Detailed information for compound 1029480

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 296.15 | Formula: C10H15Cl2N3O3
  • H donors: 3 H acceptors: 5 LogP: 2.11 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1CCCN(C1)c1nc(O)nc(c1Cl)O.Cl
  • InChi: 1S/C10H14ClN3O3.ClH/c11-7-8(12-10(17)13-9(7)16)14-3-1-2-6(4-14)5-15;/h6,15H,1-5H2,(H2,12,13,16,17);1H
  • InChiKey: OTPQPUXGCJADQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli thymidine phosphorylase Starlite/ChEMBL References
Homo sapiens thymidine phosphorylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Mycobacterium ulcerans thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus granulosus thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) Get druggable targets OG5_131632 All targets in OG5_131632
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0392 0.0823
Onchocerca volvulus 0.0055 0.0301 1
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0432 0.2781 0.2781
Leishmania major mitochondrial DNA polymerase beta 0.0321 0.2051 1
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.0037 0.0037
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0037 0.0254
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.0037 0.0037
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0327 0.0327
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0878 0.6337
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0104 0.074
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0011 0.0011
Schistosoma mansoni ets-related 0.001 0.0011 0.0023
Echinococcus multilocularis neuropeptide s receptor 0.0014 0.0037 0.0037
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.0037 0.0037
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0037 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0037 0.0078
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0015 0.0015
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0239 0.1099
Loa Loa (eye worm) cytochrome P450 0.0011 0.0015 0.0092
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0037 0.0078
Onchocerca volvulus 0.0014 0.0037 0.0811
Loa Loa (eye worm) RNA binding protein 0.0068 0.0392 0.2821
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0037 0.0078
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0037 0.0037
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0014 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0015 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0015 0.0015
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.036 0.2306 0.4842
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.0037 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0014 0.0085
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0037 0.0078
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.094 0.4545
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0327 0.1535
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0321 0.2051 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0014 0.0037 0.0078
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0063 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0037 0.0037
Echinococcus multilocularis orexin receptor type 2 0.0014 0.0037 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0025 0.0104 0.0741
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0015 0.0053
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0014 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0014 0.0014
Schistosoma mansoni biogenic amine receptor 0.0014 0.0037 0.0078
Brugia malayi putative neuropeptide receptor NPR1 0.0014 0.0037 0.0253
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0003 0.0003
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0015 0.0015
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0145 0.1037
Schistosoma mansoni hypothetical protein 0.0014 0.0037 0.0078
Echinococcus granulosus dnaJ subfamily B 0.0426 0.2743 0.2743
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0011 0.0011
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.0037 0.0254
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0037 0.0078
Onchocerca volvulus 0.0014 0.0037 0.0811
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0037 0.0037
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0037 0.0254
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0015 0.0015
Brugia malayi Cytochrome P450 family protein 0.0031 0.0145 0.1037
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0011 0.0011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0014 0.0037 0.0254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0878 0.0878
Brugia malayi hypothetical protein 0.0014 0.0037 0.0253
Brugia malayi Latrophilin receptor protein 2 0.0016 0.005 0.0347
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0014 0.0014
Echinococcus granulosus microtubule associated protein 2 0.0734 0.4761 0.4761
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0239 0.1099
Schistosoma mansoni hypothetical protein 0.0426 0.2743 0.5761
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.2051 1
Brugia malayi transcription factor E74 isoform 0.001 0.0011 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0014 0.0085
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0014 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0037 0.0078
Brugia malayi G-protein coupled receptor 0.0014 0.0037 0.0253
Schistosoma mansoni amine GPCR 0.0014 0.0037 0.0078
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0085
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0015 0.0015
Brugia malayi nuclear hormone receptor 0.0011 0.0014 0.0085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0878 0.1844
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0015 0.0015
Echinococcus granulosus tumor protein p63 0.0374 0.2396 0.2396
Onchocerca volvulus 0.0014 0.0037 0.0811
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0075 0.0295
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0014 0.0085
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0014 0.0085
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2781 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0014 0.0085
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0444
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0014 0.0085
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0037 0.0078
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0014 0.0029
