Detailed information for compound 91459

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 488.596 | Formula: C25H32N2O6S
  • H donors: 1 H acceptors: 3 LogP: 3.52 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC1CCCC1)[C@@H]1CN(C[C@H]1NS(=O)(=O)C)C(=O)OCc1ccccc1
  • InChi: 1S/C25H32N2O6S/c1-31-23-13-12-19(14-24(23)33-20-10-6-7-11-20)21-15-27(16-22(21)26-34(2,29)30)25(28)32-17-18-8-4-3-5-9-18/h3-5,8-9,12-14,20-22,26H,6-7,10-11,15-17H2,1-2H3/t21-,22+/m0/s1
  • InChiKey: WELPOYTUIVJMOO-FCHUYYIVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 4B, cAMP-specific Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide receptor 0.0017 0.0091 0.0093
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.1089 0.1754
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0091 0.0104
Brugia malayi Carboxylesterase family protein 0.0022 0.0188 0.019
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0188 0.0224
Trichomonas vaginalis esterase, putative 0.0081 0.1304 0.1304
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.1089 0.1088
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0303 0.5537 0.5742
Schistosoma mansoni myosin xvIII 0.0017 0.0091 0.0093
Mycobacterium tuberculosis Probable dehydrogenase 0.0099 0.1647 0.1672
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0068 0.1064 0.1214
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Onchocerca volvulus 0.0017 0.0091 0.0091
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0014 0.0022 0.0022
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0049 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0091 0.0093
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0025 0.0233 0.0829
Loa Loa (eye worm) glutaminase 2 0.0268 0.4884 0.5576
Echinococcus granulosus dnaJ subfamily B 0.0401 0.7425 0.7538
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0049 0.0049
Brugia malayi Carboxylesterase family protein 0.0022 0.0188 0.019
Schistosoma mansoni biogenic amine receptor 0.0017 0.0091 0.0093
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0091 0.0093
Brugia malayi Pre-SET motif family protein 0.0068 0.1064 0.1192
Echinococcus granulosus beta LACTamase domain containing family member 0.0081 0.1304 0.1324
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.1304 0.1304
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1115 0.1475
Trichomonas vaginalis spcc417.12 protein, putative 0.0022 0.0188 0.0188
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Plasmodium falciparum glutathione reductase 0.0043 0.0589 0.2228
Loa Loa (eye worm) glutaminase 0.0268 0.4884 0.5576
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0235 0.0837
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0014 0.0022 0.0023
Onchocerca volvulus 0.0017 0.0091 0.0091
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.011 0.1857 0.1892
Onchocerca volvulus 0.0017 0.0091 0.0091
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0091 0.0079
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0091 0.0093
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0022 0.0022
Onchocerca volvulus 0.0017 0.0091 0.0091
Echinococcus granulosus single minded 2 0.0035 0.0438 0.0444
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Mycobacterium ulcerans lipase LipD 0.0081 0.1304 0.2117
Loa Loa (eye worm) hypothetical protein 0.0022 0.0188 0.0215
Echinococcus granulosus tar DNA binding protein 0.0071 0.1115 0.1132
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Schistosoma mansoni amine GPCR 0.0017 0.0091 0.0093
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0049 0.0049
Brugia malayi Carboxylesterase family protein 0.0132 0.2279 0.2583
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0063 0.0958 0.1094
Brugia malayi hypothetical protein 0.0017 0.0091 0.0079
Schistosoma mansoni single-minded 0.0048 0.0674 0.0881
Brugia malayi glutathione reductase 0.0043 0.0589 0.0649
Loa Loa (eye worm) hypothetical protein 0.0112 0.1893 0.2162
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0049 0.0379
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0023 0.0201 0.0229
Brugia malayi beta-lactamase family protein 0.0081 0.1304 0.1467
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0049 0.0379
Plasmodium vivax SET domain protein, putative 0.0068 0.1064 0.4094
Onchocerca volvulus 0.0081 0.1304 0.1304
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.2279 0.3049
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Echinococcus multilocularis neuropeptide receptor A26 0.0529 0.985 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0188 0.0215
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0023 0.0201 0.0255
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0014 0.0022 0.0023
Loa Loa (eye worm) TAR-binding protein 0.0071 0.1115 0.1273
Brugia malayi hypothetical protein 0.0017 0.0091 0.0079
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0022 0.0188 0.0215
Echinococcus multilocularis protoporphyrinogen oxidase 0.0023 0.0201 0.0204
Onchocerca volvulus 0.0022 0.0188 0.0188
Brugia malayi G-protein coupled receptor 0.0017 0.0091 0.0079
Mycobacterium ulcerans carboxylesterase, LipT 0.0022 0.0188 0.0235
Chlamydia trachomatis protoporphyrinogen oxidase 0.0023 0.0201 1
Onchocerca volvulus 0.0017 0.0091 0.0091
Brugia malayi hypothetical protein 0.0017 0.0091 0.0079
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.1089 0.4245
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0091 0.0093
Echinococcus granulosus acetylcholinesterase 0.0132 0.2279 0.2314
Echinococcus granulosus neuroligin 0.0022 0.0188 0.0191
Schistosoma mansoni amine GPCR 0.0017 0.0091 0.0093
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0091 0.0093
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0022 0.0022
