TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 385.247 | Formula: C10H10Cl2N4O4S2
H donors: 1 H acceptors: 5 LogP: 2.73 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Clc1sc(c(c1)S(=O)(=O)NCCCn1ccnc1[N+](=O)[O-])Cl
InChi: 1S/C10H10Cl2N4O4S2/c11-8-6-7(9(12)21-8)22(19,20)14-2-1-4-15-5-3-13-10(15)16(17)18/h3,5-6,14H,1-2,4H2
InChiKey: TWLVFSOIMVGENQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tubulin alpha chain	0.0363723	0.584283	0.700428
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.050665	0.861471	1
Trichomonas vaginalis	tubulin, putative	0.0148921	0.167703	0.088292
Echinococcus multilocularis	tubulin alpha	0.0263199	0.38933	0.466721
Leishmania major	beta tubulin	0.0492578	0.834181	1
Leishmania major	alpha tubulin	0.0363723	0.584283	0.688241
Echinococcus granulosus	tubulin alpha 1C chain	0.0363723	0.584283	0.700428
Leishmania major	beta tubulin	0.0492578	0.834181	1
Trypanosoma brucei	tubulin delta chain	0.0114278	0.100517	0.0847199
Echinococcus granulosus	tubulin beta 1 chain	0.0492578	0.834181	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0114278	0.100517	0.5
Leishmania major	beta tubulin	0.0492578	0.834181	1
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0115326	0.102549	0.122934
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0148921	0.167703	0.088292
Loa Loa (eye worm)	BEN-1 protein	0.0492578	0.834181	0.968321
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0115326	0.102549	0.122934
Leishmania major	alpha tubulin	0.0363723	0.584283	0.688241
Echinococcus granulosus	beta tubulin	0.0492578	0.834181	1
Loa Loa (eye worm)	tubulin beta chain	0.0492578	0.834181	0.968321
Entamoeba histolytica	tubulin family protein	0.0492578	0.834181	0.96634
Echinococcus multilocularis	fructose 1,6 bisphosphate aldolase	0.00968833	0.0667821	0.0800572
Brugia malayi	Uncoordinated protein 44	0.0115326	0.102549	0.119039
Echinococcus multilocularis	tubulin subunit beta	0.0492578	0.834181	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0363723	0.584283	0.635737
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0263199	0.38933	0.445028
Brugia malayi	tubulin alpha-2 chain	0.0363723	0.584283	0.678239
Brugia malayi	Tubulin alpha chain	0.0363723	0.584283	0.678239
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0492578	0.834181	1
Echinococcus multilocularis	tubulin epsilon chain	0.0263199	0.38933	0.466721
Loa Loa (eye worm)	hypothetical protein	0.0115326	0.102549	0.119039
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0363723	0.584283	0.635737
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0317855	0.495328	0.574979
Loa Loa (eye worm)	tubulin gamma chain	0.0263199	0.38933	0.451936
Trypanosoma cruzi	fructose-bisphosphate aldolase, glycosomal, putative	0.00968833	0.0667821	0.0426344
Leishmania major	beta tubulin	0.0492578	0.834181	1
Echinococcus multilocularis	Ankyrin	0.0115326	0.102549	0.122934
Brugia malayi	Tubulin gamma chain	0.0263199	0.38933	0.451936
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.050665	0.861471	1
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.050665	0.861471	0.933533
Trypanosoma brucei	tubulin gamma chain	0.0263199	0.38933	0.445028
Giardia lamblia	Epsilon tubulin	0.0114278	0.100517	0.0819305
Brugia malayi	ABC transporter family protein	0.00754677	0.0252495	0.0293098
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0363723	0.584283	0.635737
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.050665	0.861471	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0363723	0.584283	0.700428
Echinococcus multilocularis	ATP binding cassette sub family G	0.00885957	0.0507095	0.0607896
Echinococcus granulosus	ATP binding cassette sub family G	0.00885957	0.0507095	0.0607896
Mycobacterium leprae	cell division protein FtsZ	0.0114278	0.100517	0.5
Toxoplasma gondii	alpha-tubulin I, putative	0.0363723	0.584283	0.688241
