Detailed information for compound 982799

Basic information

Technical information
  • TDR Targets ID: 982799
  • Name: 2-phenyl-N-[4-[4-[(2-phenylacetyl)amino]pheny l]sulfonylphenyl]acetamide
  • MW: 484.566 | Formula: C28H24N2O4S
  • H donors: 2 H acceptors: 4 LogP: 4.26 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccccc1)Nc1ccc(cc1)S(=O)(=O)c1ccc(cc1)NC(=O)Cc1ccccc1
  • InChi: 1S/C28H24N2O4S/c31-27(19-21-7-3-1-4-8-21)29-23-11-15-25(16-12-23)35(33,34)26-17-13-24(14-18-26)30-28(32)20-22-9-5-2-6-10-22/h1-18H,19-20H2,(H,29,31)(H,30,32)
  • InChiKey: JEBYJPLNSNMWCD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[4-[(1-oxo-2-phenylethyl)amino]phenyl]sulfonylphenyl]-2-phenylacetamide
  • 2-phenyl-N-[4-[4-(2-phenylethanoylamino)phenyl]sulfonylphenyl]ethanamide
  • Oprea1_531228
  • Oprea1_491434
  • 2-Phenyl-N-[4-(4-phenylacetylamino-benzenesulfonyl)-phenyl]-acetamide
  • BAS 00720570
  • ZINC00822781
  • STK084875

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0048 0.0107 0.0212
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0139 0.0133
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0026 0.0043
Mycobacterium tuberculosis Probable esterase LipL 0.0048 0.0107 0.1203
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0788 0.2105 1
Onchocerca volvulus 0.0053 0.0122 0.0839
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0059 0.0139 0.0277
Echinococcus granulosus intermediate filament protein 0.0062 0.0146 0.014
Brugia malayi latrophilin 2 splice variant baaae 0.0087 0.0212 0.0431
Mycobacterium tuberculosis Probable lipase LipD 0.0048 0.0107 0.1203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0022 0.0189
Leishmania major carnitine/choline acetyltransferase, putative 0.0145 0.0368 0.1728
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0055 0.0128 0.0122
Schistosoma mansoni hypothetical protein 0.0087 0.0212 0.0207
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0024 0.0043 0.0179
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0368 0.1728
Echinococcus granulosus tar DNA binding protein 0.0059 0.0139 0.0133
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0788 0.2105 1
Brugia malayi beta-lactamase 0.0048 0.0107 0.0212
Onchocerca volvulus 0.0055 0.0128 0.0891
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0026 0.0043
Mycobacterium ulcerans hypothetical protein 0.0048 0.0107 1
Schistosoma mansoni thyroid hormone receptor 0.0095 0.0236 0.023
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0139 0.0133
Echinococcus granulosus tumor protein p63 0.0511 0.1357 0.1352
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0127 0.0321 0.0656
Loa Loa (eye worm) MH2 domain-containing protein 0.0091 0.0225 0.0456
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.003 0.006 0.0054
Onchocerca volvulus 0.0145 0.0368 0.3003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0083 0.0203 0.0198
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0306 0.0804 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0048 0.0107 0.0212
Schistosoma mansoni choline o-acyltransferase 0.0145 0.0368 0.0363
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0368 0.1728
Brugia malayi RNA recognition motif domain containing protein 0.0059 0.0139 0.0277
Echinococcus multilocularis musashi 0.0062 0.0146 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.023
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0145 0.0368 0.1728
Onchocerca volvulus 0.0075 0.018 0.135
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0033 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0039 0.0332
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0053 0.0122 0.0117
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0105
Loa Loa (eye worm) hypothetical protein 0.0048 0.0107 0.0212
Echinococcus multilocularis thyroid hormone receptor alpha 0.0095 0.0236 0.023
Echinococcus granulosus histone lysine methyltransferase setb 0.0055 0.0128 0.0122
Loa Loa (eye worm) hypothetical protein 0.0048 0.0107 0.0212
Loa Loa (eye worm) RNA binding protein 0.0059 0.0139 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0043 0.0369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0039 0.0332
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0128 0.0122
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0788 0.2105 0.2101
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0026 0.1305
Echinococcus granulosus lamin dm0 0.0062 0.0146 0.014
Echinococcus multilocularis tar DNA binding protein 0.0059 0.0139 0.0133
Loa Loa (eye worm) hypothetical protein 0.004 0.0087 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.023
Echinococcus multilocularis beta LACTamase domain containing family member 0.0048 0.0107 0.0102
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0013 0.0014 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.023
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0145 0.0368 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0107 0.0212
Brugia malayi Pre-SET motif family protein 0.0055 0.0128 0.0255
Brugia malayi RNA binding protein 0.0059 0.0139 0.0277
Echinococcus granulosus GPCR family 2 0.004 0.0087 0.0081
Mycobacterium ulcerans lipase LipD 0.0048 0.0107 1
Brugia malayi hypothetical protein 0.0261 0.0683 0.141
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.003 0.006 0.1492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0022 0.019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0018
Onchocerca volvulus 0.0048 0.0107 0.0712
Schistosoma mansoni hypothetical protein 0.004 0.0087 0.0081
Loa Loa (eye worm) latrophilin receptor protein 2 0.004 0.0087 0.0169
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.003 0.006 0.0258
Loa Loa (eye worm) hypothetical protein 0.0048 0.0107 0.0212
Onchocerca volvulus 0.0062 0.0146 0.105
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.006 0.0113
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0043
Onchocerca volvulus 0.0048 0.0107 0.0712
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0368 0.1728
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.0146 0.0292
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0018
Schistosoma mansoni choline o-acyltransferase 0.0145 0.0368 0.0363
Schistosoma mansoni cellular tumor antigen P53 0.0075 0.018 0.0175
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.003 0.006 0.1492
