Detailed information for compound 950285

Basic information

Technical information
  • TDR Targets ID: 950285
  • Name: 2,3,4,5-tetrachloro-6-(2,4,5,7-tetrabromo-3-h ydroxy-6-oxoxanthen-9-yl)benzoic acid
  • MW: 785.671 | Formula: C20H4Br4Cl4O5
  • H donors: 2 H acceptors: 4 LogP: 8.14 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1c(Cl)c(Cl)c(c(c1Cl)C(=O)O)c1c2cc(Br)c(=O)c(c2oc2c1cc(Br)c(c2Br)O)Br
  • InChi: 1S/C20H4Br4Cl4O5/c21-5-1-3-7(8-9(20(31)32)13(26)15(28)14(27)12(8)25)4-2-6(22)17(30)11(24)19(4)33-18(3)10(23)16(5)29/h1-2,29H,(H,31,32)
  • InChiKey: RIVZUHBWXRGVOG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,3,4,5-tetrachloro-6-(2,4,5,7-tetrabromo-3-hydroxy-6-oxo-xanthen-9-yl)benzoic acid
  • 2,3,4,5-tetrachloro-6-(2,4,5,7-tetrabromo-3-hydroxy-6-oxo-9-xanthenyl)benzoic acid
  • 2,3,4,5-tetrachloro-6-(2,4,5,7-tetrabromo-3-hydroxy-6-keto-xanthen-9-yl)benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.0201 0.207 0.2616
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0567 0.0717
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0572 0.0723
Loa Loa (eye worm) hypothetical protein 0.0065 0.0572 0.1189
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0573 0.119
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0172 0.0604
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0417 0.0527
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.1258 0.2245
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0172 0.0604
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0417 0.0417
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0349 0.3701 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0044 0.0073
Plasmodium falciparum flap endonuclease 1 0.0028 0.0172 0.4017
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0135 0.0234
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0417 0.0527
Echinococcus granulosus flap endonuclease 1 0.0028 0.0172 0.0217
Brugia malayi hypothetical protein 0.0029 0.0174 0.0348
Onchocerca volvulus 0.0079 0.0731 0.1195
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0145 0.0246
Brugia malayi beta-lactamase family protein 0.0079 0.0731 0.1525
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.005 0.0405 0.066
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0078 0.0718 0.1496
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0731 0.0924
Brugia malayi glutathione reductase 0.005 0.0411 0.0848
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.005 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0074 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0095 0.0182
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.4471 0.4471
Brugia malayi jmjC domain containing protein 0.0027 0.0152 0.0302
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0411 0.0411
Echinococcus granulosus neuropeptide s receptor 0.0525 0.5642 0.7129
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0432 0.0546
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0731 0.133
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0095 0.012
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0731 0.1266
Loa Loa (eye worm) hypothetical protein 0.0025 0.0135 0.0267
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0672 0.1221
Leishmania major hypothetical protein, conserved 0.0079 0.0731 0.3372
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0573 0.0724
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0567 0.0717
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0145 0.0246
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0731 0.133
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0052 0.0066
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0567 0.0567
Brugia malayi chromobox protein homolog 3 0.0041 0.0314 0.0645
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0432 0.0546
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0152 0.0506
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0432 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0095 0.0182
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0095 0.0095
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0027 0.0152 0.0917
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0174 0.4066
Echinococcus granulosus jumonji domain containing 1A 0.0027 0.0152 0.0192
Brugia malayi Ets-domain containing protein 0.0078 0.0718 0.1496
Schistosoma mansoni hypothetical protein 0.0379 0.4027 0.5088
Onchocerca volvulus 0.0032 0.0216 0.0227
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0432 0.0633
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.005 0.0531
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0135 0.0423
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0145 0.0246
Mycobacterium ulcerans beta-lactamase 0.0079 0.0731 0.1866
Schistosoma mansoni hypothetical protein 0.0036 0.0259 0.0327
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0245 0.0245
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0731 0.1266
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0672 0.1221
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0731 0.1266
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.005 0.0406 0.3194
Brugia malayi jmjC domain containing protein 0.0027 0.0152 0.0302
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.1118 0.1984
Mycobacterium ulcerans lipase LipD 0.0079 0.0731 0.1866
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0731 0.1525
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0095 0.0182
Echinococcus multilocularis microtubule associated protein 2 0.0732 0.7914 0.7914
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.003 0.003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0135 0.0234
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.1258 0.2245
Plasmodium falciparum ornithine aminotransferase 0.005 0.0405 0.9859
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0203 0.0409
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0731 0.1266
