Detailed information for compound 973810

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 396.489 | Formula: C18H16N6OS2
  • H donors: 3 H acceptors: 4 LogP: 3.55 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ncc(s1)CCNc1ncnc2c1scc2)Nc1ccccc1
  • InChi: 1S/C18H16N6OS2/c25-17(23-12-4-2-1-3-5-12)24-18-20-10-13(27-18)6-8-19-16-15-14(7-9-26-15)21-11-22-16/h1-5,7,9-11H,6,8H2,(H,19,21,22)(H2,20,23,24,25)
  • InChiKey: KLMNDRZFWQDVRL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aurora kinase B Starlite/ChEMBL References
Homo sapiens aurora kinase A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0849 0.4601
Trypanosoma cruzi ion transport protein, putative 0.0057 0.0305 0.0848
Mycobacterium ulcerans beta-lactamase 0.0038 0.0174 0.1335
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0068 0.0022
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0047 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0136
Echinococcus granulosus lamin 0.0061 0.033 0.0285
Schistosoma mansoni chromobox protein 0.0071 0.04 0.0355
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0117 0.1006
Entamoeba histolytica protein kinase domain containing protein 0.0137 0.0849 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0117 0.0405
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.021 0.1746
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0136
Echinococcus multilocularis small conductance calcium activated potassium 0.1349 0.9173 0.9169
Echinococcus granulosus citrate lyase subunit beta protein 0.0053 0.0278 0.0232
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0117 0.0405
Schistosoma mansoni twik family of potassium channels-related 0.0057 0.0305 0.0259
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0448 0.0403
Toxoplasma gondii ion channel protein 0.0057 0.0305 0.2969
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0068 0.0036
Onchocerca volvulus 0.0031 0.0126 0.0277
Trichomonas vaginalis glutathione reductase, putative 0.0046 0.0227 0.1032
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0061 0.033 0.0322
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.0928 0.4301
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0047 0.0012
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.09 0.0857
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.0674 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0068 0.0036
Trypanosoma brucei trypanothione reductase 0.0133 0.0821 0.2646
Loa Loa (eye worm) hypothetical protein 0.0038 0.0174 0.0152
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0057 0.0305 0.1413
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0582 0.307
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0036
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0206 0.066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0148 0.0102
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0582 0.307
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0075 0.0489
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0136
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0012
Onchocerca volvulus 0.0038 0.0174 0.0506
Brugia malayi Latrophilin receptor protein 2 0.0085 0.0492 0.228
Loa Loa (eye worm) hypothetical protein 0.0142 0.0883 0.0927
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0174 0.1335
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0181 0.044
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0117 0.0543
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0174 0.093
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0105 0.0336
Brugia malayi Thioredoxin reductase 0.0133 0.0821 0.3805
Brugia malayi exodeoxyribonuclease III family protein 0.0043 0.021 0.0971
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0099
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0046 0.0227 0.0719
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0068 0.0022
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0137 0.0849 0.0806
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0053 0.0278 0.0758
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Onchocerca volvulus 0.0057 0.0305 0.1132
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0057 0.0305 0.1413
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0057 0.0305 0.0259
Echinococcus granulosus muscleblind protein 0.0165 0.1047 0.1005
Brugia malayi hypothetical protein 0.0057 0.0305 0.1413
Brugia malayi N-terminal motif family protein 0.0184 0.1171 0.5427
Onchocerca volvulus Huntingtin homolog 0.0142 0.0883 0.3897
Echinococcus multilocularis potassium channel subfamily K 0.0057 0.0305 0.0259
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0068 0.0022
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.159 1
Schistosoma mansoni calcium-activated potassium channel 0.1349 0.9173 0.9169
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0061 0.0332 0.1637
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0068 0.0022
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0174 0.1648
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.0582 0.1757
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0174 0.093
Leishmania major hypothetical protein, conserved 0.0463 0.3092 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Schistosoma mansoni ap endonuclease 0.0043 0.021 0.0164
Entamoeba histolytica protein kinase, putative 0.0137 0.0849 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0061 0.0332 0.1637
Plasmodium vivax glutathione reductase, putative 0.0133 0.0821 0.9663
