Detailed information for compound 992750

Basic information

Technical information
  • TDR Targets ID: 992750
  • Name: 4,4-bis(4-fluorophenyl)-2-[3-(trifluoromethyl )phenyl]-3,5-dihydroimidazole
  • MW: 402.36 | Formula: C22H15F5N2
  • H donors: 1 H acceptors: 0 LogP: 5.15 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C1(CNC(=N1)c1cccc(c1)C(F)(F)F)c1ccc(cc1)F
  • InChi: 1S/C22H15F5N2/c23-18-8-4-15(5-9-18)21(16-6-10-19(24)11-7-16)13-28-20(29-21)14-2-1-3-17(12-14)22(25,26)27/h1-12H,13H2,(H,28,29)
  • InChiKey: LGNMZDDYTDVTCQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide Y receptor Y5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0035 0.0183 0.0077
Echinococcus granulosus cyclins 0.0031 0.0134 0.0042
Brugia malayi Dopamine receptor protein 2 0.0047 0.0326 0.0218
Onchocerca volvulus Putative endochitinase 0.0074 0.0661 0.1761
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0195 0.2167 0.3547
Brugia malayi Dopamine receptor 0.0047 0.0326 0.0218
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0501 0.5978 0.6212
Echinococcus granulosus cyclin B 0.005 0.0367 0.0278
Onchocerca volvulus 0.0047 0.0326 0.0691
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0037 0.0207 0.0102
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0207 0.0098
Echinococcus granulosus cyclins 0.0031 0.0134 0.0042
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Trichomonas vaginalis cyclin B3, putative 0.0031 0.0134 0.0105
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0031 0.0134 0.0025
Onchocerca volvulus 0.0064 0.0542 0.138
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0326 0.0218
Brugia malayi putative neuropeptide receptor 0.0047 0.0326 0.0218
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2288 0.2201
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0037 0.0207 0.1434
Brugia malayi pregnancy-associated plasma protein-A 0.0064 0.0542 0.0436
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0036 0.0195 0.0085
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Echinococcus multilocularis membrane bound transcription factor site 1 0.0035 0.0183 0.0077
Echinococcus granulosus cyclins 0.0031 0.0134 0.0042
Echinococcus granulosus 7TM GPCR rhodopsin 0.0047 0.0326 0.0236
Plasmodium falciparum SET domain protein, putative 0.0072 0.0637 1
Brugia malayi hypothetical protein 0.0047 0.0326 0.0218
Toxoplasma gondii subtilisin SUB9 0.0035 0.0183 0.2397
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.0011
Trichomonas vaginalis cyclin B, putative 0.005 0.0367 0.05
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0037 0.0207 0.0102
Onchocerca volvulus 0.0064 0.0542 0.138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0326 0.0218
Giardia lamblia Cyclin A 0.0031 0.0134 0.0377
Loa Loa (eye worm) hypothetical protein 0.0035 0.0183 0.0074
Giardia lamblia High cysteine membrane protein Group 2 0.0306 0.3556 1
Entamoeba histolytica cyclin, putative 0.005 0.0367 0.4426
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0047 0.0326 0.0218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0326 0.0229
Echinococcus granulosus beta-adrenergic receptor kinase 0.0101 0.1008 0.0924
Onchocerca volvulus 0.0232 0.2635 0.8072
Onchocerca volvulus 0.0047 0.0326 0.0691
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Schistosoma mansoni hypothetical protein 0.0281 0.3238 0.3162
Onchocerca volvulus Neuropeptide F receptor homolog 0.0047 0.0326 0.0691
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0098
Trypanosoma brucei mitotic cyclin 6 0.005 0.0367 1
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0035 0.0183 0.4991
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0242 0.1707
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0195 0.2167 0.3547
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0035 0.0183 0.0074
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0242 0.6585
Loa Loa (eye worm) endoprotease bli-4 0.0824 1 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0207 0.0098
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0135 0.0026
Echinococcus granulosus FTZ F1 alpha 0.0029 0.011 0.0018
Toxoplasma gondii subtilisin SUB6 0.0035 0.0183 0.2397
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0047 0.0326 0.0218
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0326 0.0229
Onchocerca volvulus 0.0047 0.0326 0.0691
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0047 0.0326 0.0236
Echinococcus granulosus collagen alpha 1VII chain 0.0037 0.0207 0.0116
Echinococcus multilocularis cyclins 0.0031 0.0134 0.0025
Onchocerca volvulus 0.0035 0.0183 0.0233
Brugia malayi Pre-SET motif family protein 0.0031 0.0135 0.0025
Echinococcus multilocularis cyclin B3 1 0.0031 0.0134 0.0025
Entamoeba histolytica elongation factor-2 kinase, putative 0.0037 0.0207 0.1383