Toxoplasma gondii ABC1 family protein 0.0079 0.0731 0.6109
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0095 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0314 0.056
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0174 0.2254
Plasmodium falciparum glutathione reductase 0.005 0.0411 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0095 0.0182
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0135 0.0159
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0172 0.0344
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.005 0.0958
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0245 0.0968
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0095 0.0182
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.005 0.0406 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0103 0.0998 0.2088
Echinococcus granulosus L aminoadipate semialdehyde 0.0177 0.1805 0.2281
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0205 0.212 0.2679
Echinococcus granulosus peregrin 0.0031 0.0201 0.0254
Brugia malayi Pre-SET motif family protein 0.0065 0.0572 0.1189
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0053 0.0444 0.0918
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0073
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0027 0.0152 0.0192
Leishmania major phosphopantetheinyl transferase-like protein 0.005 0.0406 0.1763
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0432 0.0432
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0731 0.1525
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0044 0.0044
Echinococcus multilocularis Aminotransferase class III 0.005 0.0405 0.0405
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0417 0.0527
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0565 0.1174
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0145 0.0246
Brugia malayi hypothetical protein 0.0018 0.0062 0.0112
Brugia malayi CHD4 protein 0.0016 0.003 0.0045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0059 0.0512 0.1062
Brugia malayi Fli-1 protein 0.0237 0.2466 0.5188
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0095 0.012
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0245 0.031
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0406 0.1763
Echinococcus granulosus GA binding protein alpha chain 0.0078 0.0718 0.0907
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0065 0.0029
Trypanosoma brucei trypanothione reductase 0.005 0.0411 0.1785
Trichomonas vaginalis CAMK family protein kinase 0.0201 0.207 0.3807
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0191 0.0241
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0164 0.1666 0.2105
Brugia malayi jmjC domain containing protein 0.0027 0.0152 0.0302
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.1118 0.1984
Brugia malayi N-terminal motif family protein 0.02 0.2062 0.4334
Mycobacterium tuberculosis Conserved protein 0.0079 0.0731 0.1266
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0095 0.0182
Brugia malayi nuclear hormone receptor 0.0021 0.0095 0.0182
Loa Loa (eye worm) fli-1 protein 0.0237 0.2466 0.5188
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0093 0.0093
Mycobacterium ulcerans acetylornithine aminotransferase 0.005 0.0405 0.0972
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.005 0.0406 0.0975
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0174 0.0614
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0182
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0349 0.0624
Schistosoma mansoni cpg binding protein 0.0061 0.0535 0.0676
Plasmodium falciparum thioredoxin reductase 0.0017 0.005 0.0958
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0133 0.1318 0.1666
Echinococcus granulosus geminin 0.0379 0.4027 0.5088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0135 0.0159
Onchocerca volvulus 0.0061 0.0535 0.0825
Onchocerca volvulus 0.0052 0.0432 0.0633
Brugia malayi jmjC domain containing protein 0.0164 0.1666 0.3498
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0135 0.0423
Loa Loa (eye worm) hypothetical protein 0.0019 0.0065 0.0119
Schistosoma mansoni hypothetical protein 0.0017 0.0044 0.0055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0054 0.0008
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0052 0.0052
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0152 0.0302
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0135 0.0267
Onchocerca volvulus 0.0079 0.0731 0.1195
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0335 0.0335
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0135 0.0234
Trichomonas vaginalis CAMK family protein kinase 0.0201 0.207 0.3807
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.005 0.0405 0.0972
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0095 0.012
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0044 0.0073
Loa Loa (eye worm) hypothetical protein 0.0067 0.0593 0.1233
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0182
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0411 0.5544
Trypanosoma brucei polo-like protein kinase 0.0201 0.207 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0731 0.1525
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0095 0.012
Onchocerca volvulus 0.0079 0.0731 0.1195
Mycobacterium leprae conserved hypothetical protein 0.005 0.0406 0.0759
Plasmodium vivax glutathione reductase, putative 0.005 0.0411 0.5544
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0259 0.0527
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.005 0.0405 0.0756
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0052 0.0052
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0095 0.012
Echinococcus granulosus chromobox protein 1 0.0074 0.0672 0.0849
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0095 0.012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0145 0.0246
Brugia malayi Ets-domain containing protein 0.0078 0.0718 0.1496
