Detailed information for compound 954471

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 191.225 | Formula: C8H17NO4
  • H donors: 5 H acceptors: 4 LogP: -1.56 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1N[C@@H]([C@H]([C@@H]1O)O)CC(O)C
  • InChi: 1S/C8H17NO4/c1-4(11)2-5-7(12)8(13)6(3-10)9-5/h4-13H,2-3H2,1H3/t4?,5-,6-,7-,8-/m1/s1
  • InChiKey: SKCBFFYDHKQEQU-NMBMWNOXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0304 0.0875
Trypanosoma cruzi Aminopeptidase M1, putative 0.007 0.0699 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0549 0.7843
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0624 0.8913
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0026 0.032
Echinococcus granulosus puromycin sensitive aminopeptidase 0.007 0.0699 0.0699
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0624 0.8913
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.004 0.0304 0.1166
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0384 0.0384
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0304 0.4318
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0025 0.0094 0.0361
Brugia malayi TATA binding protein associated factor 0.0025 0.0094 0.0321
Plasmodium falciparum thioredoxin reductase 0.0046 0.0384 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0624 0.8913
Mycobacterium tuberculosis Conserved protein 0.004 0.0304 0.0875
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0304 0.0875
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0094 0.1665
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.0699 0.0699
Schistosoma mansoni hypothetical protein 0.0129 0.1495 0.1495
Loa Loa (eye worm) hypothetical protein 0.0038 0.0271 0.1041
Mycobacterium ulcerans lipase LipD 0.004 0.0304 0.4131
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0025 0.0094 0.0094
Entamoeba histolytica hypothetical protein 0.0037 0.026 0.3477
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0045 0.0371 0.0371
Brugia malayi hypothetical protein 0.007 0.0699 0.2382
Schistosoma mansoni thyroid hormone receptor 0.014 0.1634 0.1634
Brugia malayi acetyltransferase, GNAT family protein 0.0164 0.1952 0.6647
Echinococcus granulosus zinc finger protein 0.0027 0.0123 0.0123
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0045 0.0371 0.5282
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0188 0.2279 0.2279
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.007 0.0699 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.1495 0.1495
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.007 0.0699 1
Schistosoma mansoni aminopeptidase A (M01 family) 0.0025 0.0094 0.0094
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0094 0.1299
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.1634 0.1634
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0026
Schistosoma mansoni microtubule-associated protein tau 0.0766 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0304 0.1166
Loa Loa (eye worm) hypothetical protein 0.004 0.0304 0.1166
Mycobacterium tuberculosis Conserved protein 0.004 0.0304 0.0875
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0384 0.1473
Loa Loa (eye worm) hypothetical protein 0.0045 0.0371 0.1423
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0025 0.0094 0.1902
Mycobacterium ulcerans aminopeptidase N PepN 0.007 0.0699 1
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0384 0.8757
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0094 0.1299
Brugia malayi PHD-finger family protein 0.0033 0.0206 0.0701
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0361
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0642 0.0642
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0094 0.0094
Trypanosoma cruzi aminopeptidase, putative 0.007 0.0699 1
Trichomonas vaginalis esterase, putative 0.004 0.0304 0.4131
Loa Loa (eye worm) glutathione reductase 0.0046 0.0384 0.1473
Brugia malayi glutathione reductase 0.0046 0.0384 0.1308
Brugia malayi Bromodomain containing protein 0.0049 0.0414 0.141
Leishmania major cathepsin L-like protease 0.0064 0.0624 0.8913
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0384 0.1126
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0094 0.1299
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.026 0.026
Brugia malayi RNA binding protein 0.0066 0.0642 0.2186
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.007 0.0699 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0304 0.4131
Toxoplasma gondii ABC1 family protein 0.004 0.0304 0.6803
Toxoplasma gondii aminopeptidase N, putative 0.0025 0.0094 0.1665
Loa Loa (eye worm) hypothetical protein 0.0054 0.0482 0.1847
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0031 0.0031
Echinococcus granulosus tar DNA binding protein 0.0066 0.0642 0.0642
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0346 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0026 0.032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0304 0.0304
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0642 0.0642
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.0699 0.0699
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0435 0.6072
Brugia malayi beta-lactamase 0.004 0.0304 0.1036
Echinococcus multilocularis zinc finger protein 0.0027 0.0123 0.0123
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1333 0.4112
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.044 0.6273
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.0699 0.0699
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0304 0.4131
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0094 0.1665
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0624 0.8913
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0624 0.8913
Trypanosoma brucei Aminopeptidase M1, putative 0.007 0.0699 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.026 0.026
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0117 0.0117
Brugia malayi TAR-binding protein 0.0066 0.0642 0.2186
