Detailed information for compound 1040335

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 419.907 | Formula: C23H22ClN5O
  • H donors: 3 H acceptors: 2 LogP: 3.52 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)c(N[C@H]1CN3CC[C@H]1CC3)c(c(=O)[nH]2)c1nc2c([nH]1)cccc2
  • InChi: 1S/C23H22ClN5O/c24-14-5-6-16-15(11-14)21(25-19-12-29-9-7-13(19)8-10-29)20(23(30)28-16)22-26-17-3-1-2-4-18(17)27-22/h1-6,11,13,19H,7-10,12H2,(H,26,27)(H2,25,28,30)/t19-/m0/s1
  • InChiKey: MOVBBVMDHIRCTG-IBGZPJMESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens checkpoint kinase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Serine/threonine-protein kinase Chk1, putative Get druggable targets OG5_130454 All targets in OG5_130454
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130454 All targets in OG5_130454
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0178 0.2274 0.2586
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0491 0.092
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0 0.0001
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0077 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.007
Trichomonas vaginalis set domain proteins, putative 0.0732 1 1
Plasmodium falciparum thioredoxin reductase 0.0046 0.044 1
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Onchocerca volvulus 0.0038 0.0324 0.0161
Brugia malayi PHD-finger family protein 0.0024 0.0136 0.0155
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0178 0.2274 0.6491
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0046 0.0439 0.0501
Brugia malayi G-protein coupled receptor 0.0178 0.2274 0.2596
Brugia malayi Thioredoxin reductase 0.0046 0.044 0.0502
Onchocerca volvulus 0.0178 0.2274 0.2144
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1262 0.6411
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0178 0.2274 0.4341
Brugia malayi Serotonin receptor 0.0178 0.2274 0.2596
Schistosoma mansoni myosin xvIII 0.0178 0.2274 0.6491
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0084 0.014
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0203 0.2632 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0058 0.0192
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0178 0.2274 0.6491
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0178 0.2274 0.2596
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0178 0.2274 0.4341
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0077 0.0125
Echinococcus multilocularis neuropeptides capa receptor 0.0178 0.2274 0.4341
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0173 0.0153
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0071 1
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1262 0.6411
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0203 0.2632 0.2994
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0077 0.0125
Schistosoma mansoni hypothetical protein 0.0178 0.2274 0.6491
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.3898 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0071 0.0081
Schistosoma mansoni biogenic amine receptor 0.0178 0.2274 0.6491
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Schistosoma mansoni ap endonuclease 0.002 0.0071 0.0188
Echinococcus granulosus tachykinin peptides receptor 99D 0.0178 0.2274 0.4341
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0178 0.2274 0.6491
Onchocerca volvulus Neuropeptide F receptor homolog 0.0178 0.2274 0.2144
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0166 0.0368
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0491 0.092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0109 0.1315 0.3747
Onchocerca volvulus 0.0178 0.2274 0.2144
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0178 0.2274 0.2596
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0178 0.2274 0.2586
Echinococcus granulosus neuropeptides capa receptor 0.0178 0.2274 0.4341
Echinococcus granulosus hypothetical protein 0.0178 0.2274 0.4341
Echinococcus granulosus g-protein coupled receptor 0.0178 0.2274 0.4341
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0071 0.0169
Schistosoma mansoni amine GPCR 0.0178 0.2274 0.6491
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0194 0.163
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.3898 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.2632 0.2617
Schistosoma mansoni amine GPCR 0.0178 0.2274 0.6491
Echinococcus granulosus orexin receptor type 2 0.0178 0.2274 0.4341
Echinococcus multilocularis g protein coupled receptor 0.0178 0.2274 0.4341
Brugia malayi glutathione reductase 0.0046 0.044 0.0502
Echinococcus granulosus rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Echinococcus granulosus serotonin receptor 0.0178 0.2274 0.4341
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0828 0.2352
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0077 0.0125
Echinococcus multilocularis g-protein coupled receptor 0.0178 0.2274 0.4341
Mycobacterium ulcerans hypothetical protein 0.0155 0.1957 0.5566
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0077 0.0125
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1738 0.4452
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0178 0.2274 0.4341
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0178 0.2274 0.2596
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0643 0.8762 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0491 0.1388
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0104 0.0177
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0362
