TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 680.952 | Formula: C39H68O9
H donors: 3 H acceptors: 6 LogP: 8.04 Rotable bonds: 30
Rule of 5 violations (Lipinski): 2
SMILES: CCCCCCCCCCCC[C@H]([C@H]1CC[C@@H](O1)[C@@H](CC(OC(=O)C)CCCCC(=O)CCCCC(CCC1=C[C@@H](OC1=O)C)O)O)O
InChi: 1S/C39H68O9/c1-4-5-6-7-8-9-10-11-12-13-22-35(43)37-25-26-38(48-37)36(44)28-34(47-30(3)40)21-17-16-19-32(41)18-14-15-20-33(42)24-23-31-27-29(2)46-39(31)45/h27,29,33-38,42-44H,4-26,28H2,1-3H3/t29-,33?,34?,35+,36+,37+,38+/m0/s1
InChiKey: OJFDGOAJDAPKNG-QZBJIPNWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0146	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.022	0.183
Schistosoma mansoni	hypothetical protein	0.004	0.0432	0.1112
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Onchocerca volvulus		0.0028	0.0283	0.5383
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0683	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0146	0.0386
Echinococcus multilocularis	protein patched	0.0041	0.0451	0.0439
Loa Loa (eye worm)	fibroinase	0.0009	0.0042	0.011
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1149	0.3036
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0.0048	0.0095
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.1149	0.1138
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.022	0.1753
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0009	0.0042	0.0293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0009	0.0042	0.011
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0099	0.1179	0.1168
Loa Loa (eye worm)	hypothetical protein	0.001	0.0048	0.0127
Leishmania major	cathepsin L-like protease	0.0009	0.0042	0.0247
Plasmodium falciparum	serine repeat antigen 8	0.0009	0.0042	0.2851
Echinococcus multilocularis	cysteine protease	0.0009	0.0042	0.0029
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0012	0.0033
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0009	0.0042	0.011
Echinococcus granulosus	cpg binding protein	0.003	0.0303	0.077
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0042	0.011
Trypanosoma cruzi	cysteine proteinase, putative	0.0009	0.0042	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0023	0.022	0.0582
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0042	0.0293
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0014	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0146	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0042	0.011
Leishmania major	cathepsin L-like protease	0.0009	0.0042	0.0247
Onchocerca volvulus		0.0009	0.0042	0.0792
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0042	0.0247
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0042	0.011
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0012	0.0077	1
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0012	0.0077	0.2947
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0009	0.0042	0.2851
Schistosoma mansoni	fatty-acid amide hydrolase	0.0099	0.1179	0.3092
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2864	0.7566
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0012	0.0033
Schistosoma mansoni	patched 1	0.0041	0.0451	0.1162
Echinococcus multilocularis	cpg binding protein	0.003	0.0303	0.0291
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0012	0.0033
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0146	1
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0012	0.0546
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.1149	1
Mycobacterium leprae	PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	0.0012	0.0077	0.3107
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.0042	0.0258
Onchocerca volvulus		0.0009	0.0042	0.0792
Echinococcus multilocularis	cathepsin L	0.0009	0.0042	0.0029
Plasmodium vivax	serine-repeat antigen (SERA)	0.0009	0.0042	0.2851
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0012	0.0077	0.3483
Mycobacterium ulcerans	amidase	0.0012	0.0077	0.3107
Plasmodium vivax	serine-repeat antigen (SERA)	0.0009	0.0042	0.2851
Onchocerca volvulus		0.0009	0.0042	0.0792
Brugia malayi	topoisomerase	0.001	0.0048	0.0127
Onchocerca volvulus		0.0009	0.0042	0.0792
Onchocerca volvulus		0.0009	0.0042	0.0792
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0009	0.0042	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0012	0.0033
Leishmania major	cathepsin L-like protease	0.0009	0.0042	0.0247
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0048	0.1722
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0048	0.0348
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.022	0.1753
Plasmodium falciparum	serine repeat antigen 2	0.0009	0.0042	0.2851
Plasmodium falciparum	serine repeat antigen 4	0.0009	0.0042	0.2851
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0042	0.011
Mycobacterium ulcerans	amidase	0.0012	0.0077	0.3107
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0012	0.0546
Plasmodium vivax	vivapain-3	0.0009	0.0042	0.2851
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0009	0.0042	0.0293
Leishmania major	hypothetical protein, conserved	0.0012	0.0077	0.0545
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0012	0.0077	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0048	0.0348
Loa Loa (eye worm)	hypothetical protein	0.001	0.0048	0.0127
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0009	0.0042	0.0078
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0009	0.0042	0.0293
Loa Loa (eye worm)	ctsf protein	0.0009	0.0042	0.011
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0042	0.011
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0048	0.0127
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0009	0.0042	0.0078
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0012	0.0546
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0048	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0023	0.022	0.0582
