Detailed information for compound 995035

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 415.936 | Formula: C21H22ClN3O2S
  • H donors: 2 H acceptors: 2 LogP: 5.67 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Nc1scc(n1)c1cccc(c1)NC(=O)C(C)(C)C)Cl
  • InChi: 1S/C21H22ClN3O2S/c1-21(2,3)19(26)23-15-7-5-6-13(10-15)17-12-28-20(25-17)24-16-11-14(22)8-9-18(16)27-4/h5-12H,1-4H3,(H,23,26)(H,24,25)
  • InChiKey: LSOWBTNAWOGQOI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0014 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0128
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0058 0.042 0.0398
Brugia malayi hypothetical protein 0.0109 0.089 0.4087
Schistosoma mansoni myelin transcription factor 1 myt1 0.0047 0.0317 0.0296
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0039 0.018
Giardia lamblia Histone deacetylase 0.0054 0.0386 0.5155
Schistosoma mansoni ap endonuclease 0.0017 0.0039 0.0017
Entamoeba histolytica hypothetical protein 0.002 0.0069 0.0679
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0057 0.0411 0.3223
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0069 0.0478
Loa Loa (eye worm) hypothetical protein 0.0082 0.0641 0.2943
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0318
Onchocerca volvulus 0.0082 0.0641 0.5161
Echinococcus granulosus intermediate filament protein 0.0023 0.01 0.009
Echinococcus multilocularis polycomb protein SCMH1 0.0041 0.0265 0.0243
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0044 0.0295 0.0274
Loa Loa (eye worm) hypothetical protein 0.0144 0.1216 0.5582
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0057 0.0411 0.1885
Echinococcus multilocularis transcription factor Dp 1 0.0033 0.0189 0.0168
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0089 0.0711 1
Onchocerca volvulus 0.0023 0.01 0.0606
Entamoeba histolytica hypothetical protein 0.002 0.0069 0.0679
Onchocerca volvulus Huntingtin homolog 0.0109 0.089 0.7259
Brugia malayi Histone deacetylase 1 0.0054 0.0386 0.177
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0086 0.0487
Brugia malayi Histone deacetylase family protein 0.0015 0.0028 0.0128
Loa Loa (eye worm) hypothetical protein 0.0144 0.1216 0.5582
Brugia malayi mbt repeat family protein 0.0041 0.0265 0.1216
Leishmania major histone deacetylase, putative 0.0054 0.0386 0.3012
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0034 0.0012
Brugia malayi Associated with TFs and helicases family protein 0.002 0.0069 0.0318
Loa Loa (eye worm) hypothetical protein 0.0144 0.1216 0.5582
Schistosoma mansoni hypothetical protein 0.0078 0.0611 0.059
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0144 0.1216 1
Schistosoma mansoni hypothetical protein 0.0078 0.0611 0.059
Trichomonas vaginalis chromobox protein, putative 0.002 0.0069 0.0478
Trichomonas vaginalis histone deacetylase, putative 0.0054 0.0386 0.3675
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0069 0.0478
Loa Loa (eye worm) CHromoDomain protein family member 0.002 0.0069 0.0318
Toxoplasma gondii histone deacetylase HDAC2 0.0054 0.0386 0.3012
Loa Loa (eye worm) hypothetical protein 0.009 0.0715 0.3285
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0086 0.0848
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0034 0.0086
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0611 0.0681
Echinococcus granulosus transcription factor Dp 1 0.0033 0.0189 0.0193
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0064 0.0482 0.3824
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.002 0.0069 0.0055
Brugia malayi Smad1 0.0017 0.0038 0.0175
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0034 0.0049
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0047 0.0317 0.0296
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0611 0.059
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0039 0.0017
Schistosoma mansoni chromodomain helicase DNA binding protein 0.002 0.0069 0.0047
Brugia malayi histone deacetylase 11 0.0015 0.0028 0.0128
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.002 0.0069 0.0047
Trypanosoma cruzi UDP-galactopyranose mutase 0.0144 0.1216 1
Echinococcus multilocularis histone deacetylase 1 0.0054 0.0386 0.0364
Plasmodium vivax histone deacetylase 1, putative 0.0054 0.0386 0.3012
Brugia malayi mbt repeat family protein 0.0041 0.0265 0.1216
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0086 0.0487
Loa Loa (eye worm) hypothetical protein 0.0082 0.0641 0.2943
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.002 0.0069 0.035
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0711 0.6964
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0248 0.2178 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.002 0.0069 0.0679
