TDR Targets

Basic information

Technical information

TDR Targets ID: 900878
Name: (2E)-6-acetyl-2-(1,3-benzodioxol-5-ylmethylid ene)-5-(4-dimethylaminophenyl)-7-methyl-5H-[1 ,3]thiazolo[3,2-a]pyrimidin-3-one
MW: 461.533 | Formula: C25H23N3O4S
H donors: 0 H acceptors: 2 LogP: 3.87 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)C1=C(C)N=c2n(C1c1ccc(cc1)N(C)C)c(=O)/c(=C\c1ccc3c(c1)OCO3)/s2
InChi: 1S/C25H23N3O4S/c1-14-22(15(2)29)23(17-6-8-18(9-7-17)27(3)4)28-24(30)21(33-25(28)26-14)12-16-5-10-19-20(11-16)32-13-31-19/h5-12,23H,13H2,1-4H3/b21-12+
InChiKey: YNSVEGFKKUBLIH-CIAFOILYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2E)-6-acetyl-2-(1,3-benzodioxol-5-ylmethylene)-5-(4-dimethylaminophenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-3-one
(2E)-2-(1,3-benzodioxol-5-ylmethylidene)-5-(4-dimethylaminophenyl)-6-ethanoyl-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-3-one
A1851/0077920
AG-205/37159082

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chromobox homolog 1	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Chromobox protein homolog 5, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Trypanosoma brucei gambiense	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Loa Loa (eye worm)	heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	Get druggable targets OG5_128367	All targets in OG5_128367
Echinococcus granulosus	expressed protein	Get druggable targets OG5_128367	All targets in OG5_128367
Leishmania mexicana	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Leishmania infantum	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Theileria parva	peptidyl-prolyl cis-trans isomerase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	Get druggable targets OG5_128367	All targets in OG5_128367
Leishmania braziliensis	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	Get druggable targets OG5_128367	All targets in OG5_128367
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128367	All targets in OG5_128367
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	Get druggable targets OG5_128367	All targets in OG5_128367
Echinococcus multilocularis	expressed protein	Get druggable targets OG5_128367	All targets in OG5_128367
Candida albicans	peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t	Get druggable targets OG5_128367	All targets in OG5_128367
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Theileria parva	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Neospora caninum	peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Trichomonas vaginalis	rotamase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	rotamase	Get druggable targets OG5_128367	All targets in OG5_128367
Brugia malayi	Heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Leishmania donovani	peptidyl-prolyl cis-trans isomerase/rotamase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Trichomonas vaginalis	rotamase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Candida albicans	peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t	Get druggable targets OG5_128367	All targets in OG5_128367
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Babesia bovis	peptidyl-prolyl cis-trans isomerase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Onchocerca volvulus		Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Trypanosoma congolense	peptidyl-prolyl cis-trans isomerase/rotamase, putative	Get druggable targets OG5_128367	All targets in OG5_128367
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus	Heterochromatin protein 1 homolog	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Toxoplasma gondii	peptidylprolyl isomerase	Get druggable targets OG5_128367	All targets in OG5_128367

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	163 aa	133 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0017	0.042	0.1458
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.042	0.0787
Brugia malayi	Cathepsin L-like precursor	0.0017	0.042	0.0482
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0014	0.0162	0.0152
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.042	0.0787
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.3991	0.4559
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.042	0.0787
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0012	0.003	0.0034
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0162	0.0304
Echinococcus multilocularis	cysteine protease	0.0017	0.042	0.0449
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0039	0.2046	0.232
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0045	0.2466	1
Schistosoma mansoni	sulfide quinone reductase	0.0012	0.003	0.0034
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0045	0.2466	0.2803
Plasmodium falciparum	thioredoxin reductase	0.013	0.8719	0.8715
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.042	0.0787
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.042	0.0787
Leishmania major	cathepsin L-like protease	0.0017	0.042	0.0449
