Detailed information for compound 102388

Basic information

Technical information
  • TDR Targets ID: 102388
  • Name: (4S)-4-[[(2S)-2-acetamido-4-hydroxy-4-oxobuta noyl]amino]-5-[[(2S)-1-[[(2S)-6-amino-1-[[(2S )-3-cyclohexyl-1-[[(2R)-1-hydroxy-1-oxo-3-sul fanylpropan-2-yl]amino]-1-oxopropan-2-yl]amin o]-1-oxohexan-2-yl]amino]-1-oxo-3,3-diphenylp ropan-2-yl]amino]-5-oxopentanoic acid
  • MW: 912.06 | Formula: C44H61N7O12S
  • H donors: 10 H acceptors: 12 LogP: 0.07 Rotable bonds: 33
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CS)CC1CCCCC1)NC(=O)[C@H](C(c1ccccc1)c1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(=O)O)CCC(=O)O
  • InChi: 1S/C44H61N7O12S/c1-26(52)46-33(24-36(55)56)42(60)47-31(20-21-35(53)54)40(58)51-38(37(28-15-7-3-8-16-28)29-17-9-4-10-18-29)43(61)48-30(19-11-12-22-45)39(57)49-32(23-27-13-5-2-6-14-27)41(59)50-34(25-64)44(62)63/h3-4,7-10,15-18,27,30-34,37-38,64H,2,5-6,11-14,19-25,45H2,1H3,(H,46,52)(H,47,60)(H,48,61)(H,49,57)(H,50,59)(H,51,58)(H,53,54)(H,55,56)(H,62,63)/t30-,31-,32-,33-,34-,38-/m0/s1
  • InChiKey: MMHRSDHCRGNWNY-PHPRXEDMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4S)-4-[[(2S)-2-acetamido-4-hydroxy-4-oxo-butanoyl]amino]-5-[[(1S)-1-[[(1S)-5-amino-1-[[(1S)-1-(cyclohexylmethyl)-2-[[(1R)-2-hydroxy-2-oxo-1-(sulfanylmethyl)ethyl]amino]-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]-2,2-diphenyl-ethyl]amino]-5-oxo-pentanoic acid
  • (4S)-4-[[(2S)-2-acetamido-4-hydroxy-1,4-dioxobutyl]amino]-5-[[(1S)-1-[[[(1S)-5-amino-1-[[[(1S)-1-(cyclohexylmethyl)-2-[[(1R)-2-hydroxy-1-(mercaptomethyl)-2-oxoethyl]amino]-2-oxoethyl]amino]-oxomethyl]pentyl]amino]-oxomethyl]-2,2-diphenylethyl]amino]-5-oxopentanoic acid
  • (4S)-4-[[(2S)-2-acetamido-4-hydroxy-4-oxo-butanoyl]amino]-5-[[(2S)-1-[[(2S)-6-azanyl-1-[[(2S)-3-cyclohexyl-1-[[(2R)-1-hydroxy-1-oxo-3-sulfanyl-propan-2-yl]amino]-1-oxo-propan-2-yl]amino]-1-oxo-hexan-2-yl]amino]-1-oxo-3,3-diphenyl-propan-2-yl]amino]-5-oxo-pentanoic acid
  • (4S)-4-[[(2S)-2-acetamido-4-hydroxy-4-keto-butanoyl]amino]-5-[[(1S)-1-[[(1S)-5-amino-1-[[(1S)-1-(cyclohexylmethyl)-2-[[(1R)-2-hydroxy-2-keto-1-(mercaptomethyl)ethyl]amino]-2-keto-ethyl]carbamoyl]pentyl]carbamoyl]-2,2-diphenyl-ethyl]amino]-5-keto-valeric acid
  • (4S)-4-[[(2S)-2-acetamido-4-hydroxy-4-oxobutanoyl]amino]-5-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-3-cyclohexyl-1-[[(2R)-1-hydroxy-1-oxo-3-sulfanylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxo-3,3-di(phenyl)propan-2-yl]amino]-5-oxopentanoic acid
  • (4S)-4-[[(2S)-2-acetamido-4-hydroxy-4-oxo-butanoyl]amino]-5-[[(1S)-1-[[(1S)-5-amino-1-[[(1S)-1-(cyclohexylmethyl)-2-[[(1R)-2-hydroxy-2-oxo-1-(sulfanylmethyl)ethyl]amino]-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]-2,2-di(phenyl)ethyl]amino]-5-oxo-pentanoic acid
  • (4S)-4-[[(2S)-2-acetamido-4-hydroxy-1,4-dioxobutyl]amino]-5-[[(1S)-1-[[[(1S)-5-amino-1-[[[(1S)-1-(cyclohexylmethyl)-2-[[(1R)-2-hydroxy-1-(mercaptomethyl)-2-oxoethyl]amino]-2-oxoethyl]amino]-oxomethyl]pentyl]amino]-oxomethyl]-2,2-di(phenyl)ethyl]amino]-5-oxopentanoic acid
  • (4S)-4-[[(2S)-2-acetamido-4-hydroxy-4-keto-butanoyl]amino]-5-[[(1S)-1-[[(1S)-5-amino-1-[[(1S)-1-(cyclohexylmethyl)-2-[[(1R)-2-hydroxy-2-keto-1-(mercaptomethyl)ethyl]amino]-2-keto-ethyl]carbamoyl]pentyl]carbamoyl]-2,2-di(phenyl)ethyl]amino]-5-keto-valeric acid
  • (4S)-4-[[(2S)-2-acetamido-4-hydroxy-4-oxo-butanoyl]amino]-5-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-3-cyclohexyl-1-[[(2R)-1-hydroxy-1-oxo-3-sulfanyl-propan-2-yl]amino]-1-oxo-propan-2-yl]amino]-1-oxo-hexan-2-yl]amino]-1-oxo-3,3-di(phenyl)propan-2-yl]amino]-5-oxo-pentanoic acid
  • AIDS-106184
  • AIDS106184
  • AcAsp-Glu-Dif(3,3-diphenylalanine)-Lys-Cha-(beta-cyclohexylalanine)-Cys
  • (R)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Acetylamino-3-carboxy-propanoylamino)-4-carboxy-butanoylamino]-3,3-diphenyl-propanoylamino}-6-amino-hexanoylamino)-3-cyclohexyl-propanoylamino]-3-mercapto-propionic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Hepatitis C virus Hepatitis C virus NS3 protease/helicase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia Translation initiation factor eIF-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium falciparum eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum Eukaryotic initiation factor 4A-III, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium vivax RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus granulosus eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Theileria parva RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Treponema pallidum ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus granulosus eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum ATP-dependent RNA helicase eIF4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Toxoplasma gondii eukaryotic initiation factor-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania donovani Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium yoelii RNA helicase-1 Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma congolense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Entamoeba histolytica DEAD/DEAH box helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium berghei eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Cryptosporidium hominis eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei gambiense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium knowlesi eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Onchocerca volvulus Eukaryotic initiation factor 4A homolog Get druggable targets OG5_126984 All targets in OG5_126984