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0178 0.2274 0.4341
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0017
Brugia malayi hypothetical protein 0.0178 0.2274 0.2596
Brugia malayi hypothetical protein 0.0178 0.2274 0.2596
Brugia malayi glutaminase DH11.1 0.0266 0.3501 0.3996
Brugia malayi Serotonin receptor 0.0178 0.2274 0.2596
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Brugia malayi hypothetical protein 0.0178 0.2274 0.2596
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0615 0.069
Brugia malayi MH2 domain containing protein 0.0117 0.1431 0.1633
Echinococcus granulosus axis inhibition protein axin 0.002 0.0077 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0324 0.0357
Loa Loa (eye worm) hypothetical protein 0.0038 0.0324 0.0357
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Brugia malayi hypothetical protein 0.0178 0.2274 0.2596
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0077 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0194 0.0208
Mycobacterium ulcerans glutaminase 0.0266 0.3501 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0104 0.0281
Schistosoma mansoni neuropeptide receptor 0.0178 0.2274 0.6491
Echinococcus granulosus rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0203 0.2632 0.7503
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.05 0.1272
Echinococcus granulosus chromobox protein 1 0.0068 0.0744 0.1404
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.1084 0.2057
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.002 0.0038
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1738 0.4452
Echinococcus granulosus rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Brugia malayi PXA domain containing protein 0.002 0.0077 0.0087
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0178 0.2274 0.4341
Brugia malayi G protein-coupled receptor 0.0178 0.2274 0.2596
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0077 0.0203
Brugia malayi hypothetical protein 0.002 0.0077 0.0087
Brugia malayi Tachykinin-like peptides receptor 99D 0.0178 0.2274 0.2596
Echinococcus multilocularis somatostatin receptor 0.0178 0.2274 0.4341
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0058 0.0192
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0074
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0071 0.0068
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.007
Schistosoma mansoni regulator of G protein signaling 0.002 0.0077 0.0203
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.044 0.0822
Brugia malayi hypothetical protein 0.0178 0.2274 0.2596
Brugia malayi putative neuropeptide receptor 0.0178 0.2274 0.2596
Schistosoma mansoni chromobox protein 0.0068 0.0744 0.2112
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0608 0.1145
Toxoplasma gondii thioredoxin reductase 0.0046 0.044 0.3945
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0073 0.0492
Loa Loa (eye worm) hypothetical protein 0.0046 0.0439 0.0488
Loa Loa (eye worm) matrixin family protein 0.0091 0.107 0.121
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0178 0.2274 0.4341
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0077 0.0087
Echinococcus granulosus neuropeptide Y receptor 0.0178 0.2274 0.4341
Brugia malayi Matrixin family protein 0.0038 0.0324 0.037
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0084 0.0225
Echinococcus multilocularis neuropeptide Y receptor 0.0178 0.2274 0.4341
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0084 0.0083
Echinococcus multilocularis sex peptide receptor 0.0178 0.2274 0.4341
Echinococcus granulosus peptide allatostatin:somatostatin 0.0178 0.2274 0.4341
Echinococcus granulosus fmrfamide receptor 0.0178 0.2274 0.4341
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0178 0.2274 0.6491
Plasmodium falciparum glutathione reductase 0.0046 0.044 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0178 0.2274 0.6491
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.002 0.0038
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0077 0.0125
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.002 0.0038
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0473 0.054
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.044 0.3945
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.3898 1
Echinococcus granulosus axis inhibition protein axin 0.002 0.0077 0.0125
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0104 0.0177
Schistosoma mansoni alpha-1 adrenergic receptor 0.0178 0.2274 0.6491
Echinococcus multilocularis expressed protein 0.0389 0.5224 1
Plasmodium falciparum phd finger protein, putative 0.0028 0.0194 0.4132
Echinococcus multilocularis G-protein coupled receptor, putative 0.0178 0.2274 0.4341
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.1036 0.1966
Echinococcus multilocularis neuropeptide receptor 0.0178 0.2274 0.4341
Onchocerca volvulus 0.0054 0.0544 0.0385
Echinococcus granulosus rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.002 0.0038
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0303 0.0851
Schistosoma mansoni regulator of G protein signaling 0.002 0.0077 0.0203
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0277 0.0509
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0328 0.0308
Brugia malayi hypothetical protein 0.0178 0.2274 0.2596
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.2632 0.2617
Echinococcus granulosus g protein coupled receptor 0.0178 0.2274 0.4341
