Detailed information for compound 1025509

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 345.35 | Formula: C17H19N3O5
  • H donors: 0 H acceptors: 4 LogP: 2.89 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)/C=C/C(=O)OC(Cn1c(C)ncc1[N+](=O)[O-])C
  • InChi: 1S/C17H19N3O5/c1-12(11-19-13(2)18-10-16(19)20(22)23)25-17(21)8-7-14-5-4-6-15(9-14)24-3/h4-10,12H,11H2,1-3H3/b8-7+
  • InChiKey: QQWDJYBYQDDECJ-BQYQJAHWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli 3-oxoacyl-[acyl-carrier-protein] synthase III Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Chlamydia trachomatis oxoacyl-ACP synthase III Get druggable targets OG5_129509 All targets in OG5_129509
Neospora caninum 3-oxoacyl-(acyl-carrier-protein) synthase III family protein, putative Get druggable targets OG5_129509 All targets in OG5_129509
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) Get druggable targets OG5_129509 All targets in OG5_129509
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
Mycobacterium ulcerans 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
Plasmodium berghei apicoplast beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Mycobacterium ulcerans beta-ketoacyl synthase-like protein Get druggable targets OG5_129509 All targets in OG5_129509
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Plasmodium falciparum beta-ketoacyl-ACP synthase III Get druggable targets OG5_129509 All targets in OG5_129509
Mycobacterium ulcerans 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Conserved hypothetical protein 3-oxoacyl-[acyl-carrier-protein] synthase III 317 aa 265 aa 26.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0067 0.0132
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0241 0.0518
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.0987 0.1951
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0016 0.0027
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.058 0.058
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0383 0.4032 1
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0118 0.0118
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0549 0.0549
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0118 0.0248
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0016 0.0077 0.0032
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0183 0.0294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0118 0.0248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0004 0.0004
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0031 0.009
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0183 0.0379
Mycobacterium tuberculosis Probable reductase 0.0101 0.0987 0.1951
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0021
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0027
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0031 0.0031
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0838 0.1945
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0558 0.0558
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0012 0.0031 0.006
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.1609 0.3181
Plasmodium falciparum thioredoxin reductase 0.0044 0.0378 0.0784
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0709 0.1402
Schistosoma mansoni flap endonuclease-1 0.0023 0.0154 0.0444
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0314 0.1258
Onchocerca volvulus 0.0296 0.3097 0.5913
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0181 0.0287
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0304 0.0753
Echinococcus granulosus geminin 0.0331 0.347 0.347
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1388 0.1388
Echinococcus granulosus expressed protein 0.0012 0.0031 0.0031
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0031 0.0031
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0067 0.0142
Schistosoma mansoni DNA polymerase eta 0.0016 0.0077 0.0221
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0558 0.1102
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0383 0.4032 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0558 0.1383
Echinococcus granulosus tar DNA binding protein 0.0064 0.0591 0.0591
Entamoeba histolytica serine/threonine protein kinase, putative 0.0198 0.2032 1
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0067 0.0128
Onchocerca volvulus 0.0048 0.0425 0.0805
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0118 0.0248
Plasmodium falciparum flap endonuclease 1 0.0026 0.0181 0.0287
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0012 0.0031 0.0031
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0569 0.1641
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0031 0.006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.1076 0.1076
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0241 0.0518
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0439 0.2035
Schistosoma mansoni hypothetical protein 0.0012 0.0028 0.0082
Echinococcus granulosus flap endonuclease 1 0.0026 0.0181 0.0181
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0118 0.0118
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0378 0.0815
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0013 0.0021
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0013 0.0013
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0087 0.0838 0.0838
Schistosoma mansoni hypothetical protein 0.001 0.0013 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0591 0.1703
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0304 0.077
Echinococcus multilocularis tumor protein p63 0.0331 0.3474 0.3474
Schistosoma mansoni ets-related 0.0216 0.2228 0.642
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.1431 0.4123
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0004 0.0011
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0118 0.0118
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0383 0.4032 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.1369 0.2978
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0004 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2032 0.3882
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0709 0.2044
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0112 0.1108 0.219
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0301 0.3143 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0304 0.3069
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0031 0.009
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0248