Brugia malayi isocitrate dehydrogenase 0.0016 0.0034 0.0155
Loa Loa (eye worm) hypothetical protein 0.0144 0.1216 0.5582
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0144 0.1216 0.1196
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0611 0.2803
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0069 0.0478
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0069 0.0478
Trichomonas vaginalis chromobox protein, putative 0.002 0.0069 0.0478
Echinococcus granulosus chromobox protein 1 0.0122 0.1011 0.1144
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0248 0.2178 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0054 0.0386 0.3012
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0047 0.0317 0.0342
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0039 0.0097
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0038 0.0019
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0069 0.0478
Loa Loa (eye worm) helicase 0.002 0.0069 0.0318
Loa Loa (eye worm) hypothetical protein 0.0078 0.0611 0.2803
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0144 0.1216 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0034 0.0049
Echinococcus granulosus histone deacetylase 1 0.0054 0.0386 0.042
Brugia malayi Calcitonin receptor-like protein seb-1 0.0248 0.2178 1
Echinococcus granulosus inositol monophosphatase 1 0.0064 0.0482 0.0532
Echinococcus multilocularis histone deacetylase 3 0.0054 0.0386 0.0364
Brugia malayi CHD4 protein 0.002 0.0069 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0332 0.3133
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.0393
Trichomonas vaginalis histone deacetylase, putative 0.0054 0.0386 0.3675
Schistosoma mansoni hypothetical protein 0.0253 0.2225 0.2208
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0064 0.0482 0.3824
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0069 0.0478
Schistosoma mansoni histone deacetylase 4 5 0.0015 0.0028 0.0006
Plasmodium falciparum histone deacetylase 1 0.0054 0.0386 0.3012
Brugia malayi Histone deacetylase family protein 0.0015 0.0028 0.0128
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0611 0.2803
Loa Loa (eye worm) histone deacetylase 3 0.0054 0.0386 0.177
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.002 0.0069 0.0055
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0057 0.0411 0.0449
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0064 0.0482 0.0461
Schistosoma mansoni amine oxidase 0.0144 0.1216 0.1196
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0611 0.2803
Plasmodium falciparum protoporphyrinogen oxidase 0.0144 0.1216 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0069 0.0478
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0034 0.0155
Brugia malayi Inositol-1 0.0064 0.0482 0.2214
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0069 0.0478
Echinococcus multilocularis Chromobox protein 3 0.002 0.0069 0.0047
Loa Loa (eye worm) hypothetical protein 0.0169 0.1452 0.6669
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.2133 0.9792
Echinococcus granulosus FTZ F1 alpha 0.0424 0.3811 0.4382
Loa Loa (eye worm) hypothetical protein 0.0023 0.01 0.0458
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0064 0.0482 0.3824
Echinococcus multilocularis SAM and MBT domain containing protein 0.0041 0.0265 0.0243
Plasmodium vivax heterochromatin protein 1, putative 0.002 0.0069 0.035
Echinococcus multilocularis protein kinase c iota type 0.002 0.0072 0.005
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0089 0.0711 0.5752
Mycobacterium ulcerans oxidoreductase 0.0144 0.1216 0.1196
Loa Loa (eye worm) MBCTL1 0.0047 0.0317 0.1457
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0069 0.0478
Echinococcus multilocularis serine threonine protein kinase 0.0036 0.0221 0.0199
Echinococcus granulosus lysine specific histone demethylase 1A 0.0144 0.1216 0.1381
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.0012
Entamoeba histolytica histone deacetylase, putative 0.0054 0.0386 0.782
Loa Loa (eye worm) hypothetical protein 0.0054 0.0386 0.177
Schistosoma mansoni histone deacetylase 0.0054 0.0386 0.0364
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0295 0.0274
Loa Loa (eye worm) hypothetical protein 0.0041 0.0265 0.1216
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0564 0.5481
Trichomonas vaginalis histone deacetylase, putative 0.0054 0.0386 0.3675
Echinococcus granulosus Chromo domain 0.002 0.0069 0.0055
Loa Loa (eye worm) histone deacetylase 1 0.0054 0.0386 0.177
Echinococcus granulosus polycomb protein SCMH1 0.0041 0.0265 0.0281
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.002 0.0069 0.035
