TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 415.393 | Formula: C21H21NO8
H donors: 2 H acceptors: 5 LogP: 1.38 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)/C=C\C1=C(C)C(=O)[C@]2(O1)C(=O)N[C@@]([C@@H]2O)(OC)C(=O)c1ccccc1
InChi: 1S/C21H21NO8/c1-4-29-15(23)11-10-14-12(2)16(24)20(30-14)18(26)21(28-3,22-19(20)27)17(25)13-8-6-5-7-9-13/h5-11,18,26H,4H2,1-3H3,(H,22,27)/b11-10-/t18-,20-,21-/m1/s1
InChiKey: XBGGCXWZTPGSQL-VOYSELEVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0082	0.0316	0.0245
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0078	0.0289	0.0238
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0344	0.1788	1
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0078	0.0289	0.0219
Plasmodium vivax	thioredoxin reductase, putative	0.0039	0.0069	1
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0278	0.1418	0.1373
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.0167	0.0793	0.4433
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1115	0.6134	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0078	0.0289	0.0318
Leishmania major	tyrosine specific protein phosphatase, putative	0.0078	0.0289	0.1619
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1115	0.6134	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Onchocerca volvulus		0.0078	0.0289	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1418	0.1418
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0078	0.0289	0.0219
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0098	0.0405	0.0814
Brugia malayi	hypothetical protein	0.0044	0.0097	0.0097
Echinococcus multilocularis	geminin	0.0165	0.0781	0.0714
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0082	0.0316	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1418	0.1418
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0078	0.0289	0.0289
Schistosoma mansoni	hypothetical protein	0.0044	0.0097	0.0045
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0078	0.0289	0.0219
Trypanosoma brucei	endonuclease G, putative	0.0167	0.0793	0.4433
Onchocerca volvulus		0.0078	0.0289	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0115	0.0498	0.0429
Loa Loa (eye worm)	glutaminase	0.028	0.1431	0.1431
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.1115	0.6134	0.6134
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0044	0.0097	0.0045
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0078	0.0289	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0098	0.0405	0.0814
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0078	0.0289	0.0219
Brugia malayi	MH2 domain containing protein	0.0126	0.0564	0.0564
Schistosoma mansoni	hypothetical protein	0.0165	0.0781	0.0732
Trypanosoma cruzi	trypanothione reductase, putative	0.0039	0.0069	0.0388
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0078	0.0289	0.0219
Schistosoma mansoni	hypothetical protein	0.0044	0.0097	0.0045
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0167	0.0793	0.4433
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Brugia malayi	glutathione reductase	0.0039	0.0069	0.0069
Onchocerca volvulus		0.0078	0.0289	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0078	0.0289	0.0238
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Echinococcus multilocularis	neuropeptide s receptor	0.045	0.2389	0.2334
Brugia malayi	endonuclease G, mitochondrial precursor	0.0167	0.0793	0.0793
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0078	0.0289	0.0318
Loa Loa (eye worm)	hypothetical protein	0.015	0.0698	0.0698
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0278	0.1418	0.1356
Brugia malayi	Protein-tyrosine phosphatase 1	0.0078	0.0289	0.0289
Schistosoma mansoni	lipoxygenase	0.008	0.0303	0.0252
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0082	0.0316	0.0264
Echinococcus multilocularis	gpi ethanolamine phosphate transferase 3	0.0044	0.0097	0.0025
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0078	0.0289	0.0219
Mycobacterium tuberculosis	Probable oxidoreductase	0.0098	0.0405	0.0814
Brugia malayi	Protein-tyrosine phosphatase	0.0155	0.0724	0.0724
Onchocerca volvulus		0.0077	0.0285	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0097	0.0097
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Plasmodium vivax	glutathione reductase, putative	0.0039	0.0069	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Brugia malayi	AEL166Cp	0.0044	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Onchocerca volvulus		0.0078	0.0289	0.0318
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0082	0.0316	0.0264
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0078	0.0289	0.0219
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Onchocerca volvulus		0.0078	0.0289	0.0318
Schistosoma mansoni	protein tyrosine phosphatase	0.0078	0.0289	0.0238
Trypanosoma cruzi	hypothetical protein, conserved	0.0344	0.1788	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Toxoplasma gondii	thioredoxin reductase	0.0039	0.0069	0.0876
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0078	0.0289	0.0238
Onchocerca volvulus		0.0078	0.0289	0.0318
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Schistosoma mansoni	lipoxygenase	0.0115	0.0498	0.0448
Trypanosoma brucei	endonuclease G, putative	0.0167	0.0793	0.4433
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0344	0.1788	0.2563
Brugia malayi	hypothetical protein	0.0078	0.0289	0.0289
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0278	0.1418	0.1356
Loa Loa (eye worm)	glutaminase 2	0.028	0.1431	0.1431
Echinococcus granulosus	neuropeptide s receptor	0.045	0.2389	0.2334
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.18	1	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0126	0.0564	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1418	0.1418
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.1115	0.6134	1
Brugia malayi	glutaminase DH11.1	0.028	0.1431	0.1431
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0078	0.0289	0.0238
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0088	0.035	0.8192