Onchocerca volvulus Alhambra homolog 0.0028 0.0194 0.0029
Schistosoma mansoni amine GPCR 0.0178 0.2274 0.6491
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0203 0.2632 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0058 0.0192
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0077 0.0125
Schistosoma mansoni hypothetical protein 0.0054 0.0544 0.1541
Echinococcus granulosus G protein coupled receptor 139 0.0178 0.2274 0.4341
Loa Loa (eye worm) glutathione reductase 0.0046 0.044 0.0489
Echinococcus granulosus somatostatin receptor 0.0178 0.2274 0.4341
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0137 0.1711 0.326
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1262 0.6411
Schistosoma mansoni regulator of G protein signaling 0.002 0.0077 0.0203
Echinococcus multilocularis peregrin 0.0031 0.0226 0.0411
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0071 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0608 0.1145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.002 0.0038
Echinococcus multilocularis chromobox protein 1 0.0068 0.0744 0.1404
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0077 0.0056
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0077 0.0203
Loa Loa (eye worm) G-protein coupled receptor 0.0178 0.2274 0.2586
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0077 0.0125
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.2632 0.2617
Schistosoma mansoni axis inhibition protein axin 0.002 0.0077 0.0203
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0374 0.0948
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0017
Onchocerca volvulus 0.0178 0.2274 0.2144
Schistosoma mansoni axis inhibition protein axin 0.002 0.0077 0.0203
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0203 0.2632 0.3004
Echinococcus granulosus neuropeptides capa receptor 0.0178 0.2274 0.4341
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0178 0.2274 0.6491
Schistosoma mansoni neuropeptide F-like receptor 0.0178 0.2274 0.6491
Toxoplasma gondii exonuclease III APE 0.002 0.0071 0.0479
Loa Loa (eye worm) hypothetical protein 0.0033 0.026 0.0283
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0166 0.0411
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0074
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0202 0.2615 0.2975
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0178 0.2274 0.6491
Loa Loa (eye worm) hypothetical protein 0.0049 0.0476 0.0531
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0178 0.2274 0.2586
Schistosoma mansoni biogenic amine (5HT) receptor 0.0178 0.2274 0.6491
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0166 0.0411
Brugia malayi Matrixin family protein 0.0038 0.0324 0.037
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Toxoplasma gondii hypothetical protein 0.0047 0.0459 0.4127
Onchocerca volvulus 0.0178 0.2274 0.2144
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0178 0.2274 0.4341
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0084 0.0225
Loa Loa (eye worm) matrixin family protein 0.0084 0.0965 0.109
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.002 0.0038
Brugia malayi ORL1-like opioid receptor 0.0178 0.2274 0.2596
Onchocerca volvulus 0.0178 0.2274 0.2144
Schistosoma mansoni neuropeptide receptor 0.0178 0.2274 0.6491
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.2632 0.2617
Echinococcus granulosus histone lysine methyltransferase setb 0.0109 0.1315 0.2501
Echinococcus granulosus sex peptide receptor 0.0178 0.2274 0.4341
Echinococcus granulosus 7tm_1 domain containing protein 0.0178 0.2274 0.4341
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0671 0.1711
Trichomonas vaginalis glutaminase, putative 0.0266 0.3501 0.3487
Schistosoma mansoni chromobox protein 0.0068 0.0744 0.2112
Schistosoma mansoni hypothetical protein 0.0178 0.2274 0.6491
Schistosoma mansoni hypothetical protein 0.0033 0.026 0.0726
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Onchocerca volvulus 0.0178 0.2274 0.2144
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0178 0.2274 0.6491
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1431 0.1622
Echinococcus multilocularis rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Brugia malayi G protein-coupled receptor F59B2.13 0.0178 0.2274 0.2596
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0178 0.2274 0.4341
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0491 0.056
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.1084 1
Echinococcus multilocularis neuropeptides capa receptor 0.0178 0.2274 0.4341
Schistosoma mansoni opsin-like receptor 0.0178 0.2274 0.6491
Echinococcus granulosus g protein coupled receptor 0.0178 0.2274 0.4341
Brugia malayi Dopamine receptor protein 1 0.0178 0.2274 0.2596
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0178 0.2274 0.2596
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1426 0.7254
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Brugia malayi hypothetical protein 0.002 0.0077 0.0087
Echinococcus multilocularis neuropeptide receptor A26 0.0178 0.2274 0.4341
Schistosoma mansoni zinc finger protein 0.0019 0.0064 0.0166
Echinococcus granulosus 7TM GPCR rhodopsin 0.0178 0.2274 0.4341
Brugia malayi hypothetical protein 0.0178 0.2274 0.2596
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Schistosoma mansoni hypothetical protein 0.0178 0.2274 0.6491
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0178 0.2274 0.4341
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1262 0.6411