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0026 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0039 0.0332
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0055 0.0128 0.0122
Brugia malayi Latrophilin receptor protein 2 0.004 0.0087 0.0169
Onchocerca volvulus 0.044 0.1165 1
Brugia malayi TAR-binding protein 0.0059 0.0139 0.0277
Loa Loa (eye worm) choline O-acetyltransferase 0.0145 0.0368 0.0755
Loa Loa (eye worm) intermediate filament protein 0.0062 0.0146 0.0292
Plasmodium vivax SET domain protein, putative 0.0055 0.0128 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.006 0.0512
Entamoeba histolytica hypothetical protein 0.0083 0.0203 1
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0145 0.0368 1
Brugia malayi MH2 domain containing protein 0.0091 0.0225 0.0456
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0005 0.0047
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0145 0.0368 0.1728
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0068 0.013
Echinococcus multilocularis lamin 0.0062 0.0146 0.014
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.004 0.0087 0.0081
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.003 0.006 0.1884
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0005 0.0047
Echinococcus granulosus choline O acetyltransferase 0.0145 0.0368 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0039 0.0332
Loa Loa (eye worm) hypothetical protein 0.0087 0.0212 0.0431
Loa Loa (eye worm) hypothetical protein 0.0261 0.0683 0.141
Trichomonas vaginalis penicillin-binding protein, putative 0.0048 0.0107 0.0922
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0788 0.2105 1
Echinococcus multilocularis lamin dm0 0.0062 0.0146 0.014
Mycobacterium ulcerans beta-lactamase 0.0048 0.0107 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0039 0.0332
Mycobacterium ulcerans hypothetical protein 0.0018 0.0026 0.1305
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0005 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0026 0.1305
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0128 0.0122
Loa Loa (eye worm) TAR-binding protein 0.0059 0.0139 0.0277
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0107 0.821
Echinococcus granulosus lamin 0.0062 0.0146 0.014
Schistosoma mansoni survival motor neuron protein 0.0053 0.0122 0.0116
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0014 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0048 0.0107 0.0102
Mycobacterium tuberculosis Probable hydrolase 0.0048 0.0107 0.1203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0226
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0018 0.0026 0.0179
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.003 0.006 0.0054
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.0683 0.0678
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0005 0.0047
Schistosoma mansoni hypothetical protein 0.004 0.0087 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.006 0.0512
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0018 0.0026 0.1305
Brugia malayi Choline O-acetyltransferase 0.0145 0.0368 0.0755
Trichomonas vaginalis set domain proteins, putative 0.044 0.1165 1
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0145 0.0368 0.1728
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0039 0.0332
Schistosoma mansoni intermediate filament proteins 0.0062 0.0146 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0022 0.019
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.003 0.006 0.0054
Mycobacterium tuberculosis Conserved protein 0.0048 0.0107 0.1203
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.004 0.0087 0.0081
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0048 0.0107 0.1203
Onchocerca volvulus 0.0145 0.0368 0.3003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0226
Entamoeba histolytica hypothetical protein 0.0083 0.0203 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0024 0.0043 0.0179
Loa Loa (eye worm) hypothetical protein 0.0145 0.0368 0.0755
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0139 0.0133
Schistosoma mansoni hypothetical protein 0.004 0.0087 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0022 0.019
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0145 0.0368 0.0755
Giardia lamblia GTOR 0.003 0.006 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0043 0.0369
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.003 0.006 0.0258
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0145 0.0368 1
Mycobacterium tuberculosis Conserved protein 0.0048 0.0107 0.1203
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0055 0.0128 1
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0139 0.0133
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0145 0.0368 0.0363
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0026 0.1305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0022 0.0189
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0068 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0043 0.0369
Onchocerca volvulus 0.0145 0.0368 0.3003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0055 0.0128 0.0122
Brugia malayi beta-lactamase family protein 0.0048 0.0107 0.0212
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0048 0.0107 0.0212
Leishmania major hypothetical protein, conserved 0.0048 0.0107 0.0485
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0127 0.0321 0.0656
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0018 0.0026 0.1305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0043 0.0369
Loa Loa (eye worm) hypothetical protein 0.0055 0.0128 0.0255
Mycobacterium ulcerans esterase/lipase LipP 0.0048 0.0107 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0059 0.0054
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0145 0.0368 0.1728
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0145 0.0368 0.0755
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.0146 0.0292
Loa Loa (eye worm) hypothetical protein 0.179 0.4809 1
Echinococcus multilocularis GPCR, family 2 0.004 0.0087 0.0081
Brugia malayi Calcitonin receptor-like protein seb-1 0.0127 0.0321 0.0656
Echinococcus multilocularis microtubule associated protein 2 0.3713 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0107 0.0922
Loa Loa (eye worm) hypothetical protein 0.0062 0.0146 0.0292
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0107 0.0922
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0145 0.0368 0.1728
