Detailed information for compound 1004776

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 436.53 | Formula: C22H24N6O2S
  • H donors: 1 H acceptors: 4 LogP: 3.05 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(C)(C)Cc2c1sc(n2)N1CCOc2c1cc(cc2)c1ccc(nn1)N(C)C
  • InChi: 1S/C22H24N6O2S/c1-22(2)12-15-19(20(29)24-22)31-21(23-15)28-9-10-30-17-7-5-13(11-16(17)28)14-6-8-18(26-25-14)27(3)4/h5-8,11H,9-10,12H2,1-4H3,(H,24,29)
  • InChiKey: WMJZYHJQSGVYFD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0166 0.0679 0.1755
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0166 0.0679 0.2067
Brugia malayi Sugar transporter family protein 0.0076 0.0285 0.123
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.003 0.0086 0.0369
Echinococcus granulosus solute carrier family 22 0.0076 0.0285 0.0868
Leishmania major lysyl-tRNA synthetase, putative 0.0018 0.0032 0.0412
Toxoplasma gondii glycyl-tRNA synthetase 0.003 0.0086 0.0129
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0018 0.0032 0.0412
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0027 0.007 0.0106
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0162 0.0663 1
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.007 0.0642
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0018 0.0032 0.0083
Trypanosoma cruzi hexose transporter, putative 0.0076 0.0285 0.2612
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0169 0.0691 0.2979
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0189 0.078 1
Leishmania major myo-inositol/proton symporter (MIT) 0.0076 0.0285 0.3657
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0011 0 0.0004
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0101 0.1295
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0157 0.0477
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0067 0.1395
Mycobacterium ulcerans seryl-tRNA synthetase 0.0012 0.0006 0.0119
Treponema pallidum prolyl-tRNA synthetase 0.0057 0.0203 1
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0679 0.293
Onchocerca volvulus 0.0076 0.0285 1
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0 0.0001
Plasmodium vivax calcium-dependent protein kinase, putative 0.0166 0.068 0.068
Echinococcus granulosus synaptic vesicle 2 protein 0.0076 0.0285 0.0868
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0018 0.0162
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.054 0.2319 0.5991
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trypanosoma brucei THT1 - hexose transporter, putative 0.0168 0.0687 0.8799
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0067 0.086
Echinococcus granulosus Niemann Pick C1 protein 0.0155 0.0632 0.1924
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.054 0.2319 0.7056
Brugia malayi replication factor A 73 kDa subunit 0.0015 0.0018 0.0076
Chlamydia trachomatis DNA ligase 0.0011 0 0.0002
Treponema pallidum glycyl-tRNA synthetase 0.0018 0.0033 0.1594
Brugia malayi seryl-tRNA synthetase, mitochondrial precursor, putative 0.0012 0.0006 0.0025
Mycobacterium ulcerans threonyl-tRNA synthetase 0.003 0.0086 0.1782
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0015 0.0018 0.0076
Trypanosoma brucei glucose transporter, putative 0.0168 0.0687 0.8799
Loa Loa (eye worm) hypothetical protein 0.0166 0.0679 0.293
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0034 0.0101 0.0436
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0018 0.0032 0.0139
Echinococcus granulosus glycyl tRNA synthetase 0.003 0.0086 0.0261
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0169 0.0691 0.2101
Trypanosoma brucei glucose transporter 2A 0.0168 0.0687 0.8799
Trypanosoma cruzi seryl-tRNA synthetase 0.0012 0.0006 0.0052
Schistosoma mansoni protein kinase 0.0166 0.0679 0.2067
Brugia malayi Major Facilitator Superfamily protein 0.0076 0.0285 0.123
Brugia malayi Major Facilitator Superfamily protein 0.0076 0.0285 0.123
Loa Loa (eye worm) hypothetical protein 0.0109 0.0428 0.1847
Schistosoma mansoni aspartyl-tRNA synthetase 0.0018 0.0032 0.0098
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0067 0.0244 0.2234
Echinococcus multilocularis solute carrier family 22 0.0076 0.0285 0.0737
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0121 0.0481 0.6162
Plasmodium falciparum proline--tRNA ligase, putative 0.0012 0.0006 0.0006
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0244 0.1052
Leishmania major phosphatidylinositol 3-kinase, putative 0.0034 0.0101 0.1295
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.003 0.0086 0.1098
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0873 0.3779 0.569
Schistosoma mansoni histidyl-tRNA synthetase 0.0018 0.0033 0.0099
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0034 0.0101 0.0925
Mycobacterium ulcerans hypothetical protein 0.0026 0.0067 0.1395
Onchocerca volvulus 0.0076 0.0285 1
Mycobacterium ulcerans sugar transporter 0.0076 0.0285 0.5934
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.054 0.2319 0.5991
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0034 0.0101 0.0101
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0018 0.0033 0.1136
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0043 0.0556
Entamoeba histolytica protein kinase, putative 0.0166 0.0679 0.622
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0043 0.0187
