Detailed information for compound 892195

Basic information

Technical information
  • TDR Targets ID: 892195
  • Name: 4-(4-fluorophenyl)-3,4-dihydro-1H-benzo[h]qui nolin-2-one
  • MW: 291.319 | Formula: C19H14FNO
  • H donors: 1 H acceptors: 1 LogP: 3.87 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CC(c2ccc(cc2)F)c2c(N1)c1ccccc1cc2
  • InChi: 1S/C19H14FNO/c20-14-8-5-13(6-9-14)17-11-18(22)21-19-15-4-2-1-3-12(15)7-10-16(17)19/h1-10,17H,11H2,(H,21,22)
  • InChiKey: FAMQONYPXCTFEN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_358193
  • 4-(4-Fluoro-phenyl)-3,4-dihydro-1H-benzo[h]quinolin-2-one
  • BAS 00603650
  • Oprea1_563451

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0208 0.0551
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2258 0.2959
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0278 0.0945
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0208 0.0264
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0023 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0208 0.0706
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0603 0.0784
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0048 0.0114
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0033 0.0239 0.396
Loa Loa (eye worm) hypothetical protein 0.005 0.0432 0.1165
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.1701 0.2226
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0208 0.2938
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.2771 0.9423
Echinococcus granulosus solute carrier family 22 0.003 0.0208 0.0264
Echinococcus granulosus bloom syndrome protein 0.0021 0.0112 0.0138
Loa Loa (eye worm) hypothetical protein 0.0026 0.0168 0.0444
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.0707 0.106
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0707 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0114
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trypanosoma cruzi hexose transporter 0.0066 0.0612 0.8663
Trypanosoma brucei glucose transporter, putative 0.0066 0.0612 0.8663
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0029 0.02 0.3335
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0612 0.8663
Brugia malayi jmjC domain containing protein 0.0016 0.0048 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0612 0.2082
Leishmania major glucose transporter, lmgt2 0.0066 0.0612 0.8663
Onchocerca volvulus Huntingtin homolog 0.0122 0.1247 0.5563
Echinococcus granulosus geminin 0.0169 0.1774 0.2322
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2258 0.2959
Plasmodium vivax JmjC domain containing protein 0.0016 0.0048 0.0042
Echinococcus multilocularis solute carrier family 22 0.003 0.0208 0.0264
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0048 0.0055
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0532 0.0691
Schistosoma mansoni inositol monophosphatase 0.0033 0.0239 0.0305
Toxoplasma gondii sugar transporter ST2 0.003 0.0208 0.0305
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0343 0.3728 0.5632
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0212 0.2258 0.2959
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0006 0.0089
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0612 0.2082
Brugia malayi hypothetical protein 0.003 0.0208 0.0618
Echinococcus multilocularis solute carrier family 22 0.003 0.0208 0.0264
Loa Loa (eye worm) glutaminase 0.0273 0.294 0.8037
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0208 0.0201
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.2771 0.9423
Onchocerca volvulus 0.003 0.0208 0.0838
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Loa Loa (eye worm) hypothetical protein 0.0064 0.0588 0.1594
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0184 0.1938 0.5291
Leishmania major glucose transporter, lmgt1 0.0066 0.0612 0.8663
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0612 0.8663
Entamoeba histolytica protein kinase, putative 0.0065 0.0603 1
Brugia malayi Pre-SET motif family protein 0.0026 0.0168 0.0498
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0432 0.1307
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0239 0.3378
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0048 0.0055
Schistosoma mansoni glutaminase 0.0273 0.294 0.3855
Loa Loa (eye worm) hypothetical protein 0.0016 0.0049 0.0117
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0015 0.0046 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0603 0.0784
Plasmodium vivax SET domain protein, putative 0.0026 0.0168 0.0162
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0012 0.0006 0.0104
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0603 0.0784
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.1701 0.5207
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0405 0.0523
Schistosoma mansoni hypothetical protein 0.0034 0.0255 0.0326
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1774 0.6033
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0168 0.0213
Trypanosoma brucei glucose transporter, putative 0.0066 0.0612 0.8663
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.0168 0.0213
Brugia malayi Sugar transporter family protein 0.003 0.0208 0.0618
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0112 0.0379
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0588 0.9755
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.1701 0.2226
Schistosoma mansoni alpha-glucosidase 0.014 0.1446 0.1892
Mycobacterium ulcerans glutaminase 0.0273 0.294 1
Brugia malayi jmjC domain containing protein 0.0016 0.0048 0.0128
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0208 0.0264
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0048 0.0681
Onchocerca volvulus 0.003 0.0208 0.0838
Brugia malayi hypothetical protein 0.0122 0.1247 0.3813
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0603 0.0597