Trypanosoma brucei polo-like protein kinase 0.0198 0.2032 0.6441
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2032 0.3882
Echinococcus multilocularis expressed protein 0.0012 0.0031 0.0031
Brugia malayi nuclear receptor NHR-88 0.002 0.0118 0.0248
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0118 0.0248
Schistosoma mansoni zinc finger protein 0.0009 0.0004 0.0011
Echinococcus granulosus tumor protein p63 0.0331 0.3474 0.3474
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0004 0.0004
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0118 0.0118
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0838 1
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0012 0.0031 0.006
Brugia malayi Ets-domain containing protein 0.0071 0.0668 0.1449
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0031 0.006
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0435 0.4588 1
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0013 0.0021
Brugia malayi hypothetical protein 0.0012 0.0031 0.006
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0004 0.0011
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0077 0.0221
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0478 0.5059 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0002 0.0002
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.058 0.665
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0304 0.077
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.058 0.058
Plasmodium vivax SET domain protein, putative 0.0063 0.058 0.1294
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0087 0.0838 0.2079
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0027
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0558 0.1595
Onchocerca volvulus 0.0075 0.0709 0.1349
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.006
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0031 0.006
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0118 0.0248
Brugia malayi hypothetical protein 0.0296 0.3097 0.6747
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0198 0.2032 0.6389
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0002
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0031 0.009
Entamoeba histolytica hypothetical protein 0.0109 0.1076 0.522
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0118 0.0118
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0118 0.0118
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0352 0.0352
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0181 0.037
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0031 0.009
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0013 0.0021
Brugia malayi Ets-domain containing protein 0.0071 0.0668 0.1449
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0241 0.0518
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0016 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0118 0.0248
Schistosoma mansoni nuclear hormone receptor 0.002 0.0118 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0118 0.0248
Brugia malayi hypothetical protein 0.0136 0.1369 0.2978
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.006
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0013 0.0013
Brugia malayi Pre-SET motif family protein 0.0435 0.4588 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0077 0.0174
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0352 0.3691
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0031 0.009
Brugia malayi ecdysteroid receptor 0.002 0.0118 0.0248
Brugia malayi hypothetical protein 0.0011 0.0016 0.0027
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0012 0.0031 0.006
Brugia malayi hypothetical protein 0.0026 0.0183 0.0392
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0709 0.6403
Leishmania major DNA polymerase kappa, putative 0.0016 0.0077 0.0032
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0012 0.0031 0.006
Mycobacterium ulcerans hypothetical protein 0.0075 0.0709 0.1759
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0383 0.4032 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0077 0.0174
Onchocerca volvulus 0.0063 0.058 0.1101
Mycobacterium ulcerans lipase LipD 0.0075 0.0709 0.1759
Brugia malayi Probable ClpP-like protease 0.0087 0.0838 0.182
Brugia malayi G-protein alpha subunit 0.0012 0.0031 0.006
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0012 0.0031 0.006
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0118 0.0248
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0067 0.0166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.2911 0.8389
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0067 0.0067
Treponema pallidum NADH oxidase 0.0015 0.0067 0.0799
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0118 0.0248
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0031 0.0031
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0183 0.0294
Entamoeba histolytica hypothetical protein 0.0109 0.1076 0.522
Schistosoma mansoni hypothetical protein 0.0331 0.347 1
Echinococcus multilocularis protein C ets 2 0.001 0.0013 0.0013
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0383 0.4032 1
Schistosoma mansoni hypothetical protein 0.0031 0.0241 0.0696
Echinococcus granulosus protein C ets 2 0.001 0.0013 0.0013
Onchocerca volvulus 0.0495 0.5235 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0067 0.0193
Loa Loa (eye worm) hypothetical protein 0.0075 0.0709 0.1539
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0279 0.2911 0.2911
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0248
Brugia malayi hypothetical protein 0.0011 0.0016 0.0027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0077 0.0032
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0352 0.0672
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0077 0.0174
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0279 0.2911 0.6341
Loa Loa (eye worm) hypothetical protein 0.0075 0.0709 0.1539
Schistosoma mansoni hypothetical protein 0.0109 0.1076 0.31
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0012 0.0031 0.006
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.2032 0.5857
Leishmania major trypanothione reductase 0.0044 0.0378 0.101
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0591 0.1703
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0975 0.2117
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0077 0.0174
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.058 0.058
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2032 0.3882
