi	Cytochrome P450 family protein	0.0058	0.0464	0.0464
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0082	0.087	0.1078
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0132	0.1745	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.087	0.0691
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0273	0.4216	0.9869
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1041	0.0865
Brugia malayi	Common central domain of tyrosinase family protein	0.0267	0.411	0.411
Echinococcus granulosus	insulin receptor	0.005	0.0314	0.0512
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.005	0.0314	0.0512
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0132	0.1745	0.2302
Schistosoma mansoni	rab6-interacting	0.0062	0.0524	0.0593
Brugia malayi	nuclear receptor NHR-88	0.0082	0.087	0.087
Echinococcus multilocularis		0.0048	0.0287	0.0261
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0043	0.0193	0.013
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0742	0.0898
Schistosoma mansoni	hypothetical protein	0.0054	0.0388	0.0403
Echinococcus multilocularis	epidermal growth factor receptor	0.0156	0.2169	0.2896
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0082	0.087	0.1078
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0132	0.1745	1
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0069	0.0649	0.0769
Brugia malayi	Carboxylesterase family protein	0.014	0.1888	0.1888
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0173	0.2469	0.2469
Loa Loa (eye worm)	hypothetical protein	0.0253	0.3862	0.3741
Echinococcus granulosus	mitogen activated protein kinase 14	0.0132	0.1745	0.3942
Echinococcus multilocularis	pikachurin	0.0052	0.0361	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0173	0.2469	0.2321
Mycobacterium ulcerans	glutaminase	0.0285	0.4439	1
Onchocerca volvulus		0.0056	0.0429	0.0602
Loa Loa (eye worm)	tyrosinase 1	0.0267	0.411	0.3994
Echinococcus granulosus	peroxidasin	0.0055	0.0404	0.0728
Schistosoma mansoni	tyrosine kinase	0.0083	0.0892	0.1108
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0132	0.1745	1
Echinococcus granulosus	Polycystic kidney disease protein	0.0062	0.0524	0.1016
Brugia malayi	laminin-like protein K08C7.3 precursor	0.0052	0.0361	0.0361
Schistosoma mansoni	tyrosine kinase	0.0083	0.0892	0.1108
Brugia malayi	nuclear receptor NHR-67	0.0082	0.087	0.087
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0404	0.0215
Brugia malayi	hypothetical protein	0.0062	0.0524	0.0524
Echinococcus multilocularis	carboxylesterase 5A	0.014	0.1888	0.2503
Brugia malayi	Nuclear hormone receptor-like 1	0.0091	0.1041	0.1041
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0173	0.2469	0.5679
Schistosoma mansoni	thyroid hormone receptor	0.0446	0.7242	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0043	0.0201	0.0142
Leishmania major	hypothetical protein, conserved	0.0074	0.0742	0.0843
Onchocerca volvulus		0.0267	0.411	1
Brugia malayi	ecdysteroid receptor	0.0173	0.2469	0.2469
Onchocerca volvulus		0.0056	0.0429	0.0602
Loa Loa (eye worm)	norepinephrine transporter	0.0253	0.3862	0.3741
Onchocerca volvulus	Chorion peroxidase homolog	0.0055	0.0404	0.0538
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0091	0.1041	0.0865
Brugia malayi	Animal haem peroxidase family protein	0.0055	0.0404	0.0404
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0173	0.2469	0.2469
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0173	0.2469	0.3316
Loa Loa (eye worm)	beta-lactamase	0.0074	0.0742	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0082	0.087	0.0691
Brugia malayi	Nuclear hormone receptor-like 1	0.0173	0.2469	0.2469
Schistosoma mansoni	peroxidasin	0.0055	0.0404	0.0425
Schistosoma mansoni	rab6-interacting	0.0062	0.0524	0.0593
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0173	0.2469	0.3316
Echinococcus granulosus	acetylcholinesterase	0.014	0.1888	0.4287
Brugia malayi	Carboxylesterase family protein	0.014	0.1888	0.1888
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0173	0.2469	0.2469
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0082	0.087	0.1846
Mycobacterium leprae	Probable lipase LipE	0.0074	0.0742	0.5
Loa Loa (eye worm)	hypothetical protein	0.0173	0.2469	0.2321
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0173	0.2469	0.2469
Loa Loa (eye worm)	hypothetical protein	0.0082	0.087	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0603	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0173	0.2469	0.2469
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0043	0.0193	0.013
Loa Loa (eye worm)	hypothetical protein	0.014	0.1888	0.1729
Brugia malayi	steroid hormone receptor	0.0173	0.2469	0.2469