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0278 0.0945
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0048 0.0063
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0588 0.1787
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0255 0.0763
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0239 0.0812
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0612 0.2082
Schistosoma mansoni glucose transporter 0.003 0.0208 0.0264
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Schistosoma mansoni sugar transporter 0.003 0.0208 0.0264
Loa Loa (eye worm) sugar transporter 0.0212 0.2258 0.6169
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.1774 0.7958
Onchocerca volvulus 0.003 0.0208 0.0838
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0343 0.3728 0.3724
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.2771 0.9423
Mycobacterium ulcerans sugar transporter 0.003 0.0208 0.0686
Echinococcus multilocularis frizzled 0.0015 0.0046 0.0052
Plasmodium vivax hexose transporter 0.0212 0.2258 0.2253
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0405 0.1358
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0405 0.1358
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0324 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Echinococcus granulosus microtubule associated protein 2 0.0688 0.7618 1
Echinococcus multilocularis smoothened 0.0343 0.3737 0.4901
Onchocerca volvulus 0.0209 0.2223 1
Echinococcus multilocularis frizzled 5 0.0015 0.0046 0.0052
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1774 0.6033
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0049 0.0056
Schistosoma mansoni glucose transport protein 0.0212 0.2258 0.2959
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0015 0.0046 0.0123
Brugia malayi hypothetical protein 0.003 0.0208 0.0618
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0112 0.0379
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0208 0.0618
Echinococcus multilocularis geminin 0.0169 0.1774 0.2322
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0023 0.0079
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0301 0.3261 1
Trypanosoma brucei glucose transporter, putative 0.0066 0.0612 0.8663
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0023 0.0328
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0006 0.0089
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0208 0.0264
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0056
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0432 0.1165
Echinococcus granulosus frizzled 0.0015 0.0046 0.0052
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0603 0.1833
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2258 0.2959
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0278 0.3932
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0612 0.8663
Onchocerca volvulus 0.003 0.0208 0.0838
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0405 0.6849
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0056
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0048 0.0042
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0023 0.0328
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0603 0.0597
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0603 0.0597
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0278 0.0744
Loa Loa (eye worm) hypothetical protein 0.0047 0.0405 0.1091
Trichomonas vaginalis inositol monophosphatase, putative 0.0033 0.0239 0.0812
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0588 1
Trichomonas vaginalis glutaminase, putative 0.0273 0.294 1
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.0707 0.0701
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0023 0.0328
Brugia malayi MH2 domain containing protein 0.0119 0.1212 0.3705
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0125 0.0404
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0208 0.6328
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1774 0.6033
Leishmania major hypothetical protein, conserved 0.0016 0.0048 0.0681
Brugia malayi Sugar transporter family protein 0.003 0.0208 0.0618
Echinococcus multilocularis solute carrier family 22 0.003 0.0208 0.0264
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0603 0.0597
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0558 0.0724
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2258 0.2959
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0278 0.0357
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0405 0.1376
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.0168 0.0213
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0006 0.0021
Trypanosoma brucei glucose transporter 1E 0.0066 0.0612 0.8663
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0056
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0048 0.0055
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0125 1
Leishmania major hypothetical protein, conserved 0.003 0.0208 0.2938
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0048 0.0055
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0603 0.0597
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0603 0.0903
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0048 0.0055
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0603 0.853
Brugia malayi hypothetical protein 0.003 0.0208 0.0618
Onchocerca volvulus 0.003 0.0208 0.0838
Echinococcus granulosus phd:f box containing protein 0.0016 0.0048 0.0055
Toxoplasma gondii sugar transporter ST3 0.003 0.0208 0.0305
Trypanosoma brucei glucose transporter, putative 0.0066 0.0612 0.8663
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0278 0.0945
Leishmania major protein kinase, putative 0.0065 0.0603 0.853
Trypanosoma brucei glucose transporter, putative 0.0066 0.0612 0.8663
Echinococcus multilocularis GPCR, family 2 0.0016 0.0049 0.0056
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0006 0.0089
