Detailed information for compound 985473

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 473.18 | Formula: C20H17Cl4N3O2
  • H donors: 0 H acceptors: 3 LogP: 7.35 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOC(=O)Cn1nc(c(n1)c1ccc(cc1Cl)Cl)c1ccc(cc1Cl)Cl
  • InChi: 1S/C20H17Cl4N3O2/c1-2-3-8-29-18(28)11-27-25-19(14-6-4-12(21)9-16(14)23)20(26-27)15-7-5-13(22)10-17(15)24/h4-7,9-10H,2-3,8,11H2,1H3
  • InChiKey: JHYLDWFPNBXQGK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cannabinoid receptor 1 (brain) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) bZIP transcription factor family protein 0.0007 0.005 0.0092
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0051 0.0191
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.2429 0.8848
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.2228 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0256 0.0256
Brugia malayi Thioredoxin reductase 0.0052 0.1005 0.1808
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0081 0.0081
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0114 0.0114
Onchocerca volvulus 0.0208 0.4345 0.8048
Trypanosoma brucei trypanothione reductase 0.0052 0.1005 0.3983
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.002
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.2228 0.2228
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.028 0.0412
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.034 0.034
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0081 0.0149
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0256 0.248
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.028 0.5
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0081 0.0149
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.028 0.028
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.028 0.0096
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.028 0.0412
Schistosoma mansoni cpg binding protein 0.0033 0.0604 0.0604
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0459 0.1872
Echinococcus multilocularis dnaJ subfamily B 0.0472 1 1
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.028 0.1049
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0114 0.0114
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0071 0.0071
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0127 0.0127
Plasmodium vivax glutathione reductase, putative 0.0052 0.1005 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.002
Echinococcus multilocularis fos transcription factor 0.0007 0.005 0.005
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.028 0.0724
Echinococcus granulosus cyclic AMP responsive element binding protein 0.0007 0.005 0.005
Echinococcus granulosus Protein son of sevenless 0.0007 0.0051 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.2228 1
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0007 0.0051 0.0171
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0196 0.0825
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0471 0.3913
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.002
Entamoeba histolytica hypothetical protein 0.0007 0.0051 0.0191
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.028 0.5
Echinococcus granulosus geminin 0.0181 0.377 0.377
Leishmania major hypothetical protein, conserved 0.0027 0.0471 0.1354
Brugia malayi RasGEF domain containing protein 0.0007 0.0051 0.0092
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0051 0.0191
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0055 0.002
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0256 0.0256
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0055 0.002
Toxoplasma gondii thioredoxin reductase 0.0052 0.1005 0.8096
Schistosoma mansoni hypothetical protein 0.0007 0.005 0.005
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0051 0.0051
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0051 0.0094
Loa Loa (eye worm) hypothetical protein 0.001 0.0114 0.0211
Trichomonas vaginalis helicase, putative 0.0008 0.0055 0.002
Echinococcus granulosus expressed protein 0.0007 0.005 0.005
Schistosoma mansoni camp-response element binding protein 0.0007 0.005 0.005
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0127 0.0127
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.2711 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0051 0.0191
Treponema pallidum NADH oxidase 0.0018 0.028 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.2228 0.2228
Echinococcus granulosus cAMP responsive element binding protein 3 0.0007 0.005 0.005
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0051 0.0051
Schistosoma mansoni smad 0.0009 0.0081 0.0081
Entamoeba histolytica hypothetical protein 0.0078 0.1563 0.7004
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.028 0.5
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.028 0.0412
Schistosoma mansoni hypothetical protein 0.0078 0.1563 0.1563
Trypanosoma cruzi hypothetical protein 0.0007 0.0051 0.0171
Brugia malayi hypothetical protein 0.001 0.0114 0.0205
Schistosoma mansoni hypothetical protein 0.0472 1 1
Loa Loa (eye worm) hypothetical protein 0.0257 0.5406 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0055 0.002
Echinococcus multilocularis smad 0.0009 0.0081 0.0081
Onchocerca volvulus 0.0257 0.5399 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0153 0.0153
Toxoplasma gondii hypothetical protein 0.001 0.0114 0.0823
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0196 0.0843
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0114 0.0211
Brugia malayi RasGEF domain containing protein 0.0007 0.0051 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.2228 0.2228
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0007 0.005 0.005