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0094 0.0321
Toxoplasma gondii aminopeptidase n, putative 0.0025 0.0094 0.1665
Loa Loa (eye worm) hypothetical protein 0.004 0.0304 0.1166
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0325 0.0325
Schistosoma mansoni hypothetical protein 0.0037 0.026 0.026
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0642 0.0642
Loa Loa (eye worm) beta-lactamase 0.004 0.0304 0.1166
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0026 0.01
Echinococcus multilocularis geminin 0.0188 0.2279 0.2279
Loa Loa (eye worm) hypothetical protein 0.0045 0.0363 0.139
Loa Loa (eye worm) hypothetical protein 0.004 0.0304 0.1166
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0031 0.0031
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0435 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0304 0.4131
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0304 0.0875
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0304 0.4131
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0435 0.6072
Loa Loa (eye worm) hypothetical protein 0.0082 0.0866 0.3318
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0384 0.0384
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0435 0.0435
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0304 0.0875
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0747 0.0747
Schistosoma mansoni hypothetical protein 0.0038 0.0271 0.0271
Mycobacterium ulcerans hypothetical protein 0.004 0.0304 0.4131
Schistosoma mansoni hypothetical protein 0.0188 0.2279 0.2279
Plasmodium vivax glutathione reductase, putative 0.0046 0.0384 0.8757
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1333 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.2004 0.768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0624 0.8913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0624 0.8913
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1176 0.3617
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0435 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.007 0.0699 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0026 0.0026
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.026 0.026
Brugia malayi beta-lactamase family protein 0.004 0.0304 0.1036
Echinococcus granulosus geminin 0.0188 0.2279 0.2279
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0435 1
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0271 0.0924
Mycobacterium ulcerans beta-lactamase 0.004 0.0304 0.4131
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0117 0.0117
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0304 0.0875
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.007 0.0699 0.0699
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0031 0.0031
Loa Loa (eye worm) TATA binding protein associated factor 0.0025 0.0094 0.0361
Brugia malayi Peptidase family M1 containing protein 0.0237 0.2937 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1176 0.3617
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.007 0.0699 0.0699
Leishmania major cathepsin L-like protease 0.0064 0.0624 0.8913
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1176 0.3617
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.1495 0.1495
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.3205 1
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.007 0.0699 1
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0304 0.4318
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1176 0.8471
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0025 0.0094 0.1902
Echinococcus multilocularis microtubule associated protein 2 0.0766 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0026 0.032
Loa Loa (eye worm) hypothetical protein 0.0213 0.2609 1
Trypanosoma brucei Aminopeptidase M1, putative 0.007 0.0699 1
Onchocerca volvulus 0.0237 0.2937 1
Plasmodium vivax hypothetical protein, conserved 0.004 0.0304 0.6803
Loa Loa (eye worm) acetyltransferase 0.0164 0.1952 0.7484
Loa Loa (eye worm) hypothetical protein 0.0045 0.0371 0.1423
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0031 0.0031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0505 0.1937
Loa Loa (eye worm) peptidase family M1 containing protein 0.0192 0.2332 0.8938
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0031 0.0031
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0361
Entamoeba histolytica hypothetical protein 0.0037 0.026 0.3477
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0026 0.0026
Brugia malayi hypothetical protein 0.0037 0.026 0.0886
Plasmodium falciparum glutathione reductase 0.0046 0.0384 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0384 0.5467
Brugia malayi beta-lactamase family protein 0.004 0.0304 0.1036
Toxoplasma gondii aminopeptidase N protein 0.0025 0.0094 0.1665
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0026
Loa Loa (eye worm) RNA binding protein 0.0066 0.0642 0.2461
Mycobacterium tuberculosis Conserved protein 0.004 0.0304 0.0875
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0624 0.8913
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0087 0.0333
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0304 0.0304
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0026 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1333 0.4112
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.1855 0.1855
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0304 0.4131
Brugia malayi hypothetical protein 0.0025 0.0094 0.0321
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.0699 0.0699
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0304 0.0304
Echinococcus granulosus puromycin sensitive aminopeptidase 0.007 0.0699 0.0699
Echinococcus granulosus puromycin sensitive aminopeptidase 0.007 0.0699 0.0699
Schistosoma mansoni bromodomain containing protein 0.0078 0.0803 0.0803
Schistosoma mansoni thyroid hormone receptor 0.014 0.1634 0.1634