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0137	0.0157
Echinococcus granulosus	expressed protein	0.004	0.2116	0.2427
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0162	0.0304
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0039	0.2046	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.013	0.8719	1
Echinococcus granulosus	Chromobox protein 3	0.0014	0.0162	0.0186
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0012	0.003	0.0055
Brugia malayi	Cathepsin L-like precursor	0.0017	0.042	0.0482
Echinococcus multilocularis	cysteine protease	0.0017	0.042	0.0449
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0045	0.2466	0.2803
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0045	0.2466	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0162	0.0186
Loa Loa (eye worm)	ctsf protein	0.0017	0.042	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0162	0.0186
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.042	0.0392
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.042	0.0787
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.004	0.2116	0.2427
Brugia malayi	glutathione reductase	0.013	0.8719	1
Mycobacterium tuberculosis	Possible methyltransferase (methylase)	0.0139	0.9381	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0162	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0162	0.0186
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.042	0.1458
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.042	0.0482
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1672	0.3132
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0012	0.003	0.0144
Schistosoma mansoni	chromobox protein	0.0014	0.0162	0.0186
Entamoeba histolytica	protein kinase, putative	0.0032	0.1516	0.741
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.2618	0.9086
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0014	0.0162	0.0186
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.3991	0.4559
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.1605	0.3008
Entamoeba histolytica	protein kinase, putative	0.0034	0.1672	0.8171
Echinococcus multilocularis	nervana 2	0.0021	0.0705	0.0777
Plasmodium vivax	vivapain-2	0.0017	0.042	0.0392
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.3991	0.4559
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0162	0.0304
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0045	0.2466	0.2443
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.042	0.0392
Brugia malayi	Cathepsin L-like precursor	0.0017	0.042	0.0482
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0051	0.2881	1
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0012	0.003	0.0144
Trichomonas vaginalis	chromobox protein, putative	0.0014	0.0162	0.0304
Schistosoma mansoni	intermediate filament proteins	0.0028	0.1196	0.1372
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0162	0.0304
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0045	0.2466	0.2605
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0162	0.0304
Echinococcus granulosus	intermediate filament protein	0.0028	0.1196	0.1372
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.042	0.0787
Trypanosoma cruzi	major cysteine proteinase, putative	0.0052	0.2955	0.3366
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0034	0.1672	0.189
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0045	0.2466	0.2605
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.042	0.1458
Plasmodium vivax	glutathione reductase, putative	0.013	0.8719	0.8715
Brugia malayi	Cathepsin L-like precursor	0.0017	0.042	0.0482
Schistosoma mansoni	glutamate synthase	0.0012	0.003	0.0034
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0014	0.0162	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0013	0.01	0.0114
Brugia malayi	chromobox protein homolog 3	0.0047	0.2618	0.3002
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1672	0.3132
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.3991	0.4559
Onchocerca volvulus		0.0012	0.003	0.0103
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0045	0.2466	0.2803
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0045	0.2466	1
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0045	0.2466	0.2803
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0012	0.003	0.0055
Schistosoma mansoni	hypothetical protein	0.0012	0.003	0.0034
Echinococcus granulosus	chromobox protein 1	0.0084	0.5337	0.6121
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.3991	0.4559
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0246	0.0282
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0045	0.2466	0.2803
Schistosoma mansoni	lamin	0.0028	0.1196	0.1372
Brugia malayi	Heterochromatin protein 1	0.0084	0.5337	0.6121
Onchocerca volvulus		0.0017	0.042	0.1458
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0014	0.0162	0.0152
Onchocerca volvulus		0.0017	0.042	0.1458
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.042	0.0449
