Detailed information for compound 912773

Basic information

Technical information
  • TDR Targets ID: 912773
  • Name: 5-[2-[5-(4-fluorophenyl)-3-thiophen-2-yl-4,5- dihydropyrazol-1-yl]-2-oxoethoxy]-2-methyl-3, 4-dihydroisoquinolin-1-one
  • MW: 463.524 | Formula: C25H22FN3O3S
  • H donors: 0 H acceptors: 2 LogP: 4.01 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C1CC(=NN1C(=O)COc1cccc2c1CCN(C2=O)C)c1cccs1
  • InChi: 1S/C25H22FN3O3S/c1-28-12-11-18-19(25(28)31)4-2-5-22(18)32-15-24(30)29-21(16-7-9-17(26)10-8-16)14-20(27-29)23-6-3-13-33-23/h2-10,13,21H,11-12,14-15H2,1H3
  • InChiKey: YMMHRANYIBCBQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[2-[5-(4-fluorophenyl)-3-(2-thienyl)-4,5-dihydropyrazol-1-yl]-2-oxo-ethoxy]-2-methyl-3,4-dihydroisoquinolin-1-one
  • 5-[2-[5-(4-fluorophenyl)-3-(2-thienyl)-4,5-dihydropyrazol-1-yl]-2-oxoethoxy]-2-methyl-3,4-dihydroisoquinolin-1-one
  • 5-[2-[5-(4-fluorophenyl)-3-(2-thienyl)-4,5-dihydropyrazol-1-yl]-2-keto-ethoxy]-2-methyl-3,4-dihydroisocarbostyril
  • 5-[2-[5-(4-fluorophenyl)-3-thiophen-2-yl-4,5-dihydropyrazol-1-yl]-2-oxo-ethoxy]-2-methyl-3,4-dihydroisoquinolin-1-one
  • MLS000723108
  • SMR000236098

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0061 0.041 0.041
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0099 0.0914
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0038 0.0232
Echinococcus granulosus hypothetical protein 0.0603 0.4438 0.4438
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.002 0.002
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0099 0.2431
Echinococcus multilocularis neuropeptide s receptor 0.0444 0.3259 0.3259
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0104 0.6796
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0013 0.0075
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0151 0.3827
Brugia malayi steroid hormone receptor 0.0011 0.0038 0.0232
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0147 0.0895
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0038 0.0038
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0096 0.0669 0.4066
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0038 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0056 0.5221
Echinococcus multilocularis microtubule associated protein 2 0.1351 1 1
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.013 0.0924 0.0924
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0013 0.0079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0104 0.1513
Plasmodium falciparum thioredoxin reductase 0.002 0.0104 0.2566
Schistosoma mansoni hypothetical protein 0.0074 0.0506 0.0506
Plasmodium falciparum thioredoxin reductase 0.0057 0.0382 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0368 0.2235
Entamoeba histolytica hypothetical protein 0.0035 0.0214 0.3094
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0013 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0038 0.0232
Echinococcus multilocularis dual specificity 0.0096 0.0673 0.0673
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0038 0.0038
Leishmania major hypothetical protein, conserved 0.0026 0.0151 0.2097
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0232
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0761 0.4622
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0761 0.4622
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0104 0.1513
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0013 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0056 0.5221
Echinococcus granulosus tumor protein p63 0.0408 0.299 0.299
Toxoplasma gondii thioredoxin reductase 0.0057 0.0382 0.4794
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0368 0.0368
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0056 0.5221
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0925 0.8949
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0382 0.3661
Echinococcus granulosus GPCR family 2 0.0034 0.0211 0.0211
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0038 0.0038
Echinococcus granulosus neuropeptide s receptor 0.0444 0.3259 0.3259
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0038 0.0038
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.001 0.0711
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0603
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0038 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0013 0.0079
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1034 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0925 0.8941
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0056 0.5221
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0013 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0232
Schistosoma mansoni coup transcription factor 0.0011 0.0038 0.0038
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.084 0.6204 0.6204
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0104 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0038 0.0232
Loa Loa (eye worm) hypothetical protein 0.0148 0.1057 0.6422
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0038 0.0232
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.006 0.0401 0.2437
Schistosoma mansoni tar DNA-binding protein 0.0061 0.041 0.041
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0038 0.0232
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0104 0.1513
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0232
Treponema pallidum NADH oxidase 0.002 0.0104 0.5
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0104 0.0104
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0013 0.0075
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0013 0.0013
Schistosoma mansoni cpg binding protein 0.0059 0.0393 0.0393
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0104 0.1513
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0711
Schistosoma mansoni myst-related protein 0.0007 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0038 0.0232
Entamoeba histolytica protein kinase, putative 0.0096 0.0673 1
Onchocerca volvulus 0.0046 0.0302 0.2089
Brugia malayi RNA binding protein 0.0061 0.041 0.2488
Plasmodium vivax glutathione reductase, putative 0.0057 0.0382 1
Schistosoma mansoni hypothetical protein 0.0034 0.0211 0.0211
Loa Loa (eye worm) TAR-binding protein 0.0061 0.041 0.2488
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0038 0.0232
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0925 0.8949
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0038 0.0232
Schistosoma mansoni hypothetical protein 0.0514 0.3776 0.3776
Loa Loa (eye worm) hypothetical protein 0.0148 0.1057 0.6422
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.0673 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0104 0.1187
