Detailed information for compound 930626

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 364.441 | Formula: C21H24N4O2
  • H donors: 3 H acceptors: 3 LogP: 3.14 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)CCCCc1ccn(n1)Cc1ccc(cc1)Nc1ccccc1
  • InChi: 1S/C21H24N4O2/c26-21(24-27)9-5-4-8-20-14-15-25(23-20)16-17-10-12-19(13-11-17)22-18-6-2-1-3-7-18/h1-3,6-7,10-15,22,27H,4-5,8-9,16H2,(H,24,26)
  • InChiKey: XXOUJCCBKBTDDB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 6 Starlite/ChEMBL References
Homo sapiens histone deacetylase 2 Starlite/ChEMBL References
Homo sapiens histone deacetylase 5 Starlite/ChEMBL References
Homo sapiens histone deacetylase 8 Starlite/ChEMBL References
Homo sapiens histone deacetylase 9 Starlite/ChEMBL References
Homo sapiens histone deacetylase 3 Starlite/ChEMBL References
Homo sapiens histone deacetylase 10 Starlite/ChEMBL References
Homo sapiens histone deacetylase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC2 Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi histone deacetylase 3 (HD3) Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deacetylase HDA2/Rpd3p Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase 1,histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Entamoeba histolytica histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Giardia lamblia Histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum ko:K01463 Hdac3 [EC:3.5.1.-], putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K06067 histone deacetylase 1/2, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 1 (HD1) Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum RPD3/HD1 histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC3 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi histone deacetylase, putative histone deacetylase 3 428 aa 374 aa 30.5 %
Plasmodium falciparum histone deacetylase 1 histone deacetylase 8 286 aa 241 aa 44.8 %
Trypanosoma brucei histone deacetylase 2 histone deacetylase 2 488 aa 427 aa 29.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major histone deacetylase, putative 0.0309 0.7568 1
Trypanosoma brucei cdc2-related kinase 3 0.005 0.0402 0.0531
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0038 0.0069 0.0092
Brugia malayi Protein kinase domain containing protein 0.0161 0.3482 0.4568
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.3482 0.4568
Echinococcus multilocularis tensin 0.0126 0.2504 0.2504
Echinococcus multilocularis histone deacetylase 8 0.0139 0.2864 0.2864
Echinococcus multilocularis histone deacetylase 6 0.0309 0.7568 0.7568
Loa Loa (eye worm) hypothetical protein 0.0243 0.5749 0.7543
Onchocerca volvulus 0.0117 0.2268 0.5091
Loa Loa (eye worm) hypothetical protein 0.0126 0.2504 0.3286
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.2268 0.3055
Echinococcus multilocularis tyrosine protein kinase csk 0.007 0.0972 0.0972
Trypanosoma brucei histone deacetylase 4 0.0309 0.7568 1
Echinococcus granulosus SH2 motif 0.0126 0.2504 0.2504
Brugia malayi p70 ribosomal S6 kinase beta 0.0046 0.0299 0.0392
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.3482 0.4568
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0117 0.2268 0.2268
Brugia malayi SH3 domain containing protein 0.0117 0.2268 0.2975
Schistosoma mansoni nck2/grb4 0.0243 0.5749 0.5749
Onchocerca volvulus 0.0161 0.3482 0.7817
Onchocerca volvulus 0.0126 0.2504 0.5622
Onchocerca volvulus 0.0117 0.2268 0.5091
Leishmania major histone deacetylase, putative 0.0309 0.7568 1
Toxoplasma gondii histone deacetylase HDAC2 0.0304 0.7423 0.9809
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.3482 0.4568
Brugia malayi SH2 domain containing protein 0.0126 0.2504 0.3286
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0311 0.7622 0.7622
Onchocerca volvulus 0.0126 0.2504 0.5622
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0402 0.0528
Schistosoma mansoni hypothetical protein 0.0117 0.2268 0.2268
Brugia malayi Spectrin alpha chain 0.0117 0.2268 0.2975
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0117 0.2268 0.2975
Echinococcus granulosus epidermal growth factor receptor kinase 0.0117 0.2268 0.2268
Loa Loa (eye worm) hypothetical protein 0.017 0.3727 0.4889
Plasmodium falciparum histone deacetylase 2 0.0309 0.7568 1
Loa Loa (eye worm) histone deacetylase 0.0309 0.7568 0.9929
Trypanosoma cruzi histone deacetylase, putative 0.0309 0.7568 1
Giardia lamblia Kinase, STE STE20 0.0084 0.1357 0.1827
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0304 0.7423 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0279 0.6727 0.6727
