Detailed information for compound 901416

Basic information

Technical information
  • TDR Targets ID: 901416
  • Name: 108790-76-7
  • MW: 208.3 | Formula: C12H20N2O
  • H donors: 0 H acceptors: 1 LogP: 0.81 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C2(C)CN3CC1(C)CN(C2)C3(C)C
  • InChi: 1S/C12H20N2O/c1-10(2)13-5-11(3)6-14(10)8-12(4,7-13)9(11)15/h5-8H2,1-4H3
  • InChiKey: ZSYSVGAURGYYKV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,2,5,7-Tetramethyl-1,3-diaza-tricyclo[3.3.1.1*3,7*]decan-6-one
  • BB_NC-0317
  • AE-848/31945019
  • STK285654
  • Oprea1_097708
  • 2,2,5,7-Tetramethyl-1,3-diazatricyclo(3.3.1.1(sup 3,7))decan-6-one
  • BAS 00334683
  • 1,3-Diazadamantan-6-one, 2,2,5,7-tetramethyl-
  • 1,3-Diazatricyclo(3.3.1.1(sup 3,7))decan-6-one, 2,2,5,7-tetramethyl-
  • Oprea1_077871

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis pten, drome, putative 0.0076 0.0237 0.049
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.0237 0.0148
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0076 0.0237 0.0305
Toxoplasma gondii NAC domain-containing protein 0.0072 0.0213 0.0862
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0076 0.0237 0.0305
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0076 0.0237 0.0305
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.0237 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0213 0.0417
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Onchocerca volvulus 0.0543 0.2934 0.4259
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0147 0.0188
Mycobacterium ulcerans hypothetical protein 0.0085 0.029 0.1019
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0543 0.2934 0.2934
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Toxoplasma gondii melibiase subfamily protein 0.0106 0.0411 0.209
Brugia malayi hypothetical protein 0.032 0.1643 0.2341
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0106 0.0411 0.0411
Echinococcus multilocularis transcription factor btf3 0.0072 0.0213 0.0213
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0138 0.0596 0.0596
Schistosoma mansoni hypothetical protein 0.0085 0.029 0.0373
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0136 0.0174
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0136 0.0174
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1251 0.7018 0.7018
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0076 0.0237 0.0305
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0543 0.2934 0.4181
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0071 0.0206 0.0395
Brugia malayi endonuclease G, mitochondrial precursor 0.0326 0.1682 0.2396
Brugia malayi hypothetical protein 0.0076 0.0237 0.0338
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0161 0.0726 0.0933
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0075 0.0096
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0085 0.029 0.0373
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0085 0.029 0.0083
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0076 0.0237 0.0305
Brugia malayi AEL166Cp 0.0085 0.029 0.0413
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3396 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0147 0.0188
Echinococcus granulosus transcription factor btf3 0.0072 0.0213 0.0274
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0543 0.2934 0.2934
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0543 0.2934 0.3771
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0411 0.0528
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0161 0.0726 0.0726
Onchocerca volvulus 0.1173 0.657 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0076 0.0237 0.0305
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0085 0.029 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3396 1
Giardia lamblia Protein tyrosine phosphatase 0.0076 0.0237 0.0556
Loa Loa (eye worm) hypothetical protein 0.0099 0.0369 0.0339
Schistosoma mansoni hypothetical protein 0.0192 0.0906 0.1165
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0085 0.029 0.0083
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0085 0.029 0.029
Echinococcus granulosus neuropeptide receptor A26 0.0959 0.5336 0.6858
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.0237 0.0148
Brugia malayi Melibiase family protein 0.0071 0.0206 0.0294
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0076 0.0237 0.0305
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Brugia malayi Protein-tyrosine phosphatase 0.0089 0.0309 0.044
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0239 0.5
Brugia malayi hypothetical protein 0.0085 0.029 0.0413
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0239 0.5
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0147 0.041
Loa Loa (eye worm) hypothetical protein 0.0543 0.2934 0.4067
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0076 0.0237 0.0305
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0239 0.0307
Brugia malayi beta-NAC-like protein 0.0072 0.0213 0.0304
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0085 0.029 1
Brugia malayi Probable ClpP-like protease 0.0077 0.0239 0.034
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0076 0.0237 0.0305
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0161 0.0726 0.0933
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0411 0.0528
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0089 0.0309 0.0397
Echinococcus multilocularis sortilin receptor 0.0062 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0071 0.0206 0.0102
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0161 0.0726 0.0726
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0085 0.029 0.0373
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.0237 0.0148
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0326 0.1682 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0136 0.0174
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0151 0.0667 0.0667
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0543 0.2934 0.2934
Treponema pallidum fructose-bisphosphate aldolase 0.0623 0.3396 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0411 0.0528
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0206 0.0265
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.0237 0.0148
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3396 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0543 0.2934 0.3771
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0151 0.0667 0.0772
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0543 0.2934 0.3771
Echinococcus multilocularis hypothetical protein 0.0076 0.0237 0.0237
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0089 0.0309 0.0397
Plasmodium vivax basic transcription factor 3b, putative 0.0072 0.0213 0.8442
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0206 0.0265
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1251 0.7018 1