Schistosoma mansoni neuropeptide receptor 0.0047 0.0326 0.0218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Brugia malayi endochitinase 0.0074 0.0661 0.0557
Onchocerca volvulus 0.0064 0.0542 0.138
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Toxoplasma gondii histone lysine methyltransferase SET8 0.0072 0.0637 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0183 0.0188
Trichomonas vaginalis WD repeat domain, putative 0.0281 0.3238 0.536
Brugia malayi AKH receptor 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Onchocerca volvulus Putative endochitinase 0.0074 0.0661 0.1761
Echinococcus granulosus dna polymerase kappa 0.004 0.0242 0.0151
Mycobacterium tuberculosis Possible chitinase 0.0063 0.0526 1
Echinococcus granulosus protein will die slowly 0.0281 0.3238 0.3175
Echinococcus multilocularis neuropeptide FF receptor 2 0.0047 0.0326 0.0229
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0035 0.0183 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1729 0.2805
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1729 0.2805
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0047 0.0326 0.0218
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0037 0.0207 0.0098
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0047 0.0326 0.0218
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0326 0.0218
Echinococcus multilocularis cyclin b3 0.0031 0.0134 0.0025
Onchocerca volvulus 0.0064 0.0542 0.138
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0326 0.0236
Brugia malayi follicle stimulating hormone receptor 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0072 0.0637 0.0533
Brugia malayi hypothetical protein 0.0064 0.0542 0.0436
Schistosoma mansoni amine GPCR 0.0047 0.0326 0.0218
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0326 0.0236
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0326 0.0236
Brugia malayi Subtilase family protein 0.0035 0.0183 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0326 0.0229
Plasmodium falciparum subtilisin-like protease 3 0.0035 0.0183 0.0978
Schistosoma mansoni survival motor neuron protein 0.0047 0.0327 0.0219
Brugia malayi hypothetical protein 0.0064 0.0542 0.0436
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.6585
Echinococcus granulosus neuropeptide FF receptor 2 0.0047 0.0326 0.0236
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2635 0.4339
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Treponema pallidum 76K protein 0.0037 0.0207 0.5
Echinococcus granulosus neuropeptide receptor 0.0047 0.0326 0.0236
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0159 0.1729 0.2805
Toxoplasma gondii microneme protein MIC2 0.0037 0.0207 0.2792
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.011 0.0018
Schistosoma mansoni hypothetical protein 0.0047 0.0326 0.0218
Echinococcus granulosus somatostatin receptor 0.0047 0.0326 0.0236
Echinococcus granulosus neuroendocrine convertase 2 0.0518 0.6189 0.6154
Echinococcus granulosus g protein coupled receptor 0.0047 0.0326 0.0236
Toxoplasma gondii subtilisin SUB4 0.0035 0.0183 0.2397
Plasmodium vivax apical sushi protein, putative 0.0064 0.0542 0.8097
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0207 0.0098
Echinococcus granulosus neuropeptide s receptor 0.0047 0.0326 0.0236
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0037 0.0207 0.0098
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0326 0.0218
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0135 0.0043
Loa Loa (eye worm) hypothetical protein 0.005 0.0367 0.026
Echinococcus multilocularis serotonin receptor 0.0047 0.0326 0.0229
Brugia malayi hypothetical protein 0.0047 0.0326 0.0218
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0326 0.0218
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0035 0.0183 0.0074
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0742 0.8981 0.897
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0098
Schistosoma mansoni histamine h1 receptor 0.0047 0.0326 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1729 0.2805
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0326 0.0229
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0047 0.0326 0.0218
Echinococcus granulosus tachykinin peptides receptor 99D 0.0047 0.0326 0.0236
Echinococcus multilocularis histone lysine n methyltransferase setd8 0.0072 0.0637 0.0558
Onchocerca volvulus Putative endochitinase 0.0074 0.0661 0.1761
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0135 0.0025
Brugia malayi Tachykinin-like peptides receptor 99D 0.0047 0.0326 0.0218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0326 0.0218
Trichomonas vaginalis cyclins, putative 0.005 0.0367 0.05