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0279 0.6727 0.6727
Entamoeba histolytica protein kinase, putative 0.0117 0.2268 0.3055
Trypanosoma brucei histone deacetylase, putative 0.0309 0.7568 1
Brugia malayi hypothetical protein 0.0126 0.2504 0.3286
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.005 0.0402 0.0402
Entamoeba histolytica protein kinase, putative 0.0048 0.0362 0.0487
Schistosoma mansoni tyrosine kinase 0.0271 0.6518 0.6518
Brugia malayi Protein kinase domain containing protein 0.0048 0.0362 0.0475
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.3482 0.4568
Loa Loa (eye worm) hypothetical protein 0.0126 0.2504 0.3286
Echinococcus granulosus suppressor of cytokine signaling 6 0.0126 0.2504 0.2504
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0117 0.2268 0.2996
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0311 0.7622 0.7622
Schistosoma mansoni shc transforming protein 0.0126 0.2504 0.2504
Echinococcus multilocularis histone deacetylase 6 0.0316 0.7774 0.7774
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0642 0.0848
Loa Loa (eye worm) hypothetical protein 0.0117 0.2268 0.2975
Brugia malayi Protein kinase domain containing protein 0.005 0.0402 0.0528
Giardia lamblia Kinase, CMGC CDK 0.005 0.0402 0.0542
Echinococcus granulosus tyrosine protein kinase csk 0.007 0.0972 0.0972
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0038 0.0069 0.0069
Loa Loa (eye worm) STAT protein 0.0126 0.2504 0.3286
Toxoplasma gondii histone deacetylase HDAC1 0.0309 0.7568 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0642 0.0848
Brugia malayi Guanylate kinase family protein 0.0117 0.2268 0.2975
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0126 0.2504 0.2504
Trichomonas vaginalis STE family protein kinase 0.0084 0.1357 0.1827
Schistosoma mansoni protein kinase 0.0084 0.1357 0.1357
Trichomonas vaginalis histone deacetylase, putative 0.0304 0.7423 1
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0117 0.2268 0.2268
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.3482 0.4568
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0117 0.2268 0.2268
Trichomonas vaginalis histone deacetylase, putative 0.0304 0.7423 1
Brugia malayi SH2 domain containing protein 0.0161 0.3482 0.4568
Loa Loa (eye worm) hypothetical protein 0.0126 0.2504 0.3286
Echinococcus granulosus RNA directed DNA polymerase 0.0044 0.0233 0.0233
Entamoeba histolytica protein kinase, putative 0.0128 0.2574 0.3467
Loa Loa (eye worm) protein-tyrosine kinase 0.0117 0.2268 0.2975
Echinococcus multilocularis SH2 domain containing protein 7 0.0126 0.2504 0.2504
Trypanosoma brucei cdc2-related kinase 1 0.005 0.0402 0.0531
Loa Loa (eye worm) hypothetical protein 0.0126 0.2504 0.3286
Plasmodium vivax histone deacetylase 2, putative 0.0309 0.7568 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.2504 0.3286
Entamoeba histolytica hypothetical protein, conserved 0.0117 0.2268 0.3055
Brugia malayi Sex muscle abnormal protein 5 0.0243 0.5749 0.7543
Entamoeba histolytica SH2 domain containing protein 0.0126 0.2504 0.3374
Brugia malayi Src substrate cortactin 0.0117 0.2268 0.2975
Loa Loa (eye worm) hypothetical protein 0.0304 0.7423 0.9739
Schistosoma mansoni C-fyn 0.0117 0.2268 0.2268
Echinococcus multilocularis histone deacetylase 1 0.0304 0.7423 0.7423
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0362 0.0487
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0126 0.2504 0.3286
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0311 0.7622 0.7622
Echinococcus multilocularis signal transduction protein lnk realted 0.0126 0.2504 0.2504
Loa Loa (eye worm) hypothetical protein 0.0126 0.2504 0.3286
Echinococcus granulosus endophilin A3 0.0117 0.2268 0.2268
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.2268 0.2996
Schistosoma mansoni growth factor receptor-bound protein 0.0243 0.5749 0.5749
Brugia malayi SH2 domain containing protein 0.0196 0.4454 0.5844
Entamoeba histolytica protein kinase, putative 0.0068 0.0895 0.1206
Echinococcus granulosus tyrosine protein kinase HCK 0.0068 0.0895 0.0895
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0311 0.7622 0.7622
Brugia malayi Variant SH3 domain containing protein 0.0117 0.2268 0.2975
Entamoeba histolytica hypothetical protein 0.0117 0.2268 0.3055
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0642 0.0848
Brugia malayi SH2 domain containing protein 0.0126 0.2504 0.3286
Schistosoma mansoni suppressor of cytokine signaling 0.0126 0.2504 0.2504
Echinococcus multilocularis NCK adaptor protein 0.0243 0.5749 0.5749