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum Eukaryotic initiation factor 4A-II, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania braziliensis eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Cryptosporidium parvum eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Babesia bovis eukaryotic translation initiation factor 4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania mexicana Get druggable targets OG5_126984 All targets in OG5_126984
Neospora caninum DEAD-box ATP-dependent RNA helicase 34 (EC 3.6.1.-), related Get druggable targets OG5_126984 All targets in OG5_126984
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) Get druggable targets OG5_126984 All targets in OG5_126984
Brugia malayi eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0048 0.022 0.0389
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0512 0.0905
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0048 0.022 0.1263
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0039 0.0433
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.1741 1
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0048 0.022 0.7275
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0765 0.2746
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0061 0.0302 0.1736
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0046
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0091
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0312 0.1797
Loa Loa (eye worm) hypothetical protein 0.0042 0.0182 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.017 0.0299
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0053 0.0303
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0048 0.022 0.7275
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0047
Brugia malayi ecdysteroid receptor 0.004 0.017 0.0301
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0109
Entamoeba histolytica hypothetical protein 0.0112 0.0615 1
Leishmania major pantothenate kinase subunit, putative 0.0013 0.0004 0.0021
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0028 0.0921
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0066
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0061 0.0302 1
Onchocerca volvulus 0.0042 0.0182 0.2641
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.017 0.0612
Brugia malayi Muscleblind-like protein 0.0152 0.0865 0.153
Loa Loa (eye worm) hypothetical protein 0.0036 0.0144 0.0253
Plasmodium falciparum glutathione reductase 0.0037 0.0149 0.4941
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0302 1
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0182 0.1145
Echinococcus multilocularis musashi 0.0028 0.0094 0.0094
Brugia malayi beta-lactamase 0.0042 0.0182 0.0322
Echinococcus granulosus survival motor neuron protein 1 0.0461 0.2786 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.017 0.0301
Mycobacterium tuberculosis Conserved protein 0.0042 0.0182 0.1145
Schistosoma mansoni hypothetical protein 0.0039 0.0165 0.095
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0182 0.1048
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0182 0.1145
Brugia malayi beta-lactamase family protein 0.0042 0.0182 0.0322
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0094 0.0164
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0053 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0063 0.0717
Onchocerca volvulus Bile acid receptor homolog 0.004 0.017 0.246
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.017 0.098
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0028 0.016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0066
Loa Loa (eye worm) hypothetical protein 0.0048 0.022 0.0387
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0182 0.1145
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0039 0.0039
Echinococcus granulosus GA binding protein alpha chain 0.0077 0.0401 0.1438
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0028 0.0028
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.003 0.0104 0.06
Brugia malayi nuclear hormone receptor 0.004 0.017 0.0301
Trypanosoma brucei inositol phosphorylceramide synthase 0.0048 0.022 0.1263
Schistosoma mansoni cpg binding protein 0.0031 0.0116 0.0667
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0066
Brugia malayi Ets-domain containing protein 0.0077 0.0401 0.0709
Onchocerca volvulus 0.0042 0.0182 0.2641
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0063 0.0717
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0293 0.1738 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.017 0.0299
Brugia malayi nuclear receptor RXR 0.0019 0.0039 0.0068
Echinococcus multilocularis protein dispatched 1 0.0047 0.021 0.021
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0121 0.0758
Brugia malayi hypothetical protein 0.0119 0.0661 0.117
Schistosoma mansoni ap endonuclease 0.0061 0.0302 0.1739