Echinococcus multilocularis	cathepsin b	0.0304	0.3785	0.3777
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.022	0.0582
Onchocerca volvulus		0.0009	0.0042	0.0792
Brugia malayi	cathepsin F-like cysteine proteinase	0.0009	0.0042	0.011
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0304	0.3785	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0009	0.0042	0.0258
Plasmodium falciparum	serine repeat antigen 1	0.0009	0.0042	0.2851
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0451	0.1191
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0009	0.0042	0.0078
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.022	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0099	0.1179	0.3092
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0009	0.0042	0.2851
Plasmodium falciparum	serine repeat antigen 5	0.0009	0.0042	0.2851
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0012	0.0546
Plasmodium vivax	vivapain-1	0.0009	0.0042	0.2851
Loa Loa (eye worm)	amidase	0.0012	0.0077	0.0203
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0042	0.0293
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0012	0.0077	0.0171
Loa Loa (eye worm)	amidase	0.0012	0.0077	0.0203
Trypanosoma brucei	cysteine peptidase C (CPC)	0.01	0.1199	1
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0042	0.011
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0134	0.6071
Echinococcus granulosus	cathepsin L	0.0009	0.0042	0.0078
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0048	0.3299
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0283	0.0747
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0042	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0042	0.011
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0042	0.011
Mycobacterium ulcerans	amidase	0.0012	0.0077	0.3107
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0042	0.011
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0134	0.6071
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0012	0.0546
Brugia malayi	fibroinase precursor	0.0009	0.0042	0.011
Schistosoma mansoni	cathepsin S (C01 family)	0.0009	0.0042	0.0078
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.022	0.0582
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Echinococcus granulosus	cathepsin l1	0.0009	0.0042	0.0078
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0009	0.0042	0.011
Onchocerca volvulus		0.0047	0.0525	1
Brugia malayi	DKFZp564C0469 protein	0.001	0.0048	0.0127
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.022	0.183
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.2864	0.2855
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0048	0.0348
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0009	0.0042	0.2851
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0014	0.0006
Onchocerca volvulus		0.0023	0.022	0.4197
Onchocerca volvulus	Cathepsin L homolog	0.0009	0.0042	0.0792
Giardia lamblia	Cathepsin B precursor	0.01	0.1199	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.1168	0.3063
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0035	0.0092
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0099	0.1179	0.3092
Echinococcus multilocularis	cathepsin L	0.0009	0.0042	0.0029
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Entamoeba histolytica	cysteine proteinase 1, putative	0.0009	0.0042	0.0258
Echinococcus granulosus	cathepsin b	0.0304	0.3785	1
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0525	0.1359
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.022	1
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0048	0.0127
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0009	0.0042	0.0293
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0451	0.1162
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0009	0.0042	0.2851
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.022	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0146	0.0386
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0009	0.0042	0.0293
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0012	0.0077	0.3483
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0009	0.0042	0.011
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0048	0.0095
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0042	0.011
Schistosoma mansoni	hypothetical protein	0.004	0.0432	0.1112
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0012	0.0077	0.3483
Plasmodium vivax	unspecified product	0.0009	0.0042	0.2851
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0048	0.0095
Echinococcus multilocularis	Niemann Pick C1 protein	0.0138	0.1674	0.1664
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0009	0.0042	0.0293
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0009	0.0042	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0146	0.0386
Mycobacterium ulcerans	amidase	0.0012	0.0077	0.3107
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0304	0.3785	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0009	0.0042	0.2851
Brugia malayi	cathepsin L-like cysteine proteinase	0.0009	0.0042	0.011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0042	0.0247
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0048	0.0315
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0042	0.0293
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0451	0.1162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Plasmodium falciparum	serine repeat antigen 7	0.0009	0.0042	0.2851
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0048	0.0095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0048	0.3299
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0042	0.0247
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Onchocerca volvulus		0.0009	0.0042	0.0792
Brugia malayi	cathepsin B-like cysteine proteinase	0.0304	0.3785	1
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.001	0.0048	0.1722