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0731 0.1866
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0411 0.0519
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.005 0.0406 0.0662
Brugia malayi Augmenter of liver regeneration 0.0035 0.0245 0.0499
Loa Loa (eye worm) hypothetical protein 0.0041 0.0314 0.0645
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0201 0.1354
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0135 0.0234
Loa Loa (eye worm) hypothetical protein 0.0079 0.0731 0.1525
Echinococcus multilocularis GA binding protein alpha chain 0.0078 0.0718 0.0718
Schistosoma mansoni ornithine--oxo-acid transaminase 0.005 0.0405 0.0512
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0135 0.0234
Plasmodium falciparum glutathione reductase 0.0017 0.005 0.0958
Brugia malayi mbt repeat family protein 0.0052 0.0432 0.0894
Schistosoma mansoni hypothetical protein 0.0031 0.0201 0.0254
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0063 0.0094
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0095 0.012
Echinococcus multilocularis ornithine aminotransferase 0.005 0.0405 0.0405
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0731 0.0924
Brugia malayi beta-lactamase 0.0079 0.0731 0.1525
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0731 0.1671
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0135 0.0234
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0731 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0512 0.1062
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0573 0.119
Echinococcus multilocularis lysine specific demethylase 5A 0.01 0.0959 0.0959
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0152 0.0302
Brugia malayi Flap endonuclease-1 0.0028 0.0172 0.0344
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0135 0.0267
Echinococcus multilocularis chromobox protein 1 0.0074 0.0672 0.0672
Onchocerca volvulus Serine\/threonine kinase homolog 0.0201 0.207 0.3709
Loa Loa (eye worm) hypothetical protein 0.0019 0.0065 0.0119
Schistosoma mansoni gabp alpha 0.0078 0.0718 0.0907
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.1165 1
Schistosoma mansoni jumonji domain containing protein 0.0027 0.0152 0.0192
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0731 0.0731
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0417 0.0527
Loa Loa (eye worm) hypothetical protein 0.02 0.2062 0.4334
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0573 0.0724
Echinococcus granulosus microtubule associated protein 2 0.0732 0.7914 1
Echinococcus granulosus neuropeptide receptor A26 0.0525 0.5642 0.7129
Schistosoma mansoni phosphatidylserine receptor 0.0027 0.0152 0.0192
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0095 0.0095
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0417 0.0861
Schistosoma mansoni chromobox protein 0.0074 0.0672 0.0849
Mycobacterium ulcerans L-lysine aminotransferase 0.005 0.0405 0.0972
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0095 0.0182
Toxoplasma gondii thioredoxin reductase 0.005 0.0411 0.3234
Brugia malayi beta-lactamase family protein 0.0079 0.0731 0.1525
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.005 0.0405 0.0972
Trichomonas vaginalis CAMK family protein kinase 0.0201 0.207 0.3807
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0095 0.0182
Echinococcus granulosus cpg binding protein 0.0065 0.0573 0.0724
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0095 0.0095
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0512 0.0512
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0572 0.0572
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0077 0.0705 0.0891
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0245 0.0968
Loa Loa (eye worm) beta-lactamase 0.0079 0.0731 0.1525
Echinococcus multilocularis chromobox protein 1 0.0074 0.0672 0.0672
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0731 0.133
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0573 0.0724
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.005 0.0405 0.0836
Brugia malayi Pre-SET motif family protein 0.0444 0.4746 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0567 0.2562
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.005 0.0958
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0145 0.0246
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0095 0.0095
Treponema pallidum 4'-phosphopantetheinyl transferase 0.005 0.0406 1
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0245 0.1753
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0573 0.0724
Loa Loa (eye worm) hypothetical protein 0.0079 0.0731 0.1525
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0095 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0314 0.056
Trypanosoma cruzi polo-like protein kinase, putative 0.0201 0.207 1
Entamoeba histolytica hypothetical protein 0.005 0.0406 0.1399
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.1118 0.1984
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0245 0.3249
Brugia malayi jmjC domain containing protein 0.0103 0.0998 0.2088
Echinococcus multilocularis lysine specific demethylase 6a 0.0027 0.0152 0.0152
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0245 0.0968
Echinococcus multilocularis GPCR, family 2 0.0017 0.0044 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0095 0.012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0152 0.0302
Echinococcus granulosus lysine specific demethylase 5A 0.0103 0.0998 0.1261
Schistosoma mansoni hypothetical protein 0.0017 0.0044 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0095 0.0182
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0095 0.012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0417 0.0527
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0191 0.0191
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0177 0.1805 0.2281
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0573 0.119
Brugia malayi steroid hormone receptor 0.0021 0.0095 0.0182