Brugia malayi CXXC zinc finger family protein 0.0032 0.0091 0.0394
Entamoeba histolytica hypothetical protein 0.0011 0 0.0001
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0018 0.0032 0.0139
Echinococcus granulosus solute carrier family 22 0.0076 0.0285 0.0868
Onchocerca volvulus 0.0076 0.0285 1
Echinococcus multilocularis General substrate transporter 0.0464 0.1987 0.5132
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0 0.0001
Loa Loa (eye worm) major facilitator superfamily transporter 0.0076 0.0285 0.123
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0164
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0179 0.0735 0.3171
Onchocerca volvulus 0.0032 0.0091 0.32
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0043 0.0397
Trypanosoma brucei seryl-tRNA synthetase 0.0012 0.0006 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0285 0.123
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0018 0.0032 0.0083
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0091 0.0394
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0015 0.0018 0.0162
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0166 0.068 0.1024
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0285 0.123
Plasmodium vivax asparagine--tRNA ligase, putative 0.0018 0.0032 0.0032
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0162 0.0663 0.1712
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0034 0.0101 0.0925
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0067 0.0244 0.1052
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0043 0.0187
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0364 0.1549 0.4001
Loa Loa (eye worm) hypothetical protein 0.0162 0.0663 0.2857
Schistosoma mansoni aspartyl-tRNA synthetase 0.0018 0.0032 0.0098
Brugia malayi hypothetical protein 0.0076 0.0285 0.123
Plasmodium vivax hexose transporter 0.054 0.2319 0.2319
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Leishmania major lysyl-tRNA synthetase, putative 0.0121 0.0481 0.6162
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.0244 0.2234
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0067 0.0614
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0043 0.0397
Toxoplasma gondii seryl-tRNA synthetase, cytoplasmic, putative 0.0012 0.0006 0.0009
Wolbachia endosymbiont of Brugia malayi seryl-tRNA synthetase 0.0012 0.0006 0.0196
Trichomonas vaginalis sugar transport protein, putative 0.0076 0.0285 0.123
Echinococcus granulosus Seryl tRNA Synthetase 0.0012 0.0006 0.0017
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0018 0.0032 0.0294
Plasmodium falciparum serine--tRNA ligase, putative 0.0012 0.0006 0.0006
Echinococcus granulosus mitogen activated protein kinase 0.0067 0.0244 0.0742
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.026 0.1092 0.471
Trypanosoma brucei THT1 - hexose transporter, putative 0.0168 0.0687 0.8799
Echinococcus multilocularis seryl tRNA synthetase, mitochondrial 0.0012 0.0006 0.0015
Echinococcus granulosus seryl tRNA synthetase mitochondrial 0.0012 0.0006 0.0017
Leishmania major aspartyl-tRNA synthetase, putative 0.0018 0.0032 0.0412
Trypanosoma brucei histidyl-tRNA synthetase 0.0018 0.0033 0.0417
Trypanosoma cruzi glucose transporter, putative 0.0076 0.0285 0.2612
Loa Loa (eye worm) hypothetical protein 0.0047 0.0157 0.0676
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0102 0.0401 1
Entamoeba histolytica protein kinase, putative 0.0011 0.000000029698 0.00000027185
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0164
Plasmodium vivax serine--tRNA ligase, putative 0.0012 0.0006 0.0006
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0018 0.0032 0.0294
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.026 0.1092 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0033 0.0834
Chlamydia trachomatis aspartate--tRNA(Asp/Asn) ligase 0.0018 0.0032 0.0669
Loa Loa (eye worm) hypothetical protein 0.0026 0.0067 0.0289
Onchocerca volvulus 0.0076 0.0285 1
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0027 0.007 0.0642
Plasmodium falciparum protein kinase 7 0.1527 0.6642 0.6642
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0011 0 0.0005
Echinococcus granulosus General substrate transporter 0.0464 0.1987 0.6043
Trypanosoma cruzi hexose transporter, putative 0.0168 0.0687 0.6285
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0285 0.123
Schistosoma mansoni hypothetical protein 0.054 0.2319 0.7056
Mycobacterium leprae PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) 0.0015 0.0018 0.0266
Giardia lamblia Lysyl-tRNA synthetase 0.0121 0.0481 0.7257
Loa Loa (eye worm) 63kd antigen 0.0018 0.0032 0.0139
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0244 0.1052
Toxoplasma gondii anticodon binding domain-containing protein 0.0018 0.0033 0.0049
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0087 0.0334 0.3056
Toxoplasma gondii lysine-tRNA ligase 0.0121 0.0481 0.0724
Loa Loa (eye worm) Sars1 protein 0.0012 0.0006 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0067 0.0289
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.003 0.0086 0.0784
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0162 0.0663 0.2016
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.0018 0.0032 0.1124
Treponema pallidum seryl-tRNA synthetase 0.0012 0.0006 0.0276