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0035 0.0183 0.3485
Brugia malayi G-protein coupled receptor 0.0047 0.0326 0.0218
Schistosoma mansoni neuropeptide receptor 0.0047 0.0326 0.0218
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0326 0.0229
Onchocerca volvulus 0.0047 0.0326 0.0691
Echinococcus granulosus G protein coupled receptor 139 0.0047 0.0326 0.0236
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0047 0.0326 0.0691
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0326 0.0218
Echinococcus granulosus cyclins 0.0031 0.0134 0.0042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Onchocerca volvulus 0.0047 0.0326 0.0691
Trichomonas vaginalis hypothetical protein 0.0159 0.1729 0.2805
Loa Loa (eye worm) hypothetical protein 0.005 0.0367 0.026
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0064 0.0542 0.0436
Brugia malayi hypothetical protein 0.0047 0.0326 0.0218
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0037 0.0207 0.1434
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0326 0.0236
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.011 0.0018
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0326 0.0229
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0742 0.8981 0.8972
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.011 0.0018
Echinococcus multilocularis Furin 1 0.0195 0.2167 0.2177
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0098
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0326 0.0229
Echinococcus multilocularis cyclins 0.0031 0.0134 0.0025
Schistosoma mansoni hypothetical protein 0.0159 0.1729 0.1636
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.26 0.2636
Brugia malayi hypothetical protein 0.0064 0.0542 0.0436
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0098
Trypanosoma brucei unspecified product 0.0034 0.0162 0.4412
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0242 0.3181
Brugia malayi ORL1-like opioid receptor 0.0047 0.0326 0.0218
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0047 0.0326 0.0229
Onchocerca volvulus 0.0064 0.0542 0.138
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0064 0.0542 0.0436
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Echinococcus multilocularis beta adrenergic receptor kinase 0.0101 0.1008 0.095
Onchocerca volvulus 0.0047 0.0326 0.0691
Brugia malayi Will die slowly protein 0.0281 0.3238 0.3162
Brugia malayi RE15519p 0.0047 0.0326 0.0218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Loa Loa (eye worm) cuticular endochitinase 0.0074 0.0661 0.0557
Loa Loa (eye worm) hypothetical protein 0.0229 0.26 0.2518
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0326 0.0218
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0326 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.6585
Loa Loa (eye worm) hypothetical protein 0.0053 0.0403 0.0296
Onchocerca volvulus 0.0047 0.0326 0.0691
Toxoplasma gondii subtilisin SUB2 0.0035 0.0183 0.2397
Echinococcus granulosus voltage dependent calcium channel subunit 0.0037 0.0207 0.0116
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0526 1
Echinococcus multilocularis cyclins 0.0031 0.0134 0.0025
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0037 0.0207 0.2792
Loa Loa (eye worm) hypothetical protein 0.0064 0.0542 0.0436
Schistosoma mansoni thyroid hormone receptor 0.0152 0.1634 0.154
Echinococcus granulosus neuropeptide receptor 0.0047 0.0326 0.0236
Brugia malayi larval opioid receptor 0.0047 0.0326 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1729 0.2805
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0098
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0195 0.2167 0.208
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0742 0.8981 0.9392
Echinococcus granulosus furin 0.0824 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1729 0.2805
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0326 0.0236
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0195 0.2167 0.3547
Echinococcus multilocularis somatostatin receptor 0.0047 0.0326 0.0229
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0195 0.0085
Echinococcus granulosus G protein coupled receptor kinase 1 0.0091 0.0877 0.0792
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0098
Brugia malayi Cyclin, N-terminal domain containing protein 0.005 0.0367 0.026
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0101 0.1008 0.0907
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0326 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.6585
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.6585
Trypanosoma cruzi CYC2-like cyclin, putative 0.005 0.0367 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0207 0.0098
Schistosoma mansoni alpha-1 adrenergic receptor 0.0047 0.0326 0.0218