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0038 0.0016
Schistosoma mansoni chromodomain helicase DNA binding protein 0.002 0.0069 0.0047
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0025 0.0118 0.054
Onchocerca volvulus 0.002 0.0069 0.035
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0318
Brugia malayi MH2 domain containing protein 0.0017 0.0038 0.0175
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0039 0.0097
Echinococcus multilocularis histone deacetylase 0.0015 0.0028 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0516 0.4997
Loa Loa (eye worm) hypothetical protein 0.0082 0.0641 0.2943
Echinococcus granulosus Smad4 0.0017 0.0038 0.0019
Schistosoma mansoni chromobox protein 0.0122 0.1011 0.0992
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0332 0.3133
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.0039 1
Echinococcus multilocularis histone deacetylase 7 0.0015 0.0028 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0039 0.0097
Echinococcus granulosus histone deacetylase 7 0.0015 0.0028 0.0007
Toxoplasma gondii exonuclease III APE 0.0017 0.0039 0.0097
Brugia malayi protein kinase C II. 0.0021 0.0079 0.0363
Echinococcus granulosus histone deacetylase 6 0.0015 0.0028 0.0007
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0089 0.0711 0.3265
Toxoplasma gondii histone deacetylase HDAC3 0.0054 0.0386 0.3012
Schistosoma mansoni Smad4 0.0017 0.0038 0.0016
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0089 0.0711 0.5752
Loa Loa (eye worm) hypothetical protein 0.0144 0.1216 0.5582
Loa Loa (eye worm) histone deacetylase 11 0.0015 0.0028 0.0128
Trypanosoma brucei protein kinase, putative 0.0089 0.0711 1
Echinococcus granulosus GPCR family 2 0.0078 0.0611 0.0681
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.01 0.0458
Schistosoma mansoni smad1 5 8 and 0.0017 0.0038 0.0016
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0564 0.5481
Schistosoma mansoni chromobox protein 0.002 0.0069 0.0047
Loa Loa (eye worm) hypothetical protein 0.0094 0.0754 0.3461
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.1457
Echinococcus multilocularis histone deacetylase 6 0.0015 0.0028 0.0006
Echinococcus granulosus Chromobox protein 3 0.002 0.0069 0.0055
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0144 0.1216 1
Trichomonas vaginalis Heterochromatin protein, putative 0.002 0.0069 0.0478
Echinococcus multilocularis lamin 0.0023 0.01 0.0078
Echinococcus granulosus Protein kinase C brain isozyme 0.0044 0.0295 0.0316
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0064 0.0482 1
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0039 0.018
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0039 0.0174
Loa Loa (eye worm) hypothetical protein 0.0068 0.0516 0.2371
Trichomonas vaginalis histone deacetylase, putative 0.0054 0.0386 0.3675
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0089 0.0711 0.5752
Echinococcus granulosus lamin 0.0023 0.01 0.009
Schistosoma mansoni chromobox protein 0.0122 0.1011 0.0992
Schistosoma mansoni lamin 0.0023 0.01 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0516 0.4997
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0069 0.0478
Schistosoma mansoni atypical protein kinase C 0.002 0.0072 0.005
Plasmodium vivax hypothetical protein, conserved 0.002 0.0069 0.035
Trypanosoma brucei histone deacetylase 1 0.0054 0.0386 0.5237
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0054 0.0386 0.3675
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0034 0.0049
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0034 0.0012
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0064 0.0482 0.665
Echinococcus multilocularis inositol monophosphatase 1 0.0064 0.0482 0.0461
Echinococcus granulosus histone deacetylase 6 0.0015 0.0028 0.0007
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0041 0.0265 0.0243
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.002 0.0069 0.035
Trichomonas vaginalis chromobox protein, putative 0.0122 0.1011 1
Loa Loa (eye worm) histone deacetylase 0.0015 0.0028 0.0128
Toxoplasma gondii histone lysine-specific demethylase 0.0144 0.1216 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0165 0.1413 0.1609
Brugia malayi MH1 domain containing protein 0.0017 0.0038 0.0175
Echinococcus multilocularis chromobox protein 1 0.0122 0.1011 0.0992
Echinococcus multilocularis Chromo domain 0.002 0.0069 0.0047
Echinococcus multilocularis lamin dm0 0.0023 0.01 0.0078
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0165 0.1413 0.1394
Plasmodium vivax hypothetical protein, conserved 0.002 0.0069 0.035
Brugia malayi intermediate filament protein 0.0023 0.01 0.0458