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0181 0.0135
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0227 0.0591
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0181 0.1672
Plasmodium vivax potassium channel, putative 0.0057 0.0305 0.3313
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0046 0.0227 0.1267
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0181 0.0769
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0181 0.044
Loa Loa (eye worm) hypothetical protein 0.0165 0.1047 0.1107
Onchocerca volvulus 0.0057 0.0305 0.1132
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0085 0.0492 0.0448
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0078 0.0386
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0046 0.0227 0.0719
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0674 0.3599
Schistosoma mansoni lamin 0.0061 0.033 0.0285
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0117 0.1006
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.0674 0.2061
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0068 0.0036
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0046 0.0227 0.1267
Onchocerca volvulus 0.0057 0.0305 0.1132
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0113 0.0067
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0078 0.036
Trypanosoma cruzi trypanothione reductase, putative 0.0133 0.0821 0.2544
Mycobacterium ulcerans lipase LipD 0.0038 0.0174 0.1335
Loa Loa (eye worm) TWK-28 protein 0.0057 0.0305 0.0295
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0582 0.307
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0582 0.307
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0036
Loa Loa (eye worm) hypothetical protein 0.0038 0.0174 0.0152
Echinococcus multilocularis potassium channel subfamily K 8 0.0057 0.0305 0.0259
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0068 0.0022
Brugia malayi intermediate filament protein 0.0061 0.033 0.1529
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0068 0.0022
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0174 0.0152
Loa Loa (eye worm) hypothetical protein 0.0038 0.0174 0.0152
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0274 0.127
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0068 0.0316
Schistosoma mansoni intermediate filament proteins 0.0061 0.033 0.0285
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Brugia malayi nuclear hormone receptor 0.0023 0.0068 0.0316
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0057 0.0305 0.0295
Loa Loa (eye worm) thioredoxin reductase 0.0133 0.0821 0.086
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.1072 0.6684
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0053 0.0278 0.0758
Loa Loa (eye worm) AUR protein kinase 0.0137 0.0849 0.089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0068 0.0316
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0117 0.0405
Loa Loa (eye worm) hypothetical protein 0.004 0.0185 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0068 0.0316
Leishmania major calcium/potassium channel (CAKC), putative 0.0057 0.0305 0.0848
Echinococcus multilocularis twik family of potassium channels 0.0057 0.0305 0.0259
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.0582 0.0598
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0174 0.093
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0148 0.0939
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0117 0.0405
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0448 0.0403
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0221 0.0701
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0078 0.0386
Trichomonas vaginalis esterase, putative 0.0038 0.0174 0.073
Loa Loa (eye worm) beta-lactamase 0.0038 0.0174 0.0152
Schistosoma mansoni twik family of potassium channels-related 0.0057 0.0305 0.0259
Leishmania major hypothetical protein, conserved 0.0038 0.0174 0.0418
Onchocerca volvulus 0.0038 0.0174 0.0506
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0582 0.307
Loa Loa (eye worm) AUR protein kinase 0.0137 0.0849 0.089
Echinococcus granulosus potassium channel subfamily K 0.0057 0.0305 0.0259
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0136
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0289 0.0796
Schistosoma mansoni calcium-activated potassium channel 0.0057 0.0305 0.0259
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0068 0.0022
Echinococcus granulosus potassium channel subfamily K 8 0.0057 0.0305 0.0259
Plasmodium vivax thioredoxin reductase, putative 0.0133 0.0821 0.9663
Toxoplasma gondii ABC1 family protein 0.0038 0.0174 0.1276
Onchocerca volvulus 0.0327 0.2159 1
Entamoeba histolytica hypothetical protein 0.0078 0.0448 0.5
Giardia lamblia NADH oxidase lateral transfer candidate 0.0046 0.0227 0.2243
Schistosoma mansoni ap endonuclease 0.0043 0.021 0.0164
Schistosoma mansoni chromobox protein 0.0071 0.04 0.0355
Brugia malayi beta-lactamase family protein 0.0038 0.0174 0.0806
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0185 0.173
Echinococcus multilocularis lamin 0.0061 0.033 0.0285
Toxoplasma gondii thioredoxin reductase 0.0133 0.0821 0.9645
Schistosoma mansoni hypothetical protein 0.0078 0.0448 0.0403
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0117 0.0881
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0068 0.0036
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0046 0.0227 0.0591
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0136
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0046 0.0227 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0068 0.0316