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0207 0.1434
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0035 0.0183 0.0074
Entamoeba histolytica hypothetical protein, conserved 0.0037 0.0207 0.1383
Onchocerca volvulus 0.0064 0.0542 0.138
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0326 0.0236
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.1268 0.1187
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0326 0.0236
Plasmodium falciparum subtilisin-like protease 1 0.0035 0.0183 0.0978
Schistosoma mansoni neuropeptide receptor 0.0047 0.0326 0.0218
Echinococcus multilocularis dna polymerase kappa 0.004 0.0242 0.0139
Loa Loa (eye worm) hypothetical protein 0.0064 0.0542 0.0436
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0121 0.3297
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0326 0.0229
Entamoeba histolytica hypothetical protein, conserved 0.0037 0.0207 0.1383
Schistosoma mansoni opsin-like receptor 0.0047 0.0326 0.0218
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0135 0.0025
Echinococcus multilocularis G-protein coupled receptor, putative 0.0047 0.0326 0.0229
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0047 0.0326 0.0218
Schistosoma mansoni cyclins 0.0031 0.0134 0.0024
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0326 0.0229
Toxoplasma gondii subtilisin SUB5 0.0035 0.0183 0.2397
Trichomonas vaginalis cyclin B, putative 0.0031 0.0134 0.0105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0326 0.0218
Echinococcus granulosus peptide allatostatin:somatostatin 0.0047 0.0326 0.0236
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0134 0.0024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0098
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Plasmodium vivax subtilisin-like serine protease, putative 0.0035 0.0183 0.0963
Echinococcus multilocularis serotonin receptor 0.0047 0.0326 0.0229
Plasmodium falciparum apical sushi protein 0.0064 0.0542 0.81
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0327 0.0219
Trichomonas vaginalis cyclin A, putative 0.005 0.0367 0.05
Echinococcus multilocularis allatostatin A receptor 0.0047 0.0326 0.0229
Schistosoma mansoni thyroid hormone receptor 0.0152 0.1634 0.154
Trichomonas vaginalis cyclins, putative 0.005 0.0367 0.05
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0501 0.5978 0.594
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0207 0.0098
Onchocerca volvulus Putative endochitinase 0.0074 0.0661 0.1761
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0183 0.0188
Leishmania major cyclin 0.005 0.0367 0.5557
Echinococcus multilocularis orexin receptor type 2 0.0047 0.0326 0.0229
Echinococcus multilocularis g-protein coupled receptor 0.0047 0.0326 0.0229
Brugia malayi von Willebrand Factor 0.0037 0.0207 0.0098
Brugia malayi Zona pellucida-like domain containing protein 0.0037 0.0207 0.0098
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Brugia malayi hypothetical protein 0.0064 0.0542 0.0436
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.1008 0.0907
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0195 0.2167 0.3547
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0047 0.0326 0.0218
Brugia malayi hypothetical protein 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Brugia malayi Pre-SET motif family protein 0.0204 0.2288 0.2201
Loa Loa (eye worm) hypothetical protein 0.0031 0.0135 0.0025
Brugia malayi Sushi domain 0.0064 0.0542 0.0436
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0207 0.0098
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0047 0.0326 0.0218
Onchocerca volvulus 0.0037 0.0207 0.0309
Brugia malayi hypothetical protein 0.0047 0.0326 0.0218
Brugia malayi hypothetical protein 0.0064 0.0542 0.0436
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0207 0.0228
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0326 0.0229
Onchocerca volvulus 0.0047 0.0326 0.0691
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Schistosoma mansoni site-1 peptidase (S08 family) 0.0035 0.0183 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1729 0.2805
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0326 0.0218
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0159 0.1729 0.2805
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0098
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0326 0.0236
Brugia malayi Zona pellucida-like domain containing protein 0.0037 0.0207 0.0098
Onchocerca volvulus 0.0047 0.0326 0.0691
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0326 0.0229
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.011 0.0018
Loa Loa (eye worm) WD40 repeat protein 0.0281 0.3238 0.3162
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0159 0.1729 0.2805
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0098