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0532 0.1441
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0612 0.2082
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0061 0.0072
Onchocerca volvulus 0.003 0.0208 0.0838
Trypanosoma brucei glucose transporter 2A 0.0066 0.0612 0.8663
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0048 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0168 0.0213
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0015 0.0046 0.0109
Trypanosoma brucei glucosidase, putative 0.0036 0.0278 0.3932
Echinococcus multilocularis frizzled 0.0015 0.0046 0.0052
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0588 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0208 0.0706
Loa Loa (eye worm) hypothetical protein 0.0064 0.0588 0.1593
Trypanosoma cruzi glucose transporter, putative 0.003 0.0208 0.2938
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0603 0.0597
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0603 0.0597
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0278 0.3932
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1212 0.3303
Schistosoma mansoni glucose transport protein 0.0212 0.2258 0.2959
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0208 0.0264
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0258 0.2771 0.8495
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0405 0.0399
Echinococcus multilocularis General substrate transporter 0.0182 0.1923 0.2518
Trypanosoma brucei glucose transporter, putative 0.0066 0.0612 0.8663
Onchocerca volvulus 0.003 0.0208 0.0838
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1876 0.6382
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0532 0.0691
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1774 0.6033
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0048 0.0063
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0239 0.0812
Echinococcus multilocularis frizzled 4 0.0015 0.0046 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0208 0.0706
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0048 0.0055
Onchocerca volvulus 0.003 0.0208 0.0838
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0006 0.0089
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0278 0.0945
Toxoplasma gondii sugar transporter ST1 0.003 0.0208 0.0305
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0603 0.0597
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0532 0.0691
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0032 0.0039
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0023 0.0079
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0208 0.0551
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1876 0.6382
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0208 0.2938
Schistosoma mansoni frizzled 0.0015 0.0046 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0603 0.205
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Echinococcus multilocularis solute carrier family 22 0.003 0.0208 0.0264
Onchocerca volvulus 0.003 0.0208 0.0838
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0603 0.0597
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0023 0.0385
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0278 0.0945
Brugia malayi Sugar transporter family protein 0.0212 0.2258 0.692
Trypanosoma cruzi hexose transporter, putative 0.003 0.0208 0.2938
Brugia malayi Inositol-1 0.0033 0.0239 0.0714
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0612 0.2082
Toxoplasma gondii facilitative glucose transporter GT1 0.0212 0.2258 0.3408
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0405 1
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0405 0.5727
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0023 0.0079
Trypanosoma brucei sugar transporter, putative 0.003 0.0208 0.2938
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0239 0.3378
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0048 0.0055
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.0168 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0612 0.2082
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1774 0.6033
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.1701 0.2226
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0405 0.1224
Echinococcus granulosus solute carrier family 22 0.003 0.0208 0.0264
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0612 0.8663
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0168 0.0213
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2258 0.2959
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0278 0.461
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0588 0.0764
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0048 0.0055
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0588 0.2
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2258 0.2959
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0023 0.0079
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1774 0.6033
Onchocerca volvulus 0.003 0.0208 0.0838
Entamoeba histolytica protein kinase, putative 0.0065 0.0603 1
Plasmodium falciparum hexose transporter 0.0212 0.2258 0.2253
Echinococcus granulosus solute carrier family 22 0.003 0.0208 0.0264
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0048 0.0055
Schistosoma mansoni protein kinase 0.0065 0.0603 0.0784
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0603 0.0784
Trypanosoma cruzi sugar transporter, putative 0.003 0.0208 0.2938
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0023 0.0079
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0208 0.0305
Brugia malayi jmjC domain containing protein 0.0016 0.0048 0.0128
Echinococcus granulosus solute carrier family 22 0.003 0.0208 0.0264
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0278 0.0945
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0023 0.0079