Brugia malayi hypothetical protein 0.0016 0.0068 0.0052
Echinococcus multilocularis transient receptor potential cation channel 0.0151 0.2654 0.2695
Brugia malayi Melatonin receptor type 1A 0.0017 0.0091 0.0079
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0014 0.0022 0.0023
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0098 0.1634 0.1659
Onchocerca volvulus 0.0022 0.0188 0.0188
Onchocerca volvulus 0.0035 0.0438 0.0438
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Onchocerca volvulus 0.0017 0.0091 0.0091
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0091 0.0093
Schistosoma mansoni opsin-like receptor 0.0017 0.0091 0.0093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0091 0.0093
Brugia malayi beta-lactamase 0.0081 0.1304 0.1467
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0026
Onchocerca volvulus 0.0017 0.0091 0.0091
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0091 0.0079
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0516 0.9606 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Brugia malayi beta-lactamase family protein 0.0081 0.1304 0.1467
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.231 0.2637
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0026
Leishmania major cAMP-specific phosphodiesterase, putative 0.0014 0.0022 0.0088
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0091 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1115 0.1475
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0847 0.0967
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0022 0.0022
Onchocerca volvulus 0.0017 0.0091 0.0091
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0091 0.0093
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0049 0.0106
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Schistosoma mansoni neuroligin 3 (S09 family) 0.0022 0.0188 0.0224
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0022 0.0022
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0049 0.021
Brugia malayi hypothetical protein 0.0017 0.0091 0.0079
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0022 0.0022
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Brugia malayi hypothetical protein 0.0017 0.0091 0.0079
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0091 0.0093
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0091 0.0079
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0099 0.1647 0.1672
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0091 0.0093
Mycobacterium tuberculosis Conserved protein 0.0081 0.1304 0.1313
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.1304 0.1731
Echinococcus granulosus lysine specific histone demethylase 1A 0.0023 0.0201 0.0204
Plasmodium falciparum thioredoxin reductase 0.0043 0.0589 0.2228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0023 0.0201 0.07
Echinococcus multilocularis ankyrin repeat protein 0.0148 0.2596 0.2636
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0206 0.3689 0.3746
Echinococcus granulosus g protein coupled receptor 0.0017 0.0091 0.0093
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0438 0.0444
Giardia lamblia Macrophage migration inhibitory factor 0.0147 0.2565 1
Mycobacterium tuberculosis Probable lipase LipE 0.0081 0.1304 0.1313
Mycobacterium tuberculosis Probable reductase 0.0099 0.1647 0.1672
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1115 0.1475
Echinococcus granulosus para nitrobenzyl esterase 0.0022 0.0188 0.0191
Leishmania major hypothetical protein, conserved 0.0081 0.1304 0.5083
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0091 0.0093
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0201 0.07
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0049 0.0379
Brugia malayi Bm-MIF-1, identical 0.0147 0.2565 0.291
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0112 0.1893 0.1922
Mycobacterium tuberculosis Possible oxidoreductase 0.0023 0.0201 0.0158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0091 0.0093
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0022 0.0022
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0194 0.1487
Loa Loa (eye worm) PDE1B protein 0.0014 0.0022 0.0026
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0063 0.0958 0.1094
Schistosoma mansoni amine GPCR 0.0017 0.0091 0.0093
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0049 0.0379
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0014 0.0022 0.0023
Echinococcus granulosus g protein coupled receptor 0.0017 0.0091 0.0093
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0099 0.1647 0.1672
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0014 0.0022 0.0172
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0022 0.0172
Schistosoma mansoni opsin-like receptor 0.0017 0.0091 0.0093
Schistosoma mansoni hypothetical protein 0.0165 0.2903 0.3892
Plasmodium vivax glutathione reductase, putative 0.0043 0.0589 0.2228
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0023 0.0201 0.07
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.1064 0.1406
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Echinococcus multilocularis somatostatin receptor 0.0017 0.0091 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1115 0.1475
Loa Loa (eye worm) hypothetical protein 0.0081 0.1304 0.1489
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0091 0.0093
Brugia malayi Serotonin receptor 0.0017 0.0091 0.0079
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0091 0.0093
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0049 0.0192
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.1089 0.1105
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0206 0.3689 0.4197
Leishmania major trypanothione reductase 0.0043 0.0589 0.2297