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0256 0.0295
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.2228 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0256 0.1095
Brugia malayi CXXC zinc finger family protein 0.0033 0.0604 0.1086
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.2228 0.4007
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.2429 0.8848
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0114 0.0114
Echinococcus multilocularis expressed protein 0.0007 0.005 0.005
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0114 0.0114
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0276 0.2681
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.0051 0.0051
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.2429 0.8848
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0256 0.0256
Echinococcus granulosus smad 0.0009 0.0081 0.0081
Brugia malayi hypothetical protein 0.001 0.0114 0.0205
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0127 0.0127
Echinococcus granulosus bloom syndrome protein 0.0026 0.0459 0.0459
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0459 0.0459
Schistosoma mansoni camp-response element binding protein-related 0.0007 0.005 0.005
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0007 0.0043 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.2228 1
Schistosoma mansoni dep domain containing protein 0.001 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0127 0.0236
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.028 0.2717
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.002
Brugia malayi hypothetical protein 0.0027 0.0471 0.0847
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.2228 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.028 0.5
Entamoeba histolytica hypothetical protein 0.0078 0.1563 0.7004
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0471 0.2067
Brugia malayi hypothetical protein 0.0208 0.4345 0.7812
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0256 0.0256
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0256 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.002
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0081 0.0081
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.028 0.1733
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0256 0.0256
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.1563 0.1563
Loa Loa (eye worm) hypothetical protein 0.0006 0.0013 0.0024
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0256 0.0256
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.2228 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.028 0.0503
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0177 0.0319
Loa Loa (eye worm) glutathione reductase 0.0052 0.1005 0.186
Brugia malayi Pax transcription factor protein 2 0.0257 0.5399 0.9707
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0051 0.0191
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0256 0.0295
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0127 0.0931
Schistosoma mansoni dishevelled 0.001 0.0114 0.0114
Schistosoma mansoni blooms syndrome DNA helicase 0.0006 0.0013 0.0013
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0127 0.0229
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0051 0.0191
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.1005 0.3053
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0051 0.0191
Schistosoma mansoni jun-related protein 0.0215 0.45 0.45
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.2711 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.028 0.1733
Echinococcus multilocularis Protein son of sevenless 0.0007 0.0051 0.0051
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0256 0.1463
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0055 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.028 0.1202
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0127 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.2228 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0256 0.0256
Plasmodium falciparum thioredoxin reductase 0.0018 0.028 0.1733
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0007 0.005 0.005
Schistosoma mansoni smad1 5 8 and 0.0009 0.0081 0.0081
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0256 0.198
Brugia malayi N-terminal motif family protein 0.0208 0.4355 0.783
Loa Loa (eye worm) hypothetical protein 0.001 0.0114 0.0211
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0153 0.0153
Echinococcus multilocularis geminin 0.0181 0.377 0.377
Echinococcus multilocularis jun protein 0.0265 0.5562 0.5562
Onchocerca volvulus 0.001 0.0114 0.0211
Echinococcus multilocularis cyclic AMP dependent transcription factor ATF 6 0.0007 0.005 0.005
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0256 0.046
Schistosoma mansoni dishevelled 0.001 0.0114 0.0114
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.1005 0.4479
Schistosoma mansoni DNA helicase recq1 0.0011 0.0127 0.0127
Brugia malayi N-terminal motif family protein 0.0007 0.0051 0.0092
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.2228 0.4128
Brugia malayi bZIP transcription factor family protein 0.0007 0.005 0.009
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0471 0.3913
Schistosoma mansoni hypothetical protein 0.0215 0.45 0.45
Brugia malayi DIX domain containing protein 0.001 0.0114 0.0205
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0177 0.0319
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.0051 0.0051
Mycobacterium tuberculosis Probable reductase 0.0118 0.2429 0.8848
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.2625 0.4855
Loa Loa (eye worm) histone methyltransferase 0.001 0.0114 0.0211