Echinococcus multilocularis chromobox protein 1 0.0071 0.04 0.0355
Trichomonas vaginalis chromobox protein, putative 0.0071 0.04 0.2028
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0078 0.0406
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0068 0.0022
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0057 0.0305 0.0259
Brugia malayi hypothetical protein 0.0327 0.2159 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0174 0.073
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0181 0.1364
Trichomonas vaginalis mercuric reductase, putative 0.0046 0.0227 0.1032
Plasmodium falciparum glutathione reductase 0.0046 0.0227 0.2349
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.021 0.0939
Brugia malayi serine/threonine kinase 12 0.0137 0.0849 0.3932
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0047 0.0216
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0047 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0068 0.0316
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0174 0.0128
Echinococcus multilocularis potassium channel subfamily K 8 0.0057 0.0305 0.0259
Loa Loa (eye worm) acetyltransferase 0.0148 0.0928 0.0977
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.1562 0.167
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.0674 0.2061
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0046 0.0227 0.0591
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0674 0.0699
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0078 0.0406
Loa Loa (eye worm) hypothetical protein 0.0184 0.1171 0.1243
Loa Loa (eye worm) glutathione reductase 0.0133 0.0821 0.086
Onchocerca volvulus 0.0057 0.0305 0.1132
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0674 0.7823
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0227 0.0591
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0046 0.0227 0.1956
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0137 0.0849 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0174 0.1335
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0057 0.0305 0.0259
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0057 0.0305 0.1413
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0057 0.0305 0.1413
Schistosoma mansoni twik family of potassium channels-related 0.0057 0.0305 0.0259
Echinococcus multilocularis calcium activated potassium channel variant 0.0057 0.0305 0.0259
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0075 0.0094
Schistosoma mansoni inositol monophosphatase 0.0039 0.0181 0.0135
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0305 0.0848
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0954 0.2981
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0174 0.0128
Mycobacterium tuberculosis Probable oxidoreductase 0.0046 0.0227 0.1267
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0075 0.0298
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0136
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0057 0.0305 0.1413
Trypanosoma brucei calcium-activated potassium channel, putative 0.0057 0.0305 0.0973
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.021 0.0939
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Echinococcus multilocularis musashi 0.0061 0.033 0.0285
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0085 0.0492 0.0448
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0057 0.0305 0.0848
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0043 0.021 0.8872
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.04 0.0399
Loa Loa (eye worm) inositol-1 0.0039 0.0181 0.0159
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0185 0.056
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0053 0.0278 0.2334
Treponema pallidum exodeoxyribonuclease (exoA) 0.0043 0.021 0.2241
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0075 0.0384
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0174 0.073
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0046 0.0227 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0267 0.1747 0.1873
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.021 0.0934
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0174 0.073
Schistosoma mansoni hypothetical protein 0.0085 0.0492 0.0448
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0085 0.0492 0.0448
Loa Loa (eye worm) intermediate filament protein 0.0061 0.033 0.0322
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0274 0.0228
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0078 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0078 0.0406
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0046 0.0227 0.1843
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0674 0.7823
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0274 0.0228
Onchocerca volvulus 0.0024 0.0078 0.0045
Entamoeba histolytica hypothetical protein 0.0078 0.0448 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0206 0.0915
Onchocerca volvulus 0.0061 0.033 0.1253
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0057 0.0305 0.1413
Loa Loa (eye worm) hypothetical protein 0.0024 0.0078 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0068 0.0316
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0046 0.0227 0.2349
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0068 0.0316
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0227 0.0591
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0057 0.0305 0.0295
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0046 0.0227 0.0591
