Detailed information for compound 1008493

Basic information

Technical information
  • TDR Targets ID: 1008493
  • Name: 6-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]-1-b enzofuran-4-ol
  • MW: 326.343 | Formula: C19H18O5
  • H donors: 1 H acceptors: 1 LogP: 4.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=C/c2cc(O)c3c(c2)occ3)cc(c1OC)OC
  • InChi: 1S/C19H18O5/c1-21-17-10-13(11-18(22-2)19(17)23-3)5-4-12-8-15(20)14-6-7-24-16(14)9-12/h4-11,20H,1-3H3/b5-4+
  • InChiKey: CKGOZQOFJSRSSW-SNAWJCMRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[(E)-2-(3,4,5-trimethoxyphenyl)vinyl]benzofuran-4-ol
  • 6-[(E)-2-(3,4,5-trimethoxyphenyl)vinyl]-4-benzofuranol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0075 0.1454 0.1692
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0129 0.2573 0.3051
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0049 0.0058
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0129 0.2573 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.019 0.0726
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0129 0.2573 0.3032
Loa Loa (eye worm) hypothetical protein 0.0075 0.1454 0.1692
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.1454 0.1483
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Leishmania major hypothetical protein, conserved 0.0026 0.0416 0.1607
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0519 0.0602
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0469 0.0544
Brugia malayi MH1 domain containing protein 0.0009 0.006 0.0066
Trypanosoma brucei unspecified product 0.0014 0.0168 0.0643
Onchocerca volvulus 0.0087 0.1706 0.1725
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0304 0.117
Schistosoma mansoni hypothetical protein 0.0031 0.0519 0.0616
Brugia malayi mothers against decapentaplegic homolog 3 0.0007 0.0023 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1128 0.1338
Loa Loa (eye worm) hypothetical protein 0.0075 0.1454 0.1692
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.1505 0.5845
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0084 0.1639 0.6364
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1276 0.1484
Brugia malayi MH2 domain containing protein 0.0242 0.4964 0.5787
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0304 0.0351
Echinococcus granulosus GPCR family 2 0.0031 0.0519 0.059
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0129 0.2573 1
Schistosoma mansoni smad 0.0017 0.0215 0.0255
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0215 0.0228
Schistosoma mansoni protein phosphatase 1 inhibitor potentiated by protein kinase C 0.0087 0.1706 0.2023
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0304 0.0351
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1454 0.1483
Mycobacterium leprae Probable lipase LipE 0.0075 0.1454 0.952
Echinococcus granulosus PKC activated phosphatase 1 inhibitor 0.0087 0.1706 0.2001
Entamoeba histolytica hypothetical protein 0.0076 0.1463 0.5108
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0215 0.0228
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.3545 0.3611
Echinococcus multilocularis dna polymerase eta 0.0021 0.0304 0.0334
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0023 0.0023
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0129 0.2573 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0031 0.0519 0.0602
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0941 0.0766
Mycobacterium leprae conserved hypothetical protein 0.0075 0.1454 0.952
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 0.2629
Loa Loa (eye worm) hypothetical protein 0.0087 0.1706 0.1986
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.1454 0.1701
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 0.2629
Leishmania major hypothetical protein, conserved 0.0075 0.1454 0.5645
Echinococcus multilocularis smad 0.0017 0.0215 0.0228
Schistosoma mansoni hypothetical protein 0.0031 0.0519 0.0616
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0049 0.0031
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.019 0.0726
Schistosoma mansoni hypothetical protein 0.0067 0.1276 0.1513
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.085 0.0983
Giardia lamblia DINP protein human, muc B family 0.0021 0.0304 0.117
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0049 0.0031
Brugia malayi RasGEF domain containing protein 0.0011 0.0101 0.0114
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.019 0.0198
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0129 0.2573 1
Brugia malayi hypothetical protein 0.0009 0.0049 0.0053
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.019 0.0726
Onchocerca volvulus 0.0075 0.1454 0.1467
Schistosoma mansoni protein kinase 0.0379 0.7839 0.9297
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.1454 0.1692
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0063 0.0048
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0114 0.0108
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0414 0.8575 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0416 0.1607
Schistosoma mansoni hypothetical protein 0.0407 0.8432 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0023 0.0023
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.019 0.0726
Brugia malayi hypothetical protein 0.0026 0.0416 0.0482
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0049 0.0058
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0129 0.2573 1
Brugia malayi Smad1 0.0017 0.0215 0.0247
Loa Loa (eye worm) hypothetical protein 0.0075 0.1454 0.1692
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0129 0.2573 0.3032
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.1454 0.1289
Schistosoma mansoni dishevelled 0.0014 0.0153 0.0181
Loa Loa (eye worm) hypothetical protein 0.0009 0.0049 0.0053
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.019 0.0198
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0063 0.0048
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.1128 0.1314