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0318
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0054 0.0386 0.3675
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.1092 1 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0021 0.0079 0.0363
Schistosoma mansoni chromobox protein 0.002 0.0069 0.0047
Entamoeba histolytica hypothetical protein 0.002 0.0069 0.0679
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0144 0.1216 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0034 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0069 0.0478
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0711 0.6964
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0039 0.0097
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0057 0.0411 0.0389
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0089 0.0711 0.5752
Brugia malayi Protein cec-1. 0.002 0.0069 0.0318
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0611 0.059
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0038 0.0019
Echinococcus granulosus lysine specific histone demethylase 1A 0.0144 0.1216 0.1381
Brugia malayi histone deacetylase 1 (HD1) 0.0054 0.0386 0.177
Onchocerca volvulus 0.0023 0.01 0.0606
Echinococcus multilocularis histone deacetylase 6 0.0015 0.0028 0.0006
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.0013
Echinococcus granulosus RNA directed DNA polymerase 0.0023 0.0101 0.0091
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0041 0.0265 0.1995
Schistosoma mansoni smad 0.0017 0.0038 0.0016
Echinococcus granulosus microtubule associated protein 2 0.0594 0.5381 0.6197
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.2133 0.9792
Echinococcus granulosus SAM and MBT domain containing protein 0.0041 0.0265 0.0281
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.002 0.0069 0.0047
Loa Loa (eye worm) intermediate filament protein 0.0023 0.01 0.0458
Onchocerca volvulus Huntingtin homolog 0.0109 0.089 0.7259
Brugia malayi amine oxidase, flavin-containing family protein 0.0144 0.1216 0.5582
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0064 0.0482 1
Onchocerca volvulus 0.002 0.0069 0.035
Schistosoma mansoni hypothetical protein 0.0078 0.0611 0.059
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.01 0.0458
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0144 0.1216 0.1196
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0069 0.0478
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0034 0.0086
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0057 0.0411 0.5603
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0047 0.0317 0.1457
Brugia malayi MH2 domain containing protein 0.0017 0.0038 0.0175
Echinococcus multilocularis Smad4 0.0017 0.0038 0.0016
Trichomonas vaginalis inositol monophosphatase, putative 0.0064 0.0482 0.465
Loa Loa (eye worm) hypothetical protein 0.0248 0.2178 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0318
Mycobacterium tuberculosis Conserved hypothetical protein 0.0144 0.1216 0.1381
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.002 0.0069 0.0679
Brugia malayi MAP kinase sur-1 0.0089 0.0711 0.3265
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0034 0.0049
Loa Loa (eye worm) Smad1 0.0017 0.0038 0.0175
Loa Loa (eye worm) hypothetical protein 0.0053 0.038 0.1745
Loa Loa (eye worm) inositol-1 0.0064 0.0482 0.2214
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0039 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0079 0.0057
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0064 0.0482 0.465
Loa Loa (eye worm) hypothetical protein 0.0109 0.089 0.4087
Schistosoma mansoni histone deacetylase 4 5 0.0015 0.0028 0.0006
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.002 0.0069 0.0679
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0069 0.0478
Echinococcus multilocularis musashi 0.0023 0.01 0.0078
Brugia malayi histone deacetylase 3 (HD3) 0.0054 0.0386 0.177
Onchocerca volvulus 0.0041 0.0265 0.1995
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0057 0.0411 0.0389
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0017 0.0039 0.002
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0057 0.0411 0.1885
Loa Loa (eye worm) hypothetical protein 0.0109 0.089 0.4087
Brugia malayi M-phase phosphoprotein, mpp8 0.002 0.0069 0.0318
Schistosoma mansoni inositol monophosphatase 0.0064 0.0482 0.0461
Schistosoma mansoni sex comb on midleg homolog 0.0041 0.0265 0.0243
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0069 0.0478
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.0012
Trichomonas vaginalis hypothetical protein 0.002 0.0069 0.0478
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0038 0.0175