Toxoplasma gondii hypothetical protein 0.0052 0.0267 0.2475
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0068 0.0316
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0047 0.0136
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0043 0.021 0.019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0068 0.0022
Echinococcus multilocularis thioredoxin glutathione reductase 0.0133 0.0821 0.0778
Schistosoma mansoni lamin 0.0061 0.033 0.0285
Plasmodium falciparum thioredoxin reductase 0.0133 0.0821 0.9663
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0674 0.0699
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0036
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0047 0.0107
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0221 0.0573
Mycobacterium ulcerans hypothetical protein 0.0053 0.0278 0.2334
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.021 0.214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0068 0.0036
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0117 0.1006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0043 0.021 0.0535
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0085 0.0492 0.0448
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0075 0.0384
Schistosoma mansoni hypothetical protein 0.0085 0.0492 0.0448
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0267 0.1747 0.8094
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0117 0.428
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0046 0.0227 0.0591
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0043 0.021 0.0164
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0068 0.0022
Trypanosoma brucei hypothetical protein, conserved 0.0463 0.3092 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.0582 0.6672
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0274 0.0228
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0274 0.0228
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0078 0.0313
Plasmodium falciparum potassium channel 0.0057 0.0305 0.3313
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0046 0.0227 0.2349
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0274 0.0228
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0057 0.0305 0.1413
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0174 0.093
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.021 0.214
Loa Loa (eye worm) hypothetical protein 0.0028 0.0106 0.0077
Brugia malayi Inositol-1 0.0039 0.0181 0.0838
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0057 0.0305 0.1413
Loa Loa (eye worm) latrophilin receptor protein 2 0.0085 0.0492 0.05
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0068 0.0316
Echinococcus granulosus twik family of potassium channels 0.0057 0.0305 0.0259
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0047 0.0136
Loa Loa (eye worm) hypothetical protein 0.0327 0.2159 0.2324
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0075 0.2083
Brugia malayi Pre-SET motif family protein 0.0034 0.0148 0.0686
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0078 0.0406
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0674 0.3599
Echinococcus granulosus lamin dm0 0.0061 0.033 0.0285
Schistosoma mansoni coup transcription factor 0.0023 0.0068 0.0022
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0181 0.1401
Loa Loa (eye worm) hypothetical protein 0.0061 0.033 0.0322
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0582 0.307
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0068 0.0036
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0085 0.0492 0.228
Echinococcus granulosus chromobox protein 1 0.0071 0.04 0.0355
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0053 0.0278 0.1324
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0068 0.0316
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0057 0.0305 0.1413
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0046 0.0227 0.105
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0053 0.0278 0.2334
Schistosoma mansoni hypothetical protein 0.0183 0.1166 0.1125
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0068 0.0022
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0117 0.0701
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0057 0.0305 0.1413
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0068 0.0316
Trypanosoma brucei aurora B kinase 0.0137 0.0849 0.2734
Echinococcus granulosus calcium activated potassium channel variant 0.0057 0.0305 0.0259
Echinococcus granulosus GPCR family 2 0.0085 0.0492 0.0448
Mycobacterium ulcerans hypothetical protein 0.0038 0.0174 0.1335
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Leishmania major ion transport protein-like protein 0.0057 0.0305 0.0848
Loa Loa (eye worm) hypothetical protein 0.0313 0.2061 0.2217
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0185 0.173
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0849 0.4601
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.0582 0.0538
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0185 0.0795
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0078 0.0102
Echinococcus multilocularis muscleblind protein 1 0.0165 0.1047 0.1005
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0057 0.0305 0.0848
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0181 0.0135
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0136 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0582 0.0538
Schistosoma mansoni hypothetical protein 0.0085 0.0492 0.0448