Echinococcus granulosus tm gpcr rhodopsin 0.0178 0.2274 0.4341
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1094 0.2077
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0077 0.0056
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0166 0.0417
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0071 0.0115
Brugia malayi Melatonin receptor type 1A 0.0178 0.2274 0.2596
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.026 0.0296
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0178 0.2274 0.6491
Echinococcus granulosus expressed protein 0.0389 0.5224 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0231
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0473 0.054
Echinococcus multilocularis zinc finger protein 0.0019 0.0064 0.01
Brugia malayi G-protein coupled receptor 0.0178 0.2274 0.2596
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0374 0.0948
Schistosoma mansoni glutaminase 0.0266 0.3501 1
Echinococcus multilocularis orexin receptor type 2 0.0178 0.2274 0.4341
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0077 0.0125
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0074
Schistosoma mansoni regulator of G protein signaling 0.002 0.0077 0.0203
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Onchocerca volvulus 0.0178 0.2274 0.2144
Echinococcus granulosus tm gpcr rhodopsin 0.0178 0.2274 0.4341
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.007
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0194 0.163
Echinococcus multilocularis dro:myosuppressin receptor 0.0178 0.2274 0.4341
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0074
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0071 0.0115
Leishmania major trypanothione reductase 0.0046 0.044 0.1116
Loa Loa (eye worm) neuropeptide F receptor 0.0178 0.2274 0.2586
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0071 0.0263
Brugia malayi chromobox protein homolog 3 0.0038 0.0328 0.0374
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0491 0.092
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0071 0.0169
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0103 0.1238 0.3527
Echinococcus multilocularis neuropeptide FF receptor 2 0.0178 0.2274 0.4341
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0368 0.0349
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.002 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0074
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Schistosoma mansoni neuropeptide receptor 0.0178 0.2274 0.6491
Echinococcus multilocularis neuropeptide receptor 0.0178 0.2274 0.4341
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0038 0.003
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Loa Loa (eye worm) hypothetical protein 0.0042 0.0377 0.0417
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Echinococcus multilocularis rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0077 0.0056
Echinococcus multilocularis g protein coupled receptor 0.0178 0.2274 0.4341
Echinococcus multilocularis G protein coupled receptor 139 0.0178 0.2274 0.4341
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0084 0.014
Schistosoma mansoni biogenic amine receptor 0.0178 0.2274 0.6491
Brugia malayi hypothetical protein 0.0178 0.2274 0.2596
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0178 0.2274 0.4341
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.002 0.0038
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0077 0.0125
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0178 0.2274 0.4341
Brugia malayi AKH receptor 0.0178 0.2274 0.2596
Echinococcus granulosus neuropeptide s receptor 0.0178 0.2274 0.4341
Echinococcus multilocularis allatostatin A receptor 0.0178 0.2274 0.4341
Brugia malayi jmjC domain containing protein 0.0093 0.1094 0.1249
Brugia malayi putative neuropeptide receptor NPR1 0.0178 0.2274 0.2596
Echinococcus granulosus neuropeptide receptor 0.0178 0.2274 0.4341
Schistosoma mansoni hypothetical protein 0.002 0.0078 0.0207
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.002 0.0038
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0671 0.0652
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0084 0.0225
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1431 0.1622
Echinococcus multilocularis rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0073 0.1246
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0744 0.0837
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0178 0.2274 0.6491
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0071 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Brugia malayi hypothetical protein 0.0178 0.2274 0.2596
Brugia malayi PHD-finger family protein 0.0028 0.0194 0.0221
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0166 0.0189
Schistosoma mansoni amine GPCR 0.0178 0.2274 0.6491
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0084 0.0083
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0166 0.0417
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.002 0.0038
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0328 0.0165
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0077 0.0125
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0077 0.0056
Echinococcus granulosus biogenic amine 5HT receptor 0.0178 0.2274 0.4341
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0178 0.2274 0.6491
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.002 0.0038
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Schistosoma mansoni neuropeptide F-like receptor 0.0178 0.2274 0.6491