Loa Loa (eye worm) sugar transporter 0.054 0.2319 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0121 0.0481 0.2073
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0034 0.0101 0.0261
Schistosoma mansoni glucose transport protein 0.054 0.2319 0.7056
Trypanosoma cruzi hexose transporter, putative 0.0168 0.0687 0.6285
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0043 0.0903
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.0436 0.1325
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0015 0.0018 0.0076
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0076 0.0285 0.3657
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.003 0.0086 0.0129
Treponema pallidum asparaginyl-tRNA synthetase 0.0018 0.0032 0.1577
Onchocerca volvulus 0.0076 0.0285 1
Schistosoma mansoni ap endonuclease 0.0021 0.0043 0.0132
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0076 0.0285 0.5934
Echinococcus multilocularis solute carrier family 22 0.0076 0.0285 0.0737
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0018 0.0032 0.0412
Schistosoma mansoni threonyl-tRNA synthetase 0.0018 0.0033 0.0099
Plasmodium falciparum nucleic acid binding protein, putative 0.0015 0.0018 0.0018
Giardia lamblia Hexose transporter 0.0076 0.0285 0.4306
Plasmodium falciparum calcium-dependent protein kinase 2 0.0166 0.068 0.068
Plasmodium vivax lysine--tRNA ligase, putative 0.0121 0.0481 0.0481
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0067 0.0244 0.3127
Leishmania major glucose transporter, lmgt3 0.0168 0.0687 0.8799
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0285 0.123
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0104 0.0409 0.1763
Trichomonas vaginalis glucose transporter, putative 0.0076 0.0285 0.123
Schistosoma mansoni seryl-tRNA synthetase 0.0012 0.0006 0.0017
Mycobacterium ulcerans hypothetical protein 0.0027 0.007 0.146
Brugia malayi hypothetical protein 0.0076 0.0285 0.123
Brugia malayi major facilitator superfamily protein 0.0076 0.0285 0.123
Echinococcus multilocularis prolyl tRNA synthetase, mitochondrial 0.0012 0.0006 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0 0.0001
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0101 0.1295
Leishmania major histidyl-tRNA synthetase, putative 0.0018 0.0033 0.0417
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0015 0.0018 0.0018
Plasmodium vivax aspartate--tRNA ligase, putative 0.0018 0.0032 0.0032
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0087 0.0334 0.1016
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0166 0.0679 0.2067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0067 0.1672
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0076 0.0285 0.7112
Entamoeba histolytica seryl-tRNA synthetase, putative 0.0012 0.0006 0.0052
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0038 0.0793
Plasmodium vivax threonine--tRNA ligase, putative 0.003 0.0086 0.0086
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.054 0.2319 0.5991
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0034 0.0101 0.0436
Toxoplasma gondii calcium-dependent protein kinase CDPK2 0.0011 0 0.0001
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0189 0.078 0.7142
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0067 0.0614
Trichomonas vaginalis myo-inositol transporter, putative 0.0076 0.0285 0.123
Trichomonas vaginalis glucose transporter, putative 0.0168 0.0687 0.296
Loa Loa (eye worm) sugar transporter 0.0076 0.0285 0.123
Echinococcus granulosus Niemann Pick C1 protein 0.0109 0.0428 0.1303
Echinococcus multilocularis Niemann Pick C1 protein 0.0109 0.0428 0.1106
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0067 0.0244 0.0367
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0 0.0001
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0087 0.0334 0.4279
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0043 0.0187
Plasmodium vivax asparagine--tRNA ligase, putative 0.0018 0.0032 0.0032
Giardia lamblia Aspartyl-tRNA synthetase 0.0018 0.0032 0.0485
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0189 0.078 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0179 0.0735 0.3171
Loa Loa (eye worm) hypothetical protein 0.0092 0.0354 0.1527
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0067 0.1395
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Plasmodium falciparum asparagine--tRNA ligase 0.0018 0.0032 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0364 0.1549 0.4711
Entamoeba histolytica hypothetical protein 0.0015 0.0018 0.0162
Schistosoma mansoni aspartyl-tRNA synthetase 0.0018 0.0032 0.0098
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0162 0.0663 0.2016
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0067 0.0289
Brugia malayi major facilitator superfamily protein 0.0076 0.0285 0.123
Giardia lamblia Prolyl-tRNA synthetase 0.0162 0.0663 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0067 0.0244 0.1052
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0166 0.0679 0.8709
Trypanosoma brucei THT1 - hexose transporter, putative 0.0168 0.0687 0.8799
Onchocerca volvulus 0.0076 0.0285 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.026 0.1092 0.471
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0067 0.0244 0.3127
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Plasmodium falciparum hexose transporter 0.054 0.2319 0.2319