Schistosoma mansoni	protein tyrosine phosphatase	0.0078	0.0289	0.0238
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1115	0.6134	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0078	0.0289	0.0219
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0097	0.0097
Echinococcus granulosus	gpi ethanolamine phosphate transferase 3	0.0044	0.0097	0.0025
Onchocerca volvulus		0.0078	0.0289	0.0318
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1115	0.6134	1
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0234	0.1172	0.1108
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.18	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.18	1	1
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0078	0.0289	0.0289
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.1115	0.6134	0.6134
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Schistosoma mansoni	hypothetical protein	0.0044	0.0097	0.0045
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0082	0.0316	0.0245
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0078	0.0289	0.0289
Mycobacterium ulcerans	glutaminase	0.028	0.1431	0.2209
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Echinococcus multilocularis		0.0078	0.0289	0.0219
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0088	0.035	0.0679
Brugia malayi	Protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Loa Loa (eye worm)	thioredoxin reductase	0.0039	0.0069	0.0069
Trypanosoma cruzi	hypothetical protein, conserved	0.0344	0.1788	1
Onchocerca volvulus		0.0078	0.0289	0.0318
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0146	0.0146
Onchocerca volvulus		0.0278	0.1418	0.2188
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0278	0.1418	0.1418
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0078	0.0289	0.0219
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.06	0.3235	0.3235
Trypanosoma cruzi	endonuclease G, putative	0.0167	0.0793	0.4433
Echinococcus multilocularis	Alkaline phosphatase, core domain	0.0044	0.0097	0.0025
Schistosoma mansoni	glutaminase	0.028	0.1431	0.1386
Echinococcus multilocularis	ectonucleotide	0.0234	0.1172	0.1108
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0771	0.4197	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0278	0.1418	0.1373
Onchocerca volvulus	4.1 G protein, putative homolog	0.0078	0.0289	0.0318
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0078	0.0289	0.0219
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0278	0.1418	0.1356
Echinococcus granulosus	ectonucleotide	0.0234	0.1172	0.1108
Loa Loa (eye worm)	hypothetical protein	0.0234	0.1172	0.1172
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1115	0.6134	1
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0078	0.0289	0.0238
Brugia malayi	hypothetical protein	0.0044	0.0097	0.0097
Brugia malayi	hypothetical protein	0.0078	0.0289	0.0289
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0078	0.0289	0.0219
Schistosoma mansoni	hypothetical protein	0.0165	0.0781	0.0732
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0078	0.0289	0.0238
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0078	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Onchocerca volvulus		0.0078	0.0289	0.0318
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0278	0.1418	0.1356
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0088	0.035	0.0679
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0088	0.035	0.0679
Schistosoma mansoni	pcd6 interacting protein-related	0.0078	0.0289	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0078	0.0289	0.0219
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.0167	0.0793	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0078	0.0289	0.0219
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0082	0.0316	0.0316
Leishmania major	endonuclease G, putative	0.0167	0.0793	0.4433
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0078	0.0289	0.1619
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0278	0.1418	0.1373
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0082	0.0316	0.0245
Brugia malayi	Thioredoxin reductase	0.0039	0.0069	0.0069
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0344	0.1788	0.2563
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0078	0.0289	0.1619
Onchocerca volvulus		0.0078	0.0289	0.0318
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0082	0.0316	0.0245
Onchocerca volvulus		0.0278	0.1418	0.2188
Echinococcus granulosus	Endonuclease G	0.0167	0.0793	0.0725
Onchocerca volvulus		0.0078	0.0289	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1115	0.6134	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0078	0.0289	0.0219
Onchocerca volvulus		0.0078	0.0289	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0278	0.1418	0.1356
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0082	0.0316	0.0245
Leishmania major	hypothetical protein, conserved	0.0344	0.1788	1
Leishmania major	trypanothione reductase	0.0039	0.0069	0.0388
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0088	0.035	0.0679
Echinococcus granulosus	neuropeptide receptor A26	0.045	0.2389	0.2334
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0044	0.0097	0.0025
Mycobacterium tuberculosis	Probable dehydrogenase	0.0088	0.035	0.0679
Onchocerca volvulus		0.1115	0.6134	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0097	0.0097
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0278	0.1418	0.1356
Echinococcus multilocularis	gpi ethanolamine phosphate transferase 1	0.0044	0.0097	0.0025
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0078	0.0289	0.1619
Onchocerca volvulus		0.0078	0.0289	0.0318
Onchocerca volvulus		0.0078	0.0289	0.0318
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0082	0.0316	0.0245
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0044	0.0097	0.0025
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0082	0.0316	0.0245
Trichomonas vaginalis	glutaminase, putative	0.028	0.1431	0.1953
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0078	0.0289	0.0219
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0044	0.0097	0.0025