Echinococcus granulosus	Tubulin beta 2C chain	0.0492578	0.834181	1
Brugia malayi	fructose-bisphosphate aldolase 2	0.00968833	0.0667821	0.077521
Echinococcus granulosus	tubulin alpha chain	0.0363723	0.584283	0.700428
Echinococcus multilocularis	Tubulin beta 2C chain	0.0492578	0.834181	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0263199	0.38933	0.445028
Loa Loa (eye worm)	alpha-tubulin	0.0363723	0.584283	0.678239
Echinococcus granulosus	tubulin alpha chain	0.0363723	0.584283	0.700428
Schistosoma mansoni	tubulin subunit beta	0.0492578	0.834181	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0492578	0.834181	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0492578	0.834181	0.968321
Loa Loa (eye worm)	alpha-tubulin	0.0363723	0.584283	0.678239
Loa Loa (eye worm)	tubulin alpha chain	0.0363723	0.584283	0.678239
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0114278	0.100517	0.0845881
Trypanosoma brucei	epsilon tubulin	0.0263199	0.38933	0.445028
Schistosoma mansoni	tubulin subunit delta	0.0114278	0.100517	0.120498
Loa Loa (eye worm)	beta-tubulin	0.0492578	0.834181	0.968321
Loa Loa (eye worm)	hypothetical protein	0.0416985	0.687578	0.798144
Trichomonas vaginalis	tubulin, putative	0.0148921	0.167703	0.088292
Echinococcus granulosus	beta tubulin	0.0492578	0.834181	1
Loa Loa (eye worm)	tubulin alpha 2	0.0100524	0.0738432	0.0857176
Schistosoma mansoni	tubulin subunit beta	0.0492578	0.834181	1
Leishmania major	ATP-binding cassette protein subfamily G, member 4, putative	0.00885957	0.0507095	0.0225831
Echinococcus multilocularis	fructose 1,6 bisphosphate aldolase	0.00968833	0.0667821	0.0800572
Trypanosoma cruzi	ATP-binding cassette protein, putative	0.00885957	0.0507095	0.0225831
Trypanosoma brucei	fructose-bisphosphate aldolase, glycosomal, putative	0.00968833	0.0667821	0.0426344
Leishmania major	alpha tubulin	0.0363723	0.584283	0.688241
Loa Loa (eye worm)	tubulin alpha chain	0.0363723	0.584283	0.678239
Echinococcus granulosus	TNFR CD27 30 40 95 cysteine rich region	0.0148291	0.166481	0.199575
Trypanosoma cruzi	ABC transporter, putative	0.00885957	0.0507095	0.0225831
Leishmania major	beta tubulin	0.0492578	0.834181	1
Trypanosoma brucei	ATP-binding cassette protein, putative	0.00885957	0.0507095	0.0225831
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.050665	0.861471	1
Trypanosoma brucei	alpha tubulin	0.0363723	0.584283	0.688241
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0115326	0.102549	0.122934
Echinococcus multilocularis	netrin receptor unc 5	0.0115326	0.102549	0.122934
Schistosoma mansoni	tubulin subunit alpha	0.0363723	0.584283	0.700428
Leishmania major	ATP-binding cassette protein subfamily G, member 6, putative	0.00885957	0.0507095	0.0225831
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0361905	0.580758	0.696202
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0249445	0.362656	0.344488
Leishmania major	alpha tubulin	0.0363723	0.584283	0.688241
Brugia malayi	tubulin alpha chain - mouse	0.0363723	0.584283	0.678239
Brugia malayi	beta-tubulin, identical	0.0492578	0.834181	0.968321
Trichomonas vaginalis	tubulin beta chain, putative	0.0363723	0.584283	0.635737
Brugia malayi	Tubulin beta chain	0.0114278	0.100517	0.11668
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.050665	0.861471	1
Schistosoma mansoni	alzheimer's disease beta-amyloid related	0.0174167	0.216663	0.259732
Plasmodium falciparum	fructose-bisphosphate aldolase	0.00968833	0.0667821	0.0426344
Trypanosoma brucei	epsilon tubulin	0.0263199	0.38933	0.445028
Echinococcus granulosus	Tubulin beta 2C chain	0.0492578	0.834181	1
Brugia malayi	Cation transporter family protein	0.0416985	0.687578	0.798144
Echinococcus granulosus	peroxisome assembly protein 26	0.0363723	0.584283	0.700428
Loa Loa (eye worm)	tubulin beta-2A chain	0.0492578	0.834181	0.968321