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0471 0.3735
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0471 0.2067
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0114 0.0205
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0114 0.0114
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0256 0.198
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.028 0.1202
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.028 0.0412
Brugia malayi isocitrate dehydrogenase 0.0017 0.0256 0.046
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0127 0.0229
Echinococcus granulosus Smad4 0.0009 0.0081 0.0081
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0114 0.0211
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.1005 0.1005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1239 1
Schistosoma mansoni fos transcription factor-related 0.0007 0.005 0.005
Schistosoma mansoni cpg binding protein 0.0035 0.0645 0.0645
Echinococcus granulosus cpg binding protein 0.0035 0.0645 0.0645
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.028 0.5
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0051 0.0191
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.028 0.2717
Schistosoma mansoni hypothetical protein 0.0181 0.377 0.377
Onchocerca volvulus 0.0007 0.005 0.0092
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0114 0.0114
Schistosoma mansoni camp-response element binding protein-related 0.0007 0.005 0.005
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0051 0.0191
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0071 0.0071
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0114 0.0114
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0127 0.0931
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.2429 0.8848
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.028 0.1049
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.028 0.0412
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0265 0.5562 0.5562
Loa Loa (eye worm) bZIP transcription factor family protein 0.0007 0.005 0.0092
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0114 0.0114
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0459 0.1872
Schistosoma mansoni hypothetical protein 0.0012 0.0153 0.0153
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.1005 0.1005
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0114 0.0211
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0114 0.0205
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0071 0.0071
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.1563 0.1563
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0051 0.0191
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0081 0.0081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.028 0.1202
Echinococcus multilocularis Smad4 0.0009 0.0081 0.0081
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0114 0.0114
Brugia malayi MH1 domain containing protein 0.0009 0.0081 0.0145
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.2228 0.4122
Brugia malayi MH2 domain containing protein 0.0009 0.0081 0.0145
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.2228 1
Schistosoma mansoni kinase 0.0055 0.1081 0.1081
Loa Loa (eye worm) hypothetical protein 0.0208 0.4355 0.8055
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0265 0.5562 0.5562
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.039 0.2991
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.2625 0.4855
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.14 0.14
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0111 0.02
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0055 0.002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.028 0.1202
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0071 0.0071
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0081 0.0081
Brugia malayi N-terminal motif family protein 0.0007 0.0051 0.0092
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0051 0.0051
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0208 0.4355 0.8066
Brugia malayi bZIP transcription factor family protein 0.0265 0.5562 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0051 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.002
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.2228 1
Brugia malayi bZIP transcription factor family protein 0.0007 0.005 0.009
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0114 0.0114
Loa Loa (eye worm) Smad1 0.0009 0.0081 0.0149
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0013 0.002
Brugia malayi hypothetical protein 0.0078 0.1563 0.2811
Brugia malayi bZIP transcription factor family protein 0.0007 0.005 0.009
Entamoeba histolytica hypothetical protein 0.0078 0.1563 0.7004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0471 0.0871
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.002
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0196 0.0665
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.2711 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0081 0.0081
Echinococcus granulosus cyclic AMP dependent transcription factor ATF 6 0.0007 0.005 0.005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0055 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.105 0.4587
Schistosoma mansoni camp-response element binding protein-related 0.0007 0.005 0.005
Echinococcus multilocularis cpg binding protein 0.0035 0.0645 0.0645
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.2228 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0471 0.4638
Schistosoma mansoni Smad4 0.0009 0.0081 0.0081
Brugia malayi bZIP transcription factor family protein 0.0007 0.005 0.009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0271 0.2106