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.0928 0.0886
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0068 0.0022
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0181 0.0571
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0046 0.0227 0.2526
Onchocerca volvulus 0.0057 0.0305 0.1132
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0068 0.0316
Schistosoma mansoni serine/threonine protein kinase 0.0137 0.0849 0.0806
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0247 0.1149
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0068 0.0316
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0057 0.0305 0.1769
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0582 0.1757
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.0357
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0043 0.021 0.2031
Brugia malayi hypothetical protein 0.0057 0.0305 0.1413
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0046 0.0227 0.0591
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0954 0.2981
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0068 0.0022
Schistosoma mansoni microtubule-associated protein tau 0.147 1 1
Toxoplasma gondii aurora kinase 0.0137 0.0849 1
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0068 0.0022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0174 0.0128
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0206 0.0915
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.021 0.0164
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0068 0.0022
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0068 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0274 0.0228
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0448 0.0403
Leishmania major hypothetical protein, conserved 0.0057 0.0305 0.0848
Loa Loa (eye worm) hypothetical protein 0.0389 0.2581 0.2785
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0043 0.021 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0148 0.0102
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0057 0.0305 0.1413
Trypanosoma brucei unspecified product 0.002 0.0047 0.0136
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0174 0.0418
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.0674 0.063
Echinococcus multilocularis geminin 0.0383 0.2543 0.2508
Leishmania major hypothetical protein, conserved 0.0057 0.0305 0.0848
Echinococcus multilocularis muscleblind protein 0.0165 0.1047 0.1005
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0181 0.6972
Schistosoma mansoni hypothetical protein 0.0383 0.2543 0.2508
Mycobacterium tuberculosis Conserved protein 0.0038 0.0174 0.093
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0113 0.0067
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0133 0.0821 0.5076
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0674 0.063
Mycobacterium ulcerans hypothetical protein 0.0053 0.0278 0.2334
Onchocerca volvulus 0.0046 0.0228 0.0765
Schistosoma mansoni twik family of potassium channels-related 0.0057 0.0305 0.0259
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0068 0.0022
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0148 0.0102
Brugia malayi ecdysteroid receptor 0.0023 0.0068 0.0316
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0117 0.0405
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0117 0.0543
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0153 0.0793
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0085
Onchocerca volvulus 0.0057 0.0305 0.1132
Loa Loa (eye worm) hypothetical protein 0.0034 0.0148 0.0123
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0139 0.0093
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0057 0.0305 0.0848
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0061 0.0332 0.1637
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0078 0.0038
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0078 0.0313
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0227 0.0591
Toxoplasma gondii NADPH-glutathione reductase 0.0046 0.0227 0.1956
Echinococcus multilocularis twik family of potassium channels 0.0057 0.0305 0.0259
Loa Loa (eye worm) uncoordinated protein 58 0.0057 0.0305 0.0295
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0227 0.0591
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0053 0.0278 0.1593
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0068 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0274 0.0228
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.0674 1
Echinococcus granulosus aurora kinase A 0.0137 0.0849 0.0806
Loa Loa (eye worm) AUR protein kinase 0.0137 0.0849 0.089
Brugia malayi 6-phosphofructokinase 0.0111 0.0674 0.3123
Loa Loa (eye worm) hypothetical protein 0.0267 0.1747 0.1873
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0043 0.021 0.1678
Schistosoma mansoni twik family of potassium channels-related 0.0057 0.0305 0.0259
Loa Loa (eye worm) hypothetical protein 0.0028 0.0106 0.0077
Loa Loa (eye worm) hypothetical protein 0.0165 0.1047 0.1107
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0057 0.0305 0.0295
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0068 0.0022
Brugia malayi beta-lactamase 0.0038 0.0174 0.0806
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0174 0.1703
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0046 0.0227 0.2349
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0046 0.0227 0.2349
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0068 0.0022
Leishmania major protein kinase, putative 0.0137 0.0849 0.2634