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0023 0.0042
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0378 0.101
Brugia malayi Fli-1 protein 0.0216 0.2228 0.4851
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0112 0.1108 0.219
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0358 0.0946
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.2911 0.8389
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0383 0.4032 0.797
Loa Loa (eye worm) hypothetical protein 0.0026 0.0183 0.0392
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0181 0.037
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0012 0.0031 0.006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0709 0.2044
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0031 0.009
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0248
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2032 0.3882
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0118 0.0218
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2032 0.3882
Toxoplasma gondii hypothetical protein 0.003 0.0225 0.2045
Brugia malayi beta-lactamase family protein 0.0075 0.0709 0.1539
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0181 0.0507
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0077 0.0159
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0225 0.2028
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.3143 1
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0013 0.0013
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0241 0.0241
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0118 0.0248
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0709 0.2088
Mycobacterium ulcerans beta-lactamase 0.0075 0.0709 0.1759
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0118 0.0248
Giardia lamblia Kinase, PLK 0.0198 0.2032 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0118 0.0118
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0838 0.1945
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0118 0.0339
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0352 0.0672
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0709 0.0709
Schistosoma mansoni coup transcription factor 0.002 0.0118 0.0339
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0558 0.0558
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0013 0.0038
Brugia malayi steroid hormone receptor 0.002 0.0118 0.0248
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0075 0.0709 0.1539
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0183 0.151
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0709 0.2088
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0668 0.1449
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0118 0.0218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0118 0.0248
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.006
Brugia malayi hypothetical protein 0.0017 0.0084 0.0174
Schistosoma mansoni hypothetical protein 0.0068 0.0635 0.1831
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0013 0.0021
Brugia malayi TAR-binding protein 0.0064 0.0591 0.128
Loa Loa (eye worm) glutathione reductase 0.0044 0.0378 0.0815
Loa Loa (eye worm) hypothetical protein 0.0136 0.1369 0.2978
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0118 0.0339
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.0516 0.0516
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0004 0.0011
Brugia malayi RNA binding protein 0.0064 0.0591 0.128
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0012 0.0031 0.006
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0591 0.128
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0181 0.0579
Echinococcus granulosus FTZ F1 alpha 0.002 0.0118 0.0118
Trichomonas vaginalis esterase, putative 0.0075 0.0709 0.1355
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0183 0.0379
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0248
Loa Loa (eye worm) G protein alpha subunit 3 0.0012 0.0031 0.006
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0709 0.1539
Brugia malayi nuclear receptor RXR 0.0011 0.0016 0.0027
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0262 0.0517
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0838 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0004 0.0004
Schistosoma mansoni nuclear receptor 0.0009 0.0004 0.0011
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.0516 0.102
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0358 0.0946
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0225 0.0398
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0031 0.006
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0031 0.006
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0016 0.0077 0.0152
Loa Loa (eye worm) hypothetical protein 0.0031 0.0241 0.0518
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0513 0.1112
Brugia malayi serine/threonine-protein kinase plk-2 0.0198 0.2032 0.4425
Brugia malayi glutathione reductase 0.0044 0.0378 0.0815
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0004 0.0004
Schistosoma mansoni ets-related 0.001 0.0013 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0118 0.0248
Onchocerca volvulus 0.0075 0.0709 0.1349
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0304 0.1361
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0067 0.0128
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0077 0.0174
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0002 0.0006
Echinococcus multilocularis neuropeptide s receptor 0.0937 1 1
Leishmania major DNA polymerase eta, putative 0.0016 0.0077 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0591 0.1703
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0077 0.0032
Loa Loa (eye worm) inositol-1 0.0037 0.0304 0.0654
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0013 0.0013
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0019 0.0034
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0077 0.0221
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0067 0.0166
Brugia malayi beta-lactamase 0.0075 0.0709 0.1539
Onchocerca volvulus 0.0028 0.0205 0.0385
Brugia malayi Pre-SET motif family protein 0.0063 0.058 0.1257
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0591 0.1703
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0028 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0957 0.1827
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0439 0.2035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0279 0.2911 0.2911