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Onchocerca volvulus Putative endochitinase 0.0074 0.0661 0.1761
Echinococcus multilocularis cyclin B 0.005 0.0367 0.0272
Brugia malayi neuropeptide F receptor 0.0047 0.0326 0.0218
Trypanosoma cruzi cyclin 6, putative 0.005 0.0367 1
Loa Loa (eye worm) TYRA-2 protein 0.0047 0.0326 0.0218
Plasmodium vivax subtilisin-like protease 1 0.0035 0.0183 0.0963
Loa Loa (eye worm) melatonin receptor type 1A 0.0047 0.0326 0.0218
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0135 0.0025
Loa Loa (eye worm) hypothetical protein 0.0063 0.0526 0.042
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Plasmodium falciparum thrombospondin-related anonymous protein 0.0037 0.0207 0.1448
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.1008 0.0907
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0326 0.0236
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0824 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1729 0.2805
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0035 0.0183 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0135 0.0025
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.011 0.0018
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0047 0.0326 0.0229
Trypanosoma brucei subtilisin peptidase 0.0035 0.0183 0.4991
Brugia malayi sulfakinin receptor protein 0.0047 0.0326 0.0218
Brugia malayi Dopamine receptor protein 1 0.0047 0.0326 0.0218
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0207 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.6585
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0326 0.0229
Leishmania major chitinase 0.0074 0.0661 1
Brugia malayi GCC2 and GCC3 family protein 0.0064 0.0542 0.0436
Schistosoma mansoni neuropeptide f receptor 76f 0.0047 0.0326 0.0218
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0037 0.0207 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1729 0.2805
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0195 0.2167 0.3547
Brugia malayi Cyclin, N-terminal domain containing protein 0.005 0.0367 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0326 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.6585
Trypanosoma cruzi cyclin, putative 0.005 0.0367 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Echinococcus granulosus sex peptide receptor 0.0047 0.0326 0.0236
Echinococcus multilocularis cyclins 0.0031 0.0134 0.0025
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.26 0.2531
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0047 0.0326 0.0229
Loa Loa (eye worm) hypothetical protein 0.0064 0.0542 0.0436
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0326 0.0229
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0326 0.0218
Loa Loa (eye worm) subtilase 0.0035 0.0183 0.0074
Schistosoma mansoni opsin-like receptor 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Schistosoma mansoni adenoreceptor 0.0047 0.0326 0.0218
Toxoplasma gondii subtilisin SUB12 0.0035 0.0183 0.2397
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0047 0.0326 0.0229
Schistosoma mansoni biogenic amine receptor 0.0047 0.0326 0.0218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0326 0.0229
Toxoplasma gondii subtilisin SUB8 0.0035 0.0183 0.2397
Schistosoma mansoni histone-lysine n-methyltransferase seto7 0.0072 0.0637 0.0533
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.9556 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0047 0.0326 0.0218
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0326 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0183 0.0188
Trichomonas vaginalis cyclins, putative 0.005 0.0367 0.05
Brugia malayi celfurPC protein 0.0664 0.8016 0.7994
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0242 0.3181
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0098
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Trichomonas vaginalis cyclins, putative 0.005 0.0367 0.05
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0037 0.0207 0.0098
Loa Loa (eye worm) chitinase I 0.0074 0.0661 0.0557
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0047 0.0326 0.0218
Brugia malayi G protein-coupled receptor F59B2.13 0.0047 0.0326 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0121 0.3297
Plasmodium vivax thrombospondin-related anonymous protein 0.0037 0.0207 0.1434
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Plasmodium vivax subtilisin-like protease 2, putative 0.0035 0.0183 0.0963
Schistosoma mansoni cyclin B3 0.0031 0.0134 0.0024
Echinococcus multilocularis G protein coupled receptor 139 0.0047 0.0326 0.0229
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0091 0.0877 0.0812
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0098