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0244 0.1052
Trichomonas vaginalis sugar transporter, putative 0.0168 0.0687 0.296
Loa Loa (eye worm) hypothetical protein 0.0057 0.0203 0.0874
Leishmania major glucose transporter/membrane transporter D2, putative 0.0168 0.0687 0.8799
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0015 0.0018 0.0046
Echinococcus granulosus dnaJ subfamily B 0.0451 0.1929 0.5868
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Schistosoma mansoni hypothetical protein 0.0045 0.0149 0.0454
Loa Loa (eye worm) hypothetical protein 0.0121 0.0481 0.2073
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0067 0.1395
Echinococcus multilocularis dnaJ subfamily B 0.0451 0.1929 0.4983
Trypanosoma brucei glucose transporter, putative 0.0168 0.0687 0.8799
Plasmodium falciparum replication protein A1, large subunit 0.0015 0.0018 0.0018
Plasmodium falciparum calcium-dependent protein kinase 4 0.0166 0.068 0.068
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0067 0.1395
Schistosoma mansoni glucose transporter 0.0076 0.0285 0.0868
Onchocerca volvulus 0.0026 0.0067 0.2352
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0166 0.0679 0.293
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0034 0.0101 0.0307
Plasmodium vivax serine--tRNA ligase, putative 0.0012 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0 0.0001
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0166 0.068 0.1024
Toxoplasma gondii aspartate-tRNA ligase 0.0018 0.0032 0.0048
Echinococcus multilocularis protein patched 0.0047 0.0157 0.0405
Schistosoma mansoni prolyl-tRNA synthetase 0.0012 0.0006 0.0017
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0157 0.0405
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0164
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0252 0.1059 0.9691
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0873 0.3779 0.3779
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0011 0 0.0002
Leishmania major asparaginyl-tRNA synthetase, putative 0.0018 0.0032 0.0412
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Schistosoma mansoni seryl-tRNA synthetase 0.0012 0.0006 0.0017
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0011 0 0.0004
Trypanosoma brucei sugar transporter, putative 0.0076 0.0285 0.3657
Leishmania major threonyl-tRNA synthetase, putative 0.003 0.0086 0.1098
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0087 0.0334 0.1439
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Brugia malayi Aspartyl-tRNA synthetase 0.0018 0.0032 0.0139
Schistosoma mansoni threonyl-tRNA synthetase 0.0012 0.0006 0.0017
Plasmodium vivax sugar transporter, putative 0.0076 0.0285 0.0285
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0076 0.0285 0.0285
Echinococcus granulosus mitogen activated protein kinase 3 0.0067 0.0244 0.0742
Plasmodium falciparum calcium-dependent protein kinase 3 0.0166 0.068 0.068
Chlamydia trachomatis lysine--tRNA ligase 0.0121 0.0481 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0189 0.078 0.7142
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0244 0.1052
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0027 0.007 0.0642
Plasmodium falciparum lysine--tRNA ligase 0.0121 0.0481 0.0481
Toxoplasma gondii exonuclease III APE 0.0021 0.0043 0.0065
Plasmodium falciparum histidine--tRNA ligase, putative 0.0018 0.0033 0.0033
Loa Loa (eye worm) glycyl-tRNA synthetase 0.003 0.0086 0.0369
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0018 0.0032 0.0139
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0076 0.0285 0.0737
Trypanosoma cruzi hexose transporter 0.0168 0.0687 0.6285
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0162 0.0663 0.2857
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0164
Plasmodium falciparum asparagine--tRNA ligase 0.0018 0.0032 0.0032
Onchocerca volvulus 0.0076 0.0285 1
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0018 0.0032 0.0294
Trypanosoma brucei glucose transporter, putative 0.0168 0.0687 0.8799
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0121 0.0481 0.4401
Trichomonas vaginalis sugar transporter, putative 0.0168 0.0687 0.296
Schistosoma mansoni glycyl-tRNA synthetase 0.003 0.0086 0.0261
Trypanosoma cruzi histidyl-tRNA synthetase 0.0018 0.0033 0.0298
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0067 0.1395
Onchocerca volvulus 0.0076 0.0285 1
Brugia malayi MAP kinase sur-1 0.0067 0.0244 0.1052
Entamoeba histolytica hypothetical protein 0.0207 0.086 0.7869
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0067 0.0289
Plasmodium vivax proline--tRNA ligase, putative 0.0189 0.078 0.078
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0207 0.086 0.7869
Toxoplasma gondii protein kinase, putative 0.1527 0.6642 1
Schistosoma mansoni microtubule-associated protein tau 0.0761 0.3287 1
Brugia malayi CHE-14 protein 0.0047 0.0157 0.0676
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Loa Loa (eye worm) phosphatidylinositol 3 0.0311 0.1316 0.5674
Echinococcus multilocularis solute carrier family 22 0.0076 0.0285 0.0737
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.0244 0.2234
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0038 0.0038
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0018 0.0032 0.0098