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0162	0.0304
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0014	0.0162	0.0186
Mycobacterium ulcerans	mycolic acid synthase UmaA	0.0139	0.9381	1
Leishmania major	cathepsin L-like protease	0.0066	0.3991	0.4559
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0012	0.003	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0162	0.0186
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0162	0.0792
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.1196	0.1372
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0045	0.2466	0.2605
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0034
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0162	0.0304
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1672	0.3132
Trichomonas vaginalis	glutathione reductase, putative	0.0045	0.2466	0.462
Echinococcus granulosus	cathepsin l1	0.0017	0.042	0.0482
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0162	0.0792
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0012	0.003	0.0144
Echinococcus multilocularis	musashi	0.0028	0.1196	0.1342
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0039	0.2046	0.232
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0162	0.0304
Brugia malayi	intermediate filament protein	0.0028	0.1196	0.1372
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.042	0.0787
Echinococcus granulosus	lamin	0.0028	0.1196	0.1372
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0012	0.003	0.0055
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.013	0.8719	0.9292
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.5337	1
Trichomonas vaginalis	dihydrolipoamide dehydrogenase, putative	0.0012	0.003	0.0055
Plasmodium vivax	vivapain-2	0.0017	0.042	0.0392
Onchocerca volvulus		0.0017	0.042	0.1458
Schistosoma mansoni	disulfide oxidoreductase	0.0012	0.003	0.0034
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0045	0.2466	0.2605
Mycobacterium tuberculosis	Probable oxidoreductase	0.0045	0.2466	0.2605
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0162	0.0304
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.042	0.0787
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0014	0.0162	0.0133
Onchocerca volvulus		0.0014	0.0162	0.0562
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0012	0.003	0.0055
Brugia malayi	Protein cec-1.	0.0014	0.0162	0.0186
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0021	0.0722	0.0829
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0045	0.2466	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.3991	0.4559
Trichomonas vaginalis	Heterochromatin protein, putative	0.0014	0.0162	0.0304
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0045	0.2466	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0162	0.0186
Schistosoma mansoni	glutamate synthase	0.0012	0.003	0.0034
Trichomonas vaginalis	hypothetical protein	0.0014	0.0162	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1868	0.2143
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.0012	0.003	0.0034
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0012	0.003	0.0144
Brugia malayi	Cathepsin L-like precursor	0.0017	0.042	0.0482
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0034	0.1672	0.1917
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.042	0.0482
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0162	0.0304
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.2881	0.5399
Plasmodium vivax	hypothetical protein, conserved	0.0014	0.0162	0.0133
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.1196	0.1372
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0045	0.2466	0.2828
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0039	0.2046	0.232
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.042	0.0787
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0012	0.003	0.0055
Leishmania major	cathepsin L-like protease	0.0017	0.042	0.0449
Brugia malayi	p70 ribosomal S6 kinase beta	0.0032	0.1516	0.1739
Plasmodium falciparum	glutathione reductase	0.0045	0.2466	0.2443
Echinococcus granulosus	serine threonine protein kinase nrc	0.0021	0.0722	0.0829
Schistosoma mansoni	chromobox protein	0.0084	0.5337	0.6121
Plasmodium vivax	hypothetical protein, conserved	0.0014	0.0162	0.0133
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0045	0.2466	0.2803
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0045	0.2466	0.2443
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0045	0.2466	0.2803
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.006	0.3571	0.4075
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0033	0.1585	0.1818
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0162	0.0792
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0024	0.0878	0.4292
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.042	0.0482
Schistosoma mansoni	lamin	0.0028	0.1196	0.1372
Brugia malayi	SET domain containing protein	0.0014	0.0162	0.0186