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0077 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0591 0.1703
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0067 0.0166
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0304 0.0753
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0118 0.0248
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0118 0.0248
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0118 0.0339
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0031 0.009
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0016 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0077 0.0174
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0067 0.0142
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.1431 0.1431
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0013 0.0013
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0031 0.009
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0012 0.0031 0.0031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0279 0.2911 0.2911
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0248
Loa Loa (eye worm) hypothetical protein 0.0068 0.0635 0.1377
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0538 0.6107
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0077 0.0174
Onchocerca volvulus 0.0012 0.0031 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0118 0.0248
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0241 0.0241
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0067 0.0142
Schistosoma mansoni ets 0.001 0.0013 0.0038
Echinococcus granulosus dna polymerase eta 0.0016 0.0077 0.0077
Mycobacterium tuberculosis Conserved protein 0.0075 0.0709 0.1402
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0087 0.0838 0.0838
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0077 0.0159
Schistosoma mansoni peptidase Clp (S14 family) 0.0087 0.0838 0.2416
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0838 0.2079
Onchocerca volvulus 0.0012 0.0031 0.0053
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0118 0.0118
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0838 0.2079
Loa Loa (eye worm) RNA binding protein 0.0064 0.0591 0.128
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0668 0.0668
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0591 0.0591
Echinococcus granulosus GPCR family 2 0.0031 0.0241 0.0241
Schistosoma mansoni thyroid hormone receptor 0.002 0.0118 0.0339
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0558 0.1607
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0439 0.2035
Schistosoma mansoni nuclear receptor 0.0009 0.0004 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0248
Trypanosoma cruzi DNA polymerase eta, putative 0.0016 0.0077 0.0032
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0118 0.0339
Echinococcus multilocularis dna polymerase eta 0.0016 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0557 0.1207
Echinococcus multilocularis geminin 0.0331 0.347 0.347
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0181 0.0386
Schistosoma mansoni hypothetical protein 0.001 0.0013 0.0038
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0709 0.162
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0225 0.0398
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0077 0.019
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.0987 0.1951
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0118 0.0339
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0838 1
Schistosoma mansoni cpg binding protein 0.003 0.0222 0.0641
Loa Loa (eye worm) beta-lactamase 0.0075 0.0709 0.1539
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.058 0.1671
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0004 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0279 0.2911 0.2911
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0004 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0118 0.0248
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1436 0.445
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0425 0.1225
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0635 0.1377
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0118 0.0248
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0439 0.2035
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0709 0.1402
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0118 0.0118
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0016 0.0046
Leishmania major mitochondrial DNA polymerase beta 0.0301 0.3143 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0248
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0077 0.0152
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0709 0.1355
Brugia malayi nuclear hormone receptor 0.002 0.0118 0.0248
Loa Loa (eye worm) hypothetical protein 0.0075 0.0709 0.1539
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0027
Entamoeba histolytica hypothetical protein 0.0109 0.1076 0.522
Schistosoma mansoni hypothetical protein 0.0031 0.0241 0.0696
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0709 0.1402
Plasmodium falciparum glutathione reductase 0.0044 0.0378 0.0784
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0013 0.0013
Trichomonas vaginalis set domain proteins, putative 0.0495 0.5235 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.0516 0.4656
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0031 0.0241 0.0696
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0031 0.0031
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0383 0.4032 1
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0031 0.0031
Echinococcus multilocularis GPCR, family 2 0.0031 0.0241 0.0241
Toxoplasma gondii hypothetical protein 0.0048 0.0425 0.464
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0591 0.128
Schistosoma mansoni kinase 0.01 0.0985 0.2838
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0023 0.0042
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0013 0.0013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0021 0.0021
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0012 0.0031 0.006
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0077 0.0174
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0558 0.1208
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0181 0.0181
Plasmodium vivax glutathione reductase, putative 0.0044 0.0378 0.0784
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0067 0.0142