Giardia lamblia Replication factor C, subunit 1 0.0011 0 0.0002
Echinococcus multilocularis Niemann Pick C1 protein 0.0155 0.0632 0.1634
Onchocerca volvulus 0.0011 0 0.0004
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0012 0.0006 0.0025
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0166 0.0679 0.2067
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0043 0.0655
Leishmania major glucose transporter, lmgt1 0.0168 0.0687 0.8799
Toxoplasma gondii calcium-dependent protein kinase CDPK9 0.0011 0 0.0001
Echinococcus granulosus expressed conserved protein 0.0102 0.0399 0.1215
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.0687 0.296
Leishmania major replication factor A, 51kDa subunit, putative 0.0015 0.0018 0.0226
Schistosoma mansoni sugar transporter 0.0076 0.0285 0.0868
Onchocerca volvulus 0.0076 0.0285 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0121 0.0481 1
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0015 0.0018 0.044
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0101 0.0925
Giardia lamblia Seryl-tRNA synthetase 0.0012 0.0006 0.0086
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0189 0.078 1
Echinococcus multilocularis expressed conserved protein 0.0102 0.0399 0.1032
Loa Loa (eye worm) hypothetical protein 0.0132 0.0529 0.2283
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0067 0.1672
Chlamydia trachomatis threonine--tRNA ligase 0.003 0.0086 0.1782
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trypanosoma brucei protein kinase, putative 0.0067 0.0244 0.3127
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0034 0.0101 0.0152
Leishmania major protein kinase, putative 0.0011 0 0.0005
Onchocerca volvulus 0.0076 0.0285 1
Entamoeba histolytica seryl-tRNA synthetase, putative 0.0012 0.0006 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Loa Loa (eye worm) seryl-tRNA synthetase 0.0012 0.0006 0.0025
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0087 0.0334 0.1439
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0106 0.0416 0.1792
Treponema pallidum threonyl-tRNA synthetase 0.003 0.0086 0.4211
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0015 0.0018 0.0162
Mycobacterium leprae conserved hypothetical protein 0.0027 0.007 0.1059
Echinococcus multilocularis glycyl tRNA synthetase 0.003 0.0086 0.0221
Toxoplasma gondii calcium-dependent protein kinase CDPK1 0.0011 0 0.0001
Schistosoma mansoni protein kinase 0.0166 0.0679 0.2067
Echinococcus granulosus solute carrier family 22 0.0076 0.0285 0.0868
Toxoplasma gondii sugar transporter ST3 0.0076 0.0285 0.043
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0087 0.0334 0.1439
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0018 0.0032 0.0294
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0015 0.0018 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0168 0.0687 0.296
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0157 0.0676
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Trypanosoma brucei glucose transporter, putative 0.0168 0.0687 0.8799
Toxoplasma gondii calcium-dependent protein kinase CDPK6 0.0011 0 0.0001
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0018 0.0033 0.0049
Schistosoma mansoni aspartyl-tRNA synthetase 0.0018 0.0032 0.0098
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0067 0.0244 0.2234
Schistosoma mansoni glucose transport protein 0.054 0.2319 0.7056
Trichomonas vaginalis seryl-tRNA synthetase, putative 0.0012 0.0006 0.0025
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0087 0.0334 0.3056
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.007 0.0303
Echinococcus multilocularis lysyl tRNA synthetase 0.0121 0.0481 0.1242
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0076 0.0285 0.0868
Schistosoma mansoni hypothetical protein 0.0045 0.0149 0.0454
Onchocerca volvulus 0.0076 0.0285 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0076 0.0285 0.123
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0067 0.1395
Brugia malayi lysyl-tRNA synthetase 0.0121 0.0481 0.2073
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0043 0.0132
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0067 0.086
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Schistosoma mansoni patched 1 0.0047 0.0157 0.0477
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Plasmodium vivax proline--tRNA ligase, putative 0.0012 0.0006 0.0006
Echinococcus multilocularis protein dispatched 1 0.0053 0.0186 0.0479
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0162 0.0663 0.2857
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0067 0.086
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0015 0.0018 0.0027
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0043 0.1518
Plasmodium vivax CDK-related protein kinase 6, putative 0.2293 1 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0102 0.0401 0.6055
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.003 0.0086 0.0784
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.054 0.2319 0.5991
Plasmodium falciparum threonine--tRNA ligase 0.003 0.0086 0.0086
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0076 0.0285 1
Schistosoma mansoni glucose transport protein 0.054 0.2319 0.7056
Trypanosoma cruzi Replication factor A protein 1 0.0015 0.0018 0.0162
Onchocerca volvulus 0.0076 0.0285 1