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0032	0.1516	0.1739
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0162	0.0304
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.042	0.0482
Toxoplasma gondii	PPIC-type PPIASE domain-containing protein	0.0012	0.0051	0.0025
Trypanosoma cruzi	trypanothione reductase, putative	0.013	0.8719	1
Echinococcus granulosus	chromobox protein 1	0.0084	0.5337	0.6121
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.004	0.2116	0.2427
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0045	0.2466	0.2803
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0021	0.0722	0.0797
Toxoplasma gondii	AGC kinase	0.0032	0.1516	0.1711
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0162	0.0304
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0045	0.2466	0.2803
Trichomonas vaginalis	chromobox protein, putative	0.0014	0.0162	0.0304
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0045	0.2466	0.2443
Plasmodium vivax	thioredoxin reductase, putative	0.013	0.8719	0.8715
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0045	0.2466	0.2828
Echinococcus multilocularis	lamin dm0	0.0028	0.1196	0.1342
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.1196	0.1372
Treponema pallidum	NADH oxidase	0.0045	0.2466	1
Wolbachia endosymbiont of Brugia malayi	parvulin-like peptidyl-prolyl isomerase, PPID	0.0012	0.0051	0.0089
Brugia malayi	M-phase phosphoprotein, mpp8	0.0014	0.0162	0.0186
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.3991	0.4559
Loa Loa (eye worm)	programmed cell death 8	0.0012	0.003	0.0034
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1672	0.3132
Schistosoma mansoni	serine/threonine-protein kinase	0.0024	0.0878	0.1007
Giardia lamblia	Kinase, AGC PKA	0.0021	0.0722	0.2845
Entamoeba histolytica	disulphide oxidoreductase, putative	0.0012	0.003	0.0144
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.0012	0.003	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0162	0.0304
Toxoplasma gondii	cathepsin CPL	0.0017	0.042	0.0449
Echinococcus multilocularis	chromobox protein 1	0.0084	0.5337	0.6108
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0024	0.0878	0.0977
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.042	0.2053
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.042	0.0392
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0021	0.0722	0.0695
Trypanosoma cruzi	trypanothione reductase, putative	0.0045	0.2466	0.2803
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0162	0.0304
Loa Loa (eye worm)	heterochromatin protein 1	0.0084	0.5337	0.6121
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0012	0.003	0.0055
Brugia malayi	Associated with TFs and helicases family protein	0.0014	0.0162	0.0186
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0045	0.2466	0.2443
Echinococcus granulosus	nervana 2	0.0021	0.0705	0.0809
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0014	0.0162	0.0186
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.042	0.0449
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.042	0.0787
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0039	0.2046	0.232
Brugia malayi	Cathepsin L-like precursor	0.0017	0.042	0.0482
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.042	0.0787
Trichomonas vaginalis	chromobox protein, putative	0.0014	0.0162	0.0304
Brugia malayi	hypothetical protein	0.0014	0.0162	0.0186
Brugia malayi	Protein kinase domain containing protein	0.0034	0.1672	0.1917
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0162	0.0186
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0137	0.0124
Entamoeba histolytica	cysteine protease, putative	0.0017	0.042	0.2053
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1672	0.3132
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0045	0.2466	0.2803
Onchocerca volvulus		0.0028	0.1196	0.4151
Trichomonas vaginalis	rotamase, putative	0.0039	0.2046	0.3833
Plasmodium falciparum	glutathione reductase	0.013	0.8719	0.8715
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0012	0.0051	0.0025
Echinococcus multilocularis	Glutaredoxin protein 5	0.0021	0.0705	0.0777
Leishmania major	cathepsin L-like protease	0.0017	0.042	0.0449
Trichomonas vaginalis	mercuric reductase, putative	0.0045	0.2466	0.462
Toxoplasma gondii	NADPH-glutathione reductase	0.0045	0.2466	0.2803
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.042	0.0449
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.2618	0.4905
Entamoeba histolytica	pyridine nucleotide-disulfide oxidoreductase family protein	0.0012	0.003	0.0144
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0012	0.003	0.0034
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0014	0.0162	0.0152
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0014	0.0162	0.0133
Entamoeba histolytica	protein kinase 2, putative	0.0021	0.0722	0.3531
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.042	0.0787
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.042	0.2053
