TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.705 | Formula: C29H48N2
H donors: 2 H acceptors: 0 LogP: 6.19 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N[C@@H]1CC[C@]2([C@H](C1)CC=C1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CC1NCCC1=C(C)C)C)C)C
InChi: 1S/C29H48N2/c1-18(2)22-12-15-31-27(22)16-19(3)24-8-9-25-23-7-6-20-17-21(30)10-13-28(20,4)26(23)11-14-29(24,25)5/h7,19-21,24-27,31H,6,8-17,30H2,1-5H3/t19-,20+,21-,24-,25+,26+,27?,28+,29-/m1/s1
InChiKey: VJHRMJFJZGQHMU-UGRPUGRDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0151	0.0202
Echinococcus granulosus	GPCR family 3 C terminal	0.0013	0.0089	0.012
Schistosoma mansoni	metabotropic glutamate receptor	0.0039	0.0658	0.0881
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0043	0.0736	0.5161
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0152	0.0204
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0151	0.0202
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0115	0.0154
Schistosoma mansoni	cytochrome P450	0.0014	0.0115	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0152	0.0204
Brugia malayi	beta-lactamase family protein	0.0073	0.1401	0.1876
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0192	0.3999	0.5355
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0151	0.0202
Trypanosoma brucei	cytochrome P450, putative	0.0023	0.0306	0.0702
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0306	0.0702
Onchocerca volvulus	Poor gastrulation protein homolog	0.0013	0.0089	0.0637
Loa Loa (eye worm)	acetyltransferase	0.0145	0.2971	0.3978
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0232	0.4863	0.6513
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0254	0.034
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0192	0.3999	0.5355
Echinococcus multilocularis	muscleblind protein 1	0.0291	0.6137	0.8218
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0014	0.0115	0.0636
Entamoeba histolytica	hypothetical protein	0.0036	0.0591	0.5207
Entamoeba histolytica	hypothetical protein	0.0036	0.0591	0.5207
Brugia malayi	acetyltransferase, GNAT family protein	0.0145	0.2971	0.3978
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0073	0.1401	0.2172
Brugia malayi	P38 map kinase family protein 2	0.0192	0.3999	0.5355
Toxoplasma gondii	ABC1 family protein	0.0073	0.1401	1
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0306	0.041
Echinococcus multilocularis	geminin	0.0175	0.3613	0.4839
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0073	0.1401	0.1301
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0185	0.3827	0.5125
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0192	0.3999	0.5355
Schistosoma mansoni	serine/threonine protein kinase	0.0352	0.7467	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0073	0.1401	0.1876
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0152	0.0204
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0192	0.3999	0.5355
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0023	0.0306	0.0323
Mycobacterium ulcerans	beta-lactamase	0.0073	0.1401	0.2172
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1401	0.1876
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0073	0.1401	0.1301
Schistosoma mansoni	hypothetical protein	0.0016	0.0152	0.0204
Echinococcus granulosus	beta LACTamase domain containing family member	0.0073	0.1401	0.1876
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0185	0.3827	0.5125
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0352	0.7467	1
Schistosoma mansoni	hypothetical protein	0.0175	0.3613	0.4839
Brugia malayi	Receptor family ligand binding region containing protein	0.0021	0.0254	0.034
Treponema pallidum	hypothetical protein	0.0286	0.6037	0.5
Echinococcus multilocularis	GPCR, family 3, C terminal	0.0013	0.0089	0.012
Echinococcus multilocularis	muscleblind protein	0.0291	0.6137	0.8218
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0073	0.1401	0.1301
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0043	0.0736	0.0715
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0591	0.0792
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0306	0.041
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0043	0.0736	0.0995
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0014	0.0115	0.022
Mycobacterium tuberculosis	Conserved protein	0.0073	0.1401	0.1301
Leishmania major	cytochrome p450-like protein	0.0014	0.0115	0.022
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0151	0.0202
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0352	0.7467	1
Brugia malayi	Stress-activated protein kinase jnk-1	0.0352	0.7467	1
Echinococcus granulosus	muscleblind protein	0.0291	0.6137	0.8218
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0185	0.3827	0.5125
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0043	0.0736	0.5161
Brugia malayi	beta-lactamase family protein	0.0073	0.1401	0.1876
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0591	0.0792
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0014	0.0115	0.022
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0306	0.041
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0043	0.0736	0.0986