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.007 0.0642
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0034 0.0101 0.0436
Brugia malayi Niemann-Pick C1 protein precursor 0.0109 0.0428 0.1847
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0115 0.0458 0.4193
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0018 0.0033 0.014
Schistosoma mansoni hypothetical protein 0.0045 0.0149 0.0454
Echinococcus granulosus prolyl tRNA synthetase mitochondrial 0.0012 0.0006 0.0017
Schistosoma mansoni hypothetical protein 0.0451 0.1929 0.5868
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0076 0.0285 0.5934
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0166 0.0679 0.1755
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.003 0.0086 0.2136
Echinococcus multilocularis histidyl tRNA synthetase 0.0018 0.0033 0.0084
Loa Loa (eye worm) hypothetical protein 0.0169 0.0691 0.2979
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.026 0.1092 1
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.0015 0.0018 0.0162
Chlamydia trachomatis serine--tRNA ligase 0.0012 0.0006 0.0119
Schistosoma mansoni replication factor A 1 rfa1 0.0015 0.0018 0.0054
Giardia lamblia Asparaginyl-tRNA synthetase 0.0018 0.0032 0.0485
Schistosoma mansoni hypothetical protein 0.0045 0.0149 0.0454
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0157 0.0676
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0027 0.007 0.09
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0043 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trypanosoma brucei glucose transporter, putative 0.0168 0.0687 0.8799
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Schistosoma mansoni aspartyl-tRNA synthetase 0.0018 0.0032 0.0098
Echinococcus multilocularis calcium dependent protein kinase 0.0155 0.0632 0.1634
Leishmania major replication Factor A 28 kDa subunit, putative 0.0015 0.0018 0.0226
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0102 0.0401 1
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0018 0.0033 0.0676
Trypanosoma brucei glucose transporter 1E 0.0168 0.0687 0.8799
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0034 0.0101 0.0307
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0894 0.3871 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0076 0.0285 0.0868
Schistosoma mansoni histidyl-tRNA synthetase 0.0018 0.0033 0.0099
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0189 0.078 0.1175
Schistosoma mansoni hypothetical protein 0.0015 0.0018 0.0054
Schistosoma mansoni aspartyl-tRNA synthetase 0.0018 0.0032 0.0098
Schistosoma mansoni cpg binding protein 0.0033 0.0099 0.0302
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0015 0.0018 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0244 0.0742
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.0687 0.296
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0067 0.1013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0067 0.0289
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0018 0.0033 0.0298
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0033 0.0834
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0121 0.0481 0.7257
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0043 0.2131
Leishmania major glucose transporter, lmgt2 0.0168 0.0687 0.8799
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0061 0.0219 0.3307
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0057 0.0203 0.4229
Toxoplasma gondii serine--tRNA ligase 0.0012 0.0006 0.0009
Schistosoma mansoni ap endonuclease 0.0021 0.0043 0.0132
Schistosoma mansoni protein kinase 0.0166 0.0679 0.2067
Plasmodium falciparum mitogen-activated protein kinase 2 0.0873 0.3779 0.3779
Toxoplasma gondii transporter, major facilitator family protein 0.0076 0.0285 0.043
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0079 0.03 0.2747
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0109 0.0428 0.3921
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0015 0.0018 0.044
Echinococcus multilocularis microtubule associated protein 2 0.0761 0.3287 0.8492
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0162 0.0663 0.2857
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.003 0.0086 0.3
Onchocerca volvulus Putative transporter 0.0076 0.0285 1
Trypanosoma cruzi sugar transporter, putative 0.0076 0.0285 0.2612
Onchocerca volvulus 0.0076 0.0285 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0034 0.0101 0.0261
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0018 0.0033 0.014
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0034 0.0101 0.0101
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0018 0.0032 0.0412
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0034 0.0101 0.0307
Mycobacterium ulcerans glycyl-tRNA synthetase 0.003 0.0086 0.1782
Schistosoma mansoni aspartyl-tRNA synthetase 0.0018 0.0032 0.0098
Schistosoma mansoni sugar transporter 0.0076 0.0285 0.0868
Trypanosoma brucei glucose transporter, putative 0.0168 0.0687 0.8799
Plasmodium falciparum glycine--tRNA ligase 0.0018 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0018 0.0032 0.0294
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0018 0.0032 0.0083
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0018 0.0032 0.0294
Brugia malayi Major Facilitator Superfamily protein 0.0076 0.0285 0.123