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0045	0.2466	0.2605
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.042	0.0787
Leishmania major	cathepsin L-like protease	0.0066	0.3991	0.4559
Toxoplasma gondii	peptidylprolyl isomerase	0.0039	0.2046	0.232
Entamoeba histolytica	protein kinase, putative	0.0034	0.1672	0.8171
Echinococcus multilocularis	rac serine:threonine kinase	0.0024	0.0878	0.0977
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.3991	0.4559
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0012	0.003	0.0034
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0045	0.2466	0.2803
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0012	0.0051	0.0025
Echinococcus multilocularis	Chromobox protein 3	0.0014	0.0162	0.0152
Loa Loa (eye worm)	CHromoDomain protein family member	0.0014	0.0162	0.0186
Echinococcus granulosus	chromobox protein 2	0.0014	0.0162	0.0186
Onchocerca volvulus		0.0028	0.1196	0.4151
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0162	0.0186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.042	0.0787
Leishmania major	cathepsin L-like protease	0.0017	0.042	0.0449
Schistosoma mansoni	serine/threonine-protein kinase	0.0024	0.0878	0.1007
Mycobacterium ulcerans	methyltransferase	0.0139	0.9381	1
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.042	0.1458
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.042	0.0787
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.042	0.0449
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0045	0.2466	0.2605
Schistosoma mansoni	chromobox protein	0.0014	0.0162	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0017	0.042	0.0482
Trichomonas vaginalis	glutamate synthase, putative	0.0012	0.003	0.0055
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0021	0.0722	0.0797
Brugia malayi	glutamate synthase	0.0012	0.003	0.0034
Onchocerca volvulus		0.0017	0.042	0.1458
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2618	0.3002
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.042	0.0449
Plasmodium falciparum	heterochromatin protein 1	0.0014	0.0162	0.0133
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.3991	0.4559
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.042	0.0787
Leishmania major	cathepsin L-like protease	0.0066	0.3991	0.4559
Brugia malayi	Thioredoxin reductase	0.013	0.8719	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0045	0.2466	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.3991	0.4559
Echinococcus granulosus	Chromo domain	0.0014	0.0162	0.0186
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0045	0.2466	0.2803
Plasmodium falciparum	thioredoxin reductase	0.0045	0.2466	0.2443
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0014	0.0162	0.0186
Onchocerca volvulus		0.0017	0.042	0.1458
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0021	0.0705	0.0809
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0045	0.2466	0.2828
Onchocerca volvulus		0.0017	0.042	0.1458
Loa Loa (eye worm)	glutathione reductase	0.013	0.8719	1
Echinococcus multilocularis	chromobox protein 1	0.0084	0.5337	0.6108
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0162	0.0304
Onchocerca volvulus		0.0037	0.1868	0.6485
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.3991	0.4559
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0162	0.0304
Trypanosoma cruzi	Protein kinase B	0.0024	0.0878	0.0977
Loa Loa (eye worm)	helicase	0.0014	0.0162	0.0186
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0012	0.003	0.0055
Schistosoma mansoni	sulfide quinone reductase	0.0012	0.003	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0028	0.1196	0.1372
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.042	0.0787
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0162	0.0304
Entamoeba histolytica	hypothetical protein	0.0014	0.0162	0.0792
Toxoplasma gondii	thioredoxin reductase	0.013	0.8719	1
Plasmodium vivax	heterochromatin protein 1, putative	0.0014	0.0162	0.0133
Trypanosoma brucei	trypanothione reductase	0.013	0.8719	1
Echinococcus granulosus	glutamate synthase	0.0012	0.003	0.0034
Brugia malayi	Valyl-tRNA synthetase	0.0014	0.0162	0.0186
Entamoeba histolytica	hypothetical protein	0.0014	0.0162	0.0792
Mycobacterium tuberculosis	Possible mycolic acid synthase UmaA	0.0139	0.9381	1
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0014	0.0162	0.0186
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0014	0.0162	0.0152
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0021	0.0705	0.0777
Echinococcus granulosus	nervana 2	0.0021	0.0705	0.0809
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0012	0.0051	0.0025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.042	0.0787
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.0116	0.0218
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.2618	0.4905
Brugia malayi	CHD4 protein	0.0014	0.0162	0.0186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.042	0.0787
