Detailed information for compound 997496

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 407.449 | Formula: C19H17N7O2S
  • H donors: 3 H acceptors: 4 LogP: 1.29 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=c1[nH]c(=O)c2c([nH]1)nc1c(c2c2ccc(cc2)N2CCOCC2)c(N)ncn1
  • InChi: 1S/C19H17N7O2S/c20-15-13-12(10-1-3-11(4-2-10)26-5-7-28-8-6-26)14-17(23-16(13)22-9-21-15)24-19(29)25-18(14)27/h1-4,9H,5-8H2,(H4,20,21,22,23,24,25,27,29)
  • InChiKey: WRGVVMYBUZETOO-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0451 0.1276
Loa Loa (eye worm) hypothetical protein 0.0027 0.0179 0.055
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0243 0.2863 0.2855
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0025 0.0065
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0063
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0227 0.2671 0.8389
Mycobacterium ulcerans thymidylate synthase 0.0113 0.1246 0.3653
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0243 0.2863 0.8999
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0045 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0513 0.146
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0299 0.0868
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0702 0.2148
Loa Loa (eye worm) adenosylhomocysteinase 0.0268 0.318 1
Echinococcus granulosus expressed protein 0.0032 0.0249 0.0754
Brugia malayi 6-phosphofructokinase 0.011 0.1208 0.3751
Schistosoma mansoni loxhd1 0.0021 0.0103 0.0247
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0025 0.0065
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0045 0.0061
Chlamydia trachomatis dihydrofolate reductase 0.0115 0.1273 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0451 0.1352
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0091 0.021
Onchocerca volvulus 0.0027 0.0185 0.06
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0268 0.318 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0045 0.006
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1146 0.3603
Schistosoma mansoni tar DNA-binding protein 0.0064 0.064 0.1952
Schistosoma mansoni adenosylhomocysteinase 0.0166 0.191 0.5974
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.1611 0.5051
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0025 0.0014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0185 0.057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0451 0.1419
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0063
Loa Loa (eye worm) TAR-binding protein 0.0064 0.064 0.2004
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0381 0.1066
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0091 0.0399
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1208 0.3751
Brugia malayi phosphofructokinase 0.011 0.1208 0.3751
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0035
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0065
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0045 0.006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0185 0.057
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0702 0.2148
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0416 0.0407
Plasmodium falciparum thioredoxin reductase 0.0016 0.0045 0.0063
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0045 0.0063
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1208 0.3751
Schistosoma mansoni rotamase 0.0032 0.0249 0.0712
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0045 0.0063
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1146 0.3553
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0063
Plasmodium falciparum adenosylhomocysteinase 0.0268 0.318 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0045 0.0035
Schistosoma mansoni ap endonuclease 0.002 0.0091 0.021
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0045 0.0061
Onchocerca volvulus 0.023 0.2699 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.024 0.0682
Mycobacterium tuberculosis Hypothetical protein 0.0054 0.0513 0.1612
Onchocerca volvulus 0.0049 0.0451 0.1596
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0337 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0451 0.1352
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0215 0.0569
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0045 0.0129
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0215 0.0603
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0123 0.1375 0.4306
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0702 0.2148
Schistosoma mansoni dihydrofolate reductase 0.0115 0.1273 0.3956
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0451 0.1276
Brugia malayi Pre-SET motif family protein 0.0202 0.2352 0.7378
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0103 0.0292
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0045 0.0065
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0342 0.0332
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0045 0.0108
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1146 0.3603
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0268 0.318 0.9437
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1208 0.3751
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.1208 0.38
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1146 0.3603
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.1208 0.354
Echinococcus multilocularis musashi 0.0027 0.0185 0.0175
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.064 0.2004
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0215 0.1387
Schistosoma mansoni tar DNA-binding protein 0.0064 0.064 0.1952
Echinococcus granulosus lamin 0.0027 0.0185 0.0551
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1291 0.4059
Onchocerca volvulus 0.0027 0.0185 0.06
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1208 0.354
Trichomonas vaginalis conserved hypothetical protein 0.0284 0.3368 1
Schistosoma mansoni adenosylhomocysteinase 0.0166 0.191 0.5974
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0702 0.2148
Loa Loa (eye worm) thymidylate synthase 0.0113 0.1246 0.391
Onchocerca volvulus 0.0021 0.0103 0.0292
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0025 0.0078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0274 0.0862