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0009	0.0042	0.2851
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0042	0.011
Schistosoma mansoni	fatty-acid amide hydrolase	0.0012	0.0077	0.0171
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0042	0.0293
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.01	0.1199	1
Plasmodium vivax	unspecified product	0.0009	0.0042	0.2851
Schistosoma mansoni	hypothetical protein	0.004	0.0432	0.1112
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0009	0.0042	0.011
Trypanosoma cruzi	amidase, putative	0.0012	0.0077	0.0171
Entamoeba histolytica	hypothetical protein	0.001	0.0048	0.0315
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0012	0.0077	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0451	0.0439
Loa Loa (eye worm)	hypothetical protein	0.001	0.0048	0.0127
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Echinococcus granulosus	cathepsin b	0.0304	0.3785	1
Leishmania major	cathepsin L-like protease	0.0009	0.0042	0.0247
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0099	0.1179	0.1168
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0048	0.0348
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0009	0.0042	0.2851
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0009	0.0042	0.0078
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.022	0.0582
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0042	0.0247
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0451	0.1191
Trypanosoma cruzi	cysteine protease, putative	0.0009	0.0042	0.0078
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0007	0.0012	0.0844
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0012	0.0546
Brugia malayi	cathepsin L precursor	0.0009	0.0042	0.011
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.022	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0146	0.6421
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0007	0.0012	0.0103
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0009	0.0042	0.011
Leishmania major	cysteine peptidase A (CPA)	0.0009	0.0042	0.0247
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0304	0.3785	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0009	0.0042	0.0078
Schistosoma mansoni	cpg binding protein	0.003	0.0303	0.077
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0042	0.0247
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0042	0.0293
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0012	0.0077	0.0171
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0009	0.0042	0.0078
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0009	0.0042	0.0078
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0048	0.0302
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Echinococcus granulosus	Niemann Pick C1 protein	0.0138	0.1674	0.4404
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.022	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.022	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0525	0.1387
Echinococcus granulosus	cathepsin l1	0.0009	0.0042	0.0078
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.0012	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0048	0.0348
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0012	0.0077	0.0171
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0007	0.0012	0.0844
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Mycobacterium ulcerans	hypothetical protein	0.0023	0.022	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0009	0.0042	0.2851
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0048	0.0348
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0042	0.011
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0012	0.0546
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0014	0.0006
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Entamoeba histolytica	hypothetical protein	0.0009	0.0042	0.0258
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0009	0.0042	0.2851
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0042	0.0293
Plasmodium vivax	vivapain-2	0.0009	0.0042	0.2851
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0012	0.0033
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0042	0.0247
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0012	0.0077	0.5274
Loa Loa (eye worm)	cathepsin B	0.01	0.1199	0.3169
Toxoplasma gondii	propionate-CoA ligase	0.0007	0.0012	0.0103
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0042	0.011
Brugia malayi	amidase	0.0099	0.1179	0.3114
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0009	0.0042	0.2851
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0042	0.011
Entamoeba histolytica	cysteine proteinase 2	0.0009	0.0042	0.0258
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0042	0.0293
Trypanosoma cruzi	major cysteine proteinase, putative	0.0009	0.0042	0.0078
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.022	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0042	0.0293
Trypanosoma cruzi	cysteine peptidase, putative	0.0009	0.0042	0.0078
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0283	0.0747
Loa Loa (eye worm)	oxidoreductase	0.0007	0.0012	0.0033
Schistosoma mansoni	amidase	0.0099	0.1179	0.3092
Brugia malayi	CHE-14 protein	0.0041	0.0451	0.1191
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0042	0.0293
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0048	0.0095
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0042	0.011
Trypanosoma cruzi	cysteine proteinase, putative	0.0009	0.0042	0.0078
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0009	0.0042	0.0078
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0012	0.0546
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0451	0.3723
Toxoplasma gondii	cathepsin B	0.01	0.1199	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Toxoplasma gondii	cathepsin CPL	0.0009	0.0042	0.0347