Brugia malayi Bromodomain containing protein 0.0073 0.0816 0.0931
Echinococcus granulosus peregrin 0.0031 0.0226 0.0411
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0178 0.2274 0.2586
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0166 0.0417
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0203 0.2632 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0491 0.1388
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0178 0.2274 0.2144
Schistosoma mansoni hypothetical protein 0.0178 0.2274 0.6491
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0166 0.0417
Schistosoma mansoni growth hormone secretagogue receptor 0.0178 0.2274 0.6491
Mycobacterium leprae PROBABLE HYDROLASE 0.0046 0.0439 0.2169
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.044 0.1116
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0077 0.0056
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0077 0.0125
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0194 0.0349
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0178 0.2274 0.4341
Echinococcus granulosus allatostatin A receptor 0.0178 0.2274 0.4341
Loa Loa (eye worm) TYRA-2 protein 0.0178 0.2274 0.2586
Loa Loa (eye worm) hypothetical protein 0.0048 0.0473 0.0528
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0473 0.0528
Schistosoma mansoni ap endonuclease 0.002 0.0071 0.0188
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.2632 0.2617
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0166 0.0189
Loa Loa (eye worm) hypothetical protein 0.0038 0.0324 0.0357
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Plasmodium vivax SET domain protein, putative 0.0092 0.1084 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0029 0.0068
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0012 0.0013
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0178 0.2274 0.4341
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0178 0.2274 0.6491
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0077 0.0125
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0141 0.1758 0.8971
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.002 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.002 0.0038
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Echinococcus multilocularis rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0071 0.0051
Brugia malayi Matrixin family protein 0.0038 0.0324 0.037
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0077 0.0056
Echinococcus granulosus tm gpcr rhodopsin 0.0178 0.2274 0.4341
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0077 0.0087
Brugia malayi GnHR receptor homolog 0.0178 0.2274 0.2596
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.1084 0.3084
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0074
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.3898 1
Leishmania major hypothetical protein, conserved 0.0063 0.0671 0.1711
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0178 0.2274 0.4341
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0017
Echinococcus multilocularis neuropeptide s receptor 0.0178 0.2274 0.4341
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0084 0.0096
Mycobacterium tuberculosis Probable reductase 0.0105 0.1262 0.6411
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0491 0.092
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.002 0.0017
Echinococcus granulosus neuropeptide receptor 0.0178 0.2274 0.4341
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0073 0.027
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0073 0.015
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Onchocerca volvulus 0.0178 0.2274 0.2144
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0071 0.0169
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0286 0.0526
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0178 0.2274 0.4341
Echinococcus granulosus g protein coupled receptor 0.0178 0.2274 0.4341
Echinococcus granulosus jumonji domain containing protein 0.004 0.0349 0.0647
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.002 0.0017
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1094 0.2077
Schistosoma mansoni bromodomain containing protein 0.0062 0.0657 0.1864
Brugia malayi sulfakinin receptor protein 0.0178 0.2274 0.2596
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0077 0.0087
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0166 0.0368
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0071 0.0169
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0077 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0166 0.075
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0077 0.0056
Echinococcus granulosus dro:myosuppressin receptor 0.0178 0.2274 0.4341
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0303 0.0333
Echinococcus granulosus alpha 1A adrenergic receptor 0.0178 0.2274 0.4341
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Echinococcus multilocularis fmrfamide receptor 0.0178 0.2274 0.4341
Brugia malayi Pre-SET motif family protein 0.0643 0.8762 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0178 0.2274 0.6491
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0109 0.1315 0.149
Brugia malayi Dopamine receptor 0.0178 0.2274 0.2596
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Echinococcus granulosus rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Brugia malayi neuropeptide F receptor 0.0178 0.2274 0.2596