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0065 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0038 0.0232
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0382 0.2319
Entamoeba histolytica hypothetical protein 0.0035 0.0214 0.3094
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0056 0.5221
Schistosoma mansoni beta-catenin 0.0195 0.1404 0.1404
Plasmodium falciparum glutathione reductase 0.0057 0.0382 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0056 0.5221
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0211 0.0211
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0013 0.0075
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0211 0.0211
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0013 0.0151
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0092 0.0558
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0038 0.0232
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0104 0.1513
Schistosoma mansoni microtubule-associated protein tau 0.1351 1 1
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0104 0.1187
Loa Loa (eye worm) hypothetical protein 0.0026 0.0147 0.0895
Echinococcus multilocularis protein pangolin J 0.013 0.0924 0.0924
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0214 0.0214
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0104 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0368 0.0368
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0147 0.1316
Schistosoma mansoni cpg binding protein 0.0062 0.0417 0.0417
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0925 0.8949
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0013 0.0997
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0104 0.0104
Loa Loa (eye worm) RNA binding protein 0.0061 0.041 0.2488
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0232
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0104 0.2476
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.013 0.0924 0.0924
Echinococcus granulosus geminin 0.0514 0.3776 0.3776
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0056 0.5221
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0056 0.5221
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0038 0.0232
Brugia malayi hypothetical protein 0.0035 0.0214 0.1301
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0038 0.0038
Onchocerca volvulus Cirhin homolog 0.0193 0.1395 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0214 0.0214
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0104 0.0963
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0013 0.0075
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0038 0.0232
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0091 0.0839
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0104 0.1513
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0038 0.0038
Brugia malayi glutathione reductase 0.0057 0.0382 0.2319
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0038 0.0038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0104 0.1513
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0096 0.0673 0.4088
Schistosoma mansoni hypothetical protein 0.0034 0.0211 0.0211
Loa Loa (eye worm) HMG box family protein 0.013 0.0924 0.5617
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0673 1
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.009 0.0548
Loa Loa (eye worm) hypothetical protein 0.0026 0.0147 0.0895
Onchocerca volvulus 0.006 0.0401 0.281
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0038 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0065 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0038 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0091 0.0839
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0104 0.2566
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0104 0.1513
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0104 0.5
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0065 0.0065
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0096 0.0673 1
Brugia malayi hypothetical protein 0.0227 0.1646 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0151 0.2216
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0013 0.0997
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0092 0.0092
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0147 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0147 0.1382
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0013 0.0079
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0147 1
Loa Loa (eye worm) glutathione reductase 0.0057 0.0382 0.2319
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0603
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0104 0.1383
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0368 0.0368
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0151 0.1799
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0232
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0038 0.0038
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0151 0.3827
Echinococcus granulosus pangolin 0.013 0.0924 0.0924
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0038 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0091 0.0839
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0104 0.1513
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0013 0.0079
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0013 0.0079
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0013 0.0151
Entamoeba histolytica hypothetical protein 0.0035 0.0214 0.3094
Brugia malayi HMG box family protein 0.013 0.0924 0.5617
Loa Loa (eye worm) hypothetical protein 0.0227 0.1646 1
Leishmania major trypanothione reductase 0.0057 0.0382 0.5587
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0232
Onchocerca volvulus 0.0059 0.0393 0.2747
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0147 1
Plasmodium falciparum glutathione reductase 0.002 0.0104 0.2566
Schistosoma mansoni tar DNA-binding protein 0.0061 0.041 0.041
Echinococcus multilocularis tumor protein p63 0.0408 0.299 0.299
Echinococcus multilocularis geminin 0.0514 0.3776 0.3776
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0401 0.0401
Trichomonas vaginalis hypothetical protein 0.0007 0.001 0.0711
Echinococcus multilocularis cpg binding protein 0.0062 0.0417 0.0417
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0147 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0038 0.0232
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0013 0.0151
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0104 0.1513
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0368 0.0368
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0099 0.2339
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0038 0.0232