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0045 0.0142
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0091 0.021
Brugia malayi Adenosylhomocysteinase 0.0268 0.318 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0451 0.1419
Brugia malayi isocitrate dehydrogenase 0.0016 0.0045 0.0065
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0025 0.0078
Loa Loa (eye worm) hypothetical protein 0.0036 0.0299 0.0927
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0702 0.2148
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.1662 0.519
Toxoplasma gondii adenosylhomocysteinase, putative 0.0268 0.318 0.9437
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0702 0.2148
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.1662 0.519
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0091 0.1589
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0019
Echinococcus granulosus tar DNA binding protein 0.0064 0.064 0.1988
Loa Loa (eye worm) hypothetical protein 0.0036 0.0299 0.0927
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0451 0.1276
Plasmodium falciparum glutathione reductase 0.0046 0.0416 0.1242
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0416 0.1242
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0115 0.1273 0.4003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0451 0.1352
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0299 0.0939
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0115 0.1273 0.3734
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0065
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0091 0.021
Brugia malayi Pre-SET motif family protein 0.0029 0.0207 0.0577
Loa Loa (eye worm) acetyltransferase 0.0146 0.1662 0.5221
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0381 0.1129
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.024 0.0682
Echinococcus multilocularis adenosylhomocysteinase 0.0268 0.318 0.3173
Schistosoma mansoni rab6-interacting 0.0021 0.0103 0.0247
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0207 0.0197
Schistosoma mansoni tar DNA-binding protein 0.0064 0.064 0.1952
Echinococcus granulosus transcription factor Dp 1 0.004 0.0342 0.1048
Schistosoma mansoni lamin 0.0027 0.0185 0.0508
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0381 0.1066
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0268 0.318 0.9437
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0103 0.0311
Plasmodium falciparum thioredoxin reductase 0.0046 0.0416 0.1242
Toxoplasma gondii 3-methyl-2-oxobutanoate hydroxymethyltransferase 0.0284 0.3368 1
Echinococcus granulosus RUN 0.0021 0.0103 0.0292
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0227 0.2671 0.8389
Brugia malayi hypothetical protein 0.0021 0.0103 0.0247
Echinococcus multilocularis dihydrofolate reductase 0.0115 0.1273 0.1264
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0451 0.1276
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0451 0.1352
Loa Loa (eye worm) oxidoreductase 0.0014 0.0025 0.0065
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0215 0.0603
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0451 0.1276
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0451 0.1352
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0054 0.0513 0.1547
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0045 0.0035
Leishmania major S-adenosylhomocysteine hydrolase 0.0268 0.318 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0091 0.0198
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0045 0.006
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0025 0.0078
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0091 0.021
Schistosoma mansoni tar DNA-binding protein 0.0064 0.064 0.1952
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0207 0.0577
Schistosoma mansoni ap endonuclease 0.002 0.0091 0.021
Brugia malayi glutathione reductase 0.0046 0.0416 0.1242
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0045 0.006
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0215 0.0569
Schistosoma mansoni tar DNA-binding protein 0.0064 0.064 0.1952
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0025 0.0078
Loa Loa (eye worm) hypothetical protein 0.0049 0.0451 0.1408
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2352 0.7395
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0091 0.021
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0103 0.0292
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0215 0.0603
Schistosoma mansoni rab6-interacting 0.0021 0.0103 0.0247
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0065
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0381 0.117
Brugia malayi Dihydrofolate reductase 0.0115 0.1273 0.3956
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0063
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0115 0.1273 0.3956
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0451 0.1276
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0299 0.0868
Loa Loa (eye worm) hypothetical protein 0.0036 0.0299 0.0927
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0063
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0416 0.1282
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0249 0.0712
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0337 0.0988
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0274 0.0862
Onchocerca volvulus 0.0021 0.0103 0.0292
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0103 0.0093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0207 0.0577
Mycobacterium ulcerans ketopantoate reductase, ApbA 0.0284 0.3368 1
Schistosoma mansoni polycystin 1-related 0.0021 0.0103 0.0247
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0227 0.2671 0.8389
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0215 0.1387
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0028 0.0011
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0215 0.0569
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0207 0.062
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0025 0.0078
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0215 0.0603
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0702 0.2148