Onchocerca volvulus		0.0073	0.1401	1
Onchocerca volvulus		0.0073	0.1401	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0151	0.0202
Echinococcus granulosus	GPCR family 2	0.0016	0.0152	0.0204
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.1401	0.2891
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0073	0.1389	0.1861
Echinococcus granulosus	geminin	0.0175	0.3613	0.4839
Loa Loa (eye worm)	beta-lactamase	0.0073	0.1401	0.1876
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0192	0.3999	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0151	0.031
Loa Loa (eye worm)	hypothetical protein	0.005	0.0901	0.1206
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0901	0.1206
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0178	0.3679	0.4927
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0192	0.3999	1
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0013	0.0089	0.012
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0033	0.0535	0.0716
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0192	0.3999	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.1401	0.1876
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0185	0.3827	0.5125
Echinococcus granulosus	c-Jun N-terminal kinases	0.0352	0.7467	1
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0306	0.0702
Loa Loa (eye worm)	glutamate receptor	0.008	0.1554	0.2081
Loa Loa (eye worm)	glutamate receptor	0.0032	0.0493	0.0661
Onchocerca volvulus	Metabotropic glutamate receptor homolog	0.0013	0.0089	0.0637
Brugia malayi	follicle stimulating hormone receptor	0.0232	0.4863	0.6513
Schistosoma mansoni	hypothetical protein	0.0175	0.3613	0.4839
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0151	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1401	0.1876
Echinococcus granulosus	mitogen activated protein kinase 11	0.0192	0.3999	0.5355
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.3573	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0073	0.1401	0.1301
Brugia malayi	Metabotropic glutamate receptor precursor.	0.008	0.1554	0.2081
Echinococcus multilocularis		0.0014	0.0115	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1401	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1401	0.1876
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0073	0.1401	0.1876
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0659	0.5
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0554	0.0742
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0152	0.0204
Leishmania major	cytochrome p450-like protein	0.0023	0.0306	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0291	0.6137	0.8218
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0659	0.0863
Entamoeba histolytica	hypothetical protein	0.0036	0.0591	0.5207
Echinococcus granulosus	cytochrome P450 2K1	0.0014	0.0115	0.0154
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0152	0.0204
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0145	0.2971	0.3978
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1958	0.2622
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.1401	0.1876
Leishmania major	hypothetical protein, conserved	0.0073	0.1401	0.3459
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0554	0.0742
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0089	0.012
Wolbachia endosymbiont of Brugia malayi	parvulin-like peptidyl-prolyl isomerase, PPID	0.001	0.0027	0.5
Mycobacterium ulcerans	esterase/lipase LipP	0.0073	0.1401	0.2172
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0185	0.3827	0.5125
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0535	0.0056
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0033	0.0535	0.0716
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0141	0.2882	0.3859
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0151	0.031
Brugia malayi	Muscleblind-like protein	0.0291	0.6137	0.8218
Mycobacterium tuberculosis	Probable lipase LipE	0.0073	0.1401	0.1301
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0014	0.0115	0.022
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.1401	0.3459
Schistosoma mansoni	hypothetical protein	0.0014	0.0115	0.0154
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0286	0.6037	1
Trichomonas vaginalis	rotamase, putative	0.0033	0.0535	0.0056
Trypanosoma brucei	hypothetical protein, conserved	0.0073	0.1401	0.3459
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0021	0.0254	0.034
Mycobacterium ulcerans	lipase LipD	0.0073	0.1401	0.2172
Plasmodium vivax	hypothetical protein, conserved	0.0073	0.1401	0.2125
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0033	0.0518	0.1235
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0185	0.3827	0.5125
Schistosoma mansoni	hypothetical protein	0.0016	0.0152	0.0204
Mycobacterium tuberculosis	Probable lipase LipD	0.0073	0.1401	0.1301
Schistosoma mansoni	hypothetical protein	0.0016	0.0152	0.0204
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0033	0.0518	0.1235
Brugia malayi	beta-lactamase	0.0073	0.1401	0.1876
Mycobacterium ulcerans	hypothetical protein	0.0073	0.1401	0.2172
Schistosoma mansoni	hypothetical protein	0.0013	0.0089	0.012