Mycobacterium leprae	PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	0.0012	0.0077	0.3107
Onchocerca volvulus	Cathepsin F homolog	0.0009	0.0042	0.0792
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0048	0.0348
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0042	0.0247
Echinococcus granulosus	cysteine protease	0.0009	0.0042	0.0078
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0009	0.0042	0.0293
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0009	0.0042	0.0029
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0007	0.0012	0.0103
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0048	0.0036
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3785	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0042	0.0247
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0012	0.0077	0.3107
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0009	0.0042	0.2851
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0009	0.0042	0.0078
Echinococcus multilocularis	cathepsin b	0.0304	0.3785	0.3777
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0042	0.011
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0009	0.0042	0.2851
Echinococcus multilocularis	nibrin	0.001	0.0048	0.0036
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0012	0.0077	0.0065
Trypanosoma cruzi	cysteine peptidase, putative	0.0009	0.0042	0.0078
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0602	0.5018
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0042	0.011
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.022	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.01	0.1199	0.3146
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.1149	0.3013
Onchocerca volvulus		0.0007	0.0012	0.0234
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0042	0.011
Giardia lamblia	Cathepsin B precursor	0.01	0.1199	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0146	0.6617
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.0042	0.0258
Brugia malayi	hypothetical protein	0.0231	0.2864	0.7566
Onchocerca volvulus		0.0009	0.0042	0.0792
Onchocerca volvulus		0.0007	0.0012	0.0234
Trypanosoma cruzi	major cysteine proteinase, putative	0.0009	0.0042	0.0078
Mycobacterium ulcerans	amidase	0.0012	0.0077	0.3107
Loa Loa (eye worm)	hypothetical protein	0.001	0.0048	0.0127
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Brugia malayi	Amidase family protein	0.0012	0.0077	0.0203
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0042	0.0293
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0012	0.0546
Echinococcus multilocularis	cathepsin L cysteine protease	0.0009	0.0042	0.0029
Giardia lamblia	Cathepsin B precursor	0.01	0.1199	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0134	0.6071
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0036	0.0096
Onchocerca volvulus		0.0007	0.0012	0.0234
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.022	0.183
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0042	0.011
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.0042	0.0258
Onchocerca volvulus		0.001	0.0048	0.0917
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.0042	0.0258
Echinococcus granulosus	nibrin	0.001	0.0048	0.0095
Schistosoma mansoni	topbp1	0.001	0.0048	0.0095
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0012	0.0047
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0009	0.0042	0.2851
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.1149	0.3036
Leishmania major	cathepsin L-like protease	0.0009	0.0042	0.0247
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0009	0.0042	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0569	0.1503
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0009	0.0042	0.0078
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.022	1
Onchocerca volvulus	Cathepsin L homolog	0.0009	0.0042	0.0792
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0012	0.0033
Loa Loa (eye worm)	hypothetical protein	0.001	0.0048	0.0127
Schistosoma mansoni	hypothetical protein	0.004	0.0432	0.1112
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0048	0.0401
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0048	0.0348
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.022	1
Toxoplasma gondii	cathepsin CPC2	0.0009	0.0042	0.0347
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0009	0.0042	0.011
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0012	0.0077	0.5274
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0012	0.0033
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Schistosoma mansoni	cathepsin C	0.0009	0.0042	0.0078
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Toxoplasma gondii	cathepsin CPC1	0.0009	0.0042	0.0347
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0012	0.0546
Brugia malayi	hypothetical protein	0.001	0.0048	0.0127
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.2864	0.7558
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0009	0.0042	0.0078
Trypanosoma cruzi	amidase, putative	0.0012	0.0077	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0012	0.0033
Onchocerca volvulus		0.0009	0.0042	0.0792
Brugia malayi	Amidase family protein	0.0012	0.0077	0.0203
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.022	1
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0012	0.0077	0.3483
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0042	0.011
Schistosoma mansoni	DNA ligase IV	0.001	0.0048	0.0095
Brugia malayi	hypothetical protein	0.001	0.0048	0.0127
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0012	0.0077	0.0545
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0048	0.0348
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0048	0.0401
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0042	0.0078
Echinococcus granulosus	cathepsin L	0.0009	0.0042	0.0078