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Onchocerca volvulus		0.0078	0.0289	0.0318
Onchocerca volvulus		0.0078	0.0289	0.0318
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0082	0.0316	0.0264
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0078	0.0289	0.0219
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0078	0.0289	0.0219
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1115	0.6134	1
Leishmania major	ethanolamine phosphotransferase, putative	0.0044	0.0097	0.0544
Onchocerca volvulus		0.0078	0.0289	0.0318
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0078	0.0289	0.0219
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.1115	0.6134	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0078	0.0289	0.0219
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0278	0.1418	0.1356
Onchocerca volvulus		0.0078	0.0289	0.0318
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0146	0.0146
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0082	0.0316	0.0245
Onchocerca volvulus		0.0078	0.0289	0.0318
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0078	0.0289	0.0238
Onchocerca volvulus		0.0078	0.0289	0.0318
Echinococcus multilocularis	neuropeptide receptor A26	0.045	0.2389	0.2334
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0078	0.0289	0.0219
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0278	0.1418	0.1356
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0098	0.0405	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0259	0.0259
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1115	0.6134	1
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0078	0.0289	0.0238
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0078	0.0289	0.1619
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0078	0.0289	0.0219
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.079	0.4303	0.4261
Schistosoma mansoni	hypothetical protein	0.06	0.3235	0.3199
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0053	0.0053
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0078	0.0289	0.0219
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0278	0.1418	0.1373
Loa Loa (eye worm)	MH2 domain-containing protein	0.0126	0.0564	0.0564
Onchocerca volvulus		0.0078	0.0289	0.0318
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0278	0.1418	0.1356
Giardia lamblia	Protein tyrosine phosphatase	0.0078	0.0289	0.0318
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0115	0.0498	0.0429
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0234	0.1172	0.1108
Mycobacterium tuberculosis	Probable reductase	0.0088	0.035	0.0679
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0078	0.0289	0.0219
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0082	0.0316	0.0245
Trypanosoma brucei	GPI ethanolamine phosphate transferase 3, putative	0.0044	0.0097	0.0544
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Brugia malayi	hypothetical protein	0.0078	0.0289	0.0289
Onchocerca volvulus		0.0078	0.0289	0.0318
Plasmodium falciparum	thioredoxin reductase	0.0039	0.0069	0.7134
Loa Loa (eye worm)	type I phosphodiesterase/nucleotide pyrophosphatase	0.0044	0.0097	0.0097
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0082	0.0316	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Echinococcus multilocularis	hypothetical protein	0.0078	0.0289	0.0219
Schistosoma mansoni	hypothetical protein	0.0044	0.0097	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0078	0.0289	0.0219
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0078	0.0289	0.0238
Trypanosoma brucei	endonuclease G, putative	0.0167	0.0793	0.4433
Schistosoma mansoni	endonuclease related	0.0167	0.0793	0.0744
Brugia malayi	hypothetical protein	0.0078	0.0289	0.0289
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0078	0.0289	0.0219
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0078	0.0289	0.1619
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0278	0.1418	0.1356
Echinococcus multilocularis	transferase	0.0044	0.0097	0.0025
Loa Loa (eye worm)	glutathione reductase	0.0039	0.0069	0.0069
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0078	0.0289	0.0219
Echinococcus granulosus	transferase	0.0044	0.0097	0.0025
Echinococcus multilocularis	Endonuclease G	0.0167	0.0793	0.0725
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0078	0.0289	0.0219
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0082	0.0316	0.0264
Echinococcus granulosus	geminin	0.0165	0.0781	0.0714
Schistosoma mansoni	protein tyrosine phosphatase	0.0082	0.0316	0.0264
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.18	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0289	0.0289
Trypanosoma brucei	trypanothione reductase	0.0039	0.0069	0.0388
Brugia malayi	Thrombospondin type 1 domain containing protein	0.06	0.3235	0.3235
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0078	0.0289	0.0289
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0146	0.0146
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0078	0.0289	0.0219
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0278	0.1418	0.1356
Onchocerca volvulus		0.06	0.3235	0.5197
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0167	0.0793	0.4433
Plasmodium falciparum	glutathione reductase	0.0039	0.0069	0.7134
Trypanosoma cruzi	endonuclease G, putative	0.0167	0.0793	0.4433
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0078	0.0289	0.0318
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0078	0.0289	0.0289
Brugia malayi	hypothetical protein	0.0078	0.0289	0.0289
Onchocerca volvulus		0.0078	0.0289	0.0318
Plasmodium falciparum	GPI ethanolamine phosphate transferase 3, putative	0.0044	0.0097	1
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0044	0.0097	0.0097
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0289	0.0289

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL490973

Bibliographic References

No literature references available for this target.

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Detailed information for compound 994222