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Brugia malayi Cytochrome P450 family protein 0.0023 0.0194 0.0196
Brugia malayi Carboxylesterase family protein 0.0022 0.0188 0.019
Brugia malayi Cytochrome P450 family protein 0.0023 0.0194 0.0196
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0438 0.0655
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0022 0.0172
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0023 0.0201 0.0204
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0022 0.0022
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0091 0.0093
Treponema pallidum NADH oxidase 0.0015 0.0049 0.5
Echinococcus multilocularis carboxylesterase 5A 0.0132 0.2279 0.2314
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Loa Loa (eye worm) acetylcholinesterase 1 0.0132 0.2279 0.2602
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0188 0.0224
Onchocerca volvulus 0.0022 0.0188 0.0188
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0099 0.1647 0.1672
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0065 0.1004 0.102
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0081 0.1304 0.1313
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0091 0.0093
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0022 0.0172
Schistosoma mansoni transcription factor LCR-F1 0.0121 0.2066 0.276
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0049 0.0106
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0091 0.0093
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0014 0.0022 0.0023
Schistosoma mansoni hypothetical protein 0.0401 0.7425 1
Brugia malayi hypothetical protein 0.0017 0.0091 0.0079
Echinococcus multilocularis geminin 0.0165 0.2903 0.2948
Schistosoma mansoni hypothetical protein 0.0165 0.2903 0.3892
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0589 0.4518
Schistosoma mansoni cpg binding protein 0.003 0.0332 0.0418
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0112 0.1893 0.1922
Schistosoma mansoni cpg binding protein 0.0028 0.0301 0.0376
Toxoplasma gondii ABC1 family protein 0.0081 0.1304 0.5039
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0049 0.005
Leishmania major UDP-galactopyranose mutase 0.0023 0.0201 0.0782
Plasmodium vivax hypothetical protein, conserved 0.0081 0.1304 0.5039
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.011 0.1857 0.1892
Brugia malayi hypothetical protein 0.0017 0.0091 0.0079
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0014 0.0022 0.0088
Mycobacterium ulcerans beta-lactamase 0.0081 0.1304 0.2117
Schistosoma mansoni gliotactin 0.0022 0.0188 0.0224
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0022 0.0188 0.0191
Onchocerca volvulus 0.0017 0.0091 0.0091
Onchocerca volvulus 0.0068 0.1064 0.1064
Echinococcus granulosus hypothetical protein 0.0017 0.0091 0.0093
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0952 0.1255
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0049 0.0106
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0014 0.0022 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0206 0.3689 0.3746
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0091 0.0093
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0081 0.1304 0.1467
Echinococcus multilocularis serotonin receptor 0.0017 0.0091 0.0093
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0099 0.1647 0.1672
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0091 0.0093
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0049 0.0379
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0091 0.0079
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0049 0.0192
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Loa Loa (eye worm) hypothetical protein 0.0022 0.0188 0.0215
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0091 0.0093
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0014 0.0022 0.0172
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0014 0.0022 0.0172
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0023 0.0201 0.0241
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0091 0.0093
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.1089 0.1105
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0022 0.0022
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0091 0.0093
Schistosoma mansoni biogenic amine receptor 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0091 0.0093
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0091 0.0093
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0091 0.0093
Echinococcus granulosus geminin 0.0165 0.2903 0.2948
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.1089 0.1441
Loa Loa (eye worm) carboxylesterase 0.0132 0.2279 0.2602
Echinococcus multilocularis 0.0023 0.0201 0.0204
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0091 0.0093
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0091 0.0093
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0022 0.0022
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.231 0.2637
Trypanosoma cruzi UDP-galactopyranose mutase 0.0023 0.0201 0.1538
Loa Loa (eye worm) hypothetical protein 0.0023 0.0201 0.0229
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0049 0.0379
Brugia malayi GnHR receptor homolog 0.0017 0.0091 0.0079
Echinococcus multilocularis neuropeptide s receptor 0.0529 0.985 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0049 0.0106
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Onchocerca volvulus 0.0017 0.0091 0.0091
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0049 0.0031
Leishmania major cytochrome p450-like protein 0.0023 0.0194 0.0756
Leishmania major macrophage migration inhibitory factor-like protein 0.0147 0.2565 1
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0201 0.07
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0022 0.0022