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0051 0.0094
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.1005 0.186
Loa Loa (eye worm) hypothetical protein 0.0007 0.005 0.0092
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0127 0.0236
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0051 0.0191
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.028 0.0412
Trypanosoma brucei polo-like protein kinase 0.0109 0.2228 1
Brugia malayi glutathione reductase 0.0052 0.1005 0.1808
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.105 0.4587
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.002
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0051 0.0191
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0114 0.0114
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.028 0.2173
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.2429 0.8848
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.028 0.028
Giardia lamblia Kinase, PLK 0.0109 0.2228 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0051 0.0191
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.028 0.2173
Loa Loa (eye worm) hypothetical protein 0.0007 0.0051 0.0094
Echinococcus granulosus son of sevenless 1 0.0007 0.0051 0.0051
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0051 0.0051
Brugia malayi hypothetical protein 0.0007 0.005 0.009
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0081 0.0081
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.028 0.1202
Schistosoma mansoni hypothetical protein 0.0181 0.377 0.377
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0114 0.0114
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0471 0.1354
Schistosoma mansoni smad1 5 8 and 0.0009 0.0081 0.0081
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.2711 1
Onchocerca volvulus 0.0007 0.0051 0.0095
Echinococcus granulosus ras GTP exchange factor 0.0007 0.0051 0.0051
Leishmania major trypanothione reductase 0.0052 0.1005 0.3983
Echinococcus granulosus cyclic AMP responsive element binding protein 0.0007 0.005 0.005
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.028 0.1202
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0256 0.0473
Loa Loa (eye worm) hypothetical protein 0.0133 0.2733 0.5056
Loa Loa (eye worm) bZIP transcription factor family protein 0.0007 0.005 0.0092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.028 0.1202
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0007 0.0051 0.0095
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0256 0.1095
Brugia malayi Smad1 0.0009 0.0081 0.0145
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.0051 0.0051
Brugia malayi RasGEF domain containing protein 0.0007 0.0051 0.0092
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.001 0.0114 0.0211
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0007 0.005 0.005
Echinococcus multilocularis cAMP responsive element binding protein 3 0.0007 0.005 0.005
Brugia malayi MH2 domain containing protein 0.0009 0.0081 0.0145
Brugia malayi MH1 domain containing protein 0.0009 0.0081 0.0145
Plasmodium falciparum glutathione reductase 0.0052 0.1005 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0051 0.0191
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.028 0.0412
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0071 0.0071
Echinococcus granulosus fos transcription factor 0.0007 0.005 0.005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.028 0.1202
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.028 0.1202
Echinococcus granulosus jun protein 0.0265 0.5562 0.5562
Loa Loa (eye worm) hypothetical protein 0.0007 0.0051 0.0094
Loa Loa (eye worm) pax transcription factor protein 2 0.0257 0.5399 0.9986
Brugia malayi hypothetical protein 0.0017 0.0267 0.048
Entamoeba histolytica hypothetical protein 0.0078 0.1563 0.7004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0055 0.002
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.1005 1
Loa Loa (eye worm) RecQ helicase 0.0026 0.0459 0.0848
Loa Loa (eye worm) hypothetical protein 0.0007 0.005 0.0092
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0604 0.1117
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0055 0.002
Onchocerca volvulus 0.0033 0.0604 0.1119
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.0051 0.0051
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.028 0.5
Schistosoma mansoni cpg binding protein 0.0035 0.0645 0.0645
Trypanosoma cruzi hypothetical protein 0.0007 0.0051 0.0171
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.2228 1
Plasmodium falciparum thioredoxin reductase 0.0052 0.1005 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0114 0.0114
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0114 0.0205
Plasmodium falciparum glutathione reductase 0.0018 0.028 0.1733
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.0051 0.0051
Schistosoma mansoni regulator of G protein signaling 0.001 0.0114 0.0114
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.028 0.0412
Echinococcus multilocularis son of sevenless 1 0.0007 0.0051 0.0051
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.028 0.028
Brugia malayi MH2 domain containing protein 0.0127 0.2625 0.4719
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.1563 0.1563
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0459 0.0824
Schistosoma mansoni DNA helicase recq5 0.0011 0.0127 0.0127

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1173.2 nM Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cells ChEMBL. 19095444

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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