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0038 0.0038
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.041 0.2488
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0925 0.8949
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0038 0.0183
Echinococcus multilocularis tar DNA binding protein 0.0061 0.041 0.041
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0151 0.3753
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0211 0.1285
Schistosoma mansoni tar DNA-binding protein 0.0061 0.041 0.041
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0065 0.0065
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0881 0.0881
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0038 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0038 0.0232
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0056 0.5221
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0368 0.0368
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0506 0.3077
Schistosoma mansoni cpg binding protein 0.0062 0.0417 0.0417
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0013 0.0075
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0046 0.0302 0.1833
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0474 0.348 0.348
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0782 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1034 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0038 0.0038
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0044 0.0044
Schistosoma mansoni survival motor neuron protein 0.0046 0.0302 0.0302
Echinococcus granulosus beta catenin 0.0195 0.1404 0.1404
Echinococcus granulosus tar DNA binding protein 0.0061 0.041 0.041
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0368 0.2235
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0104 0.1383
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0038 0.0183
Brugia malayi Thioredoxin reductase 0.0057 0.0382 0.2319
Loa Loa (eye worm) hypothetical protein 0.0074 0.0506 0.3077
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1034 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0035 0.0214 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0056 0.5221
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0382 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0038 0.0232
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0104 0.5
Trichomonas vaginalis helicase, putative 0.0013 0.0056 0.5221
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0147 0.2035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0091 0.0839
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0038 0.0232
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0104 0.1513
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0382 0.0382
Schistosoma mansoni tar DNA-binding protein 0.0061 0.041 0.041
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0147 1
Brugia malayi ecdysteroid receptor 0.0011 0.0038 0.0232
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0065 0.0396
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0147 0.1316
Onchocerca volvulus 0.0011 0.0042 0.0207
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0147 0.2089
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0147 0.0895
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0099 0.6421
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0603
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0013 0.0079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0038 0.0038
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0104 0.2566
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0232
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0092 0.0092
Echinococcus granulosus neuropeptide receptor A26 0.0444 0.3259 0.3259
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0038 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0211 0.0211
Onchocerca volvulus Huntingtin homolog 0.0148 0.1057 0.7556
Loa Loa (eye worm) oxidoreductase 0.0008 0.0013 0.0079
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0147 0.0895
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0147 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0603
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0104 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0147 0.1382
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0038 0.0232
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0056 0.5221
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0056 0.5221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0368 0.0368
Echinococcus granulosus dnaJ subfamily B 0.0834 0.6158 0.6158
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0038 0.0232
Brugia malayi TAR-binding protein 0.0061 0.041 0.2488
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0393 0.2385
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0104 0.1513
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0038 0.0183
Brugia malayi hypothetical protein 0.0026 0.0151 0.092
Brugia malayi nuclear receptor NHR-88 0.0011 0.0038 0.0232
Schistosoma mansoni hypothetical protein 0.0046 0.0302 0.0302
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0147 1
Mycobacterium ulcerans hypothetical protein 0.0026 0.0147 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0013 0.0151
Loa Loa (eye worm) hypothetical protein 0.0026 0.0151 0.092
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0038 0.0038
Brugia malayi hypothetical protein 0.0148 0.1057 0.6422
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.0147 0.0895
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0038 0.0232
Loa Loa (eye worm) hypothetical protein 0.0034 0.0211 0.1285
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0761 0.4622
Brugia malayi CXXC zinc finger family protein 0.0059 0.0393 0.2385
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0096 0.0673 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1034 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0013 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0038 0.0232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0368 0.0368
Entamoeba histolytica hypothetical protein 0.0096 0.0673 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0038 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0147 0.2035
Entamoeba histolytica hypothetical protein 0.0035 0.0214 0.3094
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0038 0.0038
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0013 0.0075
Schistosoma mansoni hypothetical protein 0.0514 0.3776 0.3776
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0214 0.0214
Echinococcus multilocularis dnaJ subfamily B 0.0834 0.6158 0.6158
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0013 0.0075