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0048 0.0409
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0031 0.0266
Leishmania major carnitine palmitoyltransferase-like protein 0.0145 0.0368 0.1728
Echinococcus granulosus beta LACTamase domain containing family member 0.0048 0.0107 0.0102
Onchocerca volvulus 0.0062 0.0146 0.105
Echinococcus multilocularis tumor protein p63 0.0511 0.1357 0.1352
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0368 0.1728
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0048 0.0107 0.1203
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.179 0.4809 1
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0107 0.0485
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0048 0.0107 0.1203
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.004 0.0087 0.0169
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0043
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.006 0.0113
Brugia malayi Choline O-acetyltransferase 0.0145 0.0368 0.0755
Loa Loa (eye worm) transcription factor SMAD2 0.0091 0.0225 0.0456
Entamoeba histolytica hypothetical protein 0.0083 0.0203 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.018 0.0363
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0368 0.1728
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.004 0.0087 0.0081
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.0683 0.0678
Loa Loa (eye worm) hypothetical protein 0.0127 0.0321 0.0656
Schistosoma mansoni lamin 0.0062 0.0146 0.014
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0122 0.0242
Mycobacterium tuberculosis Conserved protein 0.0048 0.0107 0.1203
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0145 0.0368 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0105
Onchocerca volvulus 0.0048 0.0107 0.0712
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0014 0.0017 0.0309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0043 0.0369
Trichomonas vaginalis penicillin-binding protein, putative 0.0048 0.0107 0.0922
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0013 0.0012 0.018
Echinococcus multilocularis choline O acetyltransferase 0.0145 0.0368 0.0363
Mycobacterium tuberculosis Probable lipase LipE 0.0048 0.0107 0.1203
Schistosoma mansoni microtubule-associated protein tau 0.3713 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0048 0.0107 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0005 0.0047
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.003 0.006 0.0258
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0018
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0788 0.2105 0.2101
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0088 0.0216 0.0211
Loa Loa (eye worm) beta-lactamase 0.0048 0.0107 0.0212
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.003 0.006 0.0258
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0088 0.0216 0.0211
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0026 0.1305
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0107 0.0922
Onchocerca volvulus 0.0145 0.0368 0.3003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.004 0.0087 0.0081
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0107 0.0485
Trichomonas vaginalis esterase, putative 0.0048 0.0107 0.0922
Schistosoma mansoni lamin 0.0062 0.0146 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0022 0.0189
Schistosoma mansoni transcription factor LCR-F1 0.0083 0.0203 0.0198
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0145 0.0368 0.0363
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0018 0.0026 0.1305
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0145 0.0368 0.0755
Schistosoma mansoni thyroid hormone receptor 0.0095 0.0236 0.023
Entamoeba histolytica hypothetical protein 0.0083 0.0203 1
Schistosoma mansoni hypothetical protein 0.004 0.0087 0.0081
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0083 0.0203 0.0198
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0026 0.0043
Brugia malayi intermediate filament protein 0.0062 0.0146 0.0292
Brugia malayi Pre-SET motif family protein 0.0386 0.1021 0.2114
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0026 0.0099
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.003 0.006 0.1884
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0013 0.0014 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.006 0.0512
Schistosoma mansoni hypothetical protein 0.0053 0.0122 0.0116
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.0368 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0386 0.1021 0.2114
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0059 0.0054
Schistosoma mansoni hypothetical protein 0.0088 0.0216 0.0211
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0026 0.0099
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0026 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0039 0.0332
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0048 0.0107 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0022 0.019
Loa Loa (eye worm) hypothetical protein 0.0061 0.0143 0.0286
Brugia malayi beta-lactamase family protein 0.0048 0.0107 0.0212
Brugia malayi hypothetical protein 0.0083 0.0203 0.0411
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0107 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0128 0.0122
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0107 0.2809
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0048 0.0107 1
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0145 0.0368 0.0755
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0145 0.0368 0.1728
Toxoplasma gondii ABC1 family protein 0.0048 0.0107 0.7715
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0024 0.0043 0.1035
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0139 0.0133
Schistosoma mansoni hypothetical protein 0.0083 0.0203 0.0198
Mycobacterium leprae Probable lipase LipE 0.0048 0.0107 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 30.4 uM Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA ChEMBL. 21440447
Inhibition (binding) = 31 % Inhibition of methyl transferase activity of SET7/9 at 50 uM using biotinylated histone H3(1-21) substrate by In-vitro time resolved fluorescence immunosorbent methyltransferase assay ChEMBL. 21440447

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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