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0299
Mycobacterium tuberculosis Probable reductase 0.0084 0.0442 0.2779
Echinococcus multilocularis protein patched 0.0041 0.0174 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.022 0.7275
Entamoeba histolytica hypothetical protein 0.0048 0.022 0.2841
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0299
Entamoeba histolytica hypothetical protein 0.0048 0.022 0.2841
Echinococcus granulosus intermediate filament protein 0.0028 0.0094 0.0338
Treponema pallidum ATP-dependent RNA helicase 0.003 0.0104 0.3448
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0048 0.022 0.0389
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0024 0.0043
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0174 0.0306
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0024 0.0043
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0442 0.867
Loa Loa (eye worm) hypothetical protein 0.0027 0.0091 0.0159
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0053 0.0093
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0182 0.0322
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0013 0.0004 0.0021
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0144 0.0827
Loa Loa (eye worm) glutathione reductase 0.0037 0.0149 0.0262
Echinococcus granulosus lamin dm0 0.0028 0.0094 0.0338
Echinococcus multilocularis lamin 0.0028 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0066
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0014 0.0024
Onchocerca volvulus 0.0042 0.0182 0.2641
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0182 0.1145
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0028 0.0047
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0028 0.0921
Brugia malayi hypothetical protein 0.0021 0.0053 0.0093
Entamoeba histolytica hypothetical protein 0.0112 0.0615 1
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0048 0.022 0.022
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0765 0.0765
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0063 0.0112
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0322 0.1854
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0782 0.4493
Loa Loa (eye worm) hypothetical protein 0.0048 0.022 0.0387
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0053 0.0303
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.017 0.017
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0177 0.1015
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0248 0.0438
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0028 0.016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0293 0.1738 0.6239
Mycobacterium ulcerans beta-lactamase 0.0042 0.0182 0.2072
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.017 0.098
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0039 0.0222
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0066
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0299
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0063 0.0717
Schistosoma mansoni survival motor neuron protein 0.0094 0.0505 0.2907
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0028 0.0921
Echinococcus multilocularis geminin 0.0171 0.098 0.098
Brugia malayi Inositol-1 0.0036 0.0144 0.0255
Schistosoma mansoni zinc finger protein 0.0019 0.0039 0.0222
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0039 0.0066
Schistosoma mansoni hypothetical protein 0.0039 0.0165 0.095
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.017 0.0301
Brugia malayi beta-lactamase family protein 0.0042 0.0182 0.0322
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0299
Echinococcus multilocularis eukaryotic initiation factor 4A 0.003 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0091
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.017 0.0612
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.017 0.098
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0066
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0144 0.4762
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.017 0.098
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0048 0.022 0.1263
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0109
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0144 0.0827
Brugia malayi Fli-1 protein 0.0235 0.1378 0.2438
Loa Loa (eye worm) steroid hormone receptor 0.004 0.017 0.0299
Schistosoma mansoni hypothetical protein 0.0171 0.098 0.5637
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.003 0.0104 0.0599
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.017 0.0301
Schistosoma mansoni nuclear receptor 0.0019 0.0039 0.0222
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0288 0.327
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0233 0.1337
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0024 0.0024
Brugia malayi hypothetical protein 0.0019 0.0039 0.0068
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0182 0.032
Entamoeba histolytica hypothetical protein 0.0112 0.0615 1
Schistosoma mansoni hypothetical protein 0.0039 0.0165 0.095
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0028 0.016
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.0333 0.1194