Brugia malayi hypothetical protein 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Plasmodium vivax SET domain protein, putative 0.0072 0.0637 1
Echinococcus granulosus g protein coupled receptor 0.0047 0.0326 0.0236
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0047 0.0326 0.0218
Brugia malayi Protein set-1 0.0072 0.0637 0.0533
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0326 0.0229
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.011 0.0018
Onchocerca volvulus 0.0047 0.0326 0.0691
Echinococcus multilocularis cyclins 0.0031 0.0134 0.0025
Trichomonas vaginalis cyclin B, putative 0.005 0.0367 0.05
Echinococcus granulosus neuropeptide receptor A26 0.0047 0.0326 0.0236
Schistosoma mansoni hypothetical protein 0.0047 0.0326 0.0218
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0242 0.6585
Echinococcus granulosus membrane bound transcription factor site 1 0.0035 0.0183 0.0092
Echinococcus multilocularis sex peptide receptor 0.0047 0.0326 0.0229
Echinococcus granulosus dro:myosuppressin receptor 0.0047 0.0326 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0134 0.0105
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0326 0.0229
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0326 0.0236
Trypanosoma cruzi cyclin, putative 0.005 0.0367 1
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1729 0.2805
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0031 0.0134 0.0042
Trichomonas vaginalis cyclin B, putative 0.005 0.0367 0.05
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0242 0.1707
Schistosoma mansoni amine GPCR 0.0047 0.0326 0.0218
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0526 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0047 0.0326 0.0218
Onchocerca volvulus 0.0047 0.0326 0.0691
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Loa Loa (eye worm) CUTiclin family member 0.0037 0.0207 0.0098
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0326 0.0229
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.1268 0.1226
Trichomonas vaginalis cyclin D, putative 0.0031 0.0134 0.0105
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0326 0.0236
Loa Loa (eye worm) hypothetical protein 0.0824 1 1
Schistosoma mansoni hypothetical protein 0.0037 0.0207 0.0098
Schistosoma mansoni biogenic amine receptor 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Schistosoma mansoni myosin xvIII 0.0047 0.0326 0.0218
Brugia malayi proprotein convertase 2 0.0518 0.6189 0.6147
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0326 0.0229
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0326 0.0218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Echinococcus multilocularis protein will die slowly 0.0281 0.3238 0.3311
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0135 0.0026
Echinococcus granulosus g-protein coupled receptor 0.0047 0.0326 0.0236
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Onchocerca volvulus 0.0037 0.0207 0.0309
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0047 0.0326 0.0218
Brugia malayi hypothetical protein 0.0064 0.0542 0.0436
Onchocerca volvulus 0.0037 0.0207 0.0309
Trichomonas vaginalis cyclin D, putative 0.0031 0.0134 0.0105
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0242 0.0287
Brugia malayi hypothetical protein 0.0047 0.0326 0.0218
Onchocerca volvulus 0.005 0.0367 0.0822
Echinococcus granulosus 7tm_1 domain containing protein 0.0047 0.0326 0.0236
Brugia malayi putative neuropeptide receptor NPR1 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0403 0.0296
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0242 0.0287
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0098
Brugia malayi GnHR receptor homolog 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Brugia malayi Endochitinase 0.0074 0.0661 0.0557
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0035 0.0183 0.3485
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0207 0.0098
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Echinococcus granulosus cyclin B3 1 0.0031 0.0134 0.0042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0501 0.5978 1
Brugia malayi hypothetical protein 0.0047 0.0326 0.0218
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0326 0.0236
Loa Loa (eye worm) hypothetical protein 0.0064 0.0542 0.0436
Echinococcus granulosus c4b binding protein beta chain 0.0064 0.0542 0.0454
Toxoplasma gondii subtilisin SUB7 0.0035 0.0183 0.2397
Echinococcus multilocularis cyclins 0.0031 0.0134 0.0025
Echinococcus granulosus serotonin receptor 0.0047 0.0326 0.0236
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0047 0.0326 0.0236
Onchocerca volvulus 0.0047 0.0326 0.0691
Onchocerca volvulus 0.0281 0.3238 1
Brugia malayi Melatonin receptor type 1A 0.0047 0.0326 0.0218