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0046 0.0227 0.0591
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0078 0.0386
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0068 0.0022
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0034 0.0143 0.0662
Treponema pallidum NADH oxidase 0.0046 0.0227 0.2526
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0105 0.0336
Echinococcus multilocularis microtubule associated protein 2 0.147 1 1
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0137 0.0849 1
Onchocerca volvulus 0.0038 0.0174 0.0506
Trichomonas vaginalis chromobox protein, putative 0.0071 0.04 0.2028
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0068 0.0022
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0221 0.0573
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0046 0.0227 0.0719
Brugia malayi Muscleblind-like protein 0.0165 0.1047 0.4849
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0117 0.1006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0036
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.0674 0.6159
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0057 0.0305 0.0973
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0078 0.036
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0174 0.0806
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.2115 0.6794
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0046 0.0227 0.0181
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.0582 0.0538
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0046 0.0227 0.1267
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0057 0.0305 0.1481
Trypanosoma cruzi ion transport protein, putative 0.0057 0.0305 0.0848
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0181 0.0769
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0047 0.0136
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0674 0.063
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0078 0.0102
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Onchocerca volvulus 0.0057 0.0305 0.1132
Loa Loa (eye worm) hypothetical protein 0.0038 0.0174 0.0152
Echinococcus granulosus intermediate filament protein 0.0061 0.033 0.0285
Schistosoma mansoni calcium-activated potassium channel 0.0979 0.6629 0.6613
Schistosoma mansoni twik family of potassium channels-related 0.0057 0.0305 0.0259
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0057 0.0305 0.322
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0117 0.0405
Brugia malayi nuclear receptor NHR-88 0.0023 0.0068 0.0316
Trichomonas vaginalis set domain proteins, putative 0.0274 0.179 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0036
Echinococcus granulosus potassium channel subfamily K 8 0.0057 0.0305 0.0259
Mycobacterium tuberculosis Conserved protein 0.0038 0.0174 0.093
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0495 0.2292
Echinococcus granulosus twik family of potassium channels 0.0057 0.0305 0.0259
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0247 0.1149
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0181 0.044
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0674 0.7823
Plasmodium vivax SET domain protein, putative 0.0034 0.0148 0.1383
Entamoeba histolytica hypothetical protein 0.0078 0.0448 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0183 0.1166 0.5403
Schistosoma mansoni protein kinase 0.0137 0.0849 0.0806
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0057 0.0305 0.1413
Echinococcus multilocularis GPCR, family 2 0.0085 0.0492 0.0448
Plasmodium falciparum serine/threonine protein kinase, putative 0.0137 0.0849 1
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0057 0.0305 0.0259
Loa Loa (eye worm) hypothetical protein 0.006 0.0322 0.0314
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0047 0.0107
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0181 0.0769
Brugia malayi glutathione reductase 0.0133 0.0821 0.3805
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0068 0.0316
Loa Loa (eye worm) hypothetical protein 0.059 0.396 0.4295
Schistosoma mansoni hypothetical protein 0.0383 0.2543 0.2508
Entamoeba histolytica protein kinase, putative 0.0137 0.0849 1
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0137 0.0849 0.0806
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0075 0.0489
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0495 0.045
Loa Loa (eye worm) phosphofructokinase 0.0111 0.0674 0.0699
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0136
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0078 0.0406
Loa Loa (eye worm) hypothetical protein 0.0183 0.1166 0.1238
Giardia lamblia Hypothetical protein 0.0057 0.0305 0.322
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Leishmania major potassium channel subunit-like protein 0.0057 0.0305 0.0848
Echinococcus granulosus chromobox protein 1 0.0071 0.04 0.0355
Mycobacterium tuberculosis Conserved protein 0.0038 0.0174 0.093
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0057 0.0305 0.1413
Echinococcus granulosus thioredoxin glutathione reductase 0.0133 0.0821 0.0778
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0184 0.1171 0.5277
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0582 0.307
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0046 0.0227 1
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0057 0.0305 0.0848
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0274 0.0261
Brugia malayi serine/threonine-protein kinase 6 0.0137 0.0849 0.3932
Trypanosoma cruzi hypothetical protein, conserved 0.0463 0.3092 1