Schistosoma mansoni hypothetical protein 0.0112 0.0615 0.3539
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.05 0.3145
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0053 0.0189
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0299
Entamoeba histolytica hypothetical protein 0.0048 0.022 0.2841
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0182 0.1145
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0144 0.0255
Echinococcus multilocularis expressed conserved protein 0.0089 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0066
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.017 0.098
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0333 0.1914
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0615 0.0615
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.017 0.0301
Echinococcus granulosus sphingomyelin synthase protein 1 0.0048 0.022 0.0789
Toxoplasma gondii exonuclease III APE 0.0061 0.0302 1
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0028 0.016
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0063 0.0362
Loa Loa (eye worm) hypothetical protein 0.0119 0.0661 0.1168
Mycobacterium ulcerans lipase LipD 0.0042 0.0182 0.2072
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0061 0.0302 0.1736
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0094 0.0167
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.017 0.017
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0333 0.1914
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.017 0.0301
Brugia malayi CXXC zinc finger family protein 0.003 0.0105 0.0187
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0302 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0039 0.0068
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0004 0.0004
Toxoplasma gondii hypothetical protein 0.0048 0.022 0.7275
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0027 0.017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0293 0.1738 0.6239
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0293 0.1738 0.3074
Loa Loa (eye worm) hypothetical protein 0.0048 0.022 0.0387
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0063 0.0112
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0442 0.2779
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.017 0.0612
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0046
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0149 0.0262
Plasmodium vivax sphingomyelin synthase 2, putative 0.0048 0.022 0.7275
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0299
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0046
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0039 0.0068
Leishmania major hypothetical protein, conserved 0.0017 0.0028 0.016
Loa Loa (eye worm) hypothetical protein 0.0048 0.022 0.0387
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0048 0.022 0.1263
Echinococcus granulosus eukaryotic initiation factor 4A 0.003 0.0104 0.0374
Onchocerca volvulus 0.004 0.017 0.246
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.017 0.0301
Schistosoma mansoni hypothetical protein 0.0036 0.0144 0.0829
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0061 0.0302 0.19
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0039 0.0066
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0182 0.6028
Loa Loa (eye worm) hypothetical protein 0.0042 0.0182 0.032
Brugia malayi Ets-domain containing protein 0.0077 0.0401 0.0709
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.017 0.0612
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.003 0.0104 0.0746
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0152 0.0547
Brugia malayi hypothetical protein 0.0461 0.2786 0.4929
Mycobacterium tuberculosis Conserved protein 0.0042 0.0182 0.1145
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.017 0.0301
Loa Loa (eye worm) hypothetical protein 0.0042 0.0182 0.032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.017 0.017
Echinococcus granulosus muscleblind protein 0.0152 0.0865 0.3104
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0027 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0248 0.0438
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.003 0.0104 0.0104
Brugia malayi jmjC domain containing protein 0.0017 0.0028 0.0049
Brugia malayi nuclear hormone receptor 0.0019 0.0039 0.0068
Mycobacterium ulcerans hypothetical protein 0.0042 0.0182 0.2072
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.017 0.0612
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0104 0.3448
Toxoplasma gondii ABC1 family protein 0.0042 0.0182 0.6028
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0174 0.0626
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0039 0.0039
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0039 0.0039
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.0322 0.1157
Onchocerca volvulus 0.003 0.0105 0.1461
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0017 0.0024 0.0139
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.017 0.098
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0063 0.0396
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0039 0.0222
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.0322 0.0322