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0013 0.0075
Onchocerca volvulus 0.0011 0.0038 0.0183
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0104 0.6796
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0104 0.1383
Schistosoma mansoni hypothetical protein 0.0834 0.6158 0.6158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0038 0.0232
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0056 0.5221
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0013 0.0119
Onchocerca volvulus 0.0026 0.0147 0.0972
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0151 0.2216
Schistosoma mansoni myst-related protein 0.0007 0.0009 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0038 0.0038
Brugia malayi nuclear hormone receptor 0.0011 0.0038 0.0232
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0038 0.0038
Schistosoma mansoni pangolin 0.013 0.0924 0.0924
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0038 0.0232
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0038 0.0038
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0013 0.0075
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0673 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0013 0.0067
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0065 0.0065
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0038 0.0038
Trypanosoma brucei trypanothione reductase 0.0057 0.0382 0.5653
Echinococcus multilocularis survival motor neuron protein 1 0.0227 0.1646 0.1646
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0104 0.0104
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0382 0.0382
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0382 0.5653
Echinococcus granulosus survival motor neuron protein 1 0.0227 0.1646 0.1646
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0038 0.0038
Echinococcus granulosus dual specificity 0.0096 0.0673 0.0673
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0195 0.1404 0.8531
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0147 0.2089
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0211 0.1285
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0104 0.1383
Loa Loa (eye worm) HMP-2 protein 0.0195 0.1404 0.8531
Schistosoma mansoni hypothetical protein 0.0012 0.0044 0.0044
Brugia malayi hypothetical protein 0.0017 0.0083 0.0501
Brugia malayi Protein kinase domain containing protein 0.0096 0.0673 0.4088
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0038 0.0232
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0038 0.0038
Echinococcus multilocularis beta catenin 0.0195 0.1404 0.1404
Entamoeba histolytica protein kinase, putative 0.0096 0.0673 1
Echinococcus multilocularis GPCR, family 2 0.0034 0.0211 0.0211
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0211 0.1285
Echinococcus granulosus cpg binding protein 0.0062 0.0417 0.0417
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0065 0.0396
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0104 0.0634
Echinococcus multilocularis neuropeptide receptor A26 0.0444 0.3259 0.3259
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0151 0.2216
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0056 0.5221
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0232
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0013 0.0075
Loa Loa (eye worm) hypothetical protein 0.0096 0.0669 0.4066
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0104 0.2476
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0104 0.5
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0104 0.6796
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0056 0.5221
Schistosoma mansoni hypothetical protein 0.0034 0.0211 0.0211
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.041 0.2488
Schistosoma mansoni hypothetical protein 0.0034 0.0211 0.0211
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0147 0.2035
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0013 0.0151
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0104 0.1513
Onchocerca volvulus Huntingtin homolog 0.0148 0.1057 0.7556
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0211 0.0211
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0038 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0056 0.5221
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0925 0.8949
Loa Loa (eye worm) hypothetical protein 0.0108 0.0761 0.4622
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0013 0.0079
Mycobacterium tuberculosis Probable reductase 0.013 0.0925 0.8949
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0147 0.2089
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0056 0.5221

Activities

Activity type Activity value Assay description Source Reference
(functional) > 13.905716496 ug/ml In vitro cytotoxicity evaluation on human fibroblasts measured by fluorescence after 72h WHO/TDR. No reference
% motility reduction (functional) = 0 % Motility reduction assay in Schistosoma mansoni Puerto Rican adult worms WHO/TDR. No reference
% motility reduction (functional) = 0 % Motility reduction assay in Onchocerca lienalis microfilariae WHO/TDR. No reference
% motility reduction (functional) = 0 % Motility Reduction against Brugia malayi adult worms at 10 uM WHO/TDR. No reference
% motility reduction (functional) = 90 % Motility reduction assay in vitro against Brugia malayi microfilariae at 10 uM WHO/TDR. No reference
IC50 (functional) = 0.947 ug/ml In vitro activity against Leishmania infantum in mouse macrophages measured by cell viability after 5 days WHO/TDR. No reference
IC50 (functional) = 0.947 ug/ml WHO-TDR: Leishmaniasis ChEMBL. No reference
IC50 (functional) = 2.301 ug/ml In vitro activity against Trypanosoma cruzi in human lung fibroblast measured by colorimetry after 7 days WHO/TDR. No reference
IC50 (functional) = 2.301 ug/ml WHO-TDR: Chagas disease ChEMBL. No reference
IC50 (functional) = 4.448810086 ug/ml WHO-TDR: Human African Trypanosomiasis (HAT) ChEMBL. No reference
IC50 (functional) = 4.4488100863 ug/ml In vitro activity against Trypanosoma brucei measured by florescence after 24h WHO/TDR. No reference
IC50 (functional) = 7.376 ug/ml In vitro activity against Plasmodium falciparum measured by colorimetry after 72h WHO/TDR. No reference
IC50 (functional) = 7.376 ug/ml WHO-TDR: Malaria ChEMBL. No reference
Inhibition (functional) = 0 % WHO-TDR: Schistosomiasis ChEMBL. No reference
Inhibition (functional) = 0 % WHO-TDR: Lymphatic Filariasis ChEMBL. No reference
Inhibition (functional) = 90 % WHO-TDR: Lymphatic Filariasis ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense
Trypanosoma cruzi ChEMBL23
Plasmodium falciparum ChEMBL23
Leishmania infantum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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