Echinococcus granulosus	fructose bisphosphate aldolase class I	0.00968833	0.0667821	0.0800572
Echinococcus multilocularis	tubulin alpha 1C chain	0.0363723	0.584283	0.700428
Trypanosoma cruzi	beta tubulin, putative	0.0492578	0.834181	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0363723	0.584283	0.700428
Trypanosoma cruzi	zeta tubulin, putative	0.0114278	0.100517	0.0847199
Leishmania major	alpha tubulin	0.0363723	0.584283	0.688241
Echinococcus multilocularis	tubulin alpha 3 chain	0.0363723	0.584283	0.700428
Giardia lamblia	Alpha-tubulin	0.0363723	0.584283	0.665581
Trypanosoma brucei	ABC transporter, putative	0.00885957	0.0507095	0.0225831
Brugia malayi	Tubulin alpha-2 chain	0.0363723	0.584283	0.678239
Echinococcus granulosus	fructose 16 bisphosphate aldolase	0.00968833	0.0667821	0.0800572
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0317855	0.495328	0.59379
Onchocerca volvulus		0.0416985	0.687578	0.798144
Toxoplasma gondii	beta-1 tubulin, putative	0.0492578	0.834181	1
Leishmania major	beta tubulin	0.0492578	0.834181	1
Loa Loa (eye worm)	hypothetical protein	0.0388179	0.631712	0.733294
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0114278	0.100517	0.0847199
Trypanosoma brucei	alpha tubulin	0.0363723	0.584283	0.688241
Leishmania major	epsilon tubulin, putative	0.0263199	0.38933	0.445028
Plasmodium falciparum	tubulin beta chain	0.0492578	0.834181	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0363723	0.584283	0.635737
Plasmodium vivax	tubulin beta chain, putative	0.0492578	0.834181	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0115326	0.102549	0.119039
Schistosoma mansoni	tubulin subunit beta	0.0492578	0.834181	1
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.050665	0.861471	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0492578	0.834181	1
Echinococcus granulosus	ATP binding cassette sub family G	0.00885957	0.0507095	0.0607896
Plasmodium falciparum	alpha tubulin 1	0.0363723	0.584283	0.688241
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0115326	0.102549	0.119039
Giardia lamblia	ABC transporter	0.00883103	0.050156	0.0211717
Trypanosoma brucei	beta tubulin	0.0492578	0.834181	1
Trypanosoma brucei	beta tubulin	0.0492578	0.834181	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0363723	0.584283	0.658114
Echinococcus multilocularis	TNFR CD27 30 40 95 cysteine rich region	0.0148291	0.166481	0.199575
Toxoplasma gondii	fructose-1,6-bisphosphate aldolase	0.00968833	0.0667821	0.0426344
Schistosoma mansoni	tubulin subunit beta	0.0114278	0.100517	0.120498
Echinococcus granulosus	Tubulin beta 2C chain	0.0492578	0.834181	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0148921	0.167703	0.088292
Echinococcus multilocularis	tubulin alpha chain	0.0363723	0.584283	0.700428
Leishmania major	beta tubulin	0.0492578	0.834181	1
Loa Loa (eye worm)	hypothetical protein	0.0363723	0.584283	0.678239
Plasmodium vivax	delta tubulin, putative	0.0114278	0.100517	0.0847199
Leishmania major	beta tubulin	0.0492578	0.834181	1
Leishmania major	beta tubulin	0.0492578	0.834181	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0492578	0.834181	0.964136
Loa Loa (eye worm)	tubulin beta chain	0.0114278	0.100517	0.11668
Trypanosoma cruzi	zeta tubulin, putative	0.0114278	0.100517	0.0847199
Loa Loa (eye worm)	tubulin alpha 2	0.0249445	0.362656	0.420973
Trypanosoma brucei	alpha tubulin	0.0363723	0.584283	0.688241
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0317855	0.495328	0.59379
Loa Loa (eye worm)	fructose-bisphosphate aldolase 2	0.00968833	0.0667821	0.077521
Trypanosoma brucei	zeta tubulin, putative	0.0114278	0.100517	0.0847199
Loa Loa (eye worm)	tubulin alpha 2	0.0249445	0.362656	0.420973
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0249445	0.362656	0.420973