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0063 0.0717
Brugia malayi CHE-14 protein 0.0041 0.0174 0.0308
Schistosoma mansoni hypothetical protein 0.0017 0.0024 0.0139
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0182 0.0654
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0615 0.2208
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0039 0.0138
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.003 0.0104 0.3448
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0149 0.4941
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0306
Echinococcus granulosus cpg binding protein 0.0031 0.0116 0.0416
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0027 0.0308
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0063 0.0362
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0021 0.0134
Onchocerca volvulus 0.0023 0.0063 0.081
Onchocerca volvulus 0.0019 0.0039 0.0433
Leishmania major eukaryotic initiation factor 4a, putative 0.003 0.0104 0.0599
Echinococcus multilocularis survival motor neuron protein 1 0.0461 0.2786 0.2786
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0288 0.1655
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.017 0.0612
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.017 0.0301
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0039 0.0138
Treponema pallidum exodeoxyribonuclease (exoA) 0.0061 0.0302 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0028 0.016
Loa Loa (eye worm) hypothetical protein 0.0152 0.0865 0.1528
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0066
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0094 0.0164
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.05 0.3145
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0182 0.1145
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0004 0.0016
Brugia malayi Cytochrome P450 family protein 0.0023 0.0064 0.0113
Schistosoma mansoni patched 1 0.0041 0.0174 0.1003
Brugia malayi hypothetical protein 0.0112 0.0615 0.1089
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0039 0.0138
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.1741 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.2786 0.4928
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0512 0.0512
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.017 0.246
Giardia lamblia Translation initiation factor eIF-4A, putative 0.003 0.0104 0.3448
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0048 0.022 0.7275
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0182 0.6028
Schistosoma mansoni cpg binding protein 0.0031 0.0116 0.0667
Schistosoma mansoni intermediate filament proteins 0.0028 0.0094 0.0542
Onchocerca volvulus Huntingtin homolog 0.0119 0.0661 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.017 0.017
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0048 0.022 0.7275
Schistosoma mansoni cpg binding protein 0.003 0.0105 0.0607
Entamoeba histolytica hypothetical protein 0.0048 0.022 0.2841
Brugia malayi intermediate filament protein 0.0028 0.0094 0.0167
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.017 0.0612
Plasmodium falciparum eukaryotic initiation factor 4A 0.003 0.0104 0.3448
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0061 0.0302 0.4333
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0505 0.0894
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0038 0.0138
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0182 0.6028
Plasmodium vivax RNA helicase-1, putative 0.003 0.0104 0.3448
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0039 0.0068
Brugia malayi hypothetical protein 0.0021 0.0053 0.0093
Echinococcus granulosus FTZ F1 alpha 0.004 0.017 0.0612
Loa Loa (eye worm) hypothetical protein 0.0042 0.0182 0.032
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0299
Loa Loa (eye worm) hypothetical protein 0.0042 0.0182 0.032
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0061 0.0302 0.1085
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0182 0.1047
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0064 0.0111
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.003 0.0104 0.0599
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0182 0.6028
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0271 0.8951
Toxoplasma gondii hypothetical protein 0.0047 0.0214 0.7092
Echinococcus multilocularis muscleblind protein 1 0.0152 0.0865 0.0865
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0028 0.016
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.1741 1
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0028 0.01
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0048 0.022 0.1263
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0182 0.2072
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0521 0.2995
Echinococcus multilocularis GA binding protein alpha chain 0.0077 0.0401 0.0401
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0293 0.1738 0.3075
Schistosoma mansoni ets-related 0.0235 0.1378 0.7926
Echinococcus granulosus lamin 0.0028 0.0094 0.0338
Schistosoma mansoni lamin 0.0028 0.0094 0.0542
Brugia malayi jmjC domain containing protein 0.0017 0.0028 0.0049
