Detailed information for compound 1047351

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 286.392 | Formula: C16H18N2OS
  • H donors: 1 H acceptors: 1 LogP: 2.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#CC1(CCCCC1)NCc1coc(n1)c1cccs1
  • InChi: 1S/C16H18N2OS/c1-2-16(8-4-3-5-9-16)17-11-13-12-19-15(18-13)14-7-6-10-20-14/h1,6-7,10,12,17H,3-5,8-9,11H2
  • InChiKey: QVRKMLRIKAKDNP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.002
Giardia lamblia Kinase, NEK 0.0005 0.0028 0.0069
Schistosoma mansoni hypothetical protein 0.0015 0.0329 0.0329
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0088 0.0088
Loa Loa (eye worm) RiNg Finger protein family member 0.0005 0.0016 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.1197 0.1197
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0006 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0029 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0029 0.0016
Trichomonas vaginalis helicase, putative 0.0005 0.0029 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0029 0.0016
Brugia malayi CXXC zinc finger family protein 0.0023 0.0579 0.0717
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.002
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0093 0.2786 0.2786
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0093 0.2786 0.3452
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0093 0.2786 0.2786
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0005 0.0016 0.0016
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.026 0.8072 0.8072
Echinococcus granulosus GPCR family 2 0.0015 0.0329 0.0329
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.026 0.8072 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0042 0.1197 0.1482
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.1197 0.1197
Schistosoma mansoni myelin transcription factor 1 myt1 0.0051 0.1486 0.1486
Brugia malayi RING finger protein 20 0.0005 0.0016 0.002
Brugia malayi hypothetical protein 0.0005 0.0016 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.2786 1
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0061 0.1781 0.1781
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0118 0.0118
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0045 0.1289 0.158
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0008 0.0118 0.0126
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0093 0.2786 1
Toxoplasma gondii ran binding protein 0.0093 0.2786 0.3438
Echinococcus multilocularis ring finger protein 113a 0.0005 0.0016 0.0016
Loa Loa (eye worm) mbt repeat family protein 0.0045 0.1289 0.1597
Onchocerca volvulus 0.0093 0.2786 0.3438
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0008 0.0118 0.0146
Leishmania major hypothetical protein, conserved 0.0093 0.2786 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0051 0.1486 0.1486
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.026 0.8072 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0045 0.1289 0.1289
Schistosoma mansoni rnf5 0.0005 0.0016 0.0016
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0865 0.1071
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0008 0.0118 0.0146
Trypanosoma cruzi WLM domain containing protein, putative 0.0093 0.2786 1
Entamoeba histolytica hypothetical protein 0.0005 0.0016 0.5
Schistosoma mansoni hypothetical protein 0.0093 0.2786 0.2786
Onchocerca volvulus 0.0093 0.2786 0.3438
Echinococcus multilocularis ring finger protein 170 0.0005 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0008 0.0118 0.0146
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0093 0.2786 0.3438
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0005 0.0016 0.0016
Brugia malayi Zinc finger protein 183 homolog 0.0005 0.0016 0.002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0042 0.1197 0.1482
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0051 0.1486 0.1486
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0006 0.0044 0.0044
Schistosoma mansoni ring finger protein 151 0.0005 0.0016 0.0016
Brugia malayi YY1-associated factor 2 0.0093 0.2786 0.3452
Schistosoma mansoni TRABID protein (C64 family) 0.0093 0.2786 0.2786
Loa Loa (eye worm) hypothetical protein 0.0093 0.2786 0.3452
Toxoplasma gondii histone lysine methyltransferase SET1 0.0043 0.1216 0.1489
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0029 0.0016
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0005 0.0016 0.0016
Echinococcus granulosus ring and YY1 binding protein 0.0093 0.2786 0.2786
Echinococcus multilocularis polycomb protein SCMH1 0.0045 0.1289 0.1289
Loa Loa (eye worm) hypothetical protein 0.022 0.6787 0.8407
Loa Loa (eye worm) hypothetical protein 0.0032 0.0865 0.1071
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0008 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.002
Entamoeba histolytica zinc finger domain containing protein 0.0005 0.0016 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0029 0.0016
Entamoeba histolytica zinc finger domain containing protein 0.0005 0.0016 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.1197 0.1197
Brugia malayi Neuralized family protein 0.0005 0.0016 0.002
Schistosoma mansoni RAR-like nuclear receptor 0.0008 0.0118 0.0118
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.026 0.8072 1
Brugia malayi mbt repeat family protein 0.0045 0.1289 0.1597