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0126 0.2504 0.2504
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0133 0.269 0.269
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0126 0.2504 0.2504
Leishmania major histone deacetylase, putative 0.0304 0.7423 0.9809
Echinococcus multilocularis SH2 motif 0.0126 0.2504 0.2504
Loa Loa (eye worm) SH2 domain-containing protein 0.0126 0.2504 0.3286
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.005 0.0402 0.0531
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0311 0.7622 0.7622
Brugia malayi Variant SH3 domain containing protein 0.0243 0.5749 0.7543
Echinococcus multilocularis dual specificity mitogen activated protein 0.0084 0.1357 0.1357
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0362 0.0487
Echinococcus multilocularis tyrosine protein kinase shark 0.0397 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0642 0.0848
Brugia malayi Peripheral plasma membrane protein CASK 0.0117 0.2268 0.2975
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0126 0.2504 0.2504
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0126 0.2504 0.2504
Schistosoma mansoni tensin-related 0.0126 0.2504 0.2504
Echinococcus granulosus protein kinase C gamma type 0.0069 0.0919 0.0919
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0402 0.0542
Echinococcus granulosus Spectrin alpha actinin 0.0117 0.2268 0.2268
Loa Loa (eye worm) SH2 domain-containing protein 0.0161 0.3477 0.4561
Echinococcus granulosus signal transduction protein lnk realted 0.0126 0.2504 0.2504
Echinococcus granulosus tyrosine kinase 0.0161 0.3482 0.3482
Echinococcus multilocularis serine threonine protein kinase 0.0069 0.0919 0.0919
Trypanosoma cruzi histone deacetylase, putative 0.0309 0.7568 1
Brugia malayi SH2 domain containing protein 0.0126 0.2504 0.3286
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0133 0.269 0.3529
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0161 0.3482 0.469
Schistosoma mansoni GTPase activating protein 0.0126 0.2504 0.2504
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0126 0.2504 0.2504
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0126 0.2504 0.3286
Onchocerca volvulus 0.0161 0.3482 0.7817
Schistosoma mansoni cell polarity protein 0.0117 0.2268 0.2268
Echinococcus granulosus tyrosine protein kinase csk 0.007 0.0972 0.0972
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0402 0.0528
Schistosoma mansoni protein kinase 0.0038 0.0069 0.0069
Trichomonas vaginalis histone deacetylase, putative 0.0304 0.7423 1
Schistosoma mansoni adapter molecule crk 0.0243 0.5749 0.5749
Schistosoma mansoni tyrosine kinase 0.0311 0.7622 0.7622
Echinococcus granulosus tyrosine protein kinase Fyn 0.0311 0.7622 0.7622
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0133 0.269 0.269
Leishmania major protein kinase, putative 0.0038 0.0069 0.0092
Onchocerca volvulus 0.0161 0.3482 0.7817
Loa Loa (eye worm) hypothetical protein 0.0047 0.0333 0.0437
Entamoeba histolytica histone deacetylase, putative 0.0304 0.7423 1
Echinococcus multilocularis RNA directed DNA polymerase 0.0044 0.0233 0.0233
Loa Loa (eye worm) thyroid receptor interactor 0.0117 0.2268 0.2975
Loa Loa (eye worm) hypothetical protein 0.0117 0.2268 0.2975
Schistosoma mansoni tyrosine kinase 0.0279 0.6727 0.6727
Trichomonas vaginalis histone deacetylase, putative 0.0304 0.7423 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0642 0.0865
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0311 0.7622 0.7622
Echinococcus granulosus tyrosine protein kinase Srms 0.0161 0.3482 0.3482
Trypanosoma brucei rac serine-threonine kinase, putative 0.0048 0.0362 0.0478
Loa Loa (eye worm) TK/ABL protein kinase 0.0161 0.3482 0.4568
Echinococcus multilocularis intersectin 2 0.0119 0.2306 0.2306
Echinococcus granulosus histone deacetylase 3 0.0304 0.7423 0.7423
Entamoeba histolytica hypothetical protein 0.0117 0.2268 0.3055
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0117 0.2268 0.2268
Plasmodium vivax histone deacetylase, putative 0.0309 0.7568 1
Toxoplasma gondii histone deacetylase HDAC4 0.0139 0.2864 0.3784
Trypanosoma cruzi histone deacetylase, putative 0.0139 0.2864 0.3784
Echinococcus multilocularis tyrosine protein kinase Srms 0.0194 0.4377 0.4377
Schistosoma mansoni sorting nexin 0.0117 0.2268 0.2268
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0402 0.0402
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0402 0.0542
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0117 0.2268 0.2268
Entamoeba histolytica hypothetical protein 0.0117 0.2268 0.3055