Plasmodium vivax	tubulin alpha chain, putative	0.0363723	0.584283	0.688241
Trypanosoma cruzi	alpha tubulin, putative	0.0363723	0.584283	0.688241
Schistosoma mansoni	tubulin subunit alpha	0.0114278	0.100517	0.120498
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0363723	0.584283	0.678239
Trichomonas vaginalis	tubulin alpha chain, putative	0.0148921	0.167703	0.088292
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG84	0.00885957	0.0507095	0.0225831
Leishmania major	alpha tubulin	0.0363723	0.584283	0.688241
Leishmania major	beta tubulin	0.0492578	0.834181	1
Schistosoma mansoni	alpha tubulin	0.0363723	0.584283	0.700428
Echinococcus granulosus	tubulin alpha chain	0.0363723	0.584283	0.700428
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0317855	0.495328	0.574979
Onchocerca volvulus	Netrin receptor homolog	0.0115326	0.102549	0.119039
Trypanosoma brucei	alpha tubulin, putative	0.0148921	0.167703	0.168538
Plasmodium vivax	fructose 1,6-bisphosphate aldolase, putative	0.00968833	0.0667821	0.0426344
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0361905	0.580758	0.661328
Brugia malayi	Protein kinase domain containing protein	0.0115326	0.102549	0.119039
Echinococcus granulosus	tubulin subunit TubB	0.0363723	0.584283	0.700428
Trypanosoma cruzi	fructose-bisphosphate aldolase, glycosomal, putative	0.00968833	0.0667821	0.0426344
Trichomonas vaginalis	tubulin beta chain, putative	0.0363723	0.584283	0.635737
Echinococcus multilocularis	fructose bisphosphate aldolase class I	0.00968833	0.0667821	0.0800572
Loa Loa (eye worm)	hypothetical protein	0.0249445	0.362656	0.420973
Schistosoma mansoni	tubulin subunit alpha	0.0363723	0.584283	0.700428
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0363723	0.584283	0.700428
Leishmania major	alpha tubulin	0.0363723	0.584283	0.688241
Echinococcus multilocularis	hypothetical protein	0.0363723	0.584283	0.700428
Brugia malayi	Telomerase reverse transcriptase	0.0175437	0.219126	0.254363
Toxoplasma gondii	beta-tubulin, putative	0.0492578	0.834181	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0492578	0.834181	0.964136
Toxoplasma gondii	alpha tubulin TUBA1	0.0363723	0.584283	0.688241
Loa Loa (eye worm)	hypothetical protein	0.0361905	0.580758	0.674147
Trichomonas vaginalis	tubulin beta chain, putative	0.0148921	0.167703	0.088292
Plasmodium vivax	tubulin gamma chain, putative	0.0263199	0.38933	0.445028
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0214802	0.29547	0.342983
Trichomonas vaginalis	tubulin alpha chain, putative	0.0148921	0.167703	0.088292
Echinococcus granulosus	ATP binding cassette sub family G	0.00885957	0.0507095	0.0607896
Plasmodium falciparum	tubulin gamma chain	0.0263199	0.38933	0.445028
Loa Loa (eye worm)	hypothetical protein	0.0102109	0.0769167	0.0892853
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0416985	0.687578	0.824255
Leishmania major	alpha tubulin	0.0363723	0.584283	0.688241
Brugia malayi	Tubulin beta chain	0.0148921	0.167703	0.19467
Trypanosoma brucei	beta tubulin	0.0492578	0.834181	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0363723	0.584283	0.700428
Echinococcus granulosus	Tubulin beta 2C chain	0.0492578	0.834181	1
Leishmania major	beta tubulin	0.0492578	0.834181	1
Brugia malayi	alpha-tubulin	0.0363723	0.584283	0.678239
Leishmania major	beta tubulin	0.0492578	0.834181	1
Loa Loa (eye worm)	hypothetical protein	0.0416985	0.687578	0.798144
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.050665	0.861471	0.854071
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.050665	0.861471	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0492578	0.834181	0.964136
Trichomonas vaginalis	tubulin gamma chain, putative	0.0263199	0.38933	0.379541
Onchocerca volvulus		0.0416985	0.687578	0.798144
Echinococcus multilocularis	tubulin subunit TubB	0.0363723	0.584283	0.700428