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0121 0.2066 0.2097
Echinococcus multilocularis tar DNA binding protein 0.0071 0.1115 0.1132
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0091 0.0093
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0091 0.0079
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.1304 0.1304
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.1089 0.1754
Mycobacterium tuberculosis Conserved protein 0.0081 0.1304 0.1313
Loa Loa (eye worm) hypothetical protein 0.0023 0.0201 0.0229
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.06 0.0609
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0112 0.1893 0.1922
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.2584 0.295
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0112 0.1893 0.1922
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.011 0.1857 1
Brugia malayi hypothetical protein 0.0023 0.0201 0.0204
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0091 0.0093
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0589 0.0673
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0081 0.1304 0.2117
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0014 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0025 0.0235 0.0269
Schistosoma mansoni neuropeptide receptor 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0023 0.0201 0.0229
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.06 0.0609
Mycobacterium ulcerans hypothetical protein 0.0081 0.1304 0.2117
Brugia malayi sulfakinin receptor protein 0.0017 0.0091 0.0079
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0091 0.0093
Mycobacterium ulcerans glutaminase 0.0268 0.4884 0.816
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0022 0.0022
Onchocerca volvulus 0.0017 0.0091 0.0091
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0194 0.0221
Echinococcus granulosus cpg binding protein 0.003 0.0332 0.0337
Plasmodium falciparum macrophage migration inhibitory factor 0.0147 0.2565 1
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0049 0.0106
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0091 0.0104
Echinococcus granulosus somatostatin receptor 0.0017 0.0091 0.0093
Onchocerca volvulus 0.0081 0.1304 0.1304
Loa Loa (eye worm) beta-lactamase 0.0081 0.1304 0.1489
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Brugia malayi neuropeptide F receptor 0.0017 0.0091 0.0079
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0014 0.0022 0.0023
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0014 0.0022 0.0023
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0132 0.2279 0.2602
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0091 0.0093
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0206 0.3689 0.4212
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0091 0.0093
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.1304 1
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0147 0.2565 0.2565
Mycobacterium tuberculosis Conserved protein 0.0081 0.1304 0.1313
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0147 0.2565 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0049 0.0106
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Brugia malayi hypothetical protein 0.016 0.282 0.3203
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0014 0.0022 0.0023
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0147 0.2565 1
Brugia malayi AKH receptor 0.0017 0.0091 0.0079
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0022 0.0022
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0091 0.0093
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0081 0.1304 0.1313
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.2565 0.2565
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0091 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0022 0.0172
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0121 0.2066 0.2097
Schistosoma mansoni neuropeptide receptor 0.0017 0.0091 0.0093
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0098 0.1634 0.1845
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0091 0.0079
Brugia malayi SWIRM domain containing protein 0.0023 0.0201 0.0204
Brugia malayi hypothetical protein 0.0022 0.0188 0.019
Echinococcus multilocularis sex peptide receptor 0.0017 0.0091 0.0093
Schistosoma mansoni amine GPCR 0.0017 0.0091 0.0093
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0301 0.0344
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0091 0.0093
Brugia malayi Dopamine receptor 0.0017 0.0091 0.0079
Brugia malayi Carboxylesterase family protein 0.0022 0.0188 0.019
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Brugia malayi putative neuropeptide receptor 0.0017 0.0091 0.0079
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Schistosoma mansoni amine oxidase 0.0023 0.0201 0.0241
Brugia malayi ORL1-like opioid receptor 0.0017 0.0091 0.0079
Brugia malayi RE15519p 0.0017 0.0091 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0325 0.5974 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0091 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0206 0.3689 0.4954
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Onchocerca volvulus 0.0017 0.0091 0.0091
Echinococcus granulosus serotonin receptor 0.0017 0.0091 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0022 0.0172
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.083 0.3175
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Onchocerca volvulus 0.0023 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0023 0.0201 0.0229
Onchocerca volvulus 0.0017 0.0091 0.0091
Echinococcus multilocularis BC026374 protein (S09 family) 0.0022 0.0188 0.0191