Brugia malayi hypothetical protein 0.0076 0.1463 0.1703
Loa Loa (eye worm) hypothetical protein 0.0098 0.1927 0.2245
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.1454 0.5645
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0129 0.2573 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.1454 0.1724
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0114 0.0108
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1189 0.141
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.019 0.0726
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.1463 0.1735
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0519 0.059
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0049 0.0031
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0129 0.2573 0.3051
Echinococcus multilocularis Smad4 0.0017 0.0215 0.0228
Loa Loa (eye worm) hypothetical protein 0.0067 0.1276 0.1484
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1128 0.1338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1128 0.1338
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0416 0.1607
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.1128 0.1314
Loa Loa (eye worm) hypothetical protein 0.006 0.1128 0.1312
Schistosoma mansoni Smad4 0.0007 0.0023 0.0027
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0129 0.2573 1
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0084 0.164 0.1923
Schistosoma mansoni hypothetical protein 0.0012 0.0114 0.0135
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.8432 1
Schistosoma mansoni DNA polymerase eta 0.0021 0.0304 0.036
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.1454 0.1289
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.085 0.0983
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0097 0.011
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.004 0.0706 0.2735
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0304 0.117
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0168 0.0643
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0519 0.059
Brugia malayi beta-lactamase family protein 0.0075 0.1454 0.1692
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.019 0.0726
Schistosoma mansoni hypothetical protein 0.0333 0.6868 0.8145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.085 0.1008
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.1128 0.1314
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.019 0.0198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.085 0.1008
Loa Loa (eye worm) Smad1 0.0017 0.0215 0.0247
Leishmania major DNA polymerase eta, putative 0.0021 0.0304 0.117
Loa Loa (eye worm) hypothetical protein 0.0009 0.0049 0.0053
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0304 0.117
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0014 0.0153 0.0133
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.1454 0.1289
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0304 0.0116
Mycobacterium tuberculosis Conserved protein 0.0075 0.1454 0.1289
Brugia malayi Isocitrate dehydrogenase 0.0015 0.019 0.0218
Brugia malayi hypothetical protein 0.0009 0.0049 0.0053
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0304 0.0351
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.1069 0.1244
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0084 0.1639 0.6364
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.1463 0.1712
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0519 0.0602
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0304 0.036
Echinococcus granulosus segment polarity protein dishevelled 0.0014 0.0153 0.0154
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0304 0.117
Brugia malayi Pre-SET motif family protein 0.006 0.1128 0.1312
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0044 0.0802 0.3449
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0304 0.0307
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0129 0.2573 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Echinococcus granulosus geminin 0.0333 0.6868 0.8139
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.01 0.0091
Echinococcus granulosus dna polymerase eta 0.0021 0.0304 0.0334
Onchocerca volvulus 0.0075 0.1454 0.1467
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0049 0.0031
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0084 0.1639 0.6364
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0084 0.164 0.1923
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0129 0.2573 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.1463 0.1712
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0084 0.164 0.1674
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.019 0.0198
Onchocerca volvulus 0.0075 0.1454 0.1467
Loa Loa (eye worm) hypothetical protein 0.0026 0.0416 0.0482
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0084 0.1639 0.6364
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.1454 0.1289
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0129 0.2573 0.3051
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.019 0.0726
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.1505 0.5845
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0084 0.164 0.191
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0129 0.2573 0.3051
Trypanosoma brucei unspecified product 0.0021 0.0304 0.117
Schistosoma mansoni smad1 5 8 and 0.0017 0.0215 0.0255
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0215 0.0228
Mycobacterium tuberculosis Conserved protein 0.0075 0.1454 0.1289
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.004 0.0706 0.082
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0049 0.0053
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0014 0.0153 0.0174
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.1454 0.1289
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0304 0.117
Echinococcus granulosus segment polarity protein dishevelled 0.0014 0.0153 0.0154
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.019 0.0198