Trypanosoma cruzi	fructose-bisphosphate aldolase, glycosomal, putative	0.00968833	0.0667821	0.0426344
Echinococcus multilocularis	tubulin alpha chain	0.0363723	0.584283	0.700428
Schistosoma mansoni	tubulin subunit beta	0.0492578	0.834181	1
Schistosoma mansoni	tubulin subunit beta	0.0492578	0.834181	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0363723	0.584283	0.700428
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0492578	0.834181	0.964136
Trypanosoma brucei	beta tubulin	0.0263199	0.38933	0.445028
Loa Loa (eye worm)	hypothetical protein	0.0214802	0.29547	0.342983
Plasmodium falciparum	tubulin delta chain, putative	0.0114278	0.100517	0.0847199
Schistosoma mansoni	alpha tubulin	0.0363723	0.584283	0.700428
Trypanosoma cruzi	tubulin delta chain	0.0114278	0.100517	0.0847199
Brugia malayi	fructose-bisphosphate aldolase 1	0.00968833	0.0667821	0.077521
Leishmania major	alpha tubulin	0.0363723	0.584283	0.688241
Entamoeba histolytica	tubulin alpha chain, putative	0.0363723	0.584283	0.658114
Plasmodium vivax	tubulin alpha chain, putative	0.0363723	0.584283	0.688241
Plasmodium vivax	tubulin epsilon chain, putative	0.0263199	0.38933	0.445028
Giardia lamblia	Beta tubulin	0.0492578	0.834181	0.967075
Trypanosoma brucei	beta tubulin	0.0492578	0.834181	1
Giardia lamblia	Alpha-tubulin	0.0363723	0.584283	0.665581
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0363723	0.584283	0.700428
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0361905	0.580758	0.683843
Trichomonas vaginalis	tubulin beta chain, putative	0.0363723	0.584283	0.635737
Giardia lamblia	Beta tubulin	0.0492578	0.834181	0.967075
Trichomonas vaginalis	tubulin gamma chain, putative	0.0263199	0.38933	0.379541
Brugia malayi	Tubulin alpha-2 chain	0.0363723	0.584283	0.678239
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.057808	1	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0263199	0.38933	0.445028
Echinococcus granulosus	fructose 16 bisphosphate aldolase	0.00968833	0.0667821	0.0800572
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0214802	0.29547	0.256196
Echinococcus multilocularis	tubulin alpha chain	0.0363723	0.584283	0.700428
Echinococcus granulosus	Tubulin alpha 1 chain	0.0363723	0.584283	0.700428
Schistosoma mansoni	tumor necrosis factor receptor related	0.0148291	0.166481	0.199575
Echinococcus granulosus	tubulin alpha	0.0263199	0.38933	0.466721
Echinococcus granulosus	tubulin alpha chain	0.0363723	0.584283	0.700428
Loa Loa (eye worm)	tubulin beta-4 chain	0.0492578	0.834181	0.968321
Echinococcus granulosus	Tubulin alpha 1 chain	0.0363723	0.584283	0.700428
Loa Loa (eye worm)	hypothetical protein	0.0115326	0.102549	0.119039
Leishmania major	alpha tubulin	0.0363723	0.584283	0.688241
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0114278	0.100517	0.0847199
Onchocerca volvulus		0.0148921	0.167703	0.19467
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0361905	0.580758	0.696202
Echinococcus granulosus	alpha tubulin	0.0363723	0.584283	0.700428
Trypanosoma brucei	zeta tubulin	0.0114278	0.100517	0.0847199
Echinococcus granulosus	netrin receptor unc 5	0.0115326	0.102549	0.122934
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0361905	0.580758	0.696202
Loa Loa (eye worm)	hypothetical protein	0.020359	0.273725	0.317741
Echinococcus granulosus	fructose 16 bisphosphate aldolase	0.00968833	0.0667821	0.0800572
Schistosoma mansoni	tubulin subunit epsilon	0.0263199	0.38933	0.466721
Echinococcus multilocularis	ATP binding cassette sub family G	0.00885957	0.0507095	0.0607896
Leishmania major	alpha tubulin	0.0363723	0.584283	0.688241
Toxoplasma gondii	beta tubulin	0.0492578	0.834181	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0363723	0.584283	0.700428
Treponema pallidum	cell division protein FtsZ	0.0114278	0.100517	0.5
Echinococcus multilocularis	fructose 1,6 bisphosphate aldolase	0.00968833	0.0667821	0.0800572