Loa Loa (eye worm) hypothetical protein 0.0122 0.1247 0.3399
Echinococcus granulosus frizzled 0.0015 0.0046 0.0052
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0208 0.0706
Brugia malayi glutaminase DH11.1 0.0273 0.294 0.9016
Trichomonas vaginalis glucose transporter, putative 0.003 0.0208 0.0706
Loa Loa (eye worm) hypothetical protein 0.0065 0.0603 0.1634
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0208 0.0706
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.7618 1
Brugia malayi Pre-SET motif family protein 0.0184 0.1938 0.5936
Plasmodium falciparum proline--tRNA ligase 0.0074 0.0707 0.0701
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2258 0.2959
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0278 0.0411
Brugia malayi Cam kinase protein 1 0.0065 0.0603 0.1833
Loa Loa (eye worm) sugar transporter 0.003 0.0208 0.0551
Loa Loa (eye worm) hypothetical protein 0.0127 0.1307 0.3562
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0029 0.02 0.6098
Brugia malayi jmjC domain containing protein 0.0059 0.0532 0.1616
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.0168 0.0213
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Brugia malayi jmjC domain containing protein 0.0059 0.0532 0.1616
Echinococcus granulosus frizzled 5 0.0015 0.0046 0.0052
Loa Loa (eye worm) hypothetical protein 0.0122 0.1247 0.3399
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0023 0.0052
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0208 0.0686
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.7618 1
Onchocerca volvulus 0.0094 0.093 0.412
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0208 0.0264
Echinococcus granulosus frizzled 0.0015 0.0046 0.0052
Echinococcus granulosus GPCR family 2 0.0016 0.0049 0.0056
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0114
Schistosoma mansoni glucose transport protein 0.0212 0.2258 0.2959
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0033 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0114
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0603 0.0784
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0023 0.0328
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0405 0.5727
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0603 0.0903
Loa Loa (eye worm) hypothetical protein 0.0064 0.0588 0.1593
Brugia malayi major facilitator superfamily protein 0.003 0.0208 0.0618
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.2771 0.9423
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0432 0.1307
Echinococcus granulosus smoothened 0.0343 0.3737 0.4901
Schistosoma mansoni hypothetical protein 0.0212 0.2258 0.2959
Onchocerca volvulus 0.003 0.0208 0.0838
Schistosoma mansoni alpha-glucosidase 0.014 0.1446 0.1892
Plasmodium falciparum protein kinase 7 0.0599 0.6614 0.6612
Trypanosoma brucei glucose transporter, putative 0.0066 0.0612 0.8663
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0405 0.0523
Schistosoma mansoni sugar transporter 0.003 0.0208 0.0264
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0603 0.0903
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.2771 0.9423
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0324 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0208 0.6328
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0278 0.3932
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0082 0.0076
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0603 0.0784
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0015 0.0046 0.0123
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0588 0.0764
Onchocerca volvulus 0.003 0.0208 0.0838
Schistosoma mansoni protein kinase 0.0065 0.0603 0.0784
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0324 0.5469
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0025 0.0157 0.0199
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0049 0.0056
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0048 0.0681
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0278 0.0357
Schistosoma mansoni frizzled-like receptor 0.0015 0.0046 0.0052
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0405 0.0603
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0532 0.0691
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0048 0.0114
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0048 0.0681
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0603 0.0784
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.1701 0.4642
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0707 1
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0612 0.8663
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0168 0.0213
Onchocerca volvulus 0.003 0.0208 0.0838
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0603 0.0784
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0049 0.0132
Loa Loa (eye worm) RecQ helicase 0.0021 0.0112 0.0288
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0049 0.0056
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0208 0.8661
Leishmania major glucose transporter, lmgt3 0.0066 0.0612 0.8663
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0405 0.0523
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0033 0.0239 0.0792
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0603 0.1634
Schistosoma mansoni hypothetical protein 0.0169 0.1774 0.2322
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0405 0.5727
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0405 0.0523
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trichomonas vaginalis set domain proteins, putative 0.0209 0.2223 0.7561
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0532 0.0691
Onchocerca volvulus Putative transporter 0.003 0.0208 0.0838
Echinococcus granulosus General substrate transporter 0.0182 0.1923 0.2518
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0048 0.0055