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.3482 0.4568
Echinococcus granulosus tyrosine protein kinase Src42A 0.0311 0.7622 0.7622
Schistosoma mansoni hypothetical protein 0.0126 0.2504 0.2504
Schistosoma mansoni tensin 0.0126 0.2504 0.2504
Echinococcus granulosus Protein kinase C brain isozyme 0.0075 0.1104 0.1104
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0133 0.269 0.269
Loa Loa (eye worm) hypothetical protein 0.0126 0.2504 0.3286
Echinococcus multilocularis raf serine:threonine protein kinase 0.0042 0.0186 0.0186
Echinococcus granulosus NCK adaptor protein 0.0243 0.5749 0.5749
Brugia malayi Myosin tail family protein 0.0117 0.2268 0.2975
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0311 0.7622 0.7622
Entamoeba histolytica unconventional myosin IB 0.0117 0.2268 0.3055
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0402 0.0402
Entamoeba histolytica protein kinase domain containing protein 0.0038 0.0069 0.0093
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0084 0.1357 0.178
Onchocerca volvulus Putative cortactin 0.0117 0.2268 0.5091
Echinococcus granulosus SH2 motif 0.0126 0.2504 0.2504
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0161 0.3482 0.3482
Echinococcus granulosus tyrosine kinase 0.0194 0.4377 0.4377
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0402 0.0542
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0161 0.3482 0.3482
Echinococcus multilocularis nostrin 0.0117 0.2268 0.2268
Onchocerca volvulus 0.0126 0.2504 0.5622
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.3482 0.4568
Echinococcus granulosus tyrosine protein kinase Fyn 0.0311 0.7622 0.7622
Echinococcus granulosus expressed protein 0.0117 0.2268 0.2268
Brugia malayi SRC-1 0.0311 0.7622 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.2268 0.2975
Brugia malayi Tensin 0.0126 0.2504 0.3286
Echinococcus granulosus nostrin 0.0117 0.2268 0.2268
Loa Loa (eye worm) variant SH3 domain-containing protein 0.013 0.2606 0.3419
Brugia malayi histone deacetylase 1 (HD1) 0.0304 0.7423 0.9739
Echinococcus multilocularis tyrosine protein kinase Abl 0.0279 0.6727 0.6727
Brugia malayi Variant SH3 domain containing protein 0.0117 0.2268 0.2975
Loa Loa (eye worm) hypothetical protein 0.0126 0.2504 0.3286
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0038 0.0069 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0642 0.0642
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0642 0.0642
Schistosoma mansoni dreadlocks/dock 0.0117 0.2268 0.2268
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.2268 0.3055
Toxoplasma gondii histone deacetylase HDAC5 0.0139 0.2864 0.3784
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.012 0.2331 0.2331
Brugia malayi Tyrosine-protein kinase abl-1 0.0279 0.6727 0.8826
Loa Loa (eye worm) hypothetical protein 0.0117 0.2268 0.2975
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0243 0.5749 0.5749
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0117 0.2268 0.2268
Echinococcus granulosus histone deacetylase 7 0.0309 0.7568 0.7568
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0126 0.2504 0.2504
Brugia malayi Variant SH3 domain containing protein 0.0117 0.2268 0.2975
Echinococcus granulosus dual specificity mitogen activated protein 0.0084 0.1357 0.1357
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0075 0.1104 0.1104
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0084 0.1357 0.1792
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0117 0.2268 0.2268
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0194 0.4377 0.4377
Schistosoma mansoni tensin 0.0126 0.2504 0.2504
Loa Loa (eye worm) hypothetical protein 0.0161 0.3482 0.4568
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0117 0.2268 0.2268
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0362 0.0487
Brugia malayi SH2 domain containing protein 0.0126 0.2504 0.3286
Trypanosoma brucei histone deacetylase 1 0.0304 0.7423 0.9809
Echinococcus multilocularis tyrosine protein kinase csk 0.007 0.0972 0.0972
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0642 0.0642
Brugia malayi Protein kinase domain containing protein 0.0161 0.3482 0.4568
Echinococcus granulosus histone deacetylase 6 0.0309 0.7568 0.7568
Schistosoma mansoni eps8-related protein 0.0117 0.2268 0.2268
Brugia malayi tRNA modification GTPase TrmE family protein 0.0126 0.2504 0.3286
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.2268 0.3055
Loa Loa (eye worm) TK protein kinase 0.0194 0.4377 0.5742
Echinococcus granulosus tyrosine protein kinase Src64B 0.0311 0.7622 0.7622
Plasmodium vivax histone deacetylase, putative 0.0139 0.2864 0.3784