Schistosoma mansoni furin-1 (S08 family) 0.0358 0.4206 0.4141
Toxoplasma gondii subtilisin SUB11 0.0035 0.0183 0.2397
Loa Loa (eye worm) hypothetical protein 0.0064 0.0542 0.0436
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Echinococcus multilocularis dro:myosuppressin receptor 0.0047 0.0326 0.0229
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0326 0.0218
Brugia malayi G protein-coupled receptor 0.0047 0.0326 0.0218
Echinococcus multilocularis cyclins 0.0031 0.0134 0.0025
Schistosoma mansoni site-1 peptidase (S08 family) 0.0035 0.0183 0.0074
Echinococcus multilocularis C type lectin domian containing protein 0.0064 0.0542 0.0457
Brugia malayi endochitinase 0.0074 0.0661 0.0557
Plasmodium falciparum subtilisin-like protease 2 0.0035 0.0183 0.0978
Toxoplasma gondii rhoptry neck protein RON1 0.0064 0.0542 0.8399
Onchocerca volvulus 0.0031 0.0135 0.0079
Echinococcus granulosus cyclin b3 0.0031 0.0134 0.0042
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0047 0.0326 0.0218
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0326 0.0218
Echinococcus granulosus histone lysine n methyltransferase setd8 0.0072 0.0637 0.055
Brugia malayi Serotonin receptor 0.0047 0.0326 0.0218
Toxoplasma gondii subtilisin SUB1 0.0035 0.0183 0.2397
Echinococcus granulosus fmrfamide receptor 0.0047 0.0326 0.0236
Brugia malayi hypothetical protein 0.0047 0.0326 0.0218
Brugia malayi hypothetical protein 0.0047 0.0326 0.0218
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0326 0.0229
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Schistosoma mansoni hypothetical protein 0.0037 0.0207 0.0098
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.011 0.0018
Echinococcus granulosus alpha 1A adrenergic receptor 0.0047 0.0326 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.6585
Treponema pallidum hypothetical protein 0.0037 0.0207 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0047 0.0326 0.0218
Onchocerca volvulus 0.0047 0.0326 0.0691
Onchocerca volvulus 0.0037 0.0207 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0183 0.0188
Schistosoma mansoni amine GPCR 0.0047 0.0326 0.0218
Brugia malayi hypothetical protein 0.0229 0.26 0.2518
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Schistosoma mansoni hypothetical protein 0.0047 0.0327 0.0219
Echinococcus multilocularis neuroendocrine convertase 2 0.0518 0.6189 0.6436
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Schistosoma mansoni hypothetical protein 0.0047 0.0326 0.0218
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0326 0.0236
Schistosoma mansoni hypothetical protein 0.0047 0.0326 0.0218
Onchocerca volvulus 0.0047 0.0326 0.0691
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0098
Onchocerca volvulus 0.0047 0.0326 0.0691
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0098
Brugia malayi G-protein coupled receptor 0.0047 0.0326 0.0218
Onchocerca volvulus 0.0047 0.0326 0.0691
Echinococcus granulosus Furin 1 0.0195 0.2167 0.2094
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.1634 0.1613
Loa Loa (eye worm) hypothetical protein 0.0323 0.3767 0.3698
Echinococcus multilocularis 0.0664 0.8016 0.837
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.005 0.0367 0.5557
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0047 0.0326 0.0218
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0047 0.0326 0.0229
Schistosoma mansoni c4b-binding protein beta chain 0.0064 0.0542 0.0436
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0162 0.4412
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0047 0.0326 0.0218
Brugia malayi neuroendocrine convertase 1 precursor 0.0518 0.6189 0.6147
Schistosoma mansoni hypothetical protein 0.0122 0.1268 0.1171
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0326 0.0218
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0035 0.0183 0.3485
Echinococcus multilocularis c4b binding protein beta chain 0.0064 0.0542 0.0457
Toxoplasma gondii subtilisin SUB10 0.0035 0.0183 0.2397
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0047 0.0326 0.0229
Leishmania major subtilisin-like serine peptidase 0.0035 0.0183 0.2774
Giardia lamblia Furin precursor putative serine protease 0.0159 0.1729 0.4862
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0326 0.0218
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0326 0.0229
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0326 0.0236
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0403 0.0296
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0501 0.5978 1
Echinococcus multilocularis neuropeptide s receptor 0.0047 0.0326 0.0229
Schistosoma mansoni neuropeptide receptor 0.0047 0.0326 0.0218
Onchocerca volvulus 0.0064 0.0542 0.138
Echinococcus granulosus cyclins 0.0031 0.0134 0.0042