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0015 0.0015
Brugia malayi Melatonin receptor type 1A 0.0014 0.0037 0.0253
Brugia malayi hypothetical protein 0.0014 0.0037 0.0253
Echinococcus granulosus allatostatin A receptor 0.0014 0.0037 0.0037
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0014 0.0037 0.0253
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0085
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0303 0.1418
Schistosoma mansoni neuropeptide receptor 0.0014 0.0037 0.0078
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0014 0.0014
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.094 0.4545
Brugia malayi Ets-domain containing protein 0.0072 0.0417 0.3002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0037 0.0037
Schistosoma mansoni amine GPCR 0.0014 0.0037 0.0078
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0036 0.0175 0.0368
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.0037 0.0037
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0015 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0015 0.0015
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0014 0.0037 0.0253
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0104 0.0104
Brugia malayi Ets-domain containing protein 0.001 0.0011 0.0064
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Echinococcus granulosus GPCR family 2 0.0016 0.005 0.005
Echinococcus multilocularis microtubule associated protein 2 0.0734 0.4761 0.4761
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0014 0.0085
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.0037 0.0037
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.0037 0.0037
Onchocerca volvulus 0.0014 0.0037 0.0811
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2781 0.2781
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0014 0.0085
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0014 0.0014
Trichomonas vaginalis ferritin, putative 0.0009 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0037 0.0037
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.2051 1
Onchocerca volvulus 0.0014 0.0037 0.0811
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0014 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0104 0.074
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0015 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0392 0.0823
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0359 0.0754
Brugia malayi G protein-coupled receptor F59B2.13 0.0014 0.0037 0.0253
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0037 0.0078
Brugia malayi putative neuropeptide receptor 0.0014 0.0037 0.0253
Loa Loa (eye worm) hypothetical protein 0.0052 0.0283 0.2036
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.005 0.0347
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.0037 0.0254
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0014 0.0029
Loa Loa (eye worm) fli-1 protein 0.0219 0.1384 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Schistosoma mansoni adenoreceptor 0.0014 0.0037 0.0078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0015 0.0015
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.0037 0.0037
Onchocerca volvulus 0.0014 0.0037 0.0811
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0003 0.0006
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0301 0.0633
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Echinococcus granulosus g protein coupled receptor 0.0014 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0014 0.0037 0.0078
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0075 0.0526
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.005 0.005
Brugia malayi larval opioid receptor 0.0014 0.0037 0.0253
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0037 0.0037
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0014 0.0029
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0011 0.0011
Brugia malayi hypothetical protein 0.0014 0.0037 0.0253
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0104 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0392 0.0823
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0037 0.0078
Brugia malayi Dopamine receptor protein 1 0.0014 0.0037 0.0253
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Echinococcus multilocularis GPCR, family 2 0.0016 0.005 0.005
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0037 0.0037
Echinococcus multilocularis sex peptide receptor 0.0014 0.0037 0.0037
Schistosoma mansoni ets-related 0.0219 0.1384 0.2907
Schistosoma mansoni opsin-like receptor 0.0014 0.0037 0.0078
Loa Loa (eye worm) hypothetical protein 0.0025 0.0104 0.0741
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0075 0.0295
Brugia malayi hypothetical protein 0.0014 0.0037 0.0253
Schistosoma mansoni biogenic amine receptor 0.0014 0.0037 0.0078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0444
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0014 0.0085
Schistosoma mansoni hypothetical protein 0.0014 0.0037 0.0078
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0015 0.0015
Trypanosoma brucei cytochrome P450, putative 0.002 0.0075 0.0295
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0085
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0014 0.0037 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0392 0.0823
Brugia malayi TAR-binding protein 0.0068 0.0392 0.2821
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Brugia malayi ORL1-like opioid receptor 0.0014 0.0037 0.0253
Brugia malayi Ets-domain containing protein 0.0072 0.0417 0.3002
Toxoplasma gondii hypothetical protein 0.0052 0.0282 0.8554
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.0037 0.0037
Schistosoma mansoni neuropeptide receptor 0.0014 0.0037 0.0078
Schistosoma mansoni hypothetical protein 0.036 0.2306 0.4842
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0037 0.0078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0878 0.0878
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0037 0.0037
Echinococcus granulosus protein C ets 2 0.001 0.0011 0.0011
Echinococcus granulosus tar DNA binding protein 0.0068 0.0392 0.0392
Brugia malayi ecdysteroid receptor 0.0011 0.0014 0.0085
Onchocerca volvulus 0.0014 0.0037 0.0811
Onchocerca volvulus 0.0014 0.0037 0.0811
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0104 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0014 0.0029