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0086 0.0487
Giardia lamblia Kinase, CMGC MAPK 0.0089 0.0711 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0089 0.0711 0.0691
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0034 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0711 0.0691
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.002 0.0069 0.035
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0711 0.6964
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0039 0.0174
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0089 0.0711 0.5752
Loa Loa (eye worm) histone deacetylase 7A 0.0015 0.0028 0.0128
Schistosoma mansoni ap endonuclease 0.0017 0.0039 0.0017
Echinococcus granulosus lamin dm0 0.0023 0.01 0.009
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.0039 0.0375
Brugia malayi chromobox protein homolog 3 0.0068 0.0516 0.2371
Brugia malayi Valyl-tRNA synthetase 0.002 0.0069 0.0318
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0034 0.0155
Schistosoma mansoni smad1 5 8 and 0.0017 0.0038 0.0016
Echinococcus multilocularis GPCR, family 2 0.0078 0.0611 0.059
Echinococcus granulosus histone acetyltransferase MYST2 0.0047 0.0317 0.0342
Brugia malayi MH1 domain containing protein 0.0017 0.0038 0.0175
Echinococcus granulosus mitogen activated protein kinase 0.0089 0.0711 0.0797
Mycobacterium ulcerans monoamine oxidase 0.0144 0.1216 0.1196
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0038 0.0016
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0089 0.0711 0.5752
Echinococcus multilocularis 0.0144 0.1216 0.1196
Loa Loa (eye worm) mbt repeat family protein 0.0041 0.0265 0.1216
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0057 0.0411 0.8386
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0057 0.0411 0.3223
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0089 0.0711 0.5752
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0069 0.0478
Trichomonas vaginalis histone deacetylase, putative 0.0054 0.0386 0.3675
Echinococcus granulosus mitogen activated protein kinase 3 0.0089 0.0711 0.0797
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0069 0.0478
Trichomonas vaginalis histone deacetylase, putative 0.0054 0.0386 0.3675
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0023 0.0101 0.0079
Loa Loa (eye worm) hypothetical protein 0.0144 0.1216 0.5582
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0318
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0039 0.0168
Echinococcus multilocularis histone acetyltransferase MYST2 0.0047 0.0317 0.0296
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0295 0.0274
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0039 0.0097
Echinococcus multilocularis protein kinase c epsilon type 0.0021 0.0079 0.0057
Schistosoma mansoni lamin 0.0023 0.01 0.0078
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0086 0.0487
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0069 0.0478
Echinococcus granulosus chromobox protein 2 0.002 0.0069 0.0055
Brugia malayi Protein kinase c protein 2 0.0033 0.0192 0.0882
Plasmodium falciparum heterochromatin protein 1 0.002 0.0069 0.035
Trichomonas vaginalis chromobox protein, putative 0.002 0.0069 0.0478
Leishmania major histone deacetylase, putative 0.0054 0.0386 0.3012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0073 0.0564 0.4516
Schistosoma mansoni inositol monophosphatase 0.0064 0.0482 0.0461
Echinococcus multilocularis chromobox protein 2 0.002 0.0069 0.0047
Schistosoma mansoni hypothetical protein 0.002 0.0069 0.0047
Onchocerca volvulus 0.002 0.0069 0.035
Brugia malayi SET domain containing protein 0.002 0.0069 0.0318
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0069 0.0478
Schistosoma mansoni sex comb on midleg homolog 0.0041 0.0265 0.0243
Echinococcus granulosus smad 0.0017 0.0038 0.0019
Loa Loa (eye worm) heterochromatin protein 1 0.0122 0.1011 0.4644
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.1092 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0318
Echinococcus granulosus protein kinase c epsilon type 0.0021 0.0079 0.0066
Schistosoma mansoni microtubule-associated protein tau 0.0594 0.5381 0.537
Mycobacterium ulcerans protoporphyrinogen oxidase 0.1092 1 1
Schistosoma mansoni histone deacetylase hda2 0.0015 0.0028 0.0006
Brugia malayi MH2 domain containing protein 0.0243 0.2133 0.9792
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0054 0.0386 0.3675
Brugia malayi hypothetical protein 0.0022 0.0086 0.0393
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0611 0.0681
Echinococcus multilocularis microtubule associated protein 2 0.0594 0.5381 0.537