Echinococcus granulosus suppressor of cytokine signaling 7 0.0126 0.2504 0.2504
Echinococcus granulosus cyclin dependent kinase 0.005 0.0402 0.0402
Echinococcus multilocularis histone deacetylase 3 0.0304 0.7423 0.7423
Onchocerca volvulus 0.0161 0.3482 0.7817
Loa Loa (eye worm) hypothetical protein 0.0117 0.2268 0.2975
Loa Loa (eye worm) hypothetical protein 0.005 0.0419 0.0549
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0642 0.0848
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0362 0.0487
Brugia malayi Variant SH3 domain containing protein 0.0117 0.2268 0.2975
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0304 0.7423 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0304 0.7423 0.9809
Plasmodium vivax histone deacetylase 1, putative 0.0304 0.7423 0.9809
Echinococcus granulosus histone deacetylase 6 0.0309 0.7568 0.7568
Echinococcus granulosus tyrosine protein kinase ABL1 0.0161 0.3482 0.3482
Schistosoma mansoni histone deacetylase 1 2 3 0.0139 0.2864 0.2864
Loa Loa (eye worm) histone deacetylase 7A 0.0309 0.7568 0.9929
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.2268 0.3055
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.012 0.2331 0.2331
Brugia malayi cytokine inducible SH2-containing protein 5 0.0126 0.2504 0.3286
Echinococcus granulosus SH2 domain containing adapter protein F 0.0126 0.2504 0.2504
Giardia lamblia Histone deacetylase 0.0304 0.7423 1
Entamoeba histolytica BAR/SH3 domain containing protein 0.0117 0.2268 0.3055
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0362 0.0487
Echinococcus granulosus raf serine:threonine protein kinase 0.0042 0.0186 0.0186
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0362 0.0487
Echinococcus granulosus activin receptor type 0.0038 0.0069 0.0069
Brugia malayi Protein kinase domain containing protein 0.0161 0.3482 0.4568
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0126 0.2504 0.3286
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.005 0.0402 0.0531
Echinococcus multilocularis 0.0126 0.2504 0.2504
Schistosoma mansoni histone deacetylase hda2 0.0316 0.7774 0.7774
Echinococcus granulosus tyrosine protein kinase Src42A 0.0158 0.3399 0.3399
Brugia malayi Variant SH3 domain containing protein 0.013 0.2606 0.3419
Brugia malayi cell division control protein 2 homolog 0.005 0.0402 0.0528
Loa Loa (eye worm) hypothetical protein 0.0126 0.2504 0.3286
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0642 0.0865
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0402 0.0402
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0038 0.0069 0.0092
Echinococcus granulosus histone deacetylase 1 0.0304 0.7423 0.7423
Echinococcus multilocularis SH2 motif 0.0126 0.2504 0.2504
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0186 0.0186
Brugia malayi STAT protein, DNA binding domain containing protein 0.0126 0.2504 0.3286
Entamoeba histolytica hypothetical protein 0.012 0.2331 0.314
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0402 0.0542
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0642 0.0865
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0133 0.269 0.269
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0117 0.2268 0.2268
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0126 0.2504 0.5622
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.005 0.0402 0.0531
Brugia malayi Histone deacetylase 1 0.0304 0.7423 0.9739
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.2268 0.3055
Echinococcus multilocularis tensin 0.0126 0.2504 0.2504
Schistosoma mansoni protein kinase 0.0038 0.0069 0.0069
Echinococcus multilocularis histone deacetylase 0.0309 0.7568 0.7568
Loa Loa (eye worm) hypothetical protein 0.0126 0.2504 0.3286
Schistosoma mansoni run and tbc1 domain containing 0.0117 0.2268 0.2268
Schistosoma mansoni tyrosine kinase 0.0311 0.7622 0.7622
Brugia malayi Histone deacetylase family protein 0.0309 0.7568 0.9929
Echinococcus granulosus tensin 0.0126 0.2504 0.2504
Leishmania major histone deacetylase, putative 0.0304 0.7423 0.9809
Brugia malayi SH2 domain containing protein 0.0126 0.2504 0.3286
Schistosoma mansoni histone deacetylase 4 5 0.0309 0.7568 0.7568
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0642 0.0848
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0084 0.1357 0.1792
Brugia malayi histone deacetylase 3 (HD3) 0.0304 0.7423 0.9739
Trichomonas vaginalis histone deacetylase, putative 0.0304 0.7423 1
Schistosoma mansoni sorbin 0.0117 0.2268 0.2268
Onchocerca volvulus 0.0126 0.2504 0.5622
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0048 0.0341 0.0447