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0304 0.0875
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0094 0.1299
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.007 0.0699 0.0699
Onchocerca volvulus 0.007 0.0699 0.2129
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.012
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0346 0.8921
Echinococcus granulosus aminopeptidase N 0.0237 0.2937 0.2937
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0361
Echinococcus granulosus puromycin sensitive aminopeptidase 0.007 0.0699 0.0699
Entamoeba histolytica aminopeptidase, putative 0.007 0.0699 1
Loa Loa (eye worm) aminopeptidase N 0.007 0.0699 0.2681
Brugia malayi Thioredoxin reductase 0.0046 0.0384 0.1308
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0031 0.0031
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0094 0.1299
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1176 0.3617
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0026 0.0089
Loa Loa (eye worm) hypothetical protein 0.0055 0.0505 0.1937
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1176 0.3617
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0304 0.1036
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0094 0.1299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0624 0.8913
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0304 0.4318
Brugia malayi Bromodomain containing protein 0.0091 0.0985 0.3353
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0624 0.8913
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0026 0.032
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0325 0.0325
Onchocerca volvulus 0.004 0.0304 0.0739
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0642 0.0642
Leishmania major trypanothione reductase 0.0046 0.0384 0.5467
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0304 0.0875
Entamoeba histolytica hypothetical protein 0.0037 0.026 0.3477
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0045 0.0371 0.0371
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0164 0.1952 0.1952
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0094 0.1299
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0094 0.1299
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.007 0.0699 1
Onchocerca volvulus 0.004 0.0304 0.0739
Schistosoma mansoni zinc finger protein 0.0027 0.0123 0.0123
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0164 0.1952 0.1952
Echinococcus multilocularis aminopeptidase N 0.0237 0.2937 0.2937
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.0094 0.1011
Brugia malayi Peptidase family M1 containing protein 0.007 0.0699 0.2382
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0642 0.2461
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0094 0.1011
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0093 0.0358
Mycobacterium tuberculosis Probable reductase 0.0106 0.1176 0.3617
Loa Loa (eye worm) hypothetical protein 0.0051 0.0452 0.1733
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0346 0.4743
Schistosoma mansoni zinc finger protein 0.0018 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0018 0.0004 0.0004
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0747 0.0747
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0505 0.1721
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0642 0.2186
Onchocerca volvulus 0.004 0.0304 0.0739
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0624 0.8913
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0505 0.1721
Trypanosoma brucei trypanothione reductase 0.0046 0.0384 0.5467
Entamoeba histolytica hypothetical protein 0.0037 0.026 0.3477
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.0699 0.0699
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0025 0.0094 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0624 0.8913
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1333 0.4112
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0642 0.0642
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0304 0.4131
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0304 0.4131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0624 0.8913
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0624 0.8913
Echinococcus granulosus leukotriene A 4 hydrolase 0.0025 0.0094 0.0094
Toxoplasma gondii thioredoxin reductase 0.0046 0.0384 0.8757
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0025 0.0094 0.0094
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0642 0.2461
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0624 0.8913
Leishmania major cathepsin L-like protease 0.0064 0.0624 0.8913
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0031 0.0031
Leishmania major hypothetical protein, conserved 0.004 0.0304 0.4318
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0026 0.5
Schistosoma mansoni hypothetical protein 0.0024 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.004 0.0304 0.1166
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.004 0.0304 0.1166
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0642 0.0642

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 260 uM Inhibition of bovine liver beta-galactosidase by spectrophotometry ChEMBL. 15165148
IC50 (binding) = 610 uM Inhibition of rat epididymis beta-mannosidase by spectrophotometry ChEMBL. 15165148
Inhibition (binding) < 50 % Inhibition of bovine epididymis alpha-L-fucosidase at 1000 uM by spectrophotometry ChEMBL. 15165148
Inhibition (binding) < 50 % Inhibition of rat intestinal maltase at 1000 uM by spectrophotometry ChEMBL. 15165148
Inhibition (binding) < 50 % Inhibition of human placental beta-glucocerebrosidase at 1000 uM by spectrophotometry ChEMBL. 15165148
Inhibition (binding) < 50 % Inhibition of coffee bean alpha-galactosidase at 1000 uM by spectrophotometry ChEMBL. 15165148

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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