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0166 0.068 0.1024
Schistosoma mansoni lysyl-tRNA synthetase 0.0121 0.0481 0.1463
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Entamoeba histolytica hypothetical protein 0.0121 0.0481 0.4401
Echinococcus granulosus solute carrier family 22 0.0076 0.0285 0.0868
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.003 0.0086 0.0221
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0067 0.1395
Schistosoma mansoni cpg binding protein 0.0032 0.0091 0.0278
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0018 0.0032 0.0669
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0015 0.0018 0.0027
Schistosoma mansoni aspartyl-tRNA synthetase 0.0015 0.0018 0.0054
Leishmania major hypothetical protein, conserved 0.0027 0.007 0.09
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0033 0.0834
Loa Loa (eye worm) hypothetical protein 0.003 0.0086 0.0369
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0038 0.0951
Giardia lamblia Kinase, CMGC MAPK 0.0067 0.0244 0.3683
Plasmodium vivax glycine--tRNA ligase, putative 0.003 0.0086 0.0086
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.026 0.1092 0.471
Echinococcus granulosus calcium dependent protein kinase 0.0155 0.0632 0.1924
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0166 0.068 0.068
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0067 0.0244 0.3127
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.007 0.0303
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0018 0.0033 0.0298
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.003 0.0086 0.3
Mycobacterium tuberculosis Conserved hypothetical protein 0.0027 0.007 0.1749
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0166 0.0679 0.293
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0162 0.0663 0.2016
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.003 0.0086 0.0784
Plasmodium vivax replication protein A1, large subunit, putative 0.0015 0.0018 0.0018
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0166 0.068 0.068
Leishmania major aspartyl-tRNA synthetase, putative 0.0018 0.0032 0.0412
Schistosoma mansoni cpg binding protein 0.0033 0.0099 0.0302
Leishmania major protein kinase, putative 0.0166 0.0679 0.8709
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0126 0.0503 0.7586
Treponema pallidum aspartyl-tRNA synthetase 0.0018 0.0032 0.1577
Chlamydia trachomatis histidine--tRNA ligase 0.0018 0.0033 0.0676
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.026 0.1092 1
Plasmodium falciparum proline--tRNA ligase 0.0189 0.078 0.078
Plasmodium falciparum calcium-dependent protein kinase 5 0.0166 0.068 0.068
Leishmania major hypothetical protein, conserved 0.0076 0.0285 0.3657
Loa Loa (eye worm) phosphatidylinositol 3 0.0079 0.03 0.1294
Echinococcus multilocularis solute carrier family 22 0.0076 0.0285 0.0737
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0121 0.0481 1
Loa Loa (eye worm) hypothetical protein 0.0162 0.0663 0.2857
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0043 0.1082
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0043 0.0397
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0162 0.0663 0.6065
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0 0.0001
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0015 0.0018 0.0076
Giardia lamblia Hypothetical protein 0.0015 0.0018 0.0266
Plasmodium falciparum aspartate--tRNA ligase 0.0018 0.0032 0.0032
Schistosoma mansoni sugar transporter 0.0076 0.0285 0.0868
Onchocerca volvulus 0.0076 0.0285 1
Toxoplasma gondii sugar transporter ST2 0.0076 0.0285 0.043
Loa Loa (eye worm) threonyl-tRNA synthetase 0.003 0.0086 0.0369
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0043 0.0556
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0018 0.0032 0.0294
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0038 0.0793
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Mycobacterium ulcerans integral membrane transport protein 0.0076 0.0285 0.5934
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0101 0.0925
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0076 0.0285 0.7112
Brugia malayi Sars1 protein 0.0012 0.0006 0.0025
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Schistosoma mansoni sugar transporter 0.0076 0.0285 0.0868
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0169 0.0691 0.1785
Onchocerca volvulus 0.0076 0.0285 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0166 0.068 0.068
Echinococcus granulosus histidyl tRNA synthetase 0.0018 0.0033 0.0099
Trypanosoma brucei Replication factor A protein 1 0.0015 0.0018 0.0226
Loa Loa (eye worm) hypothetical protein 0.0026 0.0067 0.0289
Giardia lamblia Glycyl-tRNA synthetase 0.003 0.0086 0.1293
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0043 0.0043
Trichomonas vaginalis seryl-tRNA synthetase, putative 0.0012 0.0006 0.0025
Giardia lamblia Threonyl-tRNA synthetase 0.003 0.0086 0.1293
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0034 0.0101 0.0152
Entamoeba histolytica protein kinase, putative 0.0166 0.0679 0.622
Echinococcus granulosus Threonyl tRNA synthetase C 0.003 0.0086 0.0261
Plasmodium vivax histidine--tRNA ligase, putative 0.0018 0.0033 0.0033
Echinococcus multilocularis cpg binding protein 0.0033 0.0099 0.0256