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0105
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0239 0.1099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0878 0.1844
Echinococcus multilocularis serotonin receptor 0.0014 0.0037 0.0037
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0392 0.2821
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0014 0.0085
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0011 0.0011
Brugia malayi steroid hormone receptor 0.0011 0.0014 0.0085
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0037 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0015 0.0015
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0015 0.0015
Brugia malayi Serotonin receptor 0.0014 0.0037 0.0253
Brugia malayi hypothetical protein 0.0014 0.0037 0.0253
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0085
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0878 0.0878
Schistosoma mansoni cytochrome P450 0.0011 0.0015 0.0031
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0327 0.0327
Echinococcus multilocularis protein C ets 2 0.001 0.0011 0.0011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0037 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0015 0.0015
Schistosoma mansoni amine GPCR 0.0014 0.0037 0.0078
Brugia malayi neuropeptide F receptor 0.0014 0.0037 0.0253
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Brugia malayi nuclear receptor NHR-88 0.0011 0.0014 0.0085
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0015 0.0015
Brugia malayi GnHR receptor homolog 0.0014 0.0037 0.0253
Echinococcus multilocularis G protein coupled receptor 139 0.0014 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0878 0.0878
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0014 0.0085
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Schistosoma mansoni alpha-1 adrenergic receptor 0.0014 0.0037 0.0078
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0104 0.0104
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0085
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0015 0.0015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0037 0.0078
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.001 0.0011 0.0023
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1531 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0014 0.0085
Onchocerca volvulus 0.0014 0.0037 0.0811
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0015 0.0015
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0392 0.0392
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0014 0.0037 0.0811
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.0037 0.0037
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0037 0.0254
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0037 0.0078
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0011 0.0064
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.0037 0.0037
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0014 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0037 0.0078
Echinococcus multilocularis somatostatin receptor 0.0014 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0064
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0104 0.0104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Brugia malayi G-protein coupled receptor 0.0014 0.0037 0.0253
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0014 0.0037 0.0078
Brugia malayi Cytochrome P450 family protein 0.002 0.0075 0.0526
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0014 0.0029
Brugia malayi hypothetical protein 0.0014 0.0037 0.0253
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Schistosoma mansoni microtubule-associated protein tau 0.0734 0.4761 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.0037 0.0037
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0015 0.0015
Echinococcus multilocularis tumor protein p63 0.0374 0.2396 0.2396
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0015 0.0015
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0175 0.1254
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0011 0.0064
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0037 0.0037
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0011 0.0064
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Mycobacterium ulcerans hypothetical protein 0.0025 0.0104 0.0104
Brugia malayi sulfakinin receptor protein 0.0014 0.0037 0.0253
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0014 0.0037 0.0253
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0037 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0014 0.0085
Brugia malayi neuropeptide F receptor 0.0014 0.0037 0.0253
Brugia malayi Fli-1 protein 0.0219 0.1384 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0014 0.0037 0.0811
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Brugia malayi hypothetical protein 0.0014 0.0037 0.0253
Brugia malayi hypothetical protein 0.0014 0.0037 0.0253
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0327 0.0688
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.0037 0.0037
Onchocerca volvulus 0.0014 0.0037 0.0811
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.005 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0878 0.1844
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0104 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0037 0.0078
Schistosoma mansoni hypothetical protein 0.0014 0.0037 0.0078
Echinococcus granulosus neuropeptide receptor 0.0014 0.0037 0.0037
Onchocerca volvulus 0.003 0.0139 0.4345
Echinococcus granulosus fmrfamide receptor 0.0014 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0014 0.0029
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0063 0.5
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0011 0.0011
Echinococcus multilocularis geminin 0.036 0.2306 0.2306
Schistosoma mansoni opsin-like receptor 0.0014 0.0037 0.0078
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0014 0.0037 0.0253
Echinococcus granulosus orexin receptor type 2 0.0014 0.0037 0.0037
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0014 0.0014
Brugia malayi hypothetical protein 0.0014 0.0037 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0014 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.0037 0.0254
Echinococcus granulosus sex peptide receptor 0.0014 0.0037 0.0037