Loa Loa (eye worm) hypothetical protein 0.0296 0.3097 0.6747
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0031 0.0031
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.0384 0.0384
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0709 0.0709
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0198 0.2032 0.2032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0118 0.0248
Onchocerca volvulus Huntingtin homolog 0.0136 0.1369 0.261
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0118 0.0248
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0198 0.2032 0.4425
Mycobacterium ulcerans hypothetical protein 0.0158 0.1609 0.3991
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0304 0.058
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0314 0.1413
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0118 0.0248
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.3143 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0077 0.0174
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0012 0.0031 0.009
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0087 0.0838 0.182
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0241 0.0241
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.058 0.1671
Onchocerca volvulus 0.0012 0.0031 0.0053
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0031 0.006
Schistosoma mansoni thyroid hormone receptor 0.002 0.0118 0.0339
Brugia malayi Inositol-1 0.0037 0.0304 0.0654
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0087 0.0838 0.7567
Loa Loa (eye worm) hypothetical protein 0.0075 0.0709 0.1539
Echinococcus multilocularis neuropeptide receptor A26 0.0937 1 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0016 0.0077 0.0147
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.0987 0.1951
Entamoeba histolytica hypothetical protein 0.0109 0.1076 0.522
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0004 0.0011
Onchocerca volvulus Huntingtin homolog 0.0136 0.1369 0.261
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0077 0.0174
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.1436 0.4529
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0027
Brugia malayi hypothetical protein 0.0109 0.1076 0.2338
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0181 0.0345
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0838 0.1945
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0013 0.0013
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0358 0.1075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0118 0.0248
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0013 0.0013
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0225 0.268
Giardia lamblia DINP protein human, muc B family 0.0016 0.0077 0.005
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0205 0.0439
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0016 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0118 0.0248
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0077 0.0174
Toxoplasma gondii thioredoxin reductase 0.0044 0.0378 0.4028
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0028 0.0028
Mycobacterium tuberculosis Conserved protein 0.0075 0.0709 0.1402
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0077 0.0032
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0378 0.0784
Mycobacterium tuberculosis Probable oxidoreductase 0.0112 0.1108 0.219
Trypanosoma cruzi polo-like protein kinase, putative 0.0198 0.2032 0.6389
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0181 0.1476
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.2911 0.8389
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0012 0.0031 0.006
Onchocerca volvulus 0.002 0.0118 0.0218
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0352 0.3691
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.0516 0.0516
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0558 0.1383
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0021 0.0036
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0012 0.0031 0.009
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0304 0.058
Echinococcus multilocularis cpg binding protein 0.003 0.0222 0.0222
Trypanosoma brucei trypanothione reductase 0.0044 0.0378 0.1138
Brugia malayi CXXC zinc finger family protein 0.0028 0.0205 0.0439
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0378 0.0747
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.0987 0.1951
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0118 0.0218
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0709 0.1355
Entamoeba histolytica deoxycytidyl transferase, putative 0.0016 0.0077 0.0226
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0067 0.0138
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0709 0.1355
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0002 0.0002
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0181 0.0747
Echinococcus granulosus cpg binding protein 0.003 0.0222 0.0222
Onchocerca volvulus 0.0075 0.0709 0.1349
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0077 0.0159
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0709 0.2201
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0458 0.127
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0012 0.0031 0.006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0077 0.0159
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0304 0.058
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0031 0.0031
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0031 0.009
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0241 0.0241
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0183 0.0294
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0099 0.0975 0.2117
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0709 0.1402
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0118 0.0339
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0101 0.0987 0.8907
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.0987 0.1951
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0013 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.1076 0.31
Schistosoma mansoni gabp alpha 0.0071 0.0668 0.1926
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.058 0.1671
Echinococcus multilocularis dna polymerase kappa 0.0016 0.0077 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.058 0.1671
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.1431 0.3112
Schistosoma mansoni hypothetical protein 0.0331 0.347 1
