Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Conserved hypothetical protein | 0.0231 | 0.0432 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase otk | 0.0045 | 0.0012 | 0.0015 |
Echinococcus granulosus | hemicentin 1 | 0.0045 | 0.0012 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0393 | 0.1327 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0231 | 0.0432 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0231 | 0.0432 | 0.5 |
Echinococcus granulosus | Immunoglobulin | 0.021 | 0.0384 | 0.0548 |
Echinococcus granulosus | integrin alpha 3 | 0.0114 | 0.0169 | 0.0239 |
Trichomonas vaginalis | CAMK family protein kinase | 0.135 | 0.296 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0045 | 0.0012 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0175 | 0.0591 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0213 | 0.0393 | 0.1327 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0013 | 0.0043 |
Echinococcus multilocularis | integrin alpha ps | 0.0067 | 0.0061 | 0.0086 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.1048 | 0.2278 | 0.7695 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.135 | 0.296 | 1 |
Loa Loa (eye worm) | CAMK protein kinase | 0.004 | 0.0001 | 0.0005 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0231 | 0.0432 | 0.5 |
Echinococcus multilocularis | lachesin | 0.0045 | 0.0012 | 0.0015 |
Echinococcus multilocularis | peroxidasin | 0.0045 | 0.0013 | 0.0016 |
Schistosoma mansoni | tyrosine kinase | 0.0126 | 0.0196 | 0.0195 |
Brugia malayi | Cytochrome P450 family protein | 0.0378 | 0.0765 | 0.2585 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0096 | 0.0325 |
Echinococcus granulosus | twitchin | 0.0246 | 0.0466 | 0.0666 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0045 | 0.0012 | 0.0041 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0149 | 0.0247 | 0.0835 |
Schistosoma mansoni | nephrin | 0.0049 | 0.0021 | 0.0019 |
Mycobacterium leprae | putative cytochrome p450 | 0.0231 | 0.0432 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.135 | 0.296 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.1257 | 0.2749 | 0.929 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.135 | 0.296 | 1 |
Echinococcus granulosus | aurora kinase A | 0.06 | 0.1267 | 0.1813 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0045 | 0.0012 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.0385 | 0.13 |
Toxoplasma gondii | aurora kinase | 0.06 | 0.1267 | 1 |
Echinococcus multilocularis | neuroglian | 0.0233 | 0.0436 | 0.0623 |
Echinococcus granulosus | roundabout 2 | 0.0259 | 0.0495 | 0.0706 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0049 | 0.0021 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0012 | 0.0041 |
Brugia malayi | Peroxidasin | 0.0045 | 0.0013 | 0.0043 |
Trichomonas vaginalis | CAMK family protein kinase | 0.135 | 0.296 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.021 | 0.0384 | 0.0383 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0231 | 0.0432 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.135 | 0.296 | 0.4238 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0378 | 0.0765 | 0.2585 |
Brugia malayi | cytochrome P450 | 0.0231 | 0.0432 | 0.1458 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0012 | 0.0041 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.06 | 0.1267 | 0.1813 |
Echinococcus multilocularis | Immunoglobulin | 0.021 | 0.0384 | 0.0548 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.021 | 0.0384 | 0.0383 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.06 | 0.1267 | 0.5 |
Onchocerca volvulus | 0.1004 | 0.2178 | 0.7357 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0912 | 0.1971 | 0.6661 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0049 | 0.0021 | 0.0028 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.135 | 0.296 | 0.4238 |
Echinococcus multilocularis | 0.0231 | 0.0432 | 0.0616 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.004 | 0.0001 | 0.0005 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0231 | 0.0432 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0378 | 0.0765 | 0.2585 |
Brugia malayi | hypothetical protein | 0.0338 | 0.0674 | 0.2277 |
Echinococcus multilocularis | roundabout 2 | 0.0049 | 0.0021 | 0.0028 |
Echinococcus granulosus | tyrosine protein kinase transmembrane receptor | 0.0044 | 0.0011 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0165 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.0384 | 0.1298 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0378 | 0.0765 | 0.2585 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0126 | 0.0196 | 0.0279 |
Echinococcus granulosus | integrin alpha ps | 0.0067 | 0.0061 | 0.0086 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0049 | 0.0021 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0244 | 0.0825 |