Schistosoma mansoni microtubule-associated protein tau 0.1383 0.7781 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Loa Loa (eye worm) hypothetical protein 0.0085 0.029 0.0224
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3396 1
Echinococcus multilocularis 0.0076 0.0237 0.0237
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0076 0.0237 0.0148
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.0237 0.0148
Loa Loa (eye worm) hypothetical protein 0.0085 0.029 0.0224
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0089 0.0309 0.0397
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Echinococcus multilocularis neuropeptide receptor A26 0.0959 0.5336 0.5336
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Loa Loa (eye worm) hypothetical protein 0.0077 0.0239 0.015
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.0237 0.0148
Trypanosoma brucei endonuclease G, putative 0.0326 0.1682 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0543 0.2934 0.3771
Echinococcus granulosus Endonuclease G 0.0326 0.1682 0.2161
Brugia malayi jmjC domain containing protein 0.0059 0.0136 0.0193
Echinococcus granulosus protein tyrosine phosphatase n9 0.0076 0.0237 0.0305
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0161 0.0726 0.0933
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Brugia malayi hypothetical protein 0.0076 0.0237 0.0338
Schistosoma mansoni protein tyrosine phosphatase 0.0076 0.0237 0.0305
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0239 0.0307
Schistosoma mansoni protein tyrosine phosphatase 0.0089 0.0309 0.0397
Trypanosoma brucei protein tyrosine phosphatase 1 0.0076 0.0237 0.0165
Plasmodium falciparum basic transcription factor 3b, putative 0.0072 0.0213 0.6778
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0458 0.2441 0.2441
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.0237 0.0148
Echinococcus multilocularis tumor protein p63 0.0677 0.3706 0.3706
Schistosoma mansoni transcription factor btf3 0.0072 0.0213 0.0274
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0085 0.029 0.0523
Onchocerca volvulus 0.0138 0.0596 0.0566
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0085 0.029 0.0083
Loa Loa (eye worm) protein tyrosine phosphatase 0.0076 0.0237 0.0148
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0076 0.0237 0.0237
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0543 0.2934 0.2934
Brugia malayi jmjC domain containing protein 0.0059 0.0136 0.0193
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0076 0.0237 0.0699
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0085 0.029 0.029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3396 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Loa Loa (eye worm) ICD-1 protein 0.0072 0.0213 0.0113
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1251 0.7018 0.9019
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0147 0.0147
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0138 0.0596 0.2606
Echinococcus multilocularis geminin 0.0192 0.0906 0.0906
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0458 0.2441 0.3137
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0147 0.0448
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0151 0.0667 0.0857
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0136 0.0174
Giardia lamblia Fructose-bisphosphate aldolase 0.0623 0.3396 1
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0085 0.029 0.0413
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0543 0.2934 0.3771
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0239 0.7849
Echinococcus granulosus geminin 0.0192 0.0906 0.1165
Loa Loa (eye worm) hypothetical protein 0.032 0.1643 0.219
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0076 0.0237 0.0699
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Echinococcus granulosus tumor protein p63 0.0677 0.3706 0.4763
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Brugia malayi hypothetical protein 0.0076 0.0237 0.0338
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0085 0.029 0.029
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0076 0.0237 0.0305
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0326 0.1682 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0214 0.0114
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0076 0.0237 0.0237
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.1173 0.657 0.935
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0136 0.0174
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0076 0.0237 0.0305
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Schistosoma mansoni endonuclease related 0.0326 0.1682 0.2161
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0239 0.1038
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.0237 0.0148
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0136 0.0136
Entamoeba histolytica hypothetical protein 0.0072 0.0213 0.0628
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0213 0.0417
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0138 0.0596 0.0596
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1251 0.7018 0.9019
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0085 0.029 0.0854
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1251 0.7018 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0076 0.0237 0.0237
Echinococcus multilocularis transferase 0.0085 0.029 0.029
Trypanosoma brucei endonuclease G, putative 0.0326 0.1682 1
Schistosoma mansoni hypothetical protein 0.0085 0.029 0.0373
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0326 0.1682 1
Echinococcus granulosus transferase 0.0085 0.029 0.0373
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0076 0.0237 0.0305
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0623 0.3396 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0076 0.0237 0.0237
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0089 0.0309 0.0309
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0076 0.0237 0.0237
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0138 0.0596 0.2606
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0164 0.0742 0.0742
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0543 0.2934 0.2934
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0076 0.0237 0.0305
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0239 0.1021
Brugia malayi hypothetical protein 0.0076 0.0237 0.0338
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0151 0.0667 0.0667
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0326 0.1682 1
Brugia malayi Thrombospondin type 1 domain containing protein 0.1173 0.657 0.9362
Schistosoma mansoni protein tyrosine phosphatase 0.0076 0.0237 0.0305
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0543 0.2934 0.3771
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0543 0.2934 0.3771
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0076 0.0237 0.0237
Schistosoma mansoni hypothetical protein 0.0085 0.029 0.0373
Echinococcus multilocularis neuropeptide s receptor 0.0959 0.5336 0.5336