Trypanosoma brucei histone deacetylase 2 0.0139 0.2864 0.3784
Schistosoma mansoni hypothetical protein 0.0117 0.2268 0.2268
Toxoplasma gondii histone deacetylase HDAC3 0.0304 0.7423 0.9809
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0126 0.2504 0.2504
Onchocerca volvulus Histone deacetylase 10 homolog 0.0139 0.2864 0.643
Loa Loa (eye worm) hypothetical protein 0.0126 0.2504 0.3286
Brugia malayi Fes/CIP4 homology domain containing protein 0.0117 0.2268 0.2975
Onchocerca volvulus 0.0196 0.4454 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0068 0.0895 0.0895
Giardia lamblia Kinase, CMGC CDK 0.005 0.0402 0.0542
Schistosoma mansoni dynamin-associated protein 0.0117 0.2268 0.2268
Leishmania major hypothetical protein, conserved 0.0117 0.2268 0.2996
Schistosoma mansoni SH2A 0.0126 0.2504 0.2504
Echinococcus multilocularis SH2 motif 0.0126 0.2504 0.2504
Brugia malayi hypothetical protein 0.0161 0.3482 0.4568
Onchocerca volvulus 0.012 0.2337 0.5247
Echinococcus granulosus expressed conserved protein 0.0126 0.2504 0.2504
Echinococcus multilocularis endophilin A3 0.0117 0.2268 0.2268
Echinococcus multilocularis activin receptor type 0.0038 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0178 0.3933 0.5159
Echinococcus granulosus growth factor receptor bound protein 2 0.0243 0.5749 0.5749
Brugia malayi Protein kinase domain containing protein 0.0161 0.3482 0.4568
Echinococcus multilocularis tyrosine protein kinase Blk 0.0194 0.4377 0.4377
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0311 0.7622 0.7622
Schistosoma mansoni histone deacetylase hda2 0.0139 0.2864 0.2864
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0642 0.0865
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0642 0.0848
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.2268 0.3055
Plasmodium falciparum protein kinase 5 0.005 0.0402 0.0531
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0402 0.0531
Echinococcus granulosus SH2 domain containing protein 7 0.0126 0.2504 0.2504
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0126 0.2504 0.2504
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0402 0.0531
Loa Loa (eye worm) histone deacetylase 1 0.0304 0.7423 0.9739
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0304 0.7423 1
Loa Loa (eye worm) histone deacetylase 3 0.0304 0.7423 0.9739
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.005 0.0402 0.0528
Schistosoma mansoni hypothetical protein 0.0126 0.2504 0.2504
Loa Loa (eye worm) TK protein kinase 0.0068 0.0895 0.1174
Schistosoma mansoni formin binding protein and related proteins 0.0117 0.2268 0.2268
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0117 0.2268 0.2268
Entamoeba histolytica hypothetical protein 0.0117 0.2268 0.3055
Loa Loa (eye worm) histone deacetylase 11 0.0139 0.2864 0.3758
Echinococcus multilocularis cyclin dependent kinase 0.005 0.0402 0.0402
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0402 0.0542
Echinococcus multilocularis N chimaerin 0.0133 0.269 0.269
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0046 0.0299 0.0392
Echinococcus granulosus SHC transforming protein 3 0.0126 0.2504 0.2504
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0642 0.0865
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0362 0.0487
Plasmodium falciparum histone deacetylase 1 0.0304 0.7423 0.9809
Loa Loa (eye worm) TK/CSK protein kinase 0.007 0.0972 0.1276
Onchocerca volvulus 0.0126 0.2504 0.5622
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0402 0.0531
Echinococcus multilocularis tyrosine kinase 0.0161 0.3482 0.3482
Brugia malayi protein-tyrosine kinase 0.0194 0.4377 0.5742
Echinococcus granulosus histone deacetylase 0.0309 0.7568 0.7568
Echinococcus granulosus histone deacetylase 8 0.0139 0.2864 0.2864
Entamoeba histolytica BAR/SH3 domain containing protein 0.0117 0.2268 0.3055
Echinococcus granulosus fch and double sh3 domains protein 2 0.0117 0.2268 0.2268
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0038 0.0069 0.0069
Trichomonas vaginalis STE family protein kinase 0.0084 0.1357 0.1827
Echinococcus granulosus src region 0.0117 0.2268 0.2268
Schistosoma mansoni suppressor of cytokine signaling 0.0126 0.2504 0.2504
Schistosoma mansoni tyrosine kinase 0.0161 0.3482 0.3482
Echinococcus granulosus N chimaerin 0.0133 0.269 0.269
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0117 0.2268 0.3055
Echinococcus multilocularis cyclin dependent kinase 5 0.005 0.0402 0.0402
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0243 0.5749 0.7543