Echinococcus multilocularis	cathepsin L cysteine protease	0.0009	0.0042	0.0029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Loa Loa (eye worm)	hypothetical protein	0.001	0.0048	0.0127
Schistosoma mansoni	cathepsin F (C01 family)	0.0009	0.0042	0.0078
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0009	0.0042	0.0258
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0009	0.0042	0.0347
Schistosoma mansoni	topbp1	0.001	0.0048	0.0095
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0042	0.0078
Brugia malayi	putative amidase	0.0012	0.0077	0.0203
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0042	0.0247
Plasmodium falciparum	serine repeat antigen 3	0.0009	0.0042	0.2851
Leishmania major	cathepsin L-like protease	0.0009	0.0042	0.0247
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.022	0.1753
Plasmodium vivax	vivapain-2	0.0009	0.0042	0.2851
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0042	0.0293
Schistosoma mansoni	cpg binding protein	0.003	0.0303	0.077
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0012	0.0077	0.3483
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0036	0.0024
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.01	0.1199	0.3146
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0023	0.022	0.0582
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0304	0.3785	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0036	0.0063
Schistosoma mansoni	cathepsin B (C01 family)	0.0009	0.0042	0.0078
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0012	0.0546
Schistosoma mansoni	hypothetical protein	0.0047	0.0525	0.1359
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0013	0.0096	0.0221
Echinococcus granulosus	expressed conserved protein	0.0091	0.1075	0.2816
Trypanosoma cruzi	cysteine peptidase, putative	0.0009	0.0042	0.0078
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.0042	0.0258
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.01	0.1199	1
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0042	0.011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0042	0.0247
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0042	0.0247
Schistosoma mansoni	cathepsin F (C01 family)	0.0009	0.0042	0.0078
Onchocerca volvulus	Cathepsin L homolog	0.0009	0.0042	0.0792
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Leishmania major	cathepsin L-like protease	0.0009	0.0042	0.0247
Giardia lamblia	Replication factor C, subunit 1	0.001	0.0048	0.0057
Leishmania major	cathepsin L-like protease	0.0009	0.0042	0.0247
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0304	0.3785	1
Plasmodium falciparum	serine repeat antigen 9	0.0009	0.0042	0.2851
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0042	0.0247
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0009	0.0042	0.2851
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0042	0.0247
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0048	0.0348
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0042	0.0258
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0042	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0146	0.0386
Plasmodium falciparum	serine repeat antigen 6	0.0009	0.0042	0.2851
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0042	0.011
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1179	0.3114
Onchocerca volvulus		0.0007	0.0012	0.0234
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0009	0.0042	0.011
Schistosoma mansoni	cathepsin F (C01 family)	0.0009	0.0042	0.0078
Loa Loa (eye worm)	cysteine protease	0.0009	0.0042	0.011
Echinococcus multilocularis	cysteine protease	0.0009	0.0042	0.0029
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0009	0.0042	0.2851
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0009	0.0042	0.0029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0009	0.0042	0.2851
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0042	0.011
Echinococcus granulosus	cathepsin L cysteine protease	0.0009	0.0042	0.0078
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.0012	0.0033
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0146	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0009	0.0042	0.0078
Trypanosoma cruzi	cysteine peptidase, putative	0.0009	0.0042	0.0078
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0009	0.0042	0.0293
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.0042	0.0258
Schistosoma mansoni	cpg binding protein	0.0028	0.0283	0.0717
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0009	0.0042	0.2851
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0134	0.6071
Mycobacterium ulcerans	peptide amidase, GatA	0.0012	0.0077	0.3107
Echinococcus multilocularis	expressed conserved protein	0.0091	0.1075	0.1064
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0009	0.0042	0.011
Brugia malayi	cathepsin L-like precursor	0.0009	0.0042	0.011
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.0042	0.0258
Trypanosoma cruzi	cruzipain precursor, putative	0.0009	0.0042	0.0078
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0009	0.0042	0.0293
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0525	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0042	0.011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0042	0.0293
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0014	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0042	0.0293
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0012	0.0047

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 2.6 nM	Cytotoxicity against human KB cells	ChEMBL.	16989521

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	16989521

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL447872

Bibliographic References

No literature references available for this target.

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Detailed information for compound 957323