Brugia malayi hypothetical protein 0.0005 0.0016 0.002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0005 0.0029 0.0016
Loa Loa (eye worm) hypothetical protein 0.0093 0.2786 0.3452
Trichomonas vaginalis conserved hypothetical protein 0.026 0.8072 1
Entamoeba histolytica zinc finger domain containing protein 0.0005 0.0016 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 0.1486 0.1841
Echinococcus granulosus Upstream activation factor subunit UAF30 0.026 0.8072 0.8072
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0329 0.0329
Echinococcus granulosus SAM and MBT domain containing protein 0.0045 0.1289 0.1289
Schistosoma mansoni retinoic acid receptor RXR 0.0008 0.0118 0.0118
Echinococcus granulosus mixed lineage leukemia protein mll 0.0006 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0032 0.0865 0.0865
Brugia malayi F/Y-rich N-terminus family protein 0.0007 0.0085 0.0105
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.002
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0093 0.2786 1
Schistosoma mansoni hypothetical protein 0.026 0.8072 0.8072
Schistosoma mansoni hypothetical protein 0.0274 0.851 0.851
Trypanosoma brucei hypothetical protein, conserved 0.0093 0.2786 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.2786 0.3452
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0093 0.2786 0.3452
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0088 0.0088
Echinococcus granulosus ecdysone induced protein 78C 0.0008 0.0118 0.0118
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0093 0.2786 0.3452
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0118 0.0146
Echinococcus multilocularis survival motor neuron protein 1 0.022 0.6787 0.6787
Loa Loa (eye worm) hypothetical protein 0.0046 0.1326 0.1643
Brugia malayi hypothetical protein 0.0005 0.0016 0.002
Loa Loa (eye worm) RING finger protein 20 0.0005 0.0016 0.002
Echinococcus multilocularis 0.0005 0.0016 0.0016
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0005 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0045 0.1279 0.1279
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0005 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.026 0.8072 0.8072
Loa Loa (eye worm) brahma associated protein 0.026 0.8072 1
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0005 0.0016 0.0016
Echinococcus granulosus ring finger protein 170 0.0005 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0008 0.0118 0.0146
Schistosoma mansoni fusion 0.0093 0.2786 0.2786
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0008 0.0118 0.0118
Brugia malayi hypothetical protein 0.0005 0.0016 0.002
Leishmania major hypothetical protein, conserved 0.0093 0.2786 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.026 0.8072 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0008 0.0118 0.0118
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0118 0.0118
Brugia malayi B-box zinc finger family protein 0.0005 0.0016 0.002
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0093 0.2786 0.2786
Loa Loa (eye worm) TTK protein kinase 0.0061 0.1781 0.2207
Echinococcus multilocularis geminin 0.0117 0.356 0.356
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0029 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0008 0.0118 0.0118
Brugia malayi Protein kinase domain containing protein 0.0061 0.1781 0.2207
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.1781 0.2191
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0008 0.0118 0.0118
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.026 0.8072 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0008 0.0118 0.0146
Schistosoma mansoni cpg binding protein 0.0024 0.062 0.062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.1197 0.1197
Schistosoma mansoni hypothetical protein 0.0015 0.0329 0.0329
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0118 0.0118
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0093 0.2786 1
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.2786 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0118 0.0118
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0006 0.0044 0.0044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0118 0.0146
Schistosoma mansoni peter pan-related 0.0005 0.0016 0.0016
Entamoeba histolytica zinc finger domain containing protein 0.0005 0.0016 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0329 0.0408
Plasmodium vivax hypothetical protein, conserved 0.026 0.8072 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.1197 0.1197
Onchocerca volvulus 0.0093 0.2786 0.3438
Loa Loa (eye worm) hypothetical protein 0.0093 0.2786 0.3452
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0029 0.0016
Schistosoma mansoni hypothetical protein 0.0005 0.0016 0.0016
Brugia malayi hypothetical protein 0.022 0.6787 0.8407
Schistosoma mansoni sex comb on midleg homolog 0.0045 0.1289 0.1289
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0329 0.0408
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0008 0.0118 0.0118
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0008 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.002
Schistosoma mansoni mind bomb 0.0005 0.0016 0.0016
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0005 0.0016 0.0016
Onchocerca volvulus Protein ultraspiracle homolog 0.0008 0.0118 0.0126
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0008 0.0118 0.0118
Schistosoma mansoni brg-1 associated factor 0.026 0.8072 0.8072