Schistosoma mansoni	netrin receptor unc5	0.0115326	0.102549	0.122934
Echinococcus granulosus	death domain containing protein	0.0115326	0.102549	0.122934
Trichomonas vaginalis	tubulin beta chain, putative	0.0492578	0.834181	0.964136
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.050665	0.861471	1
Echinococcus multilocularis	tubulin gamma 1 chain	0.0263199	0.38933	0.466721
Plasmodium falciparum	ABC transporter G family member 2	0.00885957	0.0507095	0.0225831
Leishmania major	beta tubulin	0.0492578	0.834181	1
Schistosoma mansoni	ABC transporter	0.00754677	0.0252495	0.0302687
Trypanosoma brucei	epsilon tubulin	0.0263199	0.38933	0.445028
Trypanosoma cruzi	tubulin gamma chain	0.0263199	0.38933	0.445028
Leishmania major	fructose-1,6-bisphosphate aldolase	0.00968833	0.0667821	0.0426344
Echinococcus granulosus	tubulin gamma 1 chain	0.0263199	0.38933	0.466721
Leishmania major	beta tubulin	0.0492578	0.834181	1
Leishmania major	delta tubulin, putative	0.0114278	0.100517	0.0847199
Onchocerca volvulus		0.0416985	0.687578	0.798144
Brugia malayi	Tubulin alpha chain	0.0114278	0.100517	0.11668
Schistosoma mansoni	hypothetical protein	0.00751823	0.024696	0.0296051
Plasmodium vivax	ABC transporter G family member 2, putative	0.00885957	0.0507095	0.0225831
Echinococcus multilocularis	Tubulin beta 2C chain	0.0492578	0.834181	1
Giardia lamblia	Gamma tubulin	0.0263199	0.38933	0.430375
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.053737	0.921049	1
Schistosoma mansoni	ankyrin 23/unc44	0.0115326	0.102549	0.122934
Brugia malayi	Cell division protein ftsZ	0.0114278	0.100517	0.11668
Echinococcus granulosus	tubulin beta 4A class IVa	0.0492578	0.834181	1
Echinococcus granulosus	Ankyrin	0.0115326	0.102549	0.122934
Trichomonas vaginalis	tubulin, putative	0.0492578	0.834181	0.964136
Echinococcus multilocularis	beta tubulin	0.0492578	0.834181	1
Mycobacterium ulcerans	cell division protein FtsZ	0.0114278	0.100517	0.0524678
Echinococcus granulosus	tubulin epsilon chain	0.0263199	0.38933	0.466721
Echinococcus granulosus	tubulin delta chain	0.0114278	0.100517	0.120498
Leishmania major	gamma-tubulin	0.0263199	0.38933	0.445028
Leishmania major	beta tubulin	0.0492578	0.834181	1
Brugia malayi	Tubulin beta-1 chain	0.0492578	0.834181	0.968321
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.050665	0.861471	1
Schistosoma mansoni	fructose 16-bisphosphate aldolase	0.00968833	0.0667821	0.0800572
Schistosoma mansoni	fructose 16-bisphosphate aldolase	0.00968833	0.0667821	0.0800572
Entamoeba histolytica	tubulin family protein	0.0492578	0.834181	0.96634
Leishmania major	beta tubulin	0.0492578	0.834181	1
Leishmania major	alpha tubulin	0.0363723	0.584283	0.688241
Echinococcus multilocularis	Tubulin beta 2C chain	0.0492578	0.834181	1
Echinococcus granulosus	tubulin alpha chain	0.0363723	0.584283	0.700428
Plasmodium falciparum	alpha tubulin 2	0.0363723	0.584283	0.688241
Leishmania major	beta tubulin	0.0492578	0.834181	1
Toxoplasma gondii	fructose-bisphosphate aldolase, putative	0.00968833	0.0667821	0.0426344
Trypanosoma cruzi	epsilon tubulin, putative	0.0263199	0.38933	0.445028
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0416985	0.687578	0.824255
Leishmania major	beta tubulin	0.0492578	0.834181	1
Entamoeba histolytica	tubulin gamma chain	0.0263199	0.38933	0.417657
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0361905	0.580758	0.696202
Echinococcus granulosus	Tubulin beta 2C chain	0.0492578	0.834181	1
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.057808	1	1
Echinococcus multilocularis	tubulin delta chain	0.0114278	0.100517	0.120498
Echinococcus multilocularis	tumor necrosis factor receptor superfamily	0.0148291	0.166481	0.199575
Echinococcus multilocularis	Tubulin beta 2C chain	0.0492578	0.834181	1