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0053 0.0278 0.0758
Loa Loa (eye worm) TWK-7 protein 0.0057 0.0305 0.0295
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0849 0.4601
Leishmania major mitochondrial DNA polymerase beta 0.0321 0.2115 0.6794
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0137 0.0849 1
Mycobacterium ulcerans ion transport protein 0.0057 0.0305 0.2598
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0674 0.3599
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0228 0.0182
Echinococcus multilocularis lamin dm0 0.0061 0.033 0.0285
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0305 0.0848
Mycobacterium ulcerans hypothetical protein 0.0169 0.1072 1
Entamoeba histolytica protein kinase , putative 0.0137 0.0849 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0136
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0137 0.0849 1
Trypanosoma brucei polo-like protein kinase 0.0098 0.0582 0.187
Brugia malayi hypothetical protein 0.0078 0.0448 0.2074
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0043 0.021 0.0535
Brugia malayi phosphofructokinase 0.0111 0.0674 0.3123
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0057 0.0305 0.1413
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0117 0.0543
Echinococcus multilocularis chromobox protein 1 0.0071 0.04 0.0355
Loa Loa (eye worm) hypothetical protein 0.0085 0.0492 0.05
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0057 0.0305 0.1413
Brugia malayi Heterochromatin protein 1 0.0071 0.04 0.1854
Onchocerca volvulus 0.0057 0.0305 0.1132
Brugia malayi steroid hormone receptor 0.0023 0.0068 0.0316
Plasmodium falciparum potassium channel 0.0057 0.0305 0.3313
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Brugia malayi 6-phosphofructokinase 0.0111 0.0674 0.3123
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.0674 0.4133
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0057 0.0305 0.1413
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0068 0.0022
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0117 0.0881
Loa Loa (eye worm) hypothetical protein 0.0024 0.0078 0.0046
Leishmania major trypanothione reductase 0.0133 0.0821 0.2544
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0068 0.0022
Onchocerca volvulus 0.0085 0.0495 0.204
Brugia malayi serine/threonine protein kinase 6 0.0137 0.0849 0.3932
Plasmodium falciparum thioredoxin reductase 0.0046 0.0227 0.2349
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0078 0.036
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0043 0.021 0.0664
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0227 0.0591
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0068 0.0316
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Brugia malayi beta-lactamase family protein 0.0038 0.0174 0.0806
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0153 0.1289
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0043 0.021 0.0535
Echinococcus multilocularis aurora kinase A 0.0137 0.0849 0.0806
Loa Loa (eye worm) hypothetical protein 0.1349 0.9173 1
Schistosoma mansoni twik family of potassium channels-related 0.0057 0.0305 0.0259
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0117 0.0405
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0136
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0034 0.0143 0.0662
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0068 0.0316
Giardia lamblia Kinase, PLK 0.0098 0.0582 0.6672
Trypanosoma cruzi hypothetical protein, conserved 0.0463 0.3092 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0174 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0185 0.0795
Schistosoma mansoni hypothetical protein 0.0085 0.0492 0.0448
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0136 0.0628
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0078 0.0102
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.0582 0.2695
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.0928 0.0886
Brugia malayi hypothetical protein 0.0142 0.0883 0.409
Schistosoma mansoni calcium-activated potassium channel 0.0057 0.0305 0.0259
Mycobacterium leprae Probable lipase LipE 0.0038 0.0174 0.1648
Loa Loa (eye worm) hypothetical protein 0.0085 0.0495 0.0503
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0148 0.0102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0227 0.0591
Loa Loa (eye worm) hypothetical protein 0.0038 0.0174 0.0152
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0495 0.045
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0046 0.0227 0.1843
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0221 0.0573
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0136
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.0674 0.063
Mycobacterium ulcerans hypothetical protein 0.0024 0.0078 0.0406
Echinococcus granulosus small conductance calcium activated potassium 0.1349 0.9173 0.9169
Schistosoma mansoni hypothetical protein 0.0057 0.0305 0.0259
Schistosoma mansoni hypothetical protein 0.1349 0.9173 0.9169
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0185 0.1843
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0174 0.073
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0068 0.0022
Brugia malayi Pre-SET motif family protein 0.024 0.1562 0.7236
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.021 0.0934
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0174 0.073
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0047 0.0216
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.021 0.215