Loa Loa (eye worm) hypothetical protein 0.0237 0.2542 0.6946
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0603 0.1634
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0048 0.0055
Brugia malayi jmjC domain containing protein 0.0016 0.0048 0.0128
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0278 0.0945
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.2771 0.9423
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Giardia lamblia Hexose transporter 0.003 0.0208 0.346
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0405 0.6849
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0707 1
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0558 0.0724
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.011 0.1108 0.1447
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0049 0.0056
Entamoeba histolytica hypothetical protein 0.0047 0.0405 0.6714
Schistosoma mansoni sugar transporter 0.003 0.0208 0.0264
Schistosoma mansoni inositol monophosphatase 0.0033 0.0239 0.0305
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0532 0.0691
Onchocerca volvulus 0.003 0.0208 0.0838
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0156
Trypanosoma brucei glucose transporter, putative 0.0066 0.0612 0.8663
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0707 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0707 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0006 0.0089
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0278 0.461
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0612 0.8663
Loa Loa (eye worm) inositol-1 0.0033 0.0239 0.0637
Loa Loa (eye worm) hypothetical protein 0.0052 0.0454 0.1226
Brugia malayi major facilitator superfamily protein 0.003 0.0208 0.0618
Loa Loa (eye worm) glutaminase 2 0.0273 0.294 0.8037
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0208 0.0686
Loa Loa (eye worm) hypothetical protein 0.003 0.0208 0.0551
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0612 0.2082
Schistosoma mansoni sugar transporter 0.003 0.0208 0.0264
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1212 0.3303
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0208 0.0706
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1774 0.6033
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0112 0.0323
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0239 0.3378
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0588 0.0764
Onchocerca volvulus 0.003 0.0208 0.0838
Onchocerca volvulus 0.003 0.0208 0.0838
Onchocerca volvulus Huntingtin homolog 0.0122 0.1247 0.5563
Schistosoma mansoni frizzled-like receptor 0.0015 0.0046 0.0052
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0603 0.0784
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0049 0.0117
Echinococcus multilocularis frizzled 10 0.0015 0.0046 0.0052
Giardia lamblia Sugar-proton symporter 0.003 0.0208 0.346
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0277 0.3914
Toxoplasma gondii protein kinase, putative 0.0599 0.6614 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0208 0.0686
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0588 0.1787
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0588 0.0764
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0405 0.0399
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0049 0.0132
Loa Loa (eye worm) hypothetical protein 0.0034 0.0255 0.068
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0112 0.0138
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0278 0.0834
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0208 0.0706
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Schistosoma mansoni protein kinase 0.0065 0.0603 0.0784
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0612 0.8663
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0048 0.0055
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0046
Echinococcus granulosus frizzled 4 0.0015 0.0046 0.0052
Onchocerca volvulus 0.0026 0.0168 0.066
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0033 0.0239 0.0352
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0208 0.0618
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0048 0.0055
Echinococcus granulosus inositol monophosphatase 1 0.0033 0.0239 0.0305
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0278 0.0945
Plasmodium vivax sugar transporter, putative 0.003 0.0208 0.0201
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Trichomonas vaginalis sugar transporter, putative 0.003 0.0208 0.0706
Plasmodium falciparum mitogen-activated protein kinase 2 0.0343 0.3728 0.3724
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0166 0.0437
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0339 0.1153
Schistosoma mansoni hypothetical protein 0.0169 0.1774 0.2322
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0258 0.2771 0.7573
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0034 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0212 0.2258 0.768
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0125 0.2978
Schistosoma mansoni alpha glucosidase 0.0036 0.0278 0.0357
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0278 0.0945
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0532 0.0691
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0023 0.0079
Plasmodium vivax CDK-related protein kinase 6, putative 0.09 1 1
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0012 0.0006 0.0104
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0208 0.0618
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0048 0.0055
Echinococcus multilocularis inositol monophosphatase 1 0.0033 0.0239 0.0305
Loa Loa (eye worm) hypothetical protein 0.0336 0.3657 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0239 0.3378

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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