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0005 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0008 0.0118 0.0146
Brugia malayi photoreceptor-specific nuclear receptor 0.0008 0.0118 0.0146
Onchocerca volvulus 0.0093 0.2786 0.3438
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0008 0.0118 0.0146
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0051 0.1486 0.1841
Echinococcus granulosus SWI:SNF matrix associated 0.026 0.8072 0.8072
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0093 0.2786 1
Brugia malayi steroid hormone receptor 0.0008 0.0118 0.0146
Onchocerca volvulus 0.0023 0.0579 0.0699
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.0008 0.0118 0.0146
Brugia malayi nuclear receptor NHR-88 0.0008 0.0118 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0118 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0029 0.0016
Schistosoma mansoni hypothetical protein 0.0015 0.0329 0.0329
Brugia malayi brahma associated protein 60 kDa 0.026 0.8072 1
Echinococcus multilocularis SWI:SNF matrix associated 0.026 0.8072 0.8072
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.002
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0093 0.2786 0.3452
Echinococcus granulosus polycomb protein SCMH1 0.0045 0.1289 0.1289
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0329 0.0329
Leishmania major hypothetical protein, conserved 0.0093 0.2786 1
Brugia malayi nuclear hormone receptor 0.0008 0.0118 0.0146
Schistosoma mansoni zinc finger protein 0.0005 0.0016 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.1197 0.1197
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0329 0.0408
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0329 0.0329
Entamoeba histolytica hypothetical protein 0.0005 0.0016 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0008 0.0118 0.0146
Echinococcus granulosus ring finger protein 113a 0.0005 0.0016 0.0016
Entamoeba histolytica zinc finger domain containing protein 0.0005 0.0016 0.5
Brugia malayi brahma associated protein 60 kDa 0.026 0.8072 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0008 0.0118 0.0146
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0008 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.026 0.8072 0.8072
Brugia malayi hypothetical protein 0.0005 0.0016 0.002
Trypanosoma brucei hypothetical protein, conserved 0.0093 0.2786 1
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0093 0.2786 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0118 0.0146
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0329 0.0329
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0118 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0008 0.0118 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0029 0.0016
Echinococcus granulosus FTZ F1 alpha 0.031 0.9645 0.9645
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0118 0.0146
Onchocerca volvulus Bile acid receptor homolog 0.0008 0.0118 0.0126
Onchocerca volvulus 0.026 0.8072 1
Entamoeba histolytica zinc finger domain containing protein 0.0005 0.0016 0.5
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0061 0.1781 0.1781
Brugia malayi ecdysteroid receptor 0.0008 0.0118 0.0146
Echinococcus granulosus survival motor neuron protein 1 0.022 0.6787 0.6787
Schistosoma mansoni sex comb on midleg homolog 0.0045 0.1289 0.1289
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0118 0.0118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0029 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0118 0.0146
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0178 0.547 0.547
Echinococcus multilocularis histone acetyltransferase MYST2 0.0051 0.1486 0.1486
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0048 0.1377 0.1377
Echinococcus multilocularis ecdysone induced protein 78C 0.0008 0.0118 0.0118
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0008 0.0118 0.0118
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0005 0.0016 0.0016
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0008 0.0118 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.2786 1
Giardia lamblia Kinase, NEK 0.0005 0.0028 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0029 0.0016
Schistosoma mansoni cpg binding protein 0.0024 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0008 0.0118 0.0146
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0028 0.0028
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0118 0.0146
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0093 0.2786 0.3438
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.1781 0.2191
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.1326 0.1643
Schistosoma mansoni hypothetical protein 0.0117 0.356 0.356
Giardia lamblia Kinase, TTK 0.0061 0.1781 1
Schistosoma mansoni cpg binding protein 0.0023 0.0579 0.0579
Echinococcus multilocularis RING finger protein 185 0.0005 0.0016 0.0016
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0005 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0008 0.0118 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0008 0.0118 0.0146
Chlamydia trachomatis SWIB complex protein 0.026 0.8072 0.5
Leishmania major hypothetical protein, conserved 0.0093 0.2786 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0118 0.0146
Schistosoma mansoni zinc finger protein 0.0093 0.2786 0.2786
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0008 0.0118 0.0146