Schistosoma mansoni biogenic amine (5HT) receptor 0.0178 0.2274 0.6491
Loa Loa (eye worm) hypothetical protein 0.0037 0.0319 0.0351
Onchocerca volvulus Matrix metalloproteinase homolog 0.0084 0.0965 0.0813
Loa Loa (eye worm) glutaminase 0.0266 0.3501 0.3988
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0178 0.2274 0.6491
Schistosoma mansoni regulator of G protein signaling 0.002 0.0077 0.0203
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.002 0.0038
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0071 0.1215
Onchocerca volvulus 0.0178 0.2274 0.2144
Onchocerca volvulus Matrilysin homolog 0.0084 0.0965 0.0813
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0166 0.0417
Onchocerca volvulus Matrilysin homolog 0.0038 0.0324 0.0161
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0166 0.0417
Mycobacterium ulcerans hypothetical protein 0.0026 0.0166 0.0417
Echinococcus multilocularis rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Echinococcus granulosus neuropeptide Y receptor 0.0178 0.2274 0.4341
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0046 0.0439 0.216
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0166 0.0417
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1426 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0178 0.2274 0.2596
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0671 0.1711
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.044 0.0489
Entamoeba histolytica hypothetical protein 0.002 0.0077 0.0021
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0286 0.0526
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0077 0.0203
Loa Loa (eye worm) hypothetical protein 0.004 0.0351 0.0388
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0078 0.0076
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.002 0.0023
Loa Loa (eye worm) glutaminase 2 0.0266 0.3501 0.3988
Brugia malayi Heterochromatin protein 1 0.0068 0.0744 0.0849
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0671 0.1711
Echinococcus multilocularis rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Brugia malayi Bromodomain containing protein 0.0031 0.0226 0.0258
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0194 0.0349
Schistosoma mansoni biogenic amine receptor 0.0178 0.2274 0.6491
Onchocerca volvulus 0.0178 0.2274 0.2144
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0077 0.0087
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0178 0.2274 0.4341
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.002 0.0038
Loa Loa (eye worm) neuropeptide F receptor 0.0178 0.2274 0.2586
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0077 0.0125
Entamoeba histolytica hypothetical protein 0.002 0.0077 0.0021
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0178 0.2274 0.4341
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.002 0.0038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0166 0.0176
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0178 0.2274 0.6491
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0029 0.0068
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.2632 0.2617
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0671 0.0652
Echinococcus granulosus neuropeptide receptor A26 0.0178 0.2274 0.4341
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.002 0.0038
Loa Loa (eye worm) RGS-3 protein 0.002 0.0077 0.0074
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0109 0.1315 0.2501
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0178 0.2274 0.6491
Echinococcus multilocularis chromobox protein 1 0.0068 0.0744 0.1404
Echinococcus multilocularis neuropeptide Y receptor 0.0178 0.2274 0.4341
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Plasmodium vivax glutathione reductase, putative 0.0046 0.044 0.3945
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1262 0.8703
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0178 0.2274 0.6491
Echinococcus multilocularis rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0077 0.0203
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0178 0.2274 0.6491
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0194 0.0538
Schistosoma mansoni opsin-like receptor 0.0178 0.2274 0.6491
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0194 0.0208
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0077 0.0087
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0178 0.2274 0.4341
Brugia malayi Dopamine receptor protein 2 0.0178 0.2274 0.2596
Brugia malayi neuropeptide F receptor 0.0178 0.2274 0.2596
Onchocerca volvulus 0.0203 0.2632 0.2508
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0368 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0173 0.0153
Onchocerca volvulus 0.0178 0.2274 0.2144
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0073 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1262 0.6411
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Giardia lamblia PHD finger protein 15 0.0028 0.0194 0.0664
Loa Loa (eye worm) melatonin receptor type 1A 0.0178 0.2274 0.2586
Brugia malayi hypothetical protein 0.0178 0.2274 0.2596
Onchocerca volvulus 0.0178 0.2274 0.2144
Onchocerca volvulus 0.0178 0.2274 0.2144
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.002 0.0038
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0194 0.163
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0178 0.2274 0.6491
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0178 0.2274 0.2586
Schistosoma mansoni histamine h1 receptor 0.0178 0.2274 0.6491