Brugia malayi	Death domain containing protein	0.0115326	0.102549	0.119039
Giardia lamblia	Delta tubulin	0.0114278	0.100517	0.0819305
Schistosoma mansoni	tubulin subunit alpha	0.0363723	0.584283	0.700428
Trypanosoma cruzi	tubulin delta chain	0.0114278	0.100517	0.0847199
Loa Loa (eye worm)	ABC transporter	0.00754677	0.0252495	0.0293098
Trichomonas vaginalis	tubulin alpha chain, putative	0.0263199	0.38933	0.379541
Echinococcus multilocularis	tubulin alpha chain	0.0363723	0.584283	0.700428
Onchocerca volvulus		0.050665	0.861471	1
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0254699	0.372844	0.432799
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.050665	0.861471	1
Echinococcus multilocularis	ATP binding cassette sub family G	0.00885957	0.0507095	0.0607896
Loa Loa (eye worm)	fructose-bisphosphate aldolase 1	0.00968833	0.0667821	0.077521
Schistosoma mansoni	tubulin subunit gamma	0.0263199	0.38933	0.466721
Brugia malayi	Amyloid A4 extracellular domain containing protein	0.0479237	0.808307	0.938287
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.050665	0.861471	1
Trypanosoma cruzi	fructose-bisphosphate aldolase, glycosomal, putative	0.00968833	0.0667821	0.0426344
Trichomonas vaginalis	tubulin beta chain, putative	0.0363723	0.584283	0.635737
Loa Loa (eye worm)	hypothetical protein	0.0377756	0.611499	0.709831
Giardia lamblia	Beta tubulin	0.0492578	0.834181	0.967075
Echinococcus granulosus	tumor necrosis factor receptor superfamily	0.0148291	0.166481	0.199575
Trichomonas vaginalis	tubulin beta chain, putative	0.0363723	0.584283	0.635737
Schistosoma mansoni	alpha tubulin	0.0363723	0.584283	0.700428
Echinococcus multilocularis	beta tubulin	0.0492578	0.834181	1
Schistosoma mansoni	hypothetical protein	0.0115326	0.102549	0.122934
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0361905	0.580758	0.696202
Schistosoma mansoni	tubulin subunit beta	0.0492578	0.834181	1
Loa Loa (eye worm)	BEN-1 protein	0.0492578	0.834181	0.968321
Toxoplasma gondii	fructose-1,6-bisphosphate aldolase	0.00968833	0.0667821	0.0426344
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0363723	0.584283	0.700428
Leishmania major	zeta tubulin, putative	0.0114278	0.100517	0.0847199
Echinococcus granulosus	tubulin subunit beta	0.0492578	0.834181	1
Schistosoma mansoni	ATP-binding cassette sub-family g2 (white protein) (abcg2)	0.00885957	0.0507095	0.0607896
Echinococcus granulosus	tubulin alpha 3 chain	0.0363723	0.584283	0.700428
Trypanosoma brucei	alpha tubulin	0.0363723	0.584283	0.688241
Echinococcus multilocularis	tubulin alpha 3 chain	0.0363723	0.584283	0.700428

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 6.99 uM	Antiparasitic activity against trypomastigote forms of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells assessed as inhibition of growth after 96 hrs by inverted microscopy	ChEMBL.	25240098
IC50 (functional)	= 13.1 uM	Antiparasitic activity against axenic amastigote forms of Leishmania donovani MHOM/ET/67/L82 assessed as inhibition of growth after 72 hrs by resazurin assay	ChEMBL.	25240098
IC50 (functional)	= 40.3 uM	Antiparasitic activity against bloodstream forms of Trypanosoma brucei rhodesiense STIB 900 assessed as inhibition of growth after 72 hrs by resazurin assay	ChEMBL.	25240098
Ratio IC50 (functional)	= 0.32	Ratio of benznidazol IC50 to compound IC50 for trypomastigote forms of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells assessed as inhibition of growth after 96 hrs by inverted microscopy	ChEMBL.	25240098

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma cruzi	ChEMBL23	25240098
Leishmania donovani	ChEMBL23	25240098

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3358476

Bibliographic References

No literature references available for this target.

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Detailed information for compound 944408