Brugia malayi RE15519p 0.0014 0.0037 0.0253
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Loa Loa (eye worm) hypothetical protein 0.0025 0.0104 0.0741
Echinococcus granulosus neuropeptide s receptor 0.0014 0.0037 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0014 0.0085
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Onchocerca volvulus 0.0014 0.0037 0.0811
Onchocerca volvulus 0.0025 0.0104 0.3151
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0015 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0104 0.044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0014 0.0037 0.0078
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0104 0.044
Onchocerca volvulus 0.0014 0.0037 0.0811
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.0037 0.0037
Brugia malayi Dopamine receptor protein 2 0.0014 0.0037 0.0253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0014 0.0085
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0085
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.0037 0.0254
Brugia malayi cytochrome P450 0.0011 0.0015 0.0091
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.094 0.4545
Brugia malayi RNA binding protein 0.0068 0.0392 0.2821
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0283 0.2036
Schistosoma mansoni amine GPCR 0.0014 0.0037 0.0078
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0037 0.0037
Schistosoma mansoni neuropeptide receptor 0.0014 0.0037 0.0078
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0015 0.0015
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0085
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0014 0.0037 0.0253
Echinococcus granulosus serotonin receptor 0.0014 0.0037 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0014 0.0014
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0037 0.0078
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0003 0.0003
Brugia malayi hypothetical protein 0.0014 0.0037 0.0253
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0104 0.0104
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0014 0.0037 0.0078
Echinococcus granulosus cpg binding protein 0.0032 0.015 0.015
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0037 0.0037
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0011 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0327 0.0327
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Schistosoma mansoni ets 0.001 0.0011 0.0023
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0175 0.1254
Schistosoma mansoni cpg binding protein 0.0032 0.015 0.0315
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0014 0.0014
Mycobacterium ulcerans thymidine phosphorylase 0.1531 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0301 0.2165
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Brugia malayi Tachykinin-like peptides receptor 99D 0.0014 0.0037 0.0253
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.005 0.0347
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0104 0.044
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.0037 0.0037
Echinococcus multilocularis 0.0011 0.0015 0.0015
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.0037 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0014 0.0014
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0015 0.0015
Mycobacterium ulcerans hypothetical protein 0.0169 0.1053 0.1053
Brugia malayi follicle stimulating hormone receptor 0.0014 0.0037 0.0253
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0104 0.0104
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0014 0.0085
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0014 0.0014
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0315 0.959
Schistosoma mansoni growth hormone secretagogue receptor 0.0014 0.0037 0.0078
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0392 0.2821
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0327 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0392 0.0823
Schistosoma mansoni opsin-like receptor 0.0014 0.0037 0.0078
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0063 0.0063
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0037 0.0254
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0014 0.0029
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0015 0.0015
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.1053 0.1053
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0014 0.0037 0.0078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Brugia malayi Cytochrome P450 family protein 0.0011 0.0015 0.0091
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0014 0.0029
Echinococcus multilocularis ets variant gene 4 0.001 0.0011 0.0011
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0011 0.0011
Echinococcus granulosus somatostatin receptor 0.0014 0.0037 0.0037
Onchocerca volvulus 0.0014 0.0037 0.0811
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0014 0.0014
Schistosoma mansoni cpg binding protein 0.003 0.0139 0.0291
Leishmania major cytochrome p450-like protein 0.002 0.0075 0.0295
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0015 0.0015
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0104 0.0375
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0417 0.0417
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0105
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0014 0.0014
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.0037 0.0254
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0015 0.0015
Echinococcus granulosus g protein coupled receptor 0.0014 0.0037 0.0037
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0417 0.3003
Brugia malayi Cytochrome P450 family protein 0.002 0.0075 0.0526
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0011 0.0011
Echinococcus granulosus hypothetical protein 0.0014 0.0037 0.0037
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0014 0.0029
Brugia malayi AKH receptor 0.0014 0.0037 0.0253
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0037 0.0037
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0014 0.0085
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0064
Schistosoma mansoni elf1 0.001 0.0011 0.0023
Schistosoma mansoni coup transcription factor 0.0011 0.0014 0.0029
Loa Loa (eye worm) hypothetical protein 0.0062 0.0348 0.2504
Onchocerca volvulus 0.0014 0.0037 0.0811
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.0037 0.0037