Onchocerca volvulus 0.0113 0.1246 0.4567
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1208 0.3792
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0063
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0123 0.1375 0.1366
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0045 0.0063
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0025 0.0078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0274 0.0862
Loa Loa (eye worm) hypothetical protein 0.0021 0.0103 0.0311
Trichomonas vaginalis hypothetical protein 0.0063 0.0633 0.182
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0215 0.5838
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0268 0.318 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0299 0.0819
Loa Loa (eye worm) hypothetical protein 0.0021 0.0103 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0424 0.1194
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0103 0.0247
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0091 0.0286
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.024 0.0682
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0268 0.318 0.9437
Trichomonas vaginalis rotamase, putative 0.0032 0.0249 0.0672
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0045 0.0063
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0065
Echinococcus granulosus intermediate filament protein 0.0027 0.0185 0.0551
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.024 0.0644
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1291 0.4012
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0113 0.1246 0.3918
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0702 0.2199
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1208 0.3751
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0451 0.1352
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0091 0.021
Plasmodium falciparum glutathione reductase 0.0016 0.0045 0.0063
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1291 0.4059
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0451 0.1352
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0025 0.0078
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0215 0.0569
Loa Loa (eye worm) hypothetical protein 0.0049 0.0451 0.1408
Brugia malayi Thioredoxin reductase 0.0046 0.0416 0.1242
Brugia malayi hypothetical protein 0.0021 0.0103 0.0247
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0227 0.2671 0.7917
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0025 0.0078
Schistosoma mansoni adenosylhomocysteinase 0.0166 0.191 0.5974
Echinococcus multilocularis tar DNA binding protein 0.0064 0.064 0.0631
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0045 0.0065
Leishmania major trypanothione reductase 0.0046 0.0416 0.1242
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1208 0.3751
Echinococcus granulosus dihydrofolate reductase 0.0115 0.1273 0.3984
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0185 0.0508
Mycobacterium tuberculosis Probable reductase 0.0105 0.1146 0.3603
Trypanosoma brucei trypanothione reductase 0.0046 0.0416 0.1242
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.024 0.0682
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0451 0.1352
Mycobacterium ulcerans 2-dehydropantoate 2-reductase 0.011 0.121 0.3545
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0185 0.057
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0243 0.2863 0.8995
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0091 0.021
Brugia malayi Doublecortin family protein 0.0021 0.0103 0.0247
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0451 0.1352
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0045 0.0063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0274 0.0862
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0045 0.0063
Loa Loa (eye worm) RNA binding protein 0.0064 0.064 0.2004
Trichomonas vaginalis rotamase, putative 0.0032 0.024 0.0644
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0207 0.0577
Schistosoma mansoni lamin 0.0027 0.0185 0.0508
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0103 0.0292
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.011
Loa Loa (eye worm) hypothetical protein 0.0049 0.0451 0.1408
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0045 0.0063
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0035
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0207 0.0544
Echinococcus multilocularis thymidylate synthase 0.0113 0.1246 0.1237
Echinococcus granulosus thymidylate synthase 0.0113 0.1246 0.3898
Brugia malayi RNA binding protein 0.0064 0.064 0.1952
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0215 0.0569
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1208 0.3792
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0215 0.0569
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0268 0.318 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0381 0.1066
Brugia malayi hypothetical protein 0.0054 0.0513 0.1547
Echinococcus multilocularis lamin 0.0027 0.0185 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0249 0.0672
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0091 0.0255
Loa Loa (eye worm) glutathione reductase 0.0046 0.0416 0.1299
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0227 0.2671 0.8389
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0227 0.2671 0.8389
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0063
Plasmodium vivax SET domain protein, putative 0.0029 0.0207 0.0577
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0091 0.0274
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0045 0.0063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0025 0.0078
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0113 0.1246 0.387
Brugia malayi intermediate filament protein 0.0027 0.0185 0.0508
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0045 0.0063
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0025 0.0078
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1208 0.354
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0268 0.318 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0207 0.0638
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.1208 0.3751