Echinococcus granulosus | defective proboscis extension response | 0.021 | 0.0384 | 0.0548 |
Schistosoma mansoni | integrin alpha-ps | 0.0067 | 0.0061 | 0.006 |
Echinococcus multilocularis | roundabout 2 | 0.0259 | 0.0495 | 0.0706 |
Schistosoma mansoni | tyrosine kinase | 0.0066 | 0.006 | 0.0059 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0049 | 0.0021 | 0.0028 |
Schistosoma mansoni | neuroglian | 0.0049 | 0.0021 | 0.0019 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0126 | 0.0196 | 0.0279 |
Schistosoma mansoni | nephrin | 0.0236 | 0.0445 | 0.0443 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0149 | 0.0248 | 0.0839 |
Schistosoma mansoni | septate junction protein | 0.0045 | 0.0012 | 0.0011 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.1257 | 0.2749 | 0.929 |
Brugia malayi | Prion-like- | 0.0045 | 0.0012 | 0.0041 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0231 | 0.0432 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0049 | 0.0021 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0021 | 0.0071 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.313 | 0.6981 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.0674 | 0.2277 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0393 | 0.1327 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0231 | 0.0432 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0012 | 0.0041 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0231 | 0.0432 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.135 | 0.296 | 1 |
Trypanosoma cruzi | aurora B kinase, putative | 0.06 | 0.1267 | 0.3304 |
Leishmania major | cytochrome p450-like protein | 0.0378 | 0.0765 | 0.1319 |
Schistosoma mansoni | integrin alpha | 0.0149 | 0.0247 | 0.0246 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.135 | 0.296 | 1 |
Brugia malayi | protein unc-22 | 0.004 | 0.0001 | 0.0005 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.135 | 0.296 | 1 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0045 | 0.0012 | 0.0036 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0049 | 0.0021 | 0.0019 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0378 | 0.0765 | 0.1319 |
Trichomonas vaginalis | CAMK family protein kinase | 0.135 | 0.296 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.135 | 0.296 | 1 |
Schistosoma mansoni | septate junction protein | 0.0045 | 0.0012 | 0.0011 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0231 | 0.0432 | 0.5 |
Echinococcus multilocularis | neurotracting:lsamp:neurotrimin:obcam | 0.0045 | 0.0012 | 0.0015 |
Schistosoma mansoni | titin | 0.0045 | 0.0012 | 0.0011 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0378 | 0.0765 | 0.2585 |
Echinococcus multilocularis | Immunoglobulin | 0.021 | 0.0384 | 0.0548 |
Loa Loa (eye worm) | TK protein kinase | 0.0149 | 0.0248 | 0.0839 |
Echinococcus multilocularis | roundabout 2 | 0.0049 | 0.0021 | 0.0028 |
Trypanosoma brucei | aurora B kinase | 0.06 | 0.1267 | 0.3304 |
Echinococcus granulosus | roundabout 2 | 0.0049 | 0.0021 | 0.0028 |
Echinococcus multilocularis | integrin alpha 3 | 0.0114 | 0.0169 | 0.0239 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0231 | 0.0432 | 0.5 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0062 | 0.0051 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.0486 | 0.1642 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0045 | 0.0012 | 0.0041 |
Trichomonas vaginalis | CAMK family protein kinase | 0.135 | 0.296 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0912 | 0.1971 | 0.6661 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0045 | 0.0012 | 0.0041 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0045 | 0.0012 | 0.0041 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0231 | 0.0432 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0231 | 0.0432 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0233 | 0.0436 | 0.0623 |
Loa Loa (eye worm) | AUR protein kinase | 0.06 | 0.1267 | 0.4281 |
Echinococcus granulosus | roundabout 2 | 0.0049 | 0.0021 | 0.0028 |
Echinococcus granulosus | peroxidasin | 0.0045 | 0.0013 | 0.0016 |
Echinococcus granulosus | contactin | 0.0049 | 0.0021 | 0.0028 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0049 | 0.0021 | 0.0071 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0213 | 0.0393 | 0.1327 |
Echinococcus granulosus | neuroglian | 0.0049 | 0.0021 | 0.0028 |
Schistosoma mansoni | protein kinase | 0.06 | 0.1267 | 0.1266 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.313 | 0.6981 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0045 | 0.0012 | 0.0041 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0049 | 0.0021 | 0.0028 |