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0327 0.0327
Echinococcus granulosus geminin 0.036 0.2306 0.2306
Onchocerca volvulus 0.0014 0.0037 0.0811
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.0037 0.0037
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0239 0.1099
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0014 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Echinococcus multilocularis cpg binding protein 0.0032 0.015 0.015
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0075 0.0526
Brugia malayi CXXC zinc finger family protein 0.003 0.0139 0.0988
Schistosoma mansoni cpg binding protein 0.0032 0.015 0.0315
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Schistosoma mansoni hypothetical protein 0.0011 0.0015 0.0031
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0015 0.0015
Schistosoma mansoni neuropeptide receptor 0.0014 0.0037 0.0078
Echinococcus granulosus g-protein coupled receptor 0.0014 0.0037 0.0037
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0037 0.0037
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0015 0.0015
Echinococcus multilocularis neuropeptide receptor A26 0.0014 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0444
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0104 0.0104
Schistosoma mansoni histamine h1 receptor 0.0014 0.0037 0.0078
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0014 0.0037 0.0078
Schistosoma mansoni biogenic amine receptor 0.0014 0.0037 0.0078
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0139 0.0989
Echinococcus multilocularis allatostatin A receptor 0.0014 0.0037 0.0037
Schistosoma mansoni neuropeptide f receptor 76f 0.0014 0.0037 0.0078
Echinococcus multilocularis serotonin receptor 0.0014 0.0037 0.0037
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0014 0.0085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0057 0.0057
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0014 0.0085
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0444
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.0037 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0014 0.0085
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0037 0.0037
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0037 0.0078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0037 0.0078
Treponema pallidum bacterioferrin (TpF1) 0.0009 0 0.5
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0063 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0015 0.0015
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0011 0.0011
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0014 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0104 0.074
Schistosoma mansoni gabp alpha 0.0072 0.0417 0.0876
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0037 0.0037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0014 0.0085
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0057 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0015 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0037 0.0037
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0896 0.5832 0.5832
Brugia malayi Dopamine receptor 0.0014 0.0037 0.0253
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.0037 0.0037
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0392 0.2821
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0104 0.0375
Echinococcus multilocularis thymidine phosphorylase 0.1531 1 1
Onchocerca volvulus 0.0014 0.0037 0.0811
Echinococcus granulosus g protein coupled receptor 0.0014 0.0037 0.0037
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0011 0.0064
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0327 0.0327
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0014 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0444
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0011 0.0011
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0417 0.0417
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0347
Brugia malayi Serotonin receptor 0.0014 0.0037 0.0253
Brugia malayi G protein-coupled receptor 0.0014 0.0037 0.0253
Schistosoma mansoni hypothetical protein 0.001 0.0011 0.0023
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0283 0.2036
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0014 0.0085
Mycobacterium leprae putative cytochrome p450 0.0011 0.0015 0.0053
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.0037 0.0037
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0037 0.0078
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0015 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0015 0.0015
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0037 0.0037
Schistosoma mansoni amine GPCR 0.0014 0.0037 0.0078
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0327 0.0688
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0283 0.2036
Schistosoma mansoni myosin xvIII 0.0014 0.0037 0.0078
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0015 0.0015
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0037 0.0037
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0878 0.6337
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0104 0.5
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0105
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0037 0.0037
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0014 0.0037 0.0078
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0014 0.0014
Echinococcus granulosus neuropeptide receptor 0.0014 0.0037 0.0037
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0015 0.0015
Onchocerca volvulus 0.0014 0.0037 0.0811
Echinococcus multilocularis dnaJ subfamily B 0.0426 0.2743 0.2743
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0254
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.005 0.005
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0104 0.0104
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.005 0.005
Loa Loa (eye worm) CYP4Cod1 0.002 0.0075 0.0526

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.4 uM Inhibition of Escherichia coli TP ChEMBL. 16337119
IC50 (binding) = 7.4 uM Inhibition of human TP purified from placenta ChEMBL. 16337119
IC50 (binding) = 9 uM Inhibition of human TP expressed in V79 cells ChEMBL. 16337119

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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