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.0086 0.0487
Echinococcus multilocularis smad 0.0017 0.0038 0.0016
Echinococcus granulosus protein kinase c iota type 0.002 0.0072 0.0058
Brugia malayi Type III restriction enzyme, res subunit family protein 0.002 0.0069 0.0318
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0064 0.0482 0.3824
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.0012
Echinococcus multilocularis RNA directed DNA polymerase 0.0023 0.0101 0.0079
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0038 0.0175
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0711 0.6964
Mycobacterium tuberculosis Possible oxidoreductase 0.0144 0.1216 0.1381
Echinococcus granulosus protoporphyrinogen oxidase 0.0949 0.8669 1
Schistosoma mansoni amine oxidase 0.0144 0.1216 0.1196
Plasmodium vivax hypothetical protein, conserved 0.0144 0.1216 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0069 0.0478
Echinococcus multilocularis protoporphyrinogen oxidase 0.1092 1 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0038 0.0016
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0144 0.1216 0.1196
Brugia malayi SWIRM domain containing protein 0.0144 0.1216 0.5582
Plasmodium vivax hypothetical protein, conserved 0.0144 0.1216 1
Schistosoma mansoni histone deacetylase 1 2 3 0.0015 0.0028 0.0006
Echinococcus granulosus histone deacetylase 3 0.0054 0.0386 0.042
Schistosoma mansoni smad1 5 8 and 0.0017 0.0038 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0069 0.0478
Mycobacterium ulcerans dehydrogenase 0.0144 0.1216 0.1196
Echinococcus granulosus histone deacetylase 0.0015 0.0028 0.0007
Trypanosoma cruzi histone deacetylase 1, putative 0.0054 0.0386 0.3012
Echinococcus granulosus histone deacetylase 8 0.0015 0.0028 0.0007
Schistosoma mansoni histone deacetylase hda2 0.0015 0.0028 0.0006
Echinococcus multilocularis histone deacetylase 6 0.0015 0.0028 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0069 0.0478
Onchocerca volvulus 0.0053 0.038 0.2965
Echinococcus multilocularis mitogen activated protein kinase 0.0089 0.0711 0.0691
Echinococcus granulosus histone deacetylase 6 0.0015 0.0028 0.0007
Leishmania major hypothetical protein, conserved 0.0022 0.0086 0.0487
Loa Loa (eye worm) hypothetical protein 0.0023 0.0096 0.044
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0039 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0318
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0144 0.1216 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0034 0.0049
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0034 0.0012
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.002 0.0069 0.035
Schistosoma mansoni hypothetical protein 0.0078 0.0611 0.059
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0034 0.0049
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0064 0.0482 0.465
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0086 0.0487
Schistosoma mansoni intermediate filament proteins 0.0023 0.01 0.0078
Mycobacterium tuberculosis Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) 0.0949 0.8669 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0069 0.0478
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.002 0.0069 0.0047
Brugia malayi hypothetical protein 0.0144 0.1216 0.5582
Brugia malayi Heterochromatin protein 1 0.0122 0.1011 0.4644
Echinococcus multilocularis chromobox protein 1 0.0122 0.1011 0.0992
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0068 0.0516 0.4113
Schistosoma mansoni histone deacetylase 0.0054 0.0386 0.0364
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.002 0.0069 0.0047
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0144 0.1216 0.1196
Brugia malayi latrophilin 2 splice variant baaae 0.0169 0.1452 0.6669
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0057 0.0411 0.3223
Loa Loa (eye worm) hypothetical protein 0.0031 0.0175 0.0805
Echinococcus multilocularis histone deacetylase 8 0.0015 0.0028 0.0006
Echinococcus granulosus chromobox protein 1 0.0122 0.1011 0.1144
Onchocerca volvulus 0.0144 0.1216 1
Echinococcus granulosus protein kinase C gamma type 0.0036 0.0221 0.023
Schistosoma mansoni hypothetical protein 0.0169 0.1452 0.1434
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0058 0.042 0.046
Trypanosoma cruzi UDP-galactopyranose mutase 0.0144 0.1216 1
Trichomonas vaginalis chromobox protein, putative 0.0122 0.1011 1
Brugia malayi hypothetical protein 0.002 0.0069 0.0318
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.002 0.0069 0.0047
Leishmania major UDP-galactopyranose mutase 0.0144 0.1216 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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