Schistosoma mansoni	hypothetical protein	0.0036	0.0591	0.0792
Schistosoma mansoni	hypothetical protein	0.0034	0.0554	0.0742
Onchocerca volvulus		0.0073	0.1401	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0185	0.3827	0.5125
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0306	0.041
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.0151	0.031
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.1401	0.3459
Loa Loa (eye worm)	cytochrome P450	0.0014	0.0115	0.0154
Echinococcus granulosus	mitogen activated protein kinase 14	0.0192	0.3999	0.5355
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0152	0.0204
Schistosoma mansoni	metabotropic glutamate receptor	0.0067	0.127	0.1701
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0151	0.0897
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0591	0.0792
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0286	0.6037	1
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0145	0.2971	0.3978
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0901	0.1206
Mycobacterium tuberculosis	Probable hydrolase	0.0073	0.1401	0.1301
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0151	0.031
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0033	0.0518	0.1235
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0099	0.1958	0.2622
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.1401	0.2891
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0286	0.6037	0.5991
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1401	0.1876
Mycobacterium tuberculosis	Conserved protein	0.0073	0.1401	0.1301
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0152	0.0204
Trichomonas vaginalis	esterase, putative	0.0073	0.1401	0.2891
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0151	0.0202
Brugia malayi	metabotropic glutamate receptor type 2	0.0039	0.0658	0.0881
Mycobacterium tuberculosis	Conserved protein	0.0073	0.1401	0.1301
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0192	0.3999	1
Mycobacterium leprae	Probable lipase LipE	0.0073	0.1401	0.2172
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0286	0.6037	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0014	0.0115	0.022
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0185	0.3827	0.5125
Brugia malayi	Cytochrome P450 family protein	0.0052	0.0948	0.127
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0091	0.1793	0.2402
Toxoplasma gondii	peptidylprolyl isomerase	0.0033	0.0518	0.357
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0152	0.0204
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0014	0.0115	0.022
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0151	0.0202
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.1401	0.2891
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0151	0.031
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0151	0.0202
Brugia malayi	cytochrome P450	0.0014	0.0115	0.0154
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0033	0.0518	0.1235
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0067	0.127	0.1701
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0021	0.0254	0.034
Schistosoma mansoni	rotamase	0.0033	0.0535	0.0716
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.1401	0.2891
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0192	0.3999	0.5355
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0099	0.1958	0.2622
Leishmania major	cytochrome p450-like protein	0.0014	0.0115	0.022
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1401	0.1876
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0185	0.3827	0.5125
Echinococcus multilocularis	expressed protein	0.0033	0.0535	0.0716
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0067	0.127	0.1701
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0659	1
Echinococcus granulosus	expressed protein	0.0033	0.0535	0.0716
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0043	0.0736	0.0715
Loa Loa (eye worm)	CYP4Cod1	0.0023	0.0306	0.041
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0073	0.1401	0.1876
Entamoeba histolytica	hypothetical protein	0.0036	0.0591	0.5207
Loa Loa (eye worm)	hypothetical protein	0.0291	0.6137	0.8218
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0152	0.0204
Schistosoma mansoni	hypothetical protein	0.0016	0.0152	0.0204
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0901	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3679	0.4927
Mycobacterium leprae	conserved hypothetical protein	0.0073	0.1401	0.2172
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0151	0.0202
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0151	0.0897
Brugia malayi	hypothetical protein	0.0036	0.0591	0.0792
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0286	0.6037	1
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0151	0.0036
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.1401	0.2891
Loa Loa (eye worm)	cytochrome P450 family protein	0.0052	0.0948	0.127

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3358086

Bibliographic References

No literature references available for this target.

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Detailed information for compound 946606