Toxoplasma gondii	ABC1 family protein	0.0074	0.0742	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0253	0.3862	0.5267
Brugia malayi	nuclear receptor RXR	0.0082	0.087	0.087
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0132	0.1745	0.2302
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0361	0.0171
Brugia malayi	Thrombospondin N-terminal -like domain containing protein	0.0052	0.0361	0.0361
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0043	0.0193	0.013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0173	0.2469	0.2321
Schistosoma mansoni	zinc finger protein	0.0082	0.087	0.1078
Brugia malayi	glutaminase DH11.1	0.0285	0.4439	0.4439
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0082	0.087	0.1078
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0404	0.0215
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0043	0.0193	0.013
Brugia malayi	Intermediate filament tail domain containing protein	0.0056	0.0429	0.0429
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0043	0.0193	0.0193
Loa Loa (eye worm)	blistered cuticle protein 3	0.0055	0.0404	0.0215
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0132	0.1745	0.2302
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0173	0.2469	0.2321
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0267	0.411	0.411
Onchocerca volvulus		0.0253	0.3862	0.9368
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0238	0.3617	0.8431
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0404	0.0215
Schistosoma mansoni	nuclear hormone receptor	0.0082	0.087	0.1078
Loa Loa (eye worm)	hypothetical protein	0.0082	0.087	0.0691
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0091	0.1041	0.1318
Echinococcus granulosus	intermediate filament protein	0.0056	0.0429	0.0787
Brugia malayi	hypothetical protein	0.0091	0.1041	0.1041
Schistosoma mansoni	RAR-like nuclear receptor	0.0173	0.2469	0.3316
Loa Loa (eye worm)	hypothetical protein	0.0253	0.3862	0.3741
Echinococcus multilocularis	transcription factor Dp 1	0.004	0.0141	0.0057
Schistosoma mansoni	lipoxygenase	0.0127	0.1671	0.2199
Echinococcus multilocularis	serotonin transporter	0.0253	0.3862	0.5267
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0082	0.087	0.087
Brugia malayi	beta-lactamase family protein	0.0074	0.0742	0.0742
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1041	0.0865
Loa Loa (eye worm)	glutaminase 2	0.0285	0.4439	0.433
Brugia malayi	Steroid receptor seven-up type 2	0.0173	0.2469	0.2469
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0161	0.2254	0.3015
Schistosoma mansoni	polycystin 1-related	0.0062	0.0524	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0082	0.087	0.0691
Brugia malayi	Serotonin receptor	0.0508	0.8329	0.8329
Schistosoma mansoni	glutaminase	0.0285	0.4439	0.6075
Schistosoma mansoni	hypothetical protein	0.0177	0.254	0.3416
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0043	0.0193	0.0193
Echinococcus granulosus	nuclear receptor nhr 48	0.0082	0.087	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0524	0.0337
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0173	0.2469	0.2469
Schistosoma mansoni	tyrosine kinase	0.0084	0.0907	0.113
Plasmodium falciparum	LCCL domain-containing protein	0.0062	0.0524	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0404	0.0215
Treponema pallidum	sodium- and chloride- dependent transporter	0.0253	0.3862	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0173	0.2469	0.2469
Onchocerca volvulus		0.0267	0.411	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0429	0.024
Loa Loa (eye worm)	hypothetical protein	0.0082	0.087	0.0691
Trypanosoma brucei	hypothetical protein, conserved	0.0074	0.0742	0.0843
Loa Loa (eye worm)	cytochrome P450 family protein	0.0058	0.0464	0.0276
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0069	0.0649	0.1316
Schistosoma mansoni	chondroitin sulfate proteoglycan-related	0.0052	0.0361	0.0364
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0742	0.0843
Echinococcus multilocularis	RUN	0.0062	0.0524	0.0593
Brugia malayi	Doublecortin family protein	0.0062	0.0524	0.0524
Schistosoma mansoni	nuclear hormone receptor	0.0173	0.2469	0.3316
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0404	0.0215
Echinococcus multilocularis	ecdysone induced protein 78C	0.0173	0.2469	0.3316
Loa Loa (eye worm)	intermediate filament protein	0.0056	0.0429	0.024
Echinococcus multilocularis	insulin receptor	0.005	0.0314	0.0299
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0132	0.1745	1
Onchocerca volvulus		0.0074	0.0742	0.1401

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 884464