Echinococcus granulosus g protein coupled receptor 0.0047 0.0326 0.0236
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Echinococcus granulosus C type lectin domian containing protein 0.0064 0.0542 0.0454
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0403 0.0296
Loa Loa (eye worm) CUTiclin-Like family member 0.0037 0.0207 0.0098
Loa Loa (eye worm) microfilarial chitinase 0.0063 0.0526 0.042
Loa Loa (eye worm) hypothetical protein 0.0064 0.0542 0.0436
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Onchocerca volvulus 0.0047 0.0326 0.0691
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0242 0.3181
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0326 0.0236
Onchocerca volvulus 0.0064 0.0542 0.138
Loa Loa (eye worm) hypothetical protein 0.0064 0.0542 0.0436
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0242 0.3181
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0135 0.1586
Trichomonas vaginalis cyclins, putative 0.0031 0.0134 0.0105
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0047 0.0326 0.0229
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0037 0.0207 0.1448
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0035 0.0183 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.6585
Entamoeba histolytica hypothetical protein 0.0037 0.0207 0.1383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0326 0.0218
Brugia malayi neuropeptide F receptor 0.0047 0.0326 0.0218
Schistosoma mansoni biogenic amine receptor 0.0047 0.0326 0.0218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0195 0.2167 0.3547
Entamoeba histolytica chitinase, putative 0.0074 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0207 0.0098
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0035 0.0183 0.3485
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0183 0.0188
Loa Loa (eye worm) hypothetical protein 0.0064 0.0542 0.0436
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0326 0.0229
Trichomonas vaginalis cyclin B, putative 0.005 0.0367 0.05
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0326 0.0229
Giardia lamblia G2/mitotic-specific cyclin B 0.005 0.0367 0.1033
Schistosoma mansoni opsin-like receptor 0.0047 0.0326 0.0218
Echinococcus granulosus hypothetical protein 0.0047 0.0326 0.0236
Onchocerca volvulus 0.0037 0.0207 0.0309
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0326 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1729 0.2805
Onchocerca volvulus 0.0064 0.0542 0.138
Echinococcus granulosus allatostatin A receptor 0.0047 0.0326 0.0236
Mycobacterium leprae Possible secreted protease 0.0035 0.0183 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0242 0.6585
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0326 0.0236
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0037 0.0207 0.1448
Brugia malayi Serotonin receptor 0.0047 0.0326 0.0218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0183 0.0188
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0037 0.0207 0.1434
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0326 0.0229
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Schistosoma mansoni amine GPCR 0.0047 0.0326 0.0218
Brugia malayi polk-prov protein 0.003 0.0121 0.0011
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0047 0.0326 0.0218
Onchocerca volvulus 0.0047 0.0327 0.0694
Brugia malayi hypothetical protein 0.0037 0.0207 0.0098
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Brugia malayi hypothetical protein 0.0064 0.0542 0.0436
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0134 0.0024
Schistosoma mansoni hypothetical protein 0.0036 0.0195 0.0085
Giardia lamblia Hypothetical protein 0.0031 0.0134 0.0377
Schistosoma mansoni amine GPCR 0.0047 0.0326 0.0218
Loa Loa (eye worm) hypothetical protein 0.0047 0.0326 0.0218
Echinococcus multilocularis neuropeptide receptor A26 0.0047 0.0326 0.0229
Onchocerca volvulus 0.0037 0.0207 0.0309
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0326 0.0218
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0035 0.0183 0.0092
Loa Loa (eye worm) proprotein convertase 2 0.0195 0.2167 0.208
Onchocerca volvulus 0.0064 0.0542 0.138
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0326 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1729 0.2805
Echinococcus granulosus orexin receptor type 2 0.0047 0.0326 0.0236
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0326 0.0229
Schistosoma mansoni cyclin B 0.005 0.0367 0.026
Toxoplasma gondii rhoptry neck protein RON9 0.0064 0.0542 0.8399
Onchocerca volvulus 0.0037 0.0207 0.0309

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.2 nM Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells ChEMBL. 19233647

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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