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0035
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0025 0.0078
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0045 0.006
Entamoeba histolytica adenosylhomocysteinase, putative 0.0268 0.318 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0451 0.1352
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0063
Echinococcus granulosus lamin dm0 0.0027 0.0185 0.0551
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0045 0.0063
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0113 0.1246 0.387
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0215 0.0569
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0381 0.1066
Schistosoma mansoni lipoxygenase 0.0086 0.0915 0.2823
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0207 0.0197
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0702 0.0693
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0103 0.0247
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0045 0.0034
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0702 0.2184
Loa Loa (eye worm) dihydrofolate reductase 0.0115 0.1273 0.3996
Leishmania major ATP-dependent phosphofructokinase 0.011 0.1208 0.3751
Brugia malayi 6-phosphofructokinase 0.011 0.1208 0.3751
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1146 0.3603
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0091 0.0198
Toxoplasma gondii exonuclease III APE 0.002 0.0091 0.0198
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0091 0.0081
Echinococcus granulosus 6 phosphofructokinase 0.011 0.1208 0.378
Echinococcus granulosus adenosylhomocysteinase 0.0268 0.318 1
Schistosoma mansoni lipoxygenase 0.0123 0.1375 0.428
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.024 0.0682
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0045 0.0065
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0065
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0268 0.318 1
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0451 0.1352
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.1208 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1291 0.4059
Brugia malayi TAR-binding protein 0.0064 0.064 0.1952
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.064 0.1952
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0045 0.006
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0451 0.1276
Loa Loa (eye worm) hypothetical protein 0.0036 0.0299 0.0927
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0207 0.0577
Onchocerca volvulus 0.0029 0.0207 0.0681
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0215 0.1465
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0045 0.0063
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0268 0.318 1
Trichomonas vaginalis conserved hypothetical protein 0.0284 0.3368 1
Brugia malayi dihydrofolate reductase family protein 0.0115 0.1273 0.3956
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0091 0.0198
Schistosoma mansoni hypothetical protein 0.0021 0.0103 0.0247
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0045 0.0065
Mycobacterium tuberculosis Conserved hypothetical protein 0.011 0.121 0.3805
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0215 0.0569
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0091 0.021
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0416 0.1242
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0416 0.1299
Echinococcus multilocularis lamin dm0 0.0027 0.0185 0.0175
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0025 0.0045
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0091 1
Loa Loa (eye worm) phosphofructokinase 0.011 0.1208 0.3792
Mycobacterium ulcerans hypothetical protein 0.0049 0.0451 0.1276
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0045 0.0063
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0045 0.0063
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0299 0.2068
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0215 0.0569
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0045 0.014
Brugia malayi thymidylate synthase 0.0113 0.1246 0.387
Schistosoma mansoni adenosylhomocysteinase 0.0166 0.191 0.5974
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0193 0.0578
Toxoplasma gondii thioredoxin reductase 0.0046 0.0416 0.1172
Schistosoma mansoni intermediate filament proteins 0.0027 0.0185 0.0508
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0103 0.0093
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.1208 0.1199
Schistosoma mansoni adenosylhomocysteinase 0.0268 0.318 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0028 0.0076
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0084 0.0893 0.2598
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0215 0.0603
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1208 0.3751
Trichomonas vaginalis set domain proteins, putative 0.023 0.2699 0.7998
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0249 0.0772
Echinococcus multilocularis RUN 0.0021 0.0103 0.0093
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0268 0.318 0.9437
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0045 0.006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0416 0.131
Loa Loa (eye worm) hypothetical protein 0.0036 0.0299 0.0927
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0103 0.0093
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1208 0.3751
Plasmodium vivax glutathione reductase, putative 0.0046 0.0416 0.1242
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0045 0.0063
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1208 0.354
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0215 0.0569
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1146 0.3603
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0045 0.0065
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.1662 0.1653
Echinococcus multilocularis expressed protein 0.0032 0.0249 0.0239
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0045 0.0065
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1208 0.354
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0337 0.0988

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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