Echinococcus multilocularis	Chromo domain	0.0014	0.0162	0.0152
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0162	0.0304
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.2881	0.5399
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0033	0.1585	0.1818
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1672	0.3132
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.042	0.0449
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0045	0.2466	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0162	0.0186
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0045	0.2466	0.2803
Echinococcus granulosus	lamin dm0	0.0028	0.1196	0.1372
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.0012	0.0051	0.0025
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0045	0.2466	1
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.1605	0.3008
Plasmodium vivax	phosphoethanolamine N-methyltransferase	0.0148	1	1
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0021	0.0722	0.0695
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.5337	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0012	0.003	0.0034
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.0012	0.003	0.0034
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.0012	0.003	0.0034
Trichomonas vaginalis	glutamate synthase, putative	0.0012	0.003	0.0055
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.042	0.0482
Echinococcus granulosus	Glutaredoxin protein 5	0.0021	0.0705	0.0809
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0012	0.003	0.0055
Echinococcus multilocularis	lamin	0.0028	0.1196	0.1342
Schistosoma mansoni	rotamase	0.004	0.2116	0.2427
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0014	0.0162	0.0152
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0246	0.0282
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0162	0.0186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.042	0.0787
Echinococcus granulosus	serine/threonine protein kinase	0.0024	0.0878	0.1007
Loa Loa (eye worm)	hypothetical protein	0.0013	0.01	0.0114
Entamoeba histolytica	thioredoxin reductase, putative	0.0012	0.003	0.0144
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0162	0.0304
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.042	0.0482
Loa Loa (eye worm)	fibroinase	0.0017	0.042	0.0482
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.042	0.0787
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1672	0.3132
Echinococcus granulosus	thioredoxin glutathione reductase	0.013	0.8719	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0162	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1159	0.1329
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.042	0.0482
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0012	0.003	0.0055
Entamoeba histolytica	hypothetical protein	0.0014	0.0162	0.0792
Echinococcus multilocularis	expressed protein	0.004	0.2116	0.2401
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.0012	0.003	0.0034
Onchocerca volvulus		0.0014	0.0162	0.0562
Loa Loa (eye worm)	cysteine protease	0.0017	0.042	0.0482
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.042	0.0787
Schistosoma mansoni	chromobox protein	0.0084	0.5337	0.6121
Echinococcus multilocularis	chromobox protein 2	0.0014	0.0162	0.0152
Leishmania major	trypanothione reductase	0.013	0.8719	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0024	0.0878	0.4292
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.3991	0.4559
Schistosoma mansoni	hypothetical protein	0.0014	0.0162	0.0186
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.2116	0.3964
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.042	0.0787
Echinococcus multilocularis	nervana 2	0.0021	0.0705	0.0777
Leishmania major	cathepsin L-like protease	0.0017	0.042	0.0449
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.3991	0.4559
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0012	0.003	0.0034
Schistosoma mansoni	glutamate synthase	0.0012	0.003	0.0034
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0045	0.2466	0.2803
Onchocerca volvulus		0.0014	0.0162	0.0562
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0045	0.2466	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0137	0.0157
Loa Loa (eye worm)	thioredoxin reductase	0.013	0.8719	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.3991	0.4559
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0162	0.0304
Trichomonas vaginalis	rotamase, putative	0.004	0.2116	0.3964
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.042	0.0787
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.3991	0.4559

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	7.9433 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	26.6795 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3189807
Search by Saint Jude

Bibliographic References

No literature references available for this target.

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Detailed information for compound 900878