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0048 0.022 0.0389
Schistosoma mansoni nuclear hormone receptor 0.004 0.017 0.098
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0048 0.022 0.7275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.017 0.0299
Entamoeba histolytica hypothetical membrane-spanning protein 0.0048 0.022 0.2841
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0104 0.3448
Loa Loa (eye worm) hypothetical protein 0.0048 0.022 0.0387
Onchocerca volvulus Huntingtin homolog 0.0119 0.0661 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0039 0.0138
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0061 0.0302 1
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.003 0.0104 0.0655
Schistosoma mansoni hypothetical protein 0.0171 0.098 0.5637
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0293 0.1738 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0152 0.0152
Brugia malayi jmjC domain containing protein 0.0017 0.0028 0.0049
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.003 0.0104 0.1443
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0174 0.0174
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0182 0.1047
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0182 0.1048
Schistosoma mansoni thyroid hormone receptor 0.004 0.017 0.098
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0039 0.0433
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0048 0.022 0.1263
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0039 0.0068
Plasmodium falciparum thioredoxin reductase 0.0037 0.0149 0.4941
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0288 0.1033
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0269 0.1591 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0144 0.4762
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0014 0.0022
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0182 0.1145
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0024 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.017 0.0301
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0021 0.0134
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0144 0.0827
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0061 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0091
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0288 0.327
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0288 0.327
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0061 0.0302 0.1736
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0923 0.5652 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0182 0.2072
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0322 0.0322
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0302 1
Echinococcus multilocularis GPCR, family 2 0.0017 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.017 0.0299
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0782 0.4493
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0024 0.0024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0302 1
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0027 0.0896
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.003 0.0104 0.0599
Brugia malayi ecdysone receptor 0.0019 0.0039 0.0068
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0028 0.0047
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0177 0.1015
Loa Loa (eye worm) hypothetical protein 0.003 0.0104 0.0182
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0293 0.1738 0.1738
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0039 0.0039
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0039 0.0138
Loa Loa (eye worm) hypothetical protein 0.0119 0.0661 0.1168
Loa Loa (eye worm) hypothetical protein 0.0152 0.0865 0.1528
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0442 0.2779
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0048 0.022 0.1263
Plasmodium vivax glutathione reductase, putative 0.0037 0.0149 0.4941
Trichomonas vaginalis esterase, putative 0.0042 0.0182 0.6028
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0144 0.4762
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0028 0.016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0046
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.1741 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0182 0.6028
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0039 0.0222
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0024 0.0087
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0288 0.1655
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0039 0.0068
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0028 0.0028
Onchocerca volvulus 0.0094 0.0505 0.7606
Loa Loa (eye worm) hypothetical protein 0.0923 0.5652 1
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.017 0.0301
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.017 0.0612
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0182 0.1047
Toxoplasma gondii thioredoxin reductase 0.0037 0.0149 0.4941
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0615 0.3539
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0288 0.0288
Brugia malayi Steroid receptor seven-up type 2 0.004 0.017 0.0301
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0066