Echinococcus multilocularis synaptic vesicle 2 protein 0.0076 0.0285 0.0737
Chlamydia trachomatis proline--tRNA ligase 0.0057 0.0203 0.4229
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0087 0.0334 0.1439
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0164
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0018 0.0032 0.0098
Brugia malayi Cam kinase protein 1 0.0166 0.0679 0.293
Trypanosoma brucei glucose transporter, putative 0.0168 0.0687 0.8799
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0018 0.0032 0.0083
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0166 0.068 0.068
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0 0.0002
Leishmania major seryl-tRNA synthetase, putative 0.0012 0.0006 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0679 0.2067
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0018 0.0032 0.0098
Loa Loa (eye worm) hypothetical protein 0.0076 0.0285 0.123
Trypanosoma cruzi hexose transporter, putative 0.0092 0.0354 0.3238
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.003 0.0086 0.0369
Plasmodium falciparum serine--tRNA ligase, putative 0.0012 0.0006 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0166 0.0679 0.293
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0166 0.0679 0.1755
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0018 0.0033 0.0298
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0034 0.0101 0.0307
Echinococcus multilocularis mitogen activated protein kinase 3 0.0067 0.0244 0.063
Echinococcus granulosus cpg binding protein 0.0033 0.0099 0.0302
Toxoplasma gondii tRNA ligase class II core domain (G, H, P, S and T) domain-containing protein 0.0012 0.0006 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trichomonas vaginalis conserved hypothetical protein 0.054 0.2319 1
Brugia malayi Sugar transporter family protein 0.054 0.2319 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0033 0.0834
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0166 0.0679 0.2067
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0018 0.0032 0.0412
Trichomonas vaginalis glucose transporter, putative 0.0168 0.0687 0.296
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0034 0.0101 0.0436
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.003 0.0086 0.0369
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.003 0.0086 0.0784
Echinococcus granulosus lysyl tRNA synthetase 0.0121 0.0481 0.1463
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.054 0.2319 0.7056
Brugia malayi glycyl-tRNA synthetase 0.003 0.0086 0.0369
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.003 0.0086 0.1098
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0018 0.0032 0.0294
Schistosoma mansoni lysyl-tRNA synthetase 0.0121 0.0481 0.1463
Brugia malayi hypothetical protein 0.0076 0.0285 0.123
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0166 0.0679 0.1755
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0285 0.123
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0015 0.0018 0.0618
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.054 0.2319 0.7056
Trypanosoma cruzi hexose transporter, putative 0.0168 0.0687 0.6285
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0247 0.0751
Schistosoma mansoni aspartyl-tRNA synthetase 0.0018 0.0032 0.0098
Onchocerca volvulus 0.0076 0.0285 1
Echinococcus multilocularis mitogen activated protein kinase 0.0067 0.0244 0.063
Leishmania major hypothetical protein, conserved 0.0027 0.007 0.09
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0067 0.1013
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0215 0.0324
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0043 0.0187
Brugia malayi Sugar transporter family protein 0.0076 0.0285 0.123
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.054 0.2319 0.7056
Echinococcus granulosus microtubule associated protein 2 0.0761 0.3287 1
Toxoplasma gondii sugar transporter ST1 0.0076 0.0285 0.043
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.026 0.1092 0.471
Trypanosoma brucei glucose transporter, putative 0.0168 0.0687 0.8799
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0087 0.0334 0.3056
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.007 0.0303
Giardia lamblia Sugar-proton symporter 0.0076 0.0285 0.4306
Echinococcus multilocularis Seryl tRNA Synthetase 0.0012 0.0006 0.0015
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0038 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0034 0.0101 0.0436
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0364 0.1549 0.4711
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0067 0.0614
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0018 0.0033 0.014
Trichomonas vaginalis sugar transporter, putative 0.0076 0.0285 0.123
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.003 0.0086 0.1293
Toxoplasma gondii facilitative glucose transporter GT1 0.054 0.2319 0.3492
Leishmania major glycyl tRNA synthetase, putative 0.0018 0.0033 0.0417
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0157 0.0477

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 103 nM Inhibition of PI3Kdelta ChEMBL. 18774713
IC50 (binding) = 138 nM Inhibition of PI3Kgamma ChEMBL. 18774713

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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