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0491 0.0548
Schistosoma mansoni neuropeptide receptor 0.0178 0.2274 0.6491
Echinococcus multilocularis g protein coupled receptor 0.0178 0.2274 0.4341
Schistosoma mansoni neuropeptide f receptor 76f 0.0178 0.2274 0.6491
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0178 0.2274 0.4341
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0071 0.0479
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Echinococcus granulosus neuropeptide FF receptor 2 0.0178 0.2274 0.4341
Schistosoma mansoni adenoreceptor 0.0178 0.2274 0.6491
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0374 0.0948
Echinococcus multilocularis rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Loa Loa (eye worm) hypothetical protein 0.0026 0.0166 0.0176
Brugia malayi RE15519p 0.0178 0.2274 0.2596
Brugia malayi PXA domain containing protein 0.002 0.0077 0.0087
Schistosoma mansoni opsin-like receptor 0.0178 0.2274 0.6491
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0166 0.0368
Brugia malayi Pre-SET motif family protein 0.0092 0.1084 0.1237
Trypanosoma brucei trypanothione reductase 0.0046 0.044 0.1116
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0374 0.0948
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0137 0.1711 0.326
Schistosoma mansoni amine GPCR 0.0178 0.2274 0.6491
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1738 0.4452
Loa Loa (eye worm) hypothetical protein 0.0026 0.0166 0.0176
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1426 0.7254
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0071 0.0146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0491 0.1388
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1426 0.7254
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0077 0.0125
Loa Loa (eye worm) G-protein coupled receptor 0.0178 0.2274 0.2586
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0166 0.0411
Brugia malayi jmjC domain containing protein 0.0036 0.0303 0.0346
Echinococcus multilocularis fmrfamide receptor 0.0178 0.2274 0.4341
Brugia malayi Matrixin family protein 0.0091 0.107 0.1222
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0178 0.2274 0.6491
Onchocerca volvulus 0.0178 0.2274 0.2144
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0166 0.075
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0368 0.0206
Schistosoma mansoni hypothetical protein 0.0028 0.0194 0.0538
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0178 0.2274 0.6491
Echinococcus granulosus chromobox protein 1 0.0068 0.0744 0.1404
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0303 0.0559
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0029 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0328 0.0308
Brugia malayi follicle stimulating hormone receptor 0.0178 0.2274 0.2596
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Echinococcus multilocularis serotonin receptor 0.0178 0.2274 0.4341
Brugia malayi larval opioid receptor 0.0178 0.2274 0.2596
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0349 0.0647
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0744 0.0725
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0071 0.0195
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0744 0.0725
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0058 0.0192
Entamoeba histolytica hypothetical protein 0.002 0.0077 0.0021
Brugia malayi Protein kinase domain containing protein 0.0202 0.2615 0.2984
Brugia malayi Matrixin family protein 0.0038 0.0324 0.037
Onchocerca volvulus 0.0178 0.2274 0.2144
Onchocerca volvulus 0.0178 0.2274 0.2144
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0166 0.0189
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0109 0.1315 0.3747
Echinococcus granulosus zinc finger protein 0.0019 0.0064 0.01
Loa Loa (eye worm) matrix metalloproteinase 0.0038 0.0324 0.0357
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.009 0.1048 0.2982
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0178 0.2274 0.6491
Brugia malayi Bromodomain containing protein 0.0037 0.0318 0.0363
Echinococcus granulosus rhodopsin orphan GPCR 0.0178 0.2274 0.4341
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.044 0.2165
Brugia malayi Hemopexin family protein 0.0054 0.0544 0.0621
Onchocerca volvulus 0.0103 0.1238 0.1091
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.044 0.0822
Mycobacterium ulcerans hydrolase 0.0046 0.0439 0.1202
Onchocerca volvulus 0.003 0.0214 0.0049
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.1957 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.007
Onchocerca volvulus 0.0178 0.2274 0.2144
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0029 0.0034
Loa Loa (eye worm) hypothetical protein 0.0178 0.2274 0.2586
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0012 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.2615 0.7465
Echinococcus granulosus biogenic amine 5HT receptor 0.0178 0.2274 0.4341
Echinococcus multilocularis serotonin receptor 0.0178 0.2274 0.4341
Loa Loa (eye worm) hypothetical protein 0.0069 0.0758 0.0853
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0303 0.0851
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0178 0.2274 0.4341
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0038 0.0324 0.0911

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 7.1 Inhibition of Chk1 ChEMBL. 19385614

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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