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0329 0.0408
Echinococcus granulosus RING finger protein 185 0.0005 0.0016 0.0016
Echinococcus granulosus cell growth regulator with ring finger domain 0.0005 0.0016 0.0016
Loa Loa (eye worm) MBCTL1 0.0051 0.1486 0.1841
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0029 0.0016
Brugia malayi hypothetical protein 0.0005 0.0016 0.002
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0093 0.2786 1
Brugia malayi RING zinc finger protein 0.0005 0.0016 0.002
Giardia lamblia Kinase 0.0005 0.0028 0.0069
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0005 0.0016 0.0016
Schistosoma mansoni steroid hormone receptor ad4bp 0.0008 0.0118 0.0118
Brugia malayi Zinc finger, C2H2 type family protein 0.0005 0.0016 0.002
Leishmania major hypothetical protein, conserved 0.0093 0.2786 1
Brugia malayi mbt repeat family protein 0.0045 0.1289 0.1597
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.002
Brugia malayi SWIB/MDM2 domain containing protein 0.026 0.8072 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0118 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0029 0.0016
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0093 0.2786 1
Loa Loa (eye worm) histone methyltransferase 0.0007 0.0088 0.0109
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0029 0.0016
Echinococcus multilocularis SWI:SNF matrix associated 0.026 0.8072 0.8072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0008 0.0118 0.0146
Schistosoma mansoni hypothetical protein 0.0322 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0029 0.0016
Echinococcus granulosus zinc finger protein Ran binding 0.0093 0.2786 0.2786
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.1197 0.1197
Schistosoma mansoni survival motor neuron protein 0.0045 0.1279 0.1279
Echinococcus multilocularis SWI:SNF matrix associated 0.026 0.8072 0.8072
Loa Loa (eye worm) hypothetical protein 0.0008 0.0118 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0008 0.0118 0.0146
Schistosoma mansoni hypothetical protein 0.0005 0.0016 0.0016
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0061 0.1781 0.1781
Echinococcus granulosus geminin 0.0117 0.356 0.356
Echinococcus multilocularis thyroid hormone receptor alpha 0.0008 0.0118 0.0118
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0093 0.2786 0.3438
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0118 0.0146
Schistosoma mansoni RNA binding protein 0.0093 0.2786 0.2786
Entamoeba histolytica zinc finger domain containing protein 0.0005 0.0016 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0118 0.0146
Onchocerca volvulus 0.0008 0.0118 0.0126
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0008 0.0118 0.0118
Echinococcus multilocularis zinc finger protein Ran binding 0.0093 0.2786 0.2786
Schistosoma mansoni hypothetical protein 0.0015 0.0329 0.0329
Echinococcus granulosus Zinc finger RanBP2 type 0.0093 0.2786 0.2786
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0178 0.547 0.547
Entamoeba histolytica zinc finger domain containing protein 0.0005 0.0016 0.5
Entamoeba histolytica SPRY domain protein 0.0005 0.0016 0.5
Chlamydia trachomatis DNA topoisomerase I 0.026 0.8072 0.5
Schistosoma mansoni coup transcription factor 0.0008 0.0118 0.0118
Brugia malayi Steroid receptor seven-up type 2 0.0008 0.0118 0.0146
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0093 0.2786 0.3452
Echinococcus multilocularis GPCR, family 2 0.0015 0.0329 0.0329
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0118 0.0118
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.1326 0.1643
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.0579 0.0717
Schistosoma mansoni peter pan-related 0.0005 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0117 0.356 0.356
Schistosoma mansoni hypothetical protein 0.0005 0.0016 0.0016
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0008 0.0118 0.0118
Echinococcus multilocularis dnaJ subfamily B 0.0322 1 1
Onchocerca volvulus 0.0045 0.1279 0.1567
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0061 0.1781 0.2191
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.1326 0.1643
Echinococcus granulosus cpg binding protein 0.0024 0.062 0.062
Echinococcus multilocularis cpg binding protein 0.0024 0.062 0.062
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0045 0.1289 0.1289
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0008 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0045 0.1289 0.1597
Onchocerca volvulus 0.0045 0.1289 0.158
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0005 0.0029 0.0016
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0005 0.0016 0.0016
Echinococcus multilocularis ring and YY1 binding protein 0.0093 0.2786 0.2786
Echinococcus multilocularis FTZ F1 alpha 0.0008 0.0118 0.0118
Echinococcus granulosus histone acetyltransferase MYST2 0.0051 0.1486 0.1486
Loa Loa (eye worm) steroid hormone receptor 0.0008 0.0118 0.0146
Trypanosoma cruzi WLM domain containing protein, putative 0.0093 0.2786 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.026 0.8072 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.1279 0.1584
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0005 0.0016 0.002

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -9 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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