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0038 0.0069 0.0092
Trypanosoma brucei protein kinase, putative 0.0038 0.0069 0.0092
Brugia malayi SH2 domain containing protein 0.0126 0.2504 0.3286
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.2268 0.2996
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.012 0.2331 0.2331
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0126 0.2504 0.2504
Onchocerca volvulus 0.0117 0.2268 0.5091
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0158 0.3399 0.3399
Brugia malayi protein-tyrosine kinase 0.0117 0.2268 0.2975
Brugia malayi SH2 domain containing protein 0.0126 0.2504 0.3286
Echinococcus multilocularis tyrosine protein kinase csk 0.007 0.0972 0.0972
Entamoeba histolytica hypothetical protein 0.0117 0.2268 0.3055
Loa Loa (eye worm) AGC/AKT protein kinase 0.0048 0.0362 0.0475
Echinococcus granulosus tyrosine protein kinase Blk 0.0194 0.4377 0.4377
Loa Loa (eye worm) SH2 domain-containing protein 0.0126 0.2504 0.3286
Brugia malayi RhoGAP domain containing protein 0.0133 0.269 0.3529
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.3482 0.4568
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0311 0.7622 0.7622
Echinococcus multilocularis Spectrin alpha actinin 0.0117 0.2268 0.2268
Plasmodium vivax protein kinase Crk2 0.005 0.0402 0.0531
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0642 0.0642
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0126 0.2504 0.2504
Entamoeba histolytica hypothetical protein 0.0117 0.2268 0.3055
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0243 0.5749 0.7543
Trypanosoma brucei conserved protein 0.0117 0.2268 0.2996
Trichomonas vaginalis p67phox protein, putative 0.0117 0.2268 0.3055
Schistosoma mansoni apoptosis stimulating of P53 0.0117 0.2268 0.2268
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0126 0.2504 0.2504
Schistosoma mansoni protein kinase 0.0038 0.0069 0.0069
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0117 0.2268 0.2268
Echinococcus granulosus cyclin dependent kinase 5 0.005 0.0402 0.0402
Loa Loa (eye worm) SRC-1 0.0311 0.7622 1
Echinococcus multilocularis tyrosine protein kinase csk 0.007 0.0972 0.0972
Schistosoma mansoni tensin 0.0126 0.2504 0.2504
Loa Loa (eye worm) hypothetical protein 0.0139 0.2864 0.3758
Echinococcus multilocularis histone deacetylase 6 0.0309 0.7568 0.7568
Echinococcus granulosus tyrosine protein kinase Fyn 0.0311 0.7622 0.7622
Schistosoma mansoni tensin-related 0.0126 0.2504 0.2504
Echinococcus multilocularis growth factor receptor bound protein 2 0.0243 0.5749 0.5749
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0642 0.0842
Trypanosoma brucei histone deacetylase 3 0.0309 0.7568 1
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0126 0.2504 0.5622
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0128 0.2574 0.3467
Trypanosoma cruzi histone deacetylase, putative 0.0139 0.2864 0.3784
Schistosoma mansoni Dab2-interacting protein-like 0.0117 0.2268 0.2268
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.2268 0.3055
Brugia malayi MAP kinase sur-1 0.0059 0.0642 0.0842
Trichomonas vaginalis histone deacetylase, putative 0.0304 0.7423 1
Echinococcus granulosus intersectin 2 0.0119 0.2306 0.2306
Brugia malayi Histone deacetylase family protein 0.0309 0.7568 0.9929
Echinococcus granulosus tyrosine protein kinase Lyn 0.0313 0.7691 0.7691
Schistosoma mansoni growth factor receptor-bound protein 0.0243 0.5749 0.5749
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0117 0.2268 0.2268
Loa Loa (eye worm) guanylate kinase 0.0117 0.2268 0.2975
Brugia malayi Variant SH3 domain containing protein 0.0243 0.5749 0.7543
Schistosoma mansoni histone deacetylase 4 5 0.0309 0.7568 0.7568
Loa Loa (eye worm) hypothetical protein 0.0126 0.2504 0.3286
Echinococcus multilocularis SHC transforming protein 3 0.0126 0.2504 0.2504
Schistosoma mansoni histone deacetylase 0.0304 0.7423 0.7423
Echinococcus granulosus c src tyrosine kinase 0.0314 0.7699 0.7699
Loa Loa (eye worm) hypothetical protein 0.0044 0.0233 0.0306
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0311 0.7622 0.7622
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0194 0.4377 0.4377
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.1104 0.1104
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0117 0.2268 0.2975
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.2268 0.2996
Entamoeba histolytica protein kinase, putative 0.0048 0.0362 0.0487
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0402 0.0402
Echinococcus multilocularis histone deacetylase 7 0.0309 0.7568 0.7568