Brugia malayi hypothetical protein 0.0025 0.0235 0.0244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0026
Brugia malayi Serotonin receptor 0.0017 0.0091 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0022 0.0172
Loa Loa (eye worm) glutathione reductase 0.0043 0.0589 0.0673
Brugia malayi CXXC zinc finger family protein 0.0028 0.0301 0.0319
Brugia malayi G protein-coupled receptor 0.0017 0.0091 0.0079
Leishmania major hypothetical protein, conserved 0.0014 0.0022 0.0088
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0091 0.0093
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0091 0.0104
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0091 0.0079
Schistosoma mansoni BC026374 protein (S09 family) 0.0022 0.0188 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0022
Schistosoma mansoni adenoreceptor 0.0017 0.0091 0.0093
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0091 0.0093
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0471 0.8759 1
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0091 0.0104
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.1089 0.1441
Echinococcus multilocularis para nitrobenzyl esterase 0.0022 0.0188 0.0191
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Brugia malayi Dopamine receptor protein 1 0.0017 0.0091 0.0079
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0147 0.2565 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0201 0.0229
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.1304 0.1304
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0091 0.0093
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0091 0.0093
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0098 0.1634 0.1659
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0325 0.5974 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0049 0.0106
Echinococcus granulosus acetylcholinesterase 0.0132 0.2279 0.2314
Mycobacterium tuberculosis Probable esterase LipL 0.0081 0.1304 0.1313
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0049 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0022
Onchocerca volvulus Neuropeptide F receptor homolog 0.0017 0.0091 0.0091
Echinococcus granulosus g protein coupled receptor 0.0017 0.0091 0.0093
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0091 0.0093
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0194 0.0244
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0235 0.1661
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0081 0.1304 0.1313
Echinococcus multilocularis acetylcholinesterase 0.0132 0.2279 0.2314
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0091 0.0093
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0194 0.0221
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0049 0.0192
Mycobacterium leprae Probable lipase LipE 0.0081 0.1304 0.702
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0091 0.0104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0091 0.0093
Brugia malayi hypothetical protein 0.0121 0.2066 0.2339
Mycobacterium tuberculosis Carboxylesterase LipT 0.0022 0.0188 0.0145
Onchocerca volvulus 0.0022 0.0188 0.0188
Schistosoma mansoni amine GPCR 0.0017 0.0091 0.0093
Echinococcus multilocularis neuroligin 0.0022 0.0188 0.0191
Loa Loa (eye worm) hypothetical protein 0.0081 0.1304 0.1489
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0091 0.0093
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0091 0.0093
Echinococcus granulosus neuropeptide receptor 0.0017 0.0091 0.0093
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0091 0.0093
Schistosoma mansoni glutaminase 0.0268 0.4884 0.6567
Loa Loa (eye worm) hypothetical protein 0.0081 0.1304 0.1489
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0014 0.0022 0.0023
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0235 0.1805
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0091 0.0093
Brugia malayi RNA binding protein 0.0071 0.1115 0.125
Loa Loa (eye worm) hypothetical protein 0.0081 0.1304 0.1489
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.1089 0.4194
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0121 0.2066 0.276
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Brugia malayi hypoxia-induced factor 1 0.0148 0.2584 0.2932
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0206 0.3689 0.4954
Mycobacterium ulcerans esterase/lipase LipP 0.0081 0.1304 0.2117
Toxoplasma gondii thioredoxin reductase 0.0043 0.0589 0.2228
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0093
Trichomonas vaginalis glutaminase, putative 0.0268 0.4884 0.4884
Loa Loa (eye worm) RNA binding protein 0.0071 0.1115 0.1273
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0068 0.1064 0.4094
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.0091 0.0093
Brugia malayi amine oxidase, flavin-containing family protein 0.0023 0.0201 0.0204
Onchocerca volvulus 0.0017 0.0091 0.0091
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Mycobacterium tuberculosis Probable oxidoreductase 0.011 0.1857 0.1892
Mycobacterium tuberculosis Probable hydrolase 0.0081 0.1304 0.1313
Brugia malayi hypothetical protein 0.0017 0.0091 0.0079
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0274 0.4996 0.5072
Schistosoma mansoni acetylcholinesterase 0.0022 0.0188 0.0224
Brugia malayi Thioredoxin reductase 0.0043 0.0589 0.0649
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0201 0.0158
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.1304 0.1304
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.1064 0.1406
Echinococcus granulosus ankyrin repeat protein 0.0148 0.2596 0.2636
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0235 0.1805
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Leishmania major hypothetical protein, conserved 0.0025 0.0235 0.0918
Mycobacterium leprae conserved hypothetical protein 0.0081 0.1304 0.702