Leishmania major | protein kinase, putative | 0.06 | 0.1267 | 0.3304 |
Brugia malayi | Cytochrome P450 family protein | 0.0231 | 0.0432 | 0.1458 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0049 | 0.0021 | 0.0028 |
Brugia malayi | serine/threonine kinase 12 | 0.06 | 0.1267 | 0.4281 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0231 | 0.0432 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.06 | 0.1267 | 0.4281 |
Echinococcus multilocularis | hemicentin 1 | 0.0045 | 0.0012 | 0.0015 |
Schistosoma mansoni | cell adhesion molecule | 0.0049 | 0.0021 | 0.0019 |
Trypanosoma brucei | polo-like protein kinase | 0.135 | 0.296 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0044 | 0.0011 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0012 | 0.0041 |
Loa Loa (eye worm) | AUR protein kinase | 0.06 | 0.1267 | 0.4281 |
Schistosoma mansoni | cell adhesion molecule | 0.0049 | 0.0021 | 0.0019 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0231 | 0.0432 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0045 | 0.0012 | 0.0041 |
Echinococcus multilocularis | neuroglian | 0.0049 | 0.0021 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.0434 | 0.1466 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.135 | 0.296 | 1 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0126 | 0.0196 | 0.0279 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.135 | 0.296 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0231 | 0.0432 | 0.5 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.023 | 0.043 | 0.1451 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0012 | 0.0041 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0231 | 0.0432 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0236 | 0.0443 | 0.0441 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.0486 | 0.1642 |
Echinococcus multilocularis | aurora kinase A | 0.06 | 0.1267 | 0.1813 |
Schistosoma mansoni | hypothetical protein | 0.0231 | 0.0432 | 0.043 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.06 | 0.1267 | 0.1813 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0126 | 0.0196 | 0.0279 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0231 | 0.0432 | 0.5 |
Brugia malayi | serine/threonine protein kinase 6 | 0.06 | 0.1267 | 0.4281 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0231 | 0.0432 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0378 | 0.0765 | 0.1319 |
Brugia malayi | hypothetical protein | 0.0213 | 0.0393 | 0.1327 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.021 | 0.0384 | 0.0383 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0231 | 0.0432 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0012 | 0.0041 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0232 | 0.0434 | 0.062 |
Echinococcus multilocularis | tyrosine protein kinase transmembrane receptor | 0.0044 | 0.0011 | 0.0013 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.004 | 0.0001 | 0.0005 |
Trichomonas vaginalis | CAMK family protein kinase | 0.135 | 0.296 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0378 | 0.0765 | 0.1319 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.06 | 0.1267 | 0.5 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0113 | 0.0165 | 0.0558 |
Schistosoma mansoni | roundabout | 0.0045 | 0.0012 | 0.0011 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0231 | 0.0432 | 0.0616 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.0384 | 0.1298 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0231 | 0.0432 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.135 | 0.296 | 1 |
Schistosoma mansoni | neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule | 0.0045 | 0.0012 | 0.0011 |
Schistosoma mansoni | cell adhesion molecule | 0.0045 | 0.0012 | 0.0011 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0378 | 0.0765 | 1 |
Echinococcus multilocularis | hemicentin 1 | 0.0045 | 0.0012 | 0.0015 |
Schistosoma mansoni | serine/threonine protein kinase | 0.06 | 0.1267 | 0.1266 |
Echinococcus multilocularis | integrin alpha ps | 0.0067 | 0.0061 | 0.0086 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.021 | 0.0384 | 0.0548 |
Echinococcus granulosus | lachesin | 0.0045 | 0.0012 | 0.0015 |
Schistosoma mansoni | serine/threonine protein kinase | 0.135 | 0.296 | 0.2958 |
Loa Loa (eye worm) | cytochrome P450 | 0.0231 | 0.0432 | 0.1458 |
Echinococcus granulosus | tyrosine protein kinase otk | 0.0045 | 0.0012 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0393 | 0.1327 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0049 | 0.0021 | 0.0071 |
Schistosoma mansoni | cytochrome P450 | 0.0231 | 0.0432 | 0.043 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.06 | 0.1267 | 0.4281 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.