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.3245 0.3245
Entamoeba histolytica hypothetical protein, conserved 0.0117 0.2268 0.3055
Echinococcus granulosus hypothetical protein 0.0126 0.2504 0.2504
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.3482 0.4568
Echinococcus granulosus tyrosine protein kinase csk 0.007 0.0972 0.0972
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0084 0.1357 0.178
Echinococcus multilocularis expressed protein 0.0117 0.2268 0.2268
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0126 0.2504 0.2504
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.1104 0.1104
Schistosoma mansoni tyrosine kinase 0.0314 0.7699 0.7699
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0117 0.2268 0.2975
Echinococcus multilocularis c src tyrosine kinase 0.0314 0.7699 0.7699
Onchocerca volvulus 0.0117 0.2268 0.5091
Entamoeba histolytica protein kinase, putative 0.0046 0.0299 0.0402
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0117 0.2268 0.2268
Entamoeba histolytica hypothetical protein 0.0117 0.2268 0.3055
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0117 0.2268 0.5091
Echinococcus granulosus histone deacetylase 6 0.0316 0.7774 0.7774
Brugia malayi Variant SH3 domain containing protein 0.0117 0.2268 0.2975
Trichomonas vaginalis STE family protein kinase 0.0084 0.1357 0.1827
Schistosoma mansoni vav2 0.0135 0.2753 0.2753
Brugia malayi Variant SH3 domain containing protein 0.0133 0.269 0.3529
Loa Loa (eye worm) hypothetical protein 0.0117 0.2268 0.2975
Trypanosoma brucei protein kinase, putative 0.0059 0.0642 0.0848
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0044 0.0233 0.0233
Toxoplasma gondii AGC kinase 0.0046 0.0299 0.0395
Echinococcus multilocularis transfer RNA-Ala 0.0117 0.2268 0.2268
Onchocerca volvulus 0.0126 0.2504 0.5622
Trypanosoma cruzi histone deacetylase, putative 0.0309 0.7568 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0642 0.0848
Loa Loa (eye worm) p53BP2 0.0117 0.2268 0.2975
Loa Loa (eye worm) hypothetical protein 0.0128 0.2567 0.3368
Loa Loa (eye worm) hypothetical protein 0.0117 0.2268 0.2975
Brugia malayi Variant SH3 domain containing protein 0.0117 0.2268 0.2975
Plasmodium falciparum histone deacetylase, putative 0.0309 0.7568 1
Onchocerca volvulus 0.0161 0.3482 0.7817
Echinococcus granulosus cyclin dependent kinase 1 0.005 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0126 0.2504 0.3286
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.3482 0.4568
Schistosoma mansoni signal transduction protein lnk-related 0.0126 0.2504 0.2504
Trypanosoma cruzi histone deacetylase 1, putative 0.0304 0.7423 0.9809
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0084 0.1357 0.1792
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0279 0.6727 0.6727
Loa Loa (eye worm) hypothetical protein 0.0117 0.2268 0.2975
Brugia malayi Protein kinase c protein 2 0.0054 0.0526 0.0691
Brugia malayi Protein kinase domain containing protein 0.0161 0.3482 0.4568
Schistosoma mansoni histone deacetylase 0.0304 0.7423 0.7423
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0161 0.3482 0.3482
Plasmodium falciparum protein kinase, putative 0.0038 0.0069 0.0092
Schistosoma mansoni tyrosine kinase 0.0397 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0311 0.7622 0.7622
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0402 0.0531
Brugia malayi histone deacetylase 11 0.0139 0.2864 0.3758

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 2.2 uM Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay ChEMBL. 25218912
IC50 (binding) = 0.013 uM Inhibition of human recombinant HDAC3 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 0.025 uM Inhibition of human recombinant HDAC10 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 0.035 uM Inhibition of human recombinant HDAC1 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 0.065 uM Inhibition of human recombinant HDAC6 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 0.204 uM Inhibition of human recombinant HDAC2 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 1.024 uM Inhibition of human recombinant HDAC8 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 3.54 uM Inhibition of human recombinant HDAC5 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 18.3 uM Inhibition of human recombinant HDAC9 after 60 mins by fluorimetric assay ChEMBL. 25218912
IC50 (binding) = 56.3 uM Inhibition of human recombinant HDAC4 after 60 mins by fluorimetric assay ChEMBL. 25218912

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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