Brugia malayi Bromodomain containing protein 0.0031 0.0201 0.0405
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.005 0.0405 0.9968
Schistosoma mansoni kinase 0.0102 0.0983 0.1242
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0512 0.0647
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0095 0.012
Echinococcus granulosus Aminotransferase class III 0.005 0.0405 0.0512
Echinococcus multilocularis phd:f box containing protein 0.0027 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0095 0.0182
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0417 0.0417
Mycobacterium tuberculosis Conserved protein 0.0079 0.0731 0.1266
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0152 0.0506
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.1258 0.2245
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0201 0.207 0.2616
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0349 0.3701 1
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0411 0.0848
Schistosoma mansoni cpg binding protein 0.0065 0.0573 0.0724
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.1118 0.2755
Onchocerca volvulus 0.0505 0.5419 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0177 0.1805 0.1805
Loa Loa (eye worm) hypothetical protein 0.0079 0.0731 0.1525
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0335 0.0423
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0093 0.0118
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0432 0.0894
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0027 0.0152 0.0506
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0152 0.0302
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0444 0.4746 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0512 0.0647
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.005 0.007
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0065 0.1347
Mycobacterium ulcerans hypothetical protein 0.0079 0.0731 0.1866
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0245 0.0968
Plasmodium falciparum phd finger protein, putative 0.0031 0.0201 0.4742
Brugia malayi nuclear receptor NHR-88 0.0021 0.0095 0.0182
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0172 0.0604
Mycobacterium tuberculosis Conserved protein 0.0079 0.0731 0.1266
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0095 0.0182
Schistosoma mansoni hypothetical protein 0.0017 0.0044 0.0055
Schistosoma mansoni jumonji domain containing protein 0.0143 0.1436 0.1814
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0432 0.0546
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0095 0.012
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.005 0.0406 0.5481
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0201 0.2629
Plasmodium falciparum thioredoxin reductase 0.005 0.0411 1
Onchocerca volvulus 0.0077 0.0705 0.1146
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.1118 0.1984
Mycobacterium ulcerans hypothetical protein 0.0349 0.3701 1
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.005 0.0405 0.3184
Schistosoma mansoni ets-related 0.0237 0.2466 0.3116
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0201 0.0254
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0444 0.0918
Schistosoma mansoni hypothetical protein 0.0379 0.4027 0.5088
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0444 0.0918
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0182
Brugia malayi ecdysteroid receptor 0.0021 0.0095 0.0182
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0095 0.0182
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0182
Loa Loa (eye worm) RNA binding protein 0.0065 0.0573 0.119
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.005 0.0405 0.0972
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.003 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0054 0.0008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0216 0.0437
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.005 0.005
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.1118 0.1984
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0174 0.4066
Schistosoma mansoni flap endonuclease-1 0.0026 0.0142 0.0179
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0172 0.0604
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0201 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0095 0.0182
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0672 0.1399
Echinococcus granulosus lysine specific demethylase 6a 0.0027 0.0152 0.0192
Schistosoma mansoni hypothetical protein 0.0017 0.0044 0.0055
Echinococcus granulosus GPCR family 2 0.0017 0.0044 0.0055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0095 0.0182
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0506 0.5433 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0095 0.0182
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.005 0.0405 0.9968
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0572 0.0723
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0731 0.1266
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0731 0.133
Echinococcus granulosus dnaJ subfamily B 0.0419 0.4471 0.5649
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0135 0.0267
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0567 0.1417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0095 0.0182
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0095 0.0095
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0095 0.0095
Trichomonas vaginalis CAMK family protein kinase 0.0201 0.207 0.3807
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0201 0.0254
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0054 0.0008
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0044 0.0073
Giardia lamblia PHD finger protein 15 0.0031 0.0201 0.0747
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0095 0.012
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0172 0.2227
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0095 0.012