Schistosoma mansoni hypothetical protein 0.0085 0.029 0.0373
Trypanosoma brucei endonuclease G, putative 0.0326 0.1682 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.0237 0.0148
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0076 0.0237 0.0305
Leishmania major ethanolamine phosphotransferase, putative 0.0085 0.029 0.0934
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0369 0.0474
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.0237 0.0148
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0305 0.1555 1
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0106 0.0411 0.0528
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0085 0.029 0.0854
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0213 0.0417
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0076 0.0237 0.0338
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Echinococcus multilocularis Endonuclease G 0.0326 0.1682 0.1682
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0076 0.0237 0.0237
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0147 0.0188
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0411 0.0528
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Brugia malayi Protein-tyrosine phosphatase 1 0.0076 0.0237 0.0338
Loa Loa (eye worm) acetyltransferase 0.0164 0.0742 0.0882
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0623 0.3396 1
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0076 0.0237 0.0148
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0239 0.0654
Schistosoma mansoni hypothetical protein 0.1173 0.657 0.8443
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0161 0.0726 0.0726
Brugia malayi Protein-tyrosine phosphatase 0.0076 0.0237 0.0338
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0076 0.0237 0.0305
Onchocerca volvulus 0.0543 0.2934 0.4259
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0076 0.0237 0.0237
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3396 1
Entamoeba histolytica transcription factor BTF3, putative 0.0072 0.0213 0.0628
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Brugia malayi acetyltransferase, GNAT family protein 0.0164 0.0742 0.1058
Loa Loa (eye worm) hypothetical protein 0.0458 0.2441 0.335
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3396 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0085 0.029 0.029
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0085 0.029 0.0713
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.0237 0.0148
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0085 0.029 0.0373
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0076 0.0237 0.0699
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0239 0.1021
Brugia malayi hypothetical protein 0.0085 0.029 0.0413
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0085 0.029 0.029
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0085 0.029 0.0083
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0076 0.0237 0.0148
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0085 0.029 0.0224
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0076 0.0237 0.0305
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0052 0.0152
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Echinococcus multilocularis microtubule associated protein 2 0.1383 0.7781 0.7781
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0086 0.0111
Brugia malayi hypothetical protein 0.0076 0.0237 0.0338
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0305 0.1555 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0164 0.0742 0.0954
Echinococcus granulosus microtubule associated protein 2 0.1383 0.7781 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0076 0.0237 0.0165
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0076 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Loa Loa (eye worm) hypothetical protein 0.0085 0.029 0.0224
Loa Loa (eye worm) hypothetical protein 0.0085 0.029 0.0224
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0076 0.0237 0.0305
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0543 0.2934 0.3771
Onchocerca volvulus 0.0099 0.0369 0.0207
Trypanosoma cruzi endonuclease G, putative 0.0326 0.1682 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0106 0.0411 0.0411
Echinococcus multilocularis ectonucleotide 0.0458 0.2441 0.2441
Loa Loa (eye worm) hypothetical protein 0.0543 0.2934 0.4067
Echinococcus granulosus neuropeptide s receptor 0.0959 0.5336 0.6858
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0151 0.0667 0.0857
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0086 0.0086
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0239 0.5
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0239 0.0654
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0076 0.0237 0.0305
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0076 0.0237 0.0237
Echinococcus granulosus histone acetyltransferase KAT2B 0.0159 0.0716 0.092
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.0237 0.0148
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0543 0.2934 0.2934
Echinococcus granulosus ectonucleotide 0.0458 0.2441 0.3137
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0076 0.0237 0.0305
Loa Loa (eye worm) hypothetical protein 0.0543 0.2934 0.4067
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0543 0.2934 0.3771
Onchocerca volvulus 0.032 0.1643 0.2219
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0138 0.0596 0.0849
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.0237 0.0148
Leishmania major endonuclease G, putative 0.0326 0.1682 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0076 0.0237 0.0237
Leishmania major tyrosine specific protein phosphatase, putative 0.0138 0.0596 0.2927
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0305 0.1555 1
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0089 0.0309 0.0397
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0076 0.0237 0.0305
Mycobacterium leprae hypothetical protein 0.0085 0.029 0.1387
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0076 0.0237 0.0592
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0076 0.0237 0.0305
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0138 0.0596 0.0596
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0076 0.0237 0.0237
Schistosoma mansoni hypothetical protein 0.0192 0.0906 0.1165
Schistosoma mansoni pcd6 interacting protein-related 0.0076 0.0237 0.0305
Trypanosoma cruzi endonuclease G, putative 0.0326 0.1682 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0226 0.0132
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0076 0.0237 0.0305
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0148
Leishmania major basic transcription factor 3a, putative 0.0072 0.0213 0.0434
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3396 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.0237 0.0338

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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