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0129 0.2573 0.3032
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0304 0.0334
Toxoplasma gondii ABC1 family protein 0.0075 0.1454 0.5645
Brugia malayi Probable ClpP-like protease 0.0078 0.1505 0.1752
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0941 0.1092
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.1505 0.1763
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.4964 0.5787
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0379 0.7839 0.9295
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.1505 0.1785
Schistosoma mansoni hypothetical protein 0.0031 0.0519 0.0616
Entamoeba histolytica hypothetical protein 0.0076 0.1463 0.5108
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0941 0.1092
Plasmodium vivax SET domain protein, putative 0.006 0.1128 0.4377
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0084 0.164 0.1674
Brugia malayi hypothetical protein 0.0017 0.0222 0.0255
Echinococcus multilocularis cpg binding protein 0.003 0.0504 0.0571
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Leishmania major DNA polymerase kappa, putative 0.0021 0.0304 0.117
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.085 0.0987
Brugia malayi MH1 domain containing protein 0.0017 0.0215 0.0247
Trypanosoma brucei unspecified product 0.0014 0.0168 0.0643
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.085 0.0987
Mycobacterium tuberculosis Conserved protein 0.0075 0.1454 0.1289
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0044 0.0801 0.093
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0174
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1454 0.1483
Loa Loa (eye worm) hypothetical protein 0.0175 0.3545 0.4132
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0129 0.2573 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1454 0.1692
Brugia malayi MH2 domain containing protein 0.0007 0.0023 0.0023
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0063 0.0048
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0003 0.0004
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0049 0.0053
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0941 0.4744
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.1128 0.4377
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0304 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.1454 0.1483
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.085 0.0983
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0304 0.117
Loa Loa (eye worm) hypothetical protein 0.0084 0.164 0.191
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0129 0.2573 0.2998
Brugia malayi hypothetical protein 0.0087 0.1706 0.1986
Brugia malayi beta-lactamase 0.0075 0.1454 0.1692
Brugia malayi N-terminal motif family protein 0.0175 0.3545 0.4132
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0049 0.0031
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1927 0.2245
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1053 0.4085
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0801 0.0815
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0304 0.117
Schistosoma mansoni cpg binding protein 0.003 0.0504 0.0597
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0304 0.117
Schistosoma mansoni cpg binding protein 0.003 0.0504 0.0597
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0304 0.0307
Loa Loa (eye worm) DIX domain-containing protein 0.0014 0.0153 0.0174
Loa Loa (eye worm) hypothetical protein 0.0078 0.1505 0.1752
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.019 0.0198
Mycobacterium ulcerans lipase LipD 0.0075 0.1454 0.5645
Schistosoma mansoni cpg binding protein 0.0029 0.0469 0.0556
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0063 0.0048
Mycobacterium ulcerans hypothetical protein 0.0075 0.1454 0.5645
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.004 0.0706 0.2735
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0215 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1454 0.5645
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0304 0.036
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.004 0.0706 0.2735
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0304 0.117
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.019 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0304 0.0116
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 0.2629
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0379 0.7839 0.9295
Loa Loa (eye worm) RasGEF domain-containing protein 0.0011 0.0101 0.0114
Toxoplasma gondii hypothetical protein 0.0027 0.0432 0.1669
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.1505 0.1763
Schistosoma mansoni Smad4 0.0017 0.0215 0.0255
Trichomonas vaginalis esterase, putative 0.0075 0.1454 0.1483
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 0.2629
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.019 0.0726
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0084 0.1639 0.6364
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.085 0.0983
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.004 0.0706 0.2735
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.1454 0.5645
Mycobacterium ulcerans beta-lactamase 0.0075 0.1454 0.5645
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0129 0.2573 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0469 0.0544
Onchocerca volvulus 0.006 0.1128 0.1133
Onchocerca volvulus 0.0471 0.9776 1
Echinococcus granulosus cpg binding protein 0.003 0.0504 0.0571
Brugia malayi MH1 domain containing protein 0.0009 0.006 0.0066
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0129 0.2573 1
Entamoeba histolytica hypothetical protein 0.0076 0.1463 0.5108
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.1454 0.5645
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0215 0.0228
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1454 0.1483
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0304 0.117