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0349 0.3701 0.6823
Schistosoma mansoni hypothetical protein 0.0419 0.4471 0.5649
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0953 0.1741
Brugia malayi Heterochromatin protein 1 0.0074 0.0672 0.1399
Brugia malayi serine/threonine-protein kinase plk-2 0.0201 0.207 0.4351
Leishmania major hypothetical protein, conserved 0.0029 0.0174 0.0614
Echinococcus multilocularis neuropeptide s receptor 0.0525 0.5642 0.5642
Schistosoma mansoni coup transcription factor 0.0021 0.0095 0.012
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.005 0.0406 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0065 0.0747
Plasmodium vivax ornithine aminotransferase, putative 0.005 0.0405 0.5466
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0349 0.3701 0.6783
Schistosoma mansoni jumonji/arid domain-containing protein 0.0103 0.0998 0.1261
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0573 0.0724
Schistosoma mansoni phd/f-box containing protein 0.0027 0.0152 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0181 0.0314
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.02 0.2062 0.3694
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0095 0.0182
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0174 0.0614
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0164 0.1666 0.1666
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0573 0.0573
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0731 0.133
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0095 0.012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0152 0.0302
Mycobacterium tuberculosis Probable aminotransferase 0.0349 0.3701 0.6783
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.005 0.0531
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0095 0.012
Trichomonas vaginalis set domain proteins, putative 0.0505 0.5419 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0532 0.0672
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0512 0.0512
Brugia malayi Thioredoxin reductase 0.005 0.0411 0.0848
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0182
Echinococcus multilocularis neuropeptide receptor A26 0.0525 0.5642 0.5642
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0512 0.0647
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0572 0.0572
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0535 0.111
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0731 0.1266
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0044 0.0055
Loa Loa (eye worm) hypothetical protein 0.0029 0.0174 0.0348
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0182
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.005 0.0086
Leishmania major trypanothione reductase 0.005 0.0411 0.1785
Plasmodium vivax JmjC domain containing protein 0.0027 0.0152 0.1952
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0074 0.0115
Mycobacterium leprae Probable lipase LipE 0.0079 0.0731 0.1671
Echinococcus granulosus phd:f box containing protein 0.0027 0.0152 0.0192
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0205 0.212 0.212
Giardia lamblia Kinase, PLK 0.0201 0.207 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0731 0.0924
Loa Loa (eye worm) hypothetical protein 0.0079 0.0731 0.1525
Echinococcus multilocularis jumonji domain containing 1A 0.0027 0.0152 0.0152
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0172 0.1094
Schistosoma mansoni hypothetical protein 0.0317 0.3347 0.4229
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0349 0.0477
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.005 0.0406 0.9887
Loa Loa (eye worm) hypothetical protein 0.007 0.0628 0.1308
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0145 0.0246
Schistosoma mansoni protein phosphatase 2C 0.0027 0.0152 0.0192
Echinococcus multilocularis JmjC domain containing protein 4 0.0027 0.0152 0.0152
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0177 0.1805 0.3792
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0731 0.3372
Plasmodium falciparum JmjC domain-containing protein, putative 0.0027 0.0152 0.3522
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0444 0.0918
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0174 0.0614
Loa Loa (eye worm) hypothetical protein 0.0019 0.0065 0.0119
Leishmania major hypothetical protein, conserved 0.0027 0.0152 0.0506
Brugia malayi RNA binding protein 0.0065 0.0573 0.119
Brugia malayi TAR-binding protein 0.0065 0.0573 0.119
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0245 0.586
Trichomonas vaginalis esterase, putative 0.0079 0.0731 0.133
Echinococcus granulosus tar DNA binding protein 0.0065 0.0573 0.0724
Mycobacterium ulcerans hypothetical protein 0.0025 0.0135 0.0234
Mycobacterium tuberculosis Probable reductase 0.0114 0.1118 0.1984
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0567 0.0717
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0411 0.067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0567 0.1417
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.005 0.0063
Brugia malayi mbt repeat family protein 0.0052 0.0432 0.0894
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0567 0.1417
Echinococcus granulosus JmjC domain containing protein 4 0.0027 0.0152 0.0192
Echinococcus granulosus chromobox protein 1 0.0074 0.0672 0.0849
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0201 0.0405
Brugia malayi jmjC domain containing protein 0.0027 0.0152 0.0302
Loa Loa (eye worm) hypothetical protein 0.0025 0.0135 0.0267
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.005 0.0405 0.066
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0095 0.012
Loa Loa (eye worm) hypothetical protein 0.0177 0.1805 0.3792
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.005 0.0405 0.066
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0953 0.1741
Plasmodium vivax SET domain protein, putative 0.0065 0.0572 0.7791