Echinococcus granulosus transient receptor potential cation channel 0.0151 0.2654 0.2695
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0017 0.008 0.0227
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0098 0.1634 0.1866
Brugia malayi neuropeptide F receptor 0.0017 0.0091 0.0079
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0091 0.0104
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0194 0.0221
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0091 0.0079
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0023 0.0201 0.108
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0023 0.0201 0.07
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.1089 0.1754
Schistosoma mansoni cpg binding protein 0.003 0.0332 0.0418
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.1304 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0188 0.0145
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0091 0.0093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0091 0.0093
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Echinococcus multilocularis acetylcholinesterase 0.0132 0.2279 0.2314
Echinococcus multilocularis serotonin receptor 0.0017 0.0091 0.0093
Trypanosoma cruzi UDP-galactopyranose mutase 0.0023 0.0201 0.1538
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Loa Loa (eye worm) hypothetical protein 0.0132 0.2279 0.2602
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0091 0.0104
Echinococcus granulosus neuropeptide receptor A26 0.0529 0.985 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0049 0.2461
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0115 0.1951 0.7586
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0049 0.5
Leishmania major macrophage migration inhibitory factor-like protein 0.0147 0.2565 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0112 0.1893 0.2527
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.1064 0.108
Loa Loa (eye worm) hypothetical protein 0.0022 0.0188 0.0215
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Loa Loa (eye worm) carboxylesterase 0.0022 0.0188 0.0215
Echinococcus granulosus sex peptide receptor 0.0017 0.0091 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0206 0.3689 0.4954
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0674 0.0881
Loa Loa (eye worm) hypothetical protein 0.0022 0.0188 0.0215
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0091 0.0093
Brugia malayi larval opioid receptor 0.0017 0.0091 0.0079
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0091 0.0093
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0091 0.0093
Mycobacterium tuberculosis Probable lipase LipD 0.0081 0.1304 0.1313
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0091 0.0093
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Onchocerca volvulus 0.0081 0.1304 0.1304
Plasmodium falciparum protoporphyrinogen oxidase 0.0023 0.0201 0.07
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.7425 0.7538
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Brugia malayi PAS domain containing protein 0.0048 0.0674 0.0746
Brugia malayi G-protein coupled receptor 0.0017 0.0091 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0068 0.1064 0.1406
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0014 0.0022 0.0172
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Echinococcus granulosus allatostatin A receptor 0.0017 0.0091 0.0093
Brugia malayi Dopamine receptor protein 2 0.0017 0.0091 0.0079
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0091 0.0093
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0235 0.0837
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Schistosoma mansoni biogenic amine receptor 0.0017 0.0091 0.0093
Brugia malayi hypothetical protein 0.0017 0.0091 0.0079
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0589 0.0565
Echinococcus granulosus orexin receptor type 2 0.0017 0.0091 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0099 0.1647 0.8868
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0022 0.0172
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Onchocerca volvulus 0.0017 0.0091 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0091 0.0093
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0091 0.0093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0206 0.3689 0.3746
Loa Loa (eye worm) hypothetical protein 0.0081 0.1304 0.1489
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0049 0.0379
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0188 0.0145
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Brugia malayi MH2 domain containing protein 0.0133 0.231 0.2619
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0112 0.1893 0.7359
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0147 0.2565 0.2929
Brugia malayi Cytochrome P450 family protein 0.0057 0.0847 0.0944
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0148 0.2596 0.3477
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0022 0.0188 0.0188
Onchocerca volvulus 0.0028 0.0301 0.0301
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0235 0.0837
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0093
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0091 0.0093
Echinococcus granulosus carboxylesterase 5A 0.0132 0.2279 0.2314
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0022 0.0172
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0022 0.0022
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.1115 0.125
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0091 0.0093
Plasmodium falciparum thioredoxin reductase 0.0015 0.0049 0.0106
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0023 0.0201 0.0241
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0049 0.021