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0519 0.059
Brugia malayi isocitrate dehydrogenase 0.0015 0.019 0.0218
Schistosoma mansoni smad 0.0007 0.0023 0.0027
Loa Loa (eye worm) hypothetical protein 0.0021 0.0304 0.0351
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1454 0.5645
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.1454 0.1692
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0416 0.1607
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.1505 0.5013
Loa Loa (eye worm) hypothetical protein 0.0075 0.1454 0.1692
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.1505 0.5845
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.1454 0.1701
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.1454 0.1289
Onchocerca volvulus 0.0029 0.0469 0.0457
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0089 0.1735 0.202
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0129 0.2573 1
Schistosoma mansoni protein kinase 0.0379 0.7839 0.9297
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0168 0.0643
Echinococcus multilocularis segment polarity protein dishevelled 0.0014 0.0153 0.0154
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0129 0.2573 0.3032
Schistosoma mansoni hypothetical protein 0.0031 0.0519 0.0616
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0063 0.0075
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.1505 0.5845
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0089 0.1735 0.202
Brugia malayi DIX domain containing protein 0.0014 0.0153 0.0174
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.1505 0.5845
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0049 0.0058
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0432 0.1669
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0519 0.059
Schistosoma mansoni dishevelled 0.0014 0.0153 0.0181
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0416 0.1607
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.1505 1
Brugia malayi MH2 domain containing protein 0.0017 0.0215 0.0247
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0304 0.117
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0129 0.2573 1
Echinococcus granulosus smad 0.0017 0.0215 0.0228
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 0.2629
Schistosoma mansoni Smad4 0.0007 0.0023 0.0027
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0416 0.1607
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.019 0.0726
Brugia malayi MH1 domain containing protein 0.0017 0.0215 0.0247
Schistosoma mansoni dep domain containing protein 0.0009 0.0049 0.0058
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Loa Loa (eye worm) histone methyltransferase 0.0011 0.01 0.0113
Brugia malayi Pre-SET motif family protein 0.0414 0.8575 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.0519 0.059
Echinococcus granulosus Smad4 0.0017 0.0215 0.0228
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0304 0.117
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1927 0.2245
Plasmodium vivax hypothetical protein, conserved 0.0075 0.1454 0.5645
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.1454 0.1724
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.4964 0.5787
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0304 0.0334
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0049 0.0053
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.004 0.0706 0.2735
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0129 0.2573 1
Echinococcus multilocularis geminin 0.0333 0.6868 0.8139
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.019 0.0218
Brugia malayi beta-lactamase family protein 0.0075 0.1454 0.1692
Entamoeba histolytica hypothetical protein 0.0076 0.1463 0.5108
Echinococcus granulosus dna polymerase kappa 0.0021 0.0304 0.0334
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Loa Loa (eye worm) beta-lactamase 0.0075 0.1454 0.1692
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.1454 0.1289
Schistosoma mansoni hypothetical protein 0.0076 0.1463 0.1735
Echinococcus multilocularis segment polarity protein dishevelled 0.0014 0.0153 0.0154
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.1128 0.1338
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0215 0.0247
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1927 0.2245
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.01 0.0091
Toxoplasma gondii hypothetical protein 0.0009 0.0049 0.0178
Brugia malayi MH2 domain containing protein 0.0017 0.0215 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Echinococcus multilocularis PKC activated phosphatase 1 inhibitor 0.0087 0.1706 0.2001
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0215 0.0255
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0084 0.164 0.191
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0519 0.0602
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0044 0.0802 0.0624
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0129 0.2573 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0049 0.0031
Trichomonas vaginalis set domain proteins, putative 0.0471 0.9776 1
Loa Loa (eye worm) nuclear factor I 0.0009 0.006 0.0066
Echinococcus granulosus dnaJ subfamily B 0.0407 0.8432 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0168 0.0643
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0416 0.1607
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.1505 0.5845
Schistosoma mansoni smad1 5 8 and 0.0017 0.0215 0.0255
Schistosoma mansoni smad1 5 8 and 0.0017 0.0215 0.0255
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0941 0.0766
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.085 0.1008
Onchocerca volvulus 0.0009 0.0049 0.0026
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0432 0.1669
Schistosoma mansoni hypothetical protein 0.0333 0.6868 0.8145
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0416 0.1607

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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