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0054 0.0008
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0201 0.207 0.4351
Entamoeba histolytica serine/threonine protein kinase, putative 0.0201 0.207 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0079 0.0731 0.1525
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0567 0.464
Loa Loa (eye worm) MBCTL1 0.0059 0.0512 0.1062
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0095 0.0182
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0201 0.1354
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0201 0.207 1
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.005 0.0405 0.066
Echinococcus multilocularis peregrin 0.0031 0.0201 0.0201
Echinococcus multilocularis geminin 0.0379 0.4027 0.4027
Schistosoma mansoni jumonji/arid domain-containing protein 0.0103 0.0998 0.1261
Trichomonas vaginalis CAMK family protein kinase 0.0201 0.207 0.3807
Echinococcus granulosus ornithine aminotransferase 0.005 0.0405 0.0512
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0145 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.0201 0.207 0.3807
Onchocerca volvulus 0.0177 0.1805 0.3212
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0245 0.0499
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0172 0.0172
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.005 0.007
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.005 0.0406 0.0975
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0065 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0731 0.3372
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0095 0.0182
Onchocerca volvulus Alhambra homolog 0.0031 0.0201 0.0198
Schistosoma mansoni chromobox protein 0.0074 0.0672 0.0849
Loa Loa (eye worm) hypothetical protein 0.0036 0.0259 0.0527
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0731 0.1866
Echinococcus multilocularis cpg binding protein 0.0065 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0182
Brugia malayi CXXC zinc finger family protein 0.0061 0.0535 0.111
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0245 0.1753
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0572 0.0723
Trichomonas vaginalis CAMK family protein kinase 0.0201 0.207 0.3807
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0182
Schistosoma mansoni cpg binding protein 0.0065 0.0573 0.0724
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0417 0.0861
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0044 0.0055
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0027 0.0152 0.0917
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0172 0.0189
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.005 0.0405 0.0972
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0095 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0181 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0095 0.0182
Loa Loa (eye worm) hypothetical protein 0.0025 0.0135 0.0267
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.003 0.0038
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.1258 0.3149
Trypanosoma cruzi polo-like protein kinase, putative 0.0201 0.207 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0065 0.0436
Loa Loa (eye worm) hypothetical protein 0.0019 0.0065 0.0119
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0174 0.1112
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0164 0.0207
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0432 0.0432
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0093 0.0178
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0572 0.0723
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0095 0.012
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0095 0.012
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0349 0.0624
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0731 0.3372
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0052 0.0066
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0172 0.0296
Leishmania major hypothetical protein, conserved 0.0035 0.0245 0.0968
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0731 0.1266
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.005 0.0406 0.3194
Brugia malayi SET domain containing protein 0.0016 0.0032 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0095 0.0182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0065 0.0119
Echinococcus multilocularis ornithine aminotransferase 0.005 0.0405 0.0405
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0052 0.0432 0.0894
Brugia malayi PHD-finger family protein 0.0031 0.0201 0.0405
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0572 0.4684
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0411 0.1785
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0432 0.0546
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0201 0.207 0.207
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0135 0.0423
Loa Loa (eye worm) glutathione reductase 0.005 0.0411 0.0848
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0095 0.012
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0095 0.0182
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0567 0.0961
Schistosoma mansoni microtubule-associated protein tau 0.0732 0.7914 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0095 0.0095
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.005 0.0405 0.0756
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0135 0.0234
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.005 0.0405 0.0756
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0095 0.012
Onchocerca volvulus 0.0025 0.0135 0.0075
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0044 0.0044

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 32 uM Inhibition of recombinant MraY overexpressed in Escherichia coli membranes by continuous fluorescence assay ChEMBL. 25127465

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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