Mycobacterium ulcerans dehydrogenase 0.0023 0.0201 0.0255
Schistosoma mansoni histamine h1 receptor 0.0017 0.0091 0.0093
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0049 0.021
Loa Loa (eye worm) carboxylesterase 0.0022 0.0188 0.0215
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0235 0.0837
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0091 0.0104
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0091 0.0079
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0022 0.0172
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.1115 0.1273
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0091 0.0093
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0589 0.2228
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0188 0.0224
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0049 0.0192
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0438 0.0475
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1115 0.1475
Toxoplasma gondii histone lysine-specific demethylase 0.0023 0.0201 0.07
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0091 0.0104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0049 0.021
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0091 0.0093
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0091 0.0104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.1304 0.1731
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0091 0.0093
Brugia malayi Pre-SET motif family protein 0.0471 0.8759 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0091 0.0093
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0049 0.005
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0091 0.0093
Mycobacterium ulcerans oxidoreductase 0.0023 0.0201 0.0255
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0091 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Brugia malayi hypothetical protein 0.0017 0.0091 0.0079
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0022 0.0022
Leishmania major hypothetical protein, conserved 0.0014 0.0022 0.0088
Loa Loa (eye worm) hypothetical protein 0.0081 0.1304 0.1489
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0091 0.0093
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0091 0.0093
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0206 0.3689 0.3746
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.1304 1
Mycobacterium ulcerans monoamine oxidase 0.0023 0.0201 0.0255
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0068 0.1064 0.108
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Onchocerca volvulus 0.0017 0.0091 0.0091
Echinococcus granulosus neuropeptide s receptor 0.0529 0.985 1
Brugia malayi Carboxylesterase family protein 0.0132 0.2279 0.2583
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.0022 0.0188 0.0215
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.1304 0.1304
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.1064 0.1406
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.1064 0.108
Brugia malayi glutaminase DH11.1 0.0268 0.4884 0.5565
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0049 0.0379
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0091 0.0104
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0081 0.1304 0.1489
Echinococcus multilocularis cpg binding protein 0.003 0.0332 0.0337
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0091 0.0093
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0091 0.0093
Echinococcus granulosus BC026374 protein S09 family 0.0022 0.0188 0.0191
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0201 0.07
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0104
Echinococcus multilocularis beta LACTamase domain containing family member 0.0081 0.1304 0.1324
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0022 0.0172
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0091 0.0093
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0022 0.0188 0.0191
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Onchocerca volvulus 0.0017 0.0091 0.0091
Trypanosoma brucei trypanothione reductase 0.0043 0.0589 0.4422
Trichomonas vaginalis set domain proteins, putative 0.0536 1 1
Onchocerca volvulus 0.0022 0.0188 0.0188
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0194 0.1487
Echinococcus granulosus neuropeptide receptor 0.0017 0.0091 0.0093
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0022 0.0022
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0022 0.0022
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0014 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.016 0.282 0.322
Schistosoma mansoni opsin-like receptor 0.0017 0.0091 0.0093
Plasmodium falciparum glutathione reductase 0.0015 0.0049 0.0106
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0093
Echinococcus granulosus tm gpcr rhodopsin 0.0274 0.4996 0.5072
Schistosoma mansoni neuropeptide receptor 0.0017 0.0091 0.0093
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0017 0.0091 0.0091
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0014 0.0022 0.0026
Brugia malayi TAR-binding protein 0.0071 0.1115 0.125
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0049 0.5
Echinococcus granulosus lysine specific histone demethylase 1A 0.0023 0.0201 0.0204
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0194 0.1337
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0091 0.0093
Schistosoma mansoni amine oxidase 0.0023 0.0201 0.0241
Echinococcus granulosus fmrfamide receptor 0.0017 0.0091 0.0093

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.47 uM Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) ChEMBL. No reference
Ki (binding) = 1.47 uM Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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