Onchocerca volvulus 0.0019 0.0039 0.0433
Schistosoma mansoni hypothetical protein 0.0017 0.0024 0.0139
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0442 0.2779
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0039 0.0138
Brugia malayi nuclear receptor RXR 0.0021 0.0053 0.0093
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0028 0.01
Loa Loa (eye worm) hypothetical protein 0.0028 0.0094 0.0164
Schistosoma mansoni ap endonuclease 0.0061 0.0302 0.1739
Brugia malayi glutathione reductase 0.0037 0.0149 0.0264
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0144 0.4762
Brugia malayi tailless protein 0.0019 0.0039 0.0068
Onchocerca volvulus 0.0028 0.0094 0.1288
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0039 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0091
Entamoeba histolytica hypothetical protein 0.0048 0.022 0.2841
Loa Loa (eye worm) hypothetical protein 0.0053 0.0248 0.0436
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0061 0.0302 0.3437
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0104 0.3448
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0028 0.0028
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0144 0.1465
Echinococcus granulosus expressed conserved protein 0.0089 0.0476 0.1707
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.017 0.017
Brugia malayi eukaryotic initiation factor 4A 0.003 0.0104 0.0184
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0177 0.1015
Loa Loa (eye worm) fli-1 protein 0.0235 0.1378 0.2436
Schistosoma mansoni inositol monophosphatase 0.0036 0.0144 0.0828
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0144 0.1637
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.017 0.0301
Trypanosoma brucei trypanothione reductase 0.0037 0.0149 0.0858
Mycobacterium ulcerans hypothetical protein 0.0023 0.0063 0.0717
Leishmania major trypanothione reductase 0.0037 0.0149 0.0858
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0288 0.9516
Echinococcus multilocularis muscleblind protein 0.0152 0.0865 0.0865
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0048 0.022 0.0389
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.017 0.098
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0248 0.0436
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0066
Brugia malayi exodeoxyribonuclease III family protein 0.0061 0.0302 0.0535
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.017 0.017
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0063 0.0717
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0121 0.1315
Schistosoma mansoni nuclear receptor 0.0019 0.0039 0.0222
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0144 0.4762
Schistosoma mansoni gabp alpha 0.0077 0.0401 0.2305
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0149 0.0858
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0299
Brugia malayi nuclear receptor NHR-67 0.0019 0.0039 0.0068
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.003 0.0104 0.06
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0053 0.0091
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0046
Leishmania major hypothetical protein, conserved 0.0042 0.0182 0.1047
Schistosoma mansoni inositol monophosphatase 0.0036 0.0144 0.0828
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.088 0.5528
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0288 0.1808
Schistosoma mansoni hypothetical protein 0.0094 0.0505 0.2907
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0182 0.6028
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0144 0.0827
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0061 0.0302 0.1736
Brugia malayi jmjC domain containing protein 0.0066 0.0333 0.0589
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0442 0.2779
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0182 0.2725
Brugia malayi jmjC domain containing protein 0.0065 0.0322 0.057
Echinococcus granulosus eukaryotic initiation factor 4A III 0.003 0.0104 0.0374
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0039 0.0068
Echinococcus granulosus GPCR family 2 0.0017 0.0024 0.0087
Loa Loa (eye worm) inositol-1 0.0036 0.0144 0.0252
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0048 0.022 0.7275
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0144 0.0517
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0512 0.8122
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0063 0.0112
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0442 0.2779
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.017 0.017
Loa Loa (eye worm) DR-78 0.0019 0.0039 0.0066
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.017 0.0301
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0105 0.0184
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0063 0.0362
Brugia malayi steroid hormone receptor 0.004 0.017 0.0301
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.017 0.0301
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.017 0.017
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0063 0.0396
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.017 0.0301
Schistosoma mansoni thyroid hormone receptor 0.004 0.017 0.098
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0021 0.0134