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0012 0.0031 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0077 0.0174
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0198 0.2032 0.2032
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.0516 0.102
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0077 0.0174
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.006
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0013 0.0013
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0013 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0016 0.0027
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0012 0.0031 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2032 0.3882
Echinococcus granulosus dna polymerase kappa 0.0016 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0031 0.0241 0.0696
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0709 0.1402
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0021
Brugia malayi beta-lactamase family protein 0.0075 0.0709 0.1539
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0021 0.0021
Schistosoma mansoni inositol monophosphatase 0.0037 0.0304 0.0875
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0012 0.0031 0.006
Loa Loa (eye worm) fli-1 protein 0.0216 0.2228 0.4851
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0304 0.0901
Trypanosoma brucei unspecified product 0.0016 0.0077 0.0174
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0067 0.0166
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0957 0.1827
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0358 0.0946
Schistosoma mansoni inositol monophosphatase 0.0037 0.0304 0.0875
Leishmania major hypothetical protein, conserved 0.0075 0.0709 0.2088
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0709 0.1355
Loa Loa (eye worm) hypothetical protein 0.0075 0.0709 0.1539
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0709 0.1402
Toxoplasma gondii ABC1 family protein 0.0075 0.0709 0.8327
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0591 0.128
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0031 0.009
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0262 0.2362
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0383 0.4032 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0183 0.0516
Brugia malayi Thioredoxin reductase 0.0044 0.0378 0.0815
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0118 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0077 0.0032
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0709 0.1759
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0975 0.2117
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.1076 0.1076
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1436 0.445
Brugia malayi Flap endonuclease-1 0.0026 0.0181 0.0386
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0279 0.2911 0.6341
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0352 0.0718
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0067 0.0166
Schistosoma mansoni cpg binding protein 0.003 0.0222 0.0641
Trichomonas vaginalis DNA polymerase eta, putative 0.0016 0.0077 0.0147
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0016 0.0016
Schistosoma mansoni cpg binding protein 0.0028 0.0205 0.0591
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0118 0.0339
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0027
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0077 0.019
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0112 0.1108 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0118 0.0118
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0709 0.1539
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0118 0.0339
Echinococcus multilocularis ets variant gene 4 0.001 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0248
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0118 0.0118
Loa Loa (eye worm) acetyltransferase 0.0142 0.1431 0.3112
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0118 0.0339
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0013 0.0013
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0004 0.0004
Brugia malayi transcription factor E74 isoform 0.001 0.0013 0.0021
Onchocerca volvulus Serine\/threonine kinase homolog 0.0198 0.2032 0.3878
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0709 0.1355
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0031 0.006
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0118 0.0248
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0852 0.9083 0.9083
Mycobacterium tuberculosis Conserved protein 0.0075 0.0709 0.1402
Echinococcus granulosus neuropeptide receptor A26 0.0937 1 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0838 0.1945
Loa Loa (eye worm) hypothetical protein 0.0048 0.0425 0.0919
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2032 0.3882
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0709 0.1402
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0067 0.0067
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0439 0.2035
Trypanosoma cruzi polo-like protein kinase, putative 0.0198 0.2032 0.6389
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0314 0.0624
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0975 0.2117
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0304 0.077
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0304 0.0304
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0031 0.009
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0031 0.0031
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0709 0.1759
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0077 0.0174
Schistosoma mansoni elf1 0.001 0.0013 0.0038
Loa Loa (eye worm) hypothetical protein 0.0063 0.058 0.1257
Brugia malayi Ets-domain containing protein 0.001 0.0013 0.0021
Leishmania major hypothetical protein, conserved 0.0026 0.0183 0.0379
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0668 0.0668
Mycobacterium leprae Probable lipase LipE 0.0075 0.0709 0.6403

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2.73 pmol Inhibition of N-terminal His-tagged Escherichia coli FabH expressed in Escherichia coli BL21 (DE3) using [3H]acetyl-coA after 25 mins by liquid scintillation counting ChEMBL. 21741250
MIC (functional) > 100 ug ml-1 Antibacterial activity against Escherichia coli ATCC35218 after 24 hrs by MTT assay ChEMBL. 21741250

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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