Loa Loa (eye worm) hypothetical protein 0.0142 0.0883 0.0927
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.0674 0.2169
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Schistosoma mansoni kinase 0.005 0.0256 0.021
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0068 0.0022
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0043 0.021 0.2031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0068 0.0036
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0046 0.0227 0.0181
Onchocerca volvulus Huntingtin homolog 0.0142 0.0883 0.3897
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0174 0.093
Mycobacterium tuberculosis Conserved protein 0.0053 0.0278 0.1593
Plasmodium falciparum glutathione reductase 0.0133 0.0821 0.9663
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0057 0.0305 0.1413
Brugia malayi chromobox protein homolog 3 0.004 0.0185 0.0859
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0849 0.4601
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0674 0.3599
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0321 0.2115 0.6838
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0047 0.0115
Loa Loa (eye worm) hypothetical protein 0.0024 0.0078 0.0046
Entamoeba histolytica hypothetical protein 0.0078 0.0448 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.2115 0.6794
Echinococcus multilocularis citrate lyase subunit beta protein 0.0053 0.0278 0.0232
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0068 0.0022
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0053 0.0278 0.2334
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0148 0.0102
Toxoplasma gondii exonuclease III APE 0.0043 0.021 0.1735
Mycobacterium ulcerans transmembrane cation transporter 0.0057 0.0305 0.2598
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0078 0.0406
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0068 0.0022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0174 0.093
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0174 0.0549
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0061 0.0332 0.1637
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0117 0.428
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0036 0.0043
Echinococcus granulosus geminin 0.0383 0.2543 0.2508
Giardia lamblia Aurora kinase 0.0137 0.0849 1
Onchocerca volvulus 0.0274 0.179 0.8236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0068 0.0036
Toxoplasma gondii ion channel protein 0.0057 0.0305 0.2969
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0036
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.0582 0.2457
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0068 0.0022
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0148 0.0102
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0046 0.0227 0.0719
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0174 0.093
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0295
Brugia malayi Calcitonin receptor-like protein seb-1 0.0267 0.1747 0.8094
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0075 0.0229
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.0954 0.3077
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0046 0.0227 0.0181
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0174 0.0418
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0078 0.0406
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0043 0.021 0.1158
Brugia malayi Intermediate filament tail domain containing protein 0.0061 0.033 0.1529
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0174 0.0128
Plasmodium vivax potassium channel, putative 0.0057 0.0305 0.3313
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0068 0.0022
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0582 0.1757
Schistosoma mansoni twik family of potassium channels-related 0.0057 0.0305 0.0259
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.021 0.1746
Schistosoma mansoni inositol monophosphatase 0.0039 0.0181 0.0135
Trypanosoma cruzi aurora B kinase, putative 0.0137 0.0849 0.2634
Onchocerca volvulus 0.0061 0.033 0.1253
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0495 0.045
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0046 0.0227 0.1843

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 16 nM Cell cycle arrest in human HCT116 cells assessed as accumulation of 4N DNA phase after 16 hrs by FACS ChEMBL. 18678489
EC50 (functional) = 16 nM Cell cycle arrest in human HCT116 cells assessed as accumulation of 4N DNA by FACS analysis ChEMBL. 19646866
EC50 (functional) = 45 nM Antiproliferative activity against human HCT116 cells assessed as BrdU incorporation ChEMBL. 18678489
EC50 (functional) = 45 nM Antiproliferative activity against human HCT116 cells assessed as BrdU incorporation after 72 hrs ChEMBL. 19320489
EC50 (functional) = 45 nM Antiproliferative activity against human HCT116 cells by BrdU incorporation assay ChEMBL. 19646866
IC50 (binding) = 52 nM Inhibition of Aurora A by radiometric assay ChEMBL. 18678489
IC50 (binding) = 52 nM Inhibition of aurora A kinase ChEMBL. 19320489
IC50 (binding) = 52 nM Inhibition of Aurora A after 60 mins ChEMBL. 19646866
IC50 (binding) = 120 nM Inhibition of Aurora B by radiometric assay ChEMBL. 18678489
IC50 (binding) = 120 nM Inhibition of aurora B kinase ChEMBL. 19320489
IC50 (binding) = 120 nM Inhibition of Aurora B after 60 mins ChEMBL. 19646866

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 18678489

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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