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0039 0.0222
Mycobacterium leprae Probable lipase LipE 0.0042 0.0182 0.2725
Brugia malayi nuclear receptor NHR-88 0.0019 0.0039 0.0068
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0182 0.0182
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0028 0.0047
Loa Loa (eye worm) hypothetical protein 0.0042 0.0182 0.032
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0039 0.0222
Echinococcus multilocularis cpg binding protein 0.0031 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0091
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0063 0.0717
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.017 0.0299
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.017 0.0301
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0288 0.1652
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0048 0.022 0.7275
Mycobacterium tuberculosis Conserved protein 0.0042 0.0182 0.1145
Schistosoma mansoni coup transcription factor 0.004 0.017 0.098
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0028 0.01
Brugia malayi nuclear receptor NHR-88 0.004 0.017 0.0301
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0293 0.1738 0.1738
Trichomonas vaginalis hypothetical protein 0.0048 0.022 0.7275
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0333 0.0587
Loa Loa (eye worm) hypothetical protein 0.0066 0.0331 0.0584
Brugia malayi jmjC domain containing protein 0.0017 0.0028 0.0049
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.017 0.098
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0063 0.0717
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.05 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0077 0.0401 0.0707
Loa Loa (eye worm) hypothetical protein 0.005 0.0231 0.0407
Plasmodium vivax sphingomyelin synthase 1, putative 0.0048 0.022 0.7275
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0027 0.0896
Brugia malayi Sphingomyelin synthase-related 1 0.0048 0.022 0.0389
Schistosoma mansoni spingomyelin synthetase-related 0.0048 0.022 0.1265
Mycobacterium ulcerans hypothetical protein 0.0154 0.088 1
Loa Loa (eye worm) beta-lactamase 0.0042 0.0182 0.032
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0174 0.0626
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0061 0.0302 0.0533
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0021 0.0134
Echinococcus multilocularis lamin dm0 0.0028 0.0094 0.0094
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0028 0.016
Schistosoma mansoni hypothetical protein 0.0017 0.0024 0.0139
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0782 0.4493
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0512 0.1836
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0144 0.0144
Echinococcus multilocularis FTZ F1 alpha 0.004 0.017 0.017
Echinococcus granulosus geminin 0.0171 0.098 0.3517
Onchocerca volvulus 0.0028 0.0094 0.1288
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0177 0.1015
Brugia malayi conserved hypotetical protein 0.0019 0.0039 0.0068
Loa Loa (eye worm) hypothetical protein 0.0095 0.0512 0.0903
Schistosoma mansoni lamin 0.0028 0.0094 0.0542
Schistosoma mansoni hypothetical protein 0.0039 0.0165 0.095
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.017 0.098
Leishmania major eukaryotic initiation factor 4a, putative 0.003 0.0104 0.0599
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0039 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0293 0.1738 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0047
Plasmodium vivax JmjC domain containing protein 0.0017 0.0028 0.0921
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0053 0.0093
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0109
Echinococcus granulosus phd:f box containing protein 0.0017 0.0028 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.017 0.0299
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.017 0.0299
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0149 0.0939
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0028 0.0028
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.05 0.3145
Entamoeba histolytica hypothetical protein 0.0112 0.0615 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0174 0.5766
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.004
Brugia malayi Thioredoxin reductase 0.0037 0.0149 0.0264
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.017 0.246
Brugia malayi hypothetical protein 0.0019 0.0039 0.0068

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 8 % Inhibitory activity of the compound against hepatitis C virus (HCV) NS3 protease (isolated domain) at a concentration of 6 microM ChEMBL. 11206459
Inhibition (binding) = 8 % Inhibitory activity of the compound against hepatitis C virus (HCV) NS3 protease (isolated domain) at a concentration of 6 microM ChEMBL. 11206459
Ki (binding) = 1.24 uM Inhibitory activity against hepatitis C virus (HCV) NS3 protease (full-length) ChEMBL. 11206459
Ki (binding) = 1.24 uM Inhibitory activity against hepatitis C virus (HCV